CN105412875A - Traditional Chinese medicine composition for treating dyspepsia of children - Google Patents

Traditional Chinese medicine composition for treating dyspepsia of children Download PDF

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CN105412875A
CN105412875A CN201510926165.6A CN201510926165A CN105412875A CN 105412875 A CN105412875 A CN 105412875A CN 201510926165 A CN201510926165 A CN 201510926165A CN 105412875 A CN105412875 A CN 105412875A
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chinese medicine
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郭相君
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention relates to the field of application of traditional Chinese medicines and particularly discloses a traditional Chinese medicine composition for treating dyspepsia of children. The traditional Chinese medicine composition is prepared by mixing the following raw materials according to a certain weight ratio: tetrapanax papyriferus, cluster mallow fruits, ginger peel, phaseolus calcaratus, Chinese waxgourd peel, coix seeds, rhizoma dioscoreae septemlobae, dianthus superbus, polygonum cuspidatum, rhizoma curcumae longae, selaginella tamariscina, flos albiziae, hawthorn fruits, radix gentianae, Chinese yam, radix glycyrrhizae and Chinese dates. The traditional Chinese medicine composition is simple in preparation, good in absorbing effect, and long-lasting in efficacy, has a remarkable curative effect and no side effects, is high in safety and low in production cost and facilitates symptom relief of patients in real time.

Description

A kind of Chinese medicine composition for the treatment of infantile dyspepsia
(1) technical field
The present invention relates to application in TCM field, particularly a kind of Chinese medicine composition for the treatment of infantile dyspepsia.
(2) background technology
Dyspepsia is one of child's commonly encountered diseases.Because of eating and drinking without temperance, the gastrointestinal distress that food can not be digested and assimilated and cause.Mainly because pipe intestinal digesting enzyme secretion is not enough, or wriggling function is not normal, and the digestive functional disturbance occurred or obstacle.The dyspeptic symptom of child often shows as inappetence, asthenic body, loses weight, and just rushes down smelly dirty, even repeatedly occurs diarrhoea, and often with features such as indigestion foods in stool.
Because child is in growth period, histoorgan, function are not yet ripe and sound, body opposing and toxin expelling ability relatively weak, the medicine being not suitable for taking pharmaceutical quantities large is treated.At present, the dyspeptic medicine for the treatment of child that market provides has a lot, but mostly pharmaceutical quantities is large, side effect large, therapeutic effect is not good for these medicines.Treatment cycle is grown, is not suitable for child's body healthy growth.
(3) summary of the invention
The present invention, in order to make up the deficiencies in the prior art, provides and a kind ofly prepares a kind of Chinese medicine composition for the treatment of infantile dyspepsia simple, evident in efficacy.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for infantile dyspepsia, be made up of the raw material of following parts by weight:
Medulla Tetrapanacis 10-25 gram, Semen Abutili grass 10-20 gram, CORTEX ZINGIBERIS RHIZOMAE 15-25 gram, Semen Phaseoli 15-23 gram, Exocarpium Benincasae 10-23 gram, Semen Coicis 10-21 gram of Rhizoma Dioscoreae Septemlobae 11-21 gram, Herba Dianthi 10-22 gram, Rhizoma Polygoni Cuspidati 10-23 gram, Rhizoma Curcumae Longae 10-23 gram, Herba Selaginellae 10-24 gram, Flos Albiziae 11-25 gram, Fructus Crataegi 10-23 gram, Radix Gentianae 10-22 gram, Rhizoma Dioscoreae 10-25 gram, Radix Glycyrrhizae 10-15 gram, Fructus Jujubae 10-23 gram.
The weight proportion of its preferred each raw material is:
Medulla Tetrapanacis: cold nature, sweet in the mouth, light.Return lung meridian, stomach warp.Clearing away heat and promoting diuresis, ventilation stimulating milk secretion.Belong to the stranguria-relieving diuretic of damp-clearing drug subordinate classification.With controlling damp and hot dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.Containing inositol.Another containing poly pentose about 14.3%, poly methylpentose about 3% and arabinose, glucose, fructose, lactose, pectin, galacturonic acid.Prove with sufficient sole of the foot edema method, cotton pellet method, adjuvant arthritis experiment, the isolated triterpene glucosides of methanolic extract of fresh rice-paper plant leaf has antiinflammatory action.
