CN105434867A

CN105434867A - Traditional Chinese medicine pill used for treating stress urinary incontinence, and preparation method thereof

Info

Publication number: CN105434867A
Application number: CN201510962970.4A
Authority: CN
Inventors: 夏修菲
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-18
Filing date: 2015-12-18
Publication date: 2016-03-30

Abstract

The invention discloses a traditional Chinese medicine pill used for treating stress urinary incontinence, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine pill comprises following effective ingredients: sheep kidney, codonopsis pilosula, semen astragalicomplanati, herba epimedii, cortex cinnamomi, Chinese yam, herb of cuneate lespedeza, fructus rosae laevigatae, Chinese date, rhizoma atractylodis macrocephalae, ootheca mantidis, dwarf lilyturf tuber, semen nelumbinis, radix bupleuri, flos farfarae, rhizoma corydalis, folium perillae, rhizoma alismatis, petelot habenaria, walnut kernel, fructus psoraleae, fructus rubi, liquorice, and ginkgo nut. Material selection of the traditional Chinese medicine pill is precise and appropriate; combination is reasonable; the traditional Chinese medicine is prepared based on assistant and guide principles, suits the remedy to the case, and is capable of tonifying liver and kidney, warming kidney and enhancing yang, invigorating spleen and supplementing qi, nourishing yin and moisturizing lung, warming lung and relieving asthma, soothing liver-qi stagnation, elevating yang qi, and controlling nocturnal emission and arresting polyuria, and possesses excellent absorption effects and curative effects, no toxic or side effect or clinical adverse reaction; and it is confirmed by clinical experiments that curative ratio of the traditional Chinese medicine pill on stress urinary incontinence is relatively high.

Description

A kind of medicine pill and preparation method being used for the treatment of stress incontinence

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine pill and the preparation method that are used for the treatment of stress incontinence.

Background technology

Stress incontinence (StressUrinaryIncontinence, SUI) refers to that the abdominal pressure such as sneeze or cough occurs when increasing that involuntary urine is from external orifice of urethra seepage.The abdominal pressures such as Symptoms is cough, sneeze, laugh independently do not overflow when increasing and urinate.When sign is abdominal pressure increase, can observe that urine does not independently flow out from urethra.When urodynamics test shows as filling cystometry, in abdominal pressure increase without occurring nonvoluntary leakage of urine when detrusor contractions.This disease is very common in women, and somebody, when coughing, laughing or carrying weight, urinary incontinence occurs, and also has plenty of and just urinates wet in race toward trousers on the road in lavatory, bring very large inconvenience to the Working Life of patient.

Current doctor trained in Western medicine, for the Therapeutic Principle of stress incontinence, is mainly conservative medication or adopts operation (bladder neck or the musculus sphincter of external urethra cut) to reduce urethral resistance to reduce the treatment means of residual urine.Operative treatment is large to patient body injury, may be with and serve sequela, and the general severe patient of removing does not advise using operative treatment.And Western medicine drug is bad to the therapeutic effect of stress incontinence, and side effect is large, although and some patients effective, recurrence rate is larger.

The traditional Chinese medical science is thought, primary disease mostly is deficiency of spleen and stomach, and caused by instability of kidney QI, therefore traditional Chinese medical science prescription common is at present mainly with tonifying speen and tonifying kidney, and astringency inducing ascending is main treatment.Although these Therapeutic Method are effective, take effect slowly, treatment cycle is long.The present invention verifies through Long-term clinical, thinks that the etiology and pathogenesis of urinary incontinence is wing moon bright disturbance in functioning of QI, kidney qi, insufficiency of kidney-YANG, insufficiency of the spleenly loses in transporting, the liver failing to maintain the normal flow of QI, insufficiency of lung-QI, loses a surname Yu and falls, three burnt transporting mistake departments and causing.Therefore pill of the present invention, suit the remedy to the case for the cause of disease, there is effect of the liver and the kidney tonifying, warming the kidney to activate YANG, invigorating the spleen and benefiting QI, nourishing YIN and moistening the lung, warming the lung Dingchuan, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, controlling nocturnal emission with astringent drugs reducing urination, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to stress incontinence cure rate through clinical verification.