Semen Abutili grass: diuretic, laxation, stimulating milk secretion.Control constipation and anuresis, gonorrhea, edema, women's galactozemia, breast swell and pain.
CORTEX ZINGIBERIS RHIZOMAE: cool in nature, acrid in the mouth.Return spleen channel, lung meridian.Line water detumescence.Belong to the edema-alleviating diuretic of damp-clearing drug subordinate classification.With controlling that women's head-ornaments are impractical, extremity generalized edema with distention of the chest and abdomen, trusted subordinate's expansion, tachypnea due to upward adverseness of QI, the abdomen side of body as drum, around umbilicus feeling of distension and oppression, on capture note, indefinite, the movement of making a return journey breathes heavily weary.
Semen Phaseoli: sweet in the mouth, acid, property is put down.Return spleen channel, heart channel, small intestine meridian.Inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.Belong to the edema-alleviating diuretic in damp-clearing drug subordinate, Semen Phaseoli has effect such as enhancing cellular immunization, contraception etc.With harnessing the river, swelling is full, beriberi limb is swollen, jaundice dark coloured urine, beriberoid pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.Containing saccharide, triterpene saponin.20% Semen Phaseoli decoct has inhibitory action to staphylococcus aureus, shigella flexneri etc.Exocarpium Benincasae: sweet in the mouth, cool in nature.Return lung meridian, small intestine meridian, stomach warp.Clearing away heat and promoting diuresis, detumescence.Belong to the edema-alleviating diuretic of damp-clearing drug subordinate classification.Exocarpium Benincasae has diuresis, speed of urinating is increased, and has hypoglycemic activity.With harnessing the river, swelling is full, dysuria, summer-heat are thirsty, oliguria with reddish urine.Containing compositions such as triterpenoid compound, volatile oil, steroids.
Semen Coicis: cool in nature is sweet in the mouth, light.Return spleen channel, stomach warp, lung meridian.Invigorating spleen to remove dampness, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Belong to the stranguria-relieving diuretic of damp-clearing drug subordinate classification.With harness the river wet stop storing edema, dysuria, stranguria with turbid discharge, beriberi edema, diarrhea due to hypofunction of the spleen, the contracture of arthralgia chiefly caused by damp pathogen muscle arteries and veins, joint stuffiness or weak unable, the lung abscess of flaccidity, cough vomiting pus expectorant, acute appendicitis etc.Recent research finds that Semen Coicis is humidogene crop, under the cultivation technique of paddy field, similar to Oryza sativa L., can significantly increase production.Its kernel, containing coixenolide, Coixol etc., also generally believes that the satisfied fatty acid of certain proportioning in Semen Coicis plays a major role at anticancer aspect at present.Pharmacological evaluation also proves, this product has effects such as suppressing Skeletal Muscle Contraction, antipyretic, analgesia, antiinflammatory, antitumor and enhancing immunologic function; Slightly can also reduce blood glucose.
Rhizoma Dioscoreae Septemlobae: property is put down, bitter in the mouth.Return kidney channel, stomach warp.Dampness removing is turbid, dispel the wind blood stasis dispelling.Belong to the stranguria-relieving diuretic of damp-clearing drug subordinate classification.With dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, muscle arteries and veins joint stuffiness; Stranguria marked by chyluria, pyretic stranguria, stranguria caused by urinary stone, dysuria; The turbid urine of damp-heat in the spleen and stomach bet; Leukorrhagia, seminal emission etc. caused by damp invasion of lower energizer.Containing dioscin, Gracillin, protodioscin, former Gracillin and methyl Gracillin.After saponin hydrolysis, main diosgenin.Pharmacological research shows, this product is formed with inhibitory action to atheromatous plaque, can reduce the incidence rate of atheromatous plaque.Significant curative effect is had by its compound treatment chronic prostatitis and dermatosis bleb skin ulcer of going out.