Summary of the invention

The invention provides a kind of medicine pill and the preparation method that are used for the treatment of stress incontinence, there is effect of the liver and the kidney tonifying, warming the kidney to activate YANG, invigorating the spleen and benefiting QI, nourishing YIN and moistening the lung, warming the lung Dingchuan, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, controlling nocturnal emission with astringent drugs reducing urination, cure the disease and ask source treating both the principal and secondary aspects of a disease, to the stress incontinence that a variety of causes causes, all there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Be used for the treatment of a medicine pill for stress incontinence, raw material composition and the parts by weight of making described effective ingredient are:

Ren caprae seu ovis 72 ~ 90 parts of Radix Codonopsis 68 ~ 86 parts of Semen Astragali Complanatis 64 ~ 83 parts of Herba Epimedii 60 ~ 80 parts

Cortex Cinnamomi 57 ~ 76 portions of Rhizoma Dioscoreaes 53 ~ 72 portions of Herba Lespedezae Cuneatae 50 ~ 68 portions of Fructus Rosae Laevigatae 47 ~ 64 parts

Fructus Jujubae 44 ~ 60 parts of Rhizoma Atractylodis Macrocephalaes 41 ~ 57 parts of Ootheca Mantidiss 38 ~ 53 parts of Radix Ophiopogonis 35 ~ 50 parts

Semen Nelumbinis 32 ~ 46 parts of Radix Bupleuri 28 ~ 43 portions of Flos Farfaraees 25 ~ 40 parts of Rhizoma Corydalis 22 ~ 37 parts

Folium Perillae 20 ~ 33 portions of Rhizoma Alismatis 18 ~ 30 parts of Habenria petelotii Gagnep. 15 ~ 26 parts of semen juglandiss 12 ~ 22 parts

Fructus Psoraleae 9 ~ 18 portions of Fructus Rubies 6 ~ 14 portions of Radix Glycyrrhizaes 4 ~ 10 portions of Semen Ginkgoes 2 ~ 7 parts.

Raw material composition and the parts by weight of making described effective ingredient are:

Ren caprae seu ovis 75 ~ 86 parts of Radix Codonopsis 72 ~ 82 parts of Semen Astragali Complanatis 68 ~ 80 parts of Herba Epimedii 64 ~ 76 parts

Cortex Cinnamomi 60 ~ 73 portions of Rhizoma Dioscoreaes 57 ~ 69 portions of Herba Lespedezae Cuneatae 53 ~ 64 portions of Fructus Rosae Laevigatae 50 ~ 60 parts

Fructus Jujubae 46 ~ 57 parts of Rhizoma Atractylodis Macrocephalaes 44 ~ 53 parts of Ootheca Mantidiss 42 ~ 50 parts of Radix Ophiopogonis 38 ~ 47 parts

Semen Nelumbinis 35 ~ 43 parts of Radix Bupleuri 32 ~ 40 portions of Flos Farfaraees 28 ~ 36 parts of Rhizoma Corydalis 25 ~ 34 parts

Folium Perillae 23 ~ 30 portions of Rhizoma Alismatis 21 ~ 27 parts of Habenria petelotii Gagnep. 18 ~ 23 parts of semen juglandiss 15 ~ 20 parts

Fructus Psoraleae 12 ~ 15 portions of Fructus Rubies 8 ~ 12 portions of Radix Glycyrrhizaes 5 ~ 8 portions of Semen Ginkgoes 3 ~ 5 parts.

Ren caprae seu ovis 83 parts of Radix Codonopsis 78 parts of Semen Astragali Complanatis 75 parts of Herba Epimedii 72 parts

Cortex Cinnamomi 68 portions of Rhizoma Dioscoreaes 64 portions of Herba Lespedezae Cuneatae 60 portions of Fructus Rosae Laevigatae 56 parts

Fructus Jujubae 53 parts of Rhizoma Atractylodis Macrocephalaes 49 parts of Ootheca Mantidiss 46 parts of Radix Ophiopogonis 43 parts

Semen Nelumbinis 39 parts of Radix Bupleuri 36 portions of Flos Farfaraees 33 parts of Rhizoma Corydalis 30 parts

Folium Perillae 27 portions of Rhizoma Alismatis 24 parts of Habenria petelotii Gagnep. 21 parts of semen juglandiss 17 parts

Fructus Psoraleae 13 portions of Fructus Rubies 10 portions of Radix Glycyrrhizaes 7 portions of Semen Ginkgoes 4 parts.

Be used for the treatment of a preparation method for the medicine pill of stress incontinence, comprise following processing step:

(1) Ren caprae seu ovis, Semen Astragali Complanati, Cortex Cinnamomi, Herba Lespedezae Cuneatae, Radix Bupleuri, Fructus Rosae Laevigatae, Fructus Jujubae, Ootheca Mantidis, Radix Ophiopogonis, Semen Nelumbinis, Flos Farfarae, Folium Perillae, Habenria petelotii Gagnep., semen juglandis, Fructus Psoraleae, Fructus Rubi, Radix Glycyrrhizae, Semen Ginkgo are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) Radix Codonopsis, Herba Epimedii are put into container, add the shao-hsing rice wine of 3 ~ 5 times amount, cool after boiling, continue immersion 3 ~ 5 hours, get immersion; In remaining medicinal residues, add the shao-hsing rice wine of 2 ~ 4 times amount again, put after boiling and dry in the air, continue immersion 2 ~ 4 hours, get immersion; Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10 ~ 1.20, for subsequent use;