Herba Dianthi: cold in nature, bitter in the mouth.GUIXIN warp, small intestine meridian.Inducing diuresis for treating stranguria syndrome, removing blood stasis stimulate the menstrual flow.Belong to the stranguria-relieving diuretic of damp-clearing drug subordinate classification.Be decocted in water for oral dose or enter ball and fall apart.External is ground into powder and is dressed.With controlling pyretic stranguria, stranguria caused by urinary stone, urinary obstruction, the puckery pain of pouring drop, menstruation apolipsis.Containing saponin, saccharide vitamin A sample material.Herb is still containing a small amount of alkaloid.Pharmacological research shows, has the effect of diuresis, blood pressure lowering.Inhibitory action is had to staphylococcus aureus, escherichia coli, Bacillus typhi, shigella flexneri, bacillus pyocyaneus.
Rhizoma Polygoni Cuspidati: cold nature, mildly bitter flavor.Return Liver Channel, gallbladder meridian, lung meridian.Expelling wind and removing dampness, eliminating stasis to stop pain, relieving cough and resolving phlegm.The damp-excreting anti-icteric medicinal of classifying under belonging to damp-clearing drug.With controlling arthralgia, amenorrhea, jaundice due to damp-heat, chronic bronchitis, hyperlipidemia, burn and scald, injury from falling down etc.Containing anthraquinone derivatives, can 2.1010 be reached according to analysis total amount, based on sequestered (1.4%), conjunction type content lower (0.6%).And containing stilbene compound resvertrol (i.e. resveratrol) and glycosides resvertrol glycosides (i.e. polygonin) etc. thereof, containing a certain amount of tannin, multiple flavone compound.The content of Useful UV spectrophotography, thin layer chromatography scanning, rp-hplc determination resveratrol, or with the content (must not 1.5% be less than in emodin) of spectrophotometry general anthraquinone.Pharmacological evaluation shows, this product energy adjusting blood lipid, can delay atherosclerotic generation and development; And the glutinous state of blood height of hyperlipidemia animal can be improved, make blood viscosity recover normal, the formation of control thrombosis and Blood stasis; And have anti-liver injury, shock, antibacterial, antitussive, blood pressure lowering, the microcirculatory effect of improvement.
Rhizoma Curcumae Longae: warm in nature, bitter in the mouth, pungent.Return spleen channel, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Belong to the blood-activating analgesic of drug for invigorating blood circulation and eliminating stasis subordinate classification.With control trusted subordinate's feeling of fullness distending pain, mass in the abdomen, women's blood stasis amenorrhea, puerperal the stasis of blood stop stomachache, traumatic injury, carbuncle etc.Main containing volatile oil and phenolic substance.Volatile oil has identified 51 kinds of compositions, based on terpenoid, mainly contains turmerone, zingerene etc.; Phenolic constituent mainly contains curcumin etc.Application thin layer one colorimetric method for determining curcumin, the content of demethoxycurcumin and bisdemethoxycurcumin, and the content applying tlc scanning determination curcumin.Pharmacological research shows, the effect such as this product protects the liver, function of gallbladder promoting, antibacterial, antiinflammatory, antitumor, anti-AIDS, antifertility, blood fat reducing.
Herba Selaginellae: property is put down, acrid in the mouth.Return Liver Channel, heart channel.Blood circulation promoting and blood stasis dispelling, hemostasis.Belong to the blood-activating and menstruation-regulating medicinal of drug for invigorating blood circulation and eliminating stasis subordinate classification.For women's amenorrhea, dysmenorrhea, leprosy abdominal mass, gastral cavity abdomen stasis of blood pain, traumatic injury, congestive edema, multiple hemorrhage, burn due to hot liquid or fire.Blood circulation promoting and blood stasis dispelling, raw use; Hemostasis, the black use of many stir-frys.Containing flavone, phenolic constituent and the polysaccharide such as aminoacid, trehalose, and a small amount of tannin.Flavone component has apigenin, amentoflavone, hinokiflavone and isocryptomerin.