(3) first by even for wheat bran spreading in hot pot, cigarette of waiting rises, add yam slice stir to faint yellow for degree, take out, sieve remove wheat bran, cool, dry, pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(4) by the Rhizoma Atractylodis Macrocephalae clean put into iron pan, the micro-stir-fry of slow fire, fry to epidermis turn yellow after, spray Ji Me Lao Jiu, continue fry sallow to epidermis after, taking-up cools, and pulverizing is ground into powder, cross 120 order dusting covers, obtain fine powder, for subsequent use;

(5) dry clean for Rhizoma Corydalis, add quantitative rice vinegar and mix thoroughly, after moistening to vinegar is sucked, put in parch container, heat fried dry with slow fire, taking-up is dried, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) clean for Rhizoma Alismatis drying is put into iron pan, spray and mix thoroughly, moistening with quantitative saline, the micro-stir-fry of slow fire is slightly now yellow to performance, and taking-up is dried, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of 6 parts every.

The property of medicine of the present invention's Chinese medicine used is as follows:

Ren caprae seu ovis: sweet in the mouth; Warm in nature.Return kidney channel.The kidney invigorating; Benefit essence.Cure mainly strain of suffering from a deficiency of the kidney; Spinal column cold type of pain; Foot and knee flaccidity; Tinnitus; Deaf; Quench one's thirst; Sexual impotence; Spermatorrhea; Frequent micturition; The enuresis." Japan hanako materia medica ": tonify deficiency is deaf, cloudy weak, tonifying YANG stomach reinforcing, only urine.Control deficient night sweat.

Radix Codonopsis: sweet in the mouth; Property is put down.Return spleen; Lung meridian.Strengthening the spleen and tonifying the lung; Supplementing QI for promoting the production of body fluid.Cure mainly weakness of the spleen and stomach; Anorexia and loose stool; Limbs fatigue; The deficiency of the lung is breathed with cough; To breathe hard spontaneous perspiration; The all cards of deficiency of both QI and blood." moral joins book on Chinese herbal medicine " carries: " lung heat clearing gold, invigorating primordial QI, opens sound, helps biceps." modern medicine study confirms; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; on excited and suppress two kinds of nervous process to have impact, can raise erythrocyte, hemoglobin, reticulocyte, also have the effect of slow down aging and antioxidation, radioprotective, blood pressure lowering.

Semen Astragali Complanati: sweet in the mouth, warm in nature.Return liver, kidney channel.Temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision." Bencao Congxin ": " the kidney invigorating, reinforcing YIN-essence, benefit essence, improving eyesight.Control leukorrhagia, anal fistula, cloudy Huang.Performance controlling nocturnal emission with astringent drugs." " about can cure mirror ": " only loses drop, hematuria, urine reducing."

Herba Epimedii: acrid in the mouth; Sweet; Warm in nature.Enter liver; Kidney two warp.Kidney invigorating and YANG supporting; Expelling wind and removing dampness; Strengthening the tendons and bones.Cure mainly soreness of the waist and knees; Rheumatic arthralgia; Hemiplegia; Extremity are meciless." Bencao Jingshu " carries: " kidney tonifying liver then muscles and bones is certainly hard for liver governing tendons, kidney governing bones.Pungent can eliminating stagnation, in Gan Nenghuan, temperature can be ventilated promoting the circulation of blood, therefore the red carbuncle of main scrofula, and skin ulcer is arranged at bottom, washes out worm." modern medicine study confirmation; Herba Epimedii has more significant inhibitory action to Staphylococcus albus, staphylococcus aureus; have slight inhibitory action to Nai Shi micrococcus catarrhalis, Diplococcus pneumoniae, hemophilus influenza; can reduce red blood cell hematocrit; accelerate erythrocyte sedimentation rate; reduce whole blood contrast viscosity, improves DNA synthetic ratio.

Cortex Cinnamomi: acrid in the mouth; Bitter; Hot in nature.Enter kidney; Spleen; The heart; Liver Channel.Mend fire supporing yang; Let the fire back to its origin; Dispersing cold for relieving pain; Warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire; Aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; To lose heart dyspnea with rapid and short breath; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Dizziness and tinnitus; Dispute gruel is broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; Decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; Dysmenorrhea amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." property of medicine opinion " carries: " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, and except cough with dyspnea, stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison." modern medicine study confirmation, Cortex Cinnamomi contains the compositions such as cinnamic aldehyde, cinnamyl acetate, acetoxyphenyl group third cheese, has the effect of fragrant stomach invigorating, antipyretic-antalgic, anti-inflammation.