Flos Albiziae: property is put down, sweet in the mouth.GUIXIN warp, Liver Channel.Resolving stagnation for tranquilization.Belong to the medicine for nourishing the heart and tranquilizing the mind of sedative subordinate classification.With controlling the diseases such as uneasiness, depression are not relaxed, neurasthenia, inappetence, traumatic injury, blurring of vision of sleeping night.
Fructus Crataegi: slightly warm in nature, sour in the mouth, sweet.Return spleen channel, stomach warp, Liver Channel.Digestion-promoting spleen-invigorating, circulation of qi promoting repercussive.Belong to digestants.Orally taken for curing meat stagnation, children's's infantile dyspepsia, abdominal distention, dysentery, have loose bowels, dysmenorrhea, postnatal blood stasis stomachache, hyperlipidemia etc.Main containing organic acid (citric acid and methyl ester, malic acid etc.) and flavone compound (hyperin, Quercetin, vitexin etc.).In Fructus Crataegi, organic acid is the effective ingredient of dyspepsia and intestinal stasis relieving, and flavone compound is the active component of anti-angiocardiopathy and blood fat reducing.Germany is using the medicine of hawthorn preparation as Cardiovarscular, and manned pharmacopeia, condensation flavane (flavan polymers) is one of its quality standard.Fructus Crataegi flavone or hydrolysate are in vitro or all have cardiotonic at body toad heart; Extractum, flavone or hydrolysate can increase coronary flow; Total flavones, hydrolysate, triterpenic acid tool hypotensive effect; Extract, alcohol extractum, the blood fat reducing of total triterpene acid extract energy; In addition, tool strengthens immunity, antioxidation, antibacterial action.Toxicity: total flavones mouse peritoneal injection LDso is 165 mg/kg.
Radix Gentianae: cold in nature, bitter in the mouth.Return Liver Channel, gallbladder meridian.Clearing away liver-fire, except damp and hot, stomach invigorating.The heat clearing and fire purging medicine of classifying under belonging to antipyretic.Treatment conjunctival congestion is dizzy, deaf ear swollen, tics of hypochondriac pain bitter taste, laryngopharynx swelling and pain, infantile convulsion, damp and hot sore, eczema, swelling of the vulva, pudendal pruritus, urine leaching bitterly, inappetence.The pharmacological actions such as Radix Gentianae protects the liver, function of gallbladder promoting, stomach invigorating, antiinflammatory and immunity, anti-hyperthyroidism, antibacterial, antalgic and sedative.Containing gentiopicrin, sweroside, sweroside, trace hardship when medicine ester glycosides, erythricine and gentioflavine.Gentiana manshurica is containing G. triflora glycosides, gentiopicrin and swertiamarin.
Rhizoma Dioscoreae: property is put down, sweet in the mouth.Return spleen channel, lung meridian, kidney channel.Spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Belong to the Qi-tonifying drug of qi-restoratives medicine subordinate classification.With controlling insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating, with controlling insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.Containing dopamine, Rhizoma Dioscoreae alkali, acerin II, cholesterol, ergosterol, campesterol, cupreol; Another containing free amino acid, starch, tannin, phlegmatic temperament, glycoprotein, polyphenol oxidase etc.Modern pharmacology result of the test shows, has effects such as promoting union of fracture.
Radix Glycyrrhizae: property is put down, sweet in the mouth.GUIXIN warp, stomach warp, spleen channel, lung meridian.Invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, emergency analgesic therapy, the property of medicine that is in harmonious proportion.The Qi-tonifying drug of classifying under belonging to qi-restoratives medicine.Treatment weakness of the spleen and stomach, deficiency of QI in middle-JIAO, cough and asthma, skin sore, contraction suddenly to be had a pain, is relaxed that medicine is strong, solution poison of drug in abdomen.Heat clearing away should give birth to use, and invigorating middle warmer should process use.Excess syndrome fullness in the epigastrium and abdomen abdominal distention person avoids clothes.Containing triterpene saponin, flavone, coumarin etc.Radix Glycyrrhizae has adrenocortical hormone effect, antiinflammatory, antianaphylaxis, anticancer, antibacterial, and antiviral, prevents arteriosclerosis, anti-cerebral ischemia, and