Rhizoma Dioscoreae: sweet in the mouth; Property is put down.Enter lung; Spleen; Kidney channel.Spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Cure mainly diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula." book on Chinese herbal medicine just " carries: " Rhizoma Dioscoreae, energy spleen invigorating tonify deficiency, grows essence and reinforce the kidney, control weakness, treat five kinds of strain and seven kinds of impairment." modern medicine study confirms, Rhizoma Dioscoreae can reduce blood glucose, regulates body to non-specific irritant reaction, and effectively the Immunosuppression effect of antagonism cyclophosphamide, stimulates intestinal motility, promotes that intestinal contents is emptying, in addition can also aid digestion, antidiarrheal, eliminate the phlegm.

Herba Lespedezae Cuneatae: bitter in the mouth, puckery, cool in nature.Return lung; Liver; Kidney channel.The kidney invigorating arresting seminal emission; Invigorating spleen to remove dampness; Supplement phlegm and relieving cough; Heat-clearing and toxic substances removing.Cure mainly and suffer from a deficiency of the kidney; Seminal emission; The enuresis; Frequent micturition; Nebulousurine; Leukorrhagia; Have loose bowels; Dysentery; Edema; Infantile malnutrition; Cough and asthma; Traumatic injury; Conjunctival congestion and swelling pain; Carbuncle pyogenic infections from tumour or sore; Insect-bite." Traditional Chinese Medicine in Sichuan will ": control the weak enuresis, man's nebulousurine, woman leucorrhea, deficiency of YIN gas is weak, promoting lactation, treats infantile malnutrition.Modern study proves: Herba Lespedezae Cuneatae has cough-relieving, eliminates the phlegm, relievings asthma, the effect such as antibacterial, to the selective excitation in uterus.

Fructus Rosae Laevigatae: sour in the mouth; Puckery; Property is put down; Nontoxic.Enter kidney; Bladder; Large intestine; Spleen; Lung meridian.Controlling nocturnal emission with astringent drugs; Reducing urination; Astringing intestine to stop diarrhea; Leukorrhagia stopping.Cure mainly spermatorrhea; The enuresis; Frequent micturition; Chronic diarrhea; Chronic dysentery; Nebulousurine; Leucorrhea; Metrorrhagia; Proctoptosis; Uterine prolapse." book on Chinese herbal medicine just " carries: " born fluid, receives sweating due to debility, hold back asthenic fire, beneficial marrow, strengthening bone and muscle for emesis blood, epistaxis, and mend five and hide, nourish blood gas, flat cough, and Dingchuan is anxious, and treat palpitation with a distress feeling palpitation with fear, only the splenic diarrhea dysentery and little Shui can't help." clinic study shows; Fructus Rosae Laevigatae can suppress the spontaneous contractions of intestinal smooth; the spasmodic contraction of antagonism intestinal, smooth muscle of bladder, antagonism thoracic aorta strips contractile response, and the tannin in addition contained by Fructus Rosae Laevigatae has very high bacteriostasis to staphylococcus aureus, escherichia coli.

Fructus Jujubae: sweet in the mouth; Temperature.Return spleen; Stomach warp.Tonifying the spleen and stomach; Replenishing QI and blood; Tranquilizing mind; Battalion is adjusted to defend; And the property of medicine.Cure mainly weakness of the spleen and stomach; Insufficiency of vital energy and blood; Anorexia and loose stool; Fatigue and weakness; Palpitation and insomnia; Woman hysteria; Disharmony of nutrient QI with defensive QI." book on Chinese herbal medicine remittance speech ": Shen Shi says, and the sweet profit cream of this medicine coagulates, kind nourishing YIN sun, QI and blood, body fluid, venation, muscle Yu, bone marrow, and all are deficient, without shoulding not it.As imperial Tan Fang controls palpitation with fear palpitation with a distress feeling, dimly forgetful, will meaning stupor, spirit is not kept, or middle gas discord, poor appetite, and hundred body lazynesses are heavy, and muscle is thin, and the card that this belongs to the heart, spleen two hides unit god loss, must control it with Fructus Jujubae.Assistant Pericarpium Citri Reticulatae, adjusts the empty stagnant expectorant of the smooth middle part of gastric cavity.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Cure mainly deficiency-weakness of spleen-QI; Spiritlessness and weakness; Lack of appetite abdominal distention; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Arthralgia chiefly caused by damp pathogen is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement." herbal classic is met former " carries: " art, raw with there being dehumidifying benefit dry, expectorant diuretic, controls anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer, blood between loose waist umbilicus, and chong channel is disease, the merit of inverse gas pain in the abdomen; Make ripe, have and middle QI invigorating, slake thirst and help produce saliva, hidroschesis heat extraction, enters diet, antiabortive effect." modern medicine study confirmation, the Rhizoma Atractylodis Macrocephalae has effect that is strong and raising body resistance against diseases, strengthen the phagocytic function of reticuloendothelial system, strengthen the function of leukocytes phagocytic staphylococcus aureus, leukogenic effect is had to leukopenia, improve lymhocyte transformation rate, promote cellular immune function, to staphylococcus aureus, Hemolytic streptococcus, viridans streptococci, streptococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus subtilis has inhibitory action in various degree, to acrothesium floccosum, star-shaped nocardia, trichophyton, the dermatophytess such as Trichophyton concentricunm have certain inhibitory action.

Ootheca Mantidis: sweet in the mouth; Salty; Property is put down.Return liver; Kidney; Urinary bladder channel.Controlling nocturnal emission with astringent drugs reducing urination; Reinforcing the kidney and supporting YANG.Cure mainly seminal emission; Premature ejaculation; Sexual impotence; The enuresis; Frequent micturition; Urinary incontinence; Nebulousurine; Leukorrhagia." herbal classic " carries: " main damaging the spleen and stomach, hernia abdominal mass, impotence, the raw son of benefit essence.Woman's blood closes lumbago, logical five types of stranguria, diuresis water channel." modern medicine study confirms, Ootheca Mantidis effectively can improve body's hypoxia tolerance, can reinforcing the kidney and supporting YANG, and kind controlling nocturnal emission with astringent drugs reducing urination, is used for suffer from a deficiency of the kidney turbid urine, leukorrhagia nebulousurine again.

Radix Ophiopogonis: sweet in the mouth; Micro-hardship; Cold in nature.Return lung; Stomach; Heart channel.Nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Cure mainly dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed." not Lu ": " treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, and dry mouth is thirsty, anti-nausea, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protects god, determine lung qi, settling five organs, makes us fertile and is good for."

Semen Nelumbinis: sweet in the mouth; Puckery; Property is put down.Enter the heart; Spleen; Kidney; Stomach; Liver; Urinary bladder channel.Spleen reinforcing antidiarrheal; Supplementing the kidney to control the nocturnal; Tranquilizing by nourishing the heart.Cure mainly insufficiency of the spleen chronic diarrhea; Chronic dysentery; Emission due to deficiency of the kidney; Lingering diarrhea; Incontinence of urine; Married woman's bleeding not during menses; Malaise; Palpitation with fear; Sleeplessness." detailed outline " carries: " controlling nocturnal emission with astringent drugs gas, bone and muscle strengthening, tonifying deficiency, sharp knowledge, eliminating cold-damp, only the splenic diarrhea chronic dysentery, reddish and whitish turbid urine, all disorders of blood of woman's leukorrhagia metrorrhagia, main invigorating middle warmer, reposes, physical strength profiting for kidney of laying one's heart bear, thick the intestines and stomach.”

Radix Bupleuri: bitter in the mouth; Pungent; Cold nature.Return liver; Gallbladder meridian.Induce sweat and bring down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis." detailed outline ": " control yang-energy to sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery, and headache, dizzy, and blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition." modern medicine study confirms, Radix Bupleuri has antipyretic, calm, analgesia, antitussive, antiinflammatory action.Resist hepatic injury, function of gallbladder promoting, anti-fatty liver simultaneously, and promote that enterokinesia etc. has certain effect.

Flos Farfarae: acrid in the mouth; Micro-sweet; Warm in nature.Return lung meridian.Nourishing the lung to keep the adverse QI downward; Preventing phlegm from forming and stopping coughing.Cure mainly new chronic cough to cough; Asthma; Chronic cough hemoptysis." property of medicine opinion " carries: " the main treatment lung qi heart is urged, and anxious hot weary labor, the company of coughing is without cease, and tears saliva is sticky.Control consumptive lung disease lung abscess vomiting pus." modern medicine study confirmation, Flos Farfarae has obvious antitussive, eliminates the phlegm and antiasthmatic effect, can improve the excitement levels of respiratory system, has inhibitory action to the platelet aggregation that platelet activating factor causes, and Flos Farfarae ether extracting solution has bronchorelaxing activity.Ethyl acetate ethanol extraction, the former has phlegm-dispelling functions, and ethanol has antitussive effect.

Rhizoma Corydalis: acrid in the mouth; Bitter; Warm in nature; Nontoxic.Enter liver; Stomach; The heart; Lung; Spleen channel.Invigorate blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.Cure mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury." detailed outline " carries: " stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body, among using, simply fantastic.Invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis." modern medicine study shows, Rhizoma Corydalis has significant analgesia, calmness, hypnosis, stable effect, and excited gastrointestinal smooth muscle, significantly expands coronary vasodilator, can cause the secretion of PATH, have relaxation effect to muscle.

Folium Perillae: acrid in the mouth; Warm in nature.Return lung; Spleen; Stomach warp.Expelling cold and relieving exterior syndrome; Dispersing lung-QI and dissipating phlegm; Circulation of qi promoting and in; Antiabortive; Cowfish Eriocheir sinensis poison.Cure mainly exterior syndrome due to wind-cold; Cough with copious phlegm; Gastral cavity distension; Nausea and vomiting; Stomachache is vomited and diarrhoea; Nausea is got along well; Gestation is disliked cloudy; Ichthyophagy Eriocheir sinensis is poisoning." book on Chinese herbal medicine converge with speech " carries: " cold expelling gas, lung heat clearing gas, alleviating distention in middle-JIAO gas, antiabortive gas, lower stagnation of QI, reduce phlegm gas, be control gas refreshing medicine also." modern medicine study shows, Folium Perillae Aqueous extracts can shorten blood clotting time, blood plasma recalcification time and activated partial thromboplastin time, promotes enterokinesia, in addition antipyretic, antibacterial, blood glucose increasing and sedation in addition.

Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three Jiao." modern medicine study confirmation, Rhizoma Alismatis has reduction cholesterol and atherosclerosis effect, improves liver lipid metabolism, reduces blood glucose, blood pressure, affects function of immune system, reduces serum hemolysin.

Habenria petelotii Gagnep.: sweet in the mouth; Property is put down.Return lung; Liver; Kidney channel.The kidney invigorating lung heat clearing.Cure mainly lumbago due to renal deficiency; Sexual impotence; Bed-wetting; Hernia; Cough due to lung-heat." Xinhua's book on Chinese herbal medicine outline ": cure mainly lumbago due to renal deficiency, cough due to lung-heat, traumatic hemorrhage, sexual impotence, hernia, juvenile's enuresis.

Semen juglandis: sweet in the mouth; Puckery; Warm in nature.Return kidney; Liver; Lung meridian.Tonifying the kidney to consolidate the essence; Warming the lung Dingchuan; Loosening bowel to relieve constipation.Cure mainly: lumbago flaccidity of the lower limbs; Frequent micturition; The enuresis; Sexual impotence; Seminal emission; Chronic cough dyspnea with rapid and short breath; Dryness of the intestine constipation; Stranguria caused by urinary stone and skin infection scrofula." Records of Tradition Chinese and Western Medicine in Combination ": Semen Juglandis is the key medicine of nourishing the liver and kidney, strong muscles and bones, therefore kind control pain in the lumbar region and have a pain in the leg, all bones and muscles pain.For it can the kidney invigorating, therefore can teeth consolidating tooth, black beard and hair, control asthenia and breathe heavily and cough, gas return unit, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness, frequent micturition, all cards of woman's metrorrhagia and leukorrhagia.Its property heavily fortified point that can disappear again opens the stasis of blood, controls trusted subordinate's pain, and sand Stranguria, stranguria caused by urinary stone cane plug are done to ache, and kidney loses water of can not filtering, dysuria.Modern medicine proves: the phospholipid in semen juglandis, has fine health-care effect to cranial nerve.Walnut oil contains unsaturated fatty acid, has the arteriosclerotic effect of control.Containing indispensable trace element of human body such as zinc, manganese, chromium in semen juglandis, human body zinc, Fe content in aging course day by day reduce, and chromium has promotion glucose utilization, cholesterol metabolism and the cardiovascular function of protection.The antitussive and antiasthmatic effect of semen juglandis is also fairly obvious, winter, to chronic tracheitis and asthmatics's excellent curative.

Fructus Psoraleae: acrid in the mouth; Bitter; Warm in nature.Return kidney; Pericardium; Spleen; Stomach; Lung meridian.Reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Cure mainly: insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea; Vitiligo; Speckle is bald; Psoriasis." beautiful Chinese catalpa medicine solution ": warm water and soil, digestion diet, rise reach taste, convergence lingering diarrhea, seminal emission, leukorrhagia, drown many, just slide all cards." medical center bun want ": control deficiency and coldness and breathe heavily and cough.Modern medicine study proves: Fructus Psoraleae energy coronary artery dilator, excited heart, improves Heart Pumping Power.Uterus can be shunk and shorten the bleeding time, reducing amount of bleeding.There is estrogen-like effects, vagina keratinization can be strengthened, increase uterus weight.Cause photosensitization, take orally or be coated with skin outward, through daylight or ultraviolet radiation, can localised skin pigmentation be made.Can immunity and endocrine function be strengthened, nervous system regulation function, promote bone marrow hematogenesis.Can diastole bronchial smooth muscle.In addition hemostasis, antitumor, slow down aging, antibacterial and insecticidal action is still had.

Fructus Rubi: sweet in the mouth acid; Property is put down; Nontoxic.Return liver; Kidney channel.The liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Cure mainly impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, and blurred vision is dark, early whitening of beard and hair." Kaibao Bencao ": tonify deficiency is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs, warming middle-JIAO benefit power, treats strain wind empty, tonifying liver improving eyesight.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Semen Ginkgo: sweet in the mouth; Bitter; Puckery; Property is put down; Mild toxicity.Return lung; Kidney channel.Astringing lung QI for relieving asthma; Leukorrhagia stopping reducing urination.Cure mainly asthma phlegmatic cough; Leucorrhea; Nebulousurine; Seminal emission; Frequent micturition; Innominate toxic swelling; Zha nose; Tinea skin ulcer." book on Chinese herbal medicine is just read ": gold of above astringing the lung is except cough with dyspnea, and descending turbid damp reduces phlegm saliva.

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material, the property of medicine is suitable mutually auxiliary mutually, the cause of disease such as insufficiency of kidney-YANG, asthenia of pulmonosplenic qi, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness for initiation pressure urinary incontinence is suited the remedy to the case, there is effect of the liver and the kidney tonifying, warming the kidney to activate YANG, invigorating the spleen and benefiting QI, nourishing YIN and moistening the lung, warming the lung Dingchuan, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, controlling nocturnal emission with astringent drugs reducing urination, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to stress incontinence cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

Ren caprae seu ovis 72 ~ 90g Radix Codonopsis 68 ~ 86g Semen Astragali Complanati 64 ~ 83g Herba Epimedii 60 ~ 80g

Cortex Cinnamomi 57 ~ 76g Rhizoma Dioscoreae 53 ~ 72g Herba Lespedezae Cuneatae 50 ~ 68g Fructus Rosae Laevigatae 47 ~ 64g

Fructus Jujubae 44 ~ 60g Rhizoma Atractylodis Macrocephalae 41 ~ 57g Ootheca Mantidis 38 ~ 53g Radix Ophiopogonis 35 ~ 50g

Semen Nelumbinis 32 ~ 46g Radix Bupleuri 28 ~ 43g Flos Farfarae 25 ~ 40g Rhizoma Corydalis 22 ~ 37g

Folium Perillae 20 ~ 33g Rhizoma Alismatis 18 ~ 30g Habenria petelotii Gagnep. 15 ~ 26g semen juglandis 12 ~ 22g

Fructus Psoraleae 9 ~ 18g Fructus Rubi 6 ~ 14g Radix Glycyrrhizae 4 ~ 10g Semen Ginkgo 2 ~ 7g.

The processing step of process for preparing medicine of the present invention is:

(7) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of every 6g.

Usage and dosage: oral, every day 3 times, each 2 balls, one hour ante cibum took with warm water or warm yellow wine, within 20 days, was a course for the treatment of.

Embodiment 2

Ren caprae seu ovis 75 ~ 86g Radix Codonopsis 72 ~ 82g Semen Astragali Complanati 68 ~ 80g Herba Epimedii 64 ~ 76g

Cortex Cinnamomi 60 ~ 73g Rhizoma Dioscoreae 57 ~ 69g Herba Lespedezae Cuneatae 53 ~ 64g Fructus Rosae Laevigatae 50 ~ 60g

Fructus Jujubae 46 ~ 57g Rhizoma Atractylodis Macrocephalae 44 ~ 53g Ootheca Mantidis 42 ~ 50g Radix Ophiopogonis 38 ~ 47g

Semen Nelumbinis 35 ~ 43g Radix Bupleuri 32 ~ 40g Flos Farfarae 28 ~ 36g Rhizoma Corydalis 25 ~ 34g

Folium Perillae 23 ~ 30g Rhizoma Alismatis 21 ~ 27g Habenria petelotii Gagnep. 18 ~ 23g semen juglandis 15 ~ 20g

Fructus Psoraleae 12 ~ 15g Fructus Rubi 8 ~ 12g Radix Glycyrrhizae 5 ~ 8g Semen Ginkgo 3 ~ 5g.

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

Ren caprae seu ovis 83g Radix Codonopsis 78g Semen Astragali Complanati 75g Herba Epimedii 72g

Cortex Cinnamomi 68g Rhizoma Dioscoreae 64g Herba Lespedezae Cuneatae 60g Fructus Rosae Laevigatae 56g

Fructus Jujubae 53g Rhizoma Atractylodis Macrocephalae 49g Ootheca Mantidis 46g Radix Ophiopogonis 43g

Semen Nelumbinis 39g Radix Bupleuri 36g Flos Farfarae 33g Rhizoma Corydalis 30g

Folium Perillae 27g Rhizoma Alismatis 24g Habenria petelotii Gagnep. 21g semen juglandis 17g

Fructus Psoraleae 13g Fructus Rubi 10g Radix Glycyrrhizae 7g Semen Ginkgo 4g.

Clinical data:

1, case selection

The routine clinical observation of women with stress urinary incontinence 80 selecting my institute to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 example, wherein male 13 example, women 27 example, 27 ~ 65 years old age, 42.6 years old mean age.Matched group 40 example, wherein male 11 example, women 29 example, 29 ~ 64 years old age, 41.4 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, every day 3 times, each 2 balls, and one hour ante cibum took with warm water or warm yellow wine, within 20 days, is a course for the treatment of.Matched group, according to the patient's condition of the stress incontinence diagnosed out, gives traditional doctor trained in Western medicine expectant treatment means.

3, efficacy determination:

(1) cure: clinical symptoms disappears substantially, and urinary incontinence common sympton disappears completely.

(2) take a turn for the better: clinical symptoms obviously alleviates, and degree of urine incontinence is obviously alleviated.

(3) invalid: symptom is with treating front no significant difference.

4, result

Cure 25 examples in treatment group, take a turn for the better 11 examples, invalid 4 examples, cure rate 62.5%, total effective rate 90%.

Cure 13 examples in matched group, take a turn for the better 18 examples, no effect 9, cure rate 32.5%, total effective rate 77.5%.

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is illustrated:

1, Cai's ××, female, 35 years old.This patient, after fertility, has the phenomenon of urgent micturition always, occasionally has incontinence not too serious, and nearly two months very serious, and having incontinence phenomenon when having urine meaning to hurry up at every turn, often adhere to less than toilet, is very embarrassed, painful, brings very big inconvenience to work, life.Institute went to a doctor afterwards, was diagnosed as stress incontinence, through taking medicine of the present invention, oral, every day 3 times, each 2 balls, one hour ante cibum took with warm water or warm yellow wine, it within 20 days, is a course for the treatment of, after taking 2 courses for the treatment of, urinary incontinence phenomenon disappears substantially, after continuing to take 1 course for the treatment of, urinary incontinence phenomenon disappears completely, cures.

2, Lee's ××, female, 28 years old.Patient's readme, after having given birth to child, just usually urinary incontinence, cough eh, laugh eh, even sneeze time a small amount of urine all can be had to discharge, very awkward, to work, live and bring very big inconvenience.Institute went to a doctor afterwards, was diagnosed as stress incontinence, through taking medicine of the present invention, oral, every day 3 times, each 2 balls, one hour ante cibum took with warm water or warm yellow wine, it within 20 days, is a course for the treatment of, after taking 1 course for the treatment of, urinary incontinence phenomenon is obviously alleviated, after continuing to take 1 course for the treatment of, urinary incontinence phenomenon disappears completely, cures.

Pill of the present invention sums up configuration through Long-term clinical checking to form, and suit the remedy to the case for the cause of disease, in side, the Chinese medicine such as Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae can strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; In side, the Chinese medicine such as Ren caprae seu ovis, Herba Epimedii, Cortex Cinnamomi, Fructus Psoraleae can warming the kidney to activate YANG, helping inspiration to relieve asthma; In side, the Chinese medicine such as Rhizoma Dioscoreae, Fructus Jujubae, Semen Nelumbinis can reinforcing spleen and kidney, benefiting vital QI for tranquillizing; In side the Chinese medicine such as Flos Farfarae, Radix Ophiopogonis, Folium Perillae, Semen Ginkgo, semen juglandis can nourishing the lung to keep the adverse QI downward, warming the lung Dingchuan, preventing phlegm from forming and stopping coughing; In side, Radix Bupleuri can dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; In side, the Chinese medicine such as Semen Astragali Complanati, Fructus Rosae Laevigatae, Ootheca Mantidis, Fructus Rubi can the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination; In side, all medicines share, play effect of the liver and the kidney tonifying, warming the kidney to activate YANG, invigorating the spleen and benefiting QI, nourishing YIN and moistening the lung, warming the lung Dingchuan, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, controlling nocturnal emission with astringent drugs reducing urination altogether, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to stress incontinence cure rate through clinical verification.

Claims

1. be used for the treatment of a medicine pill for stress incontinence, it is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

2. a kind of medicine pill being used for the treatment of stress incontinence according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

3. a kind of medicine pill being used for the treatment of stress incontinence according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

4. a kind of preparation method being used for the treatment of the medicine pill of stress incontinence according to claims 1 to 3, is characterized in that, comprise following processing step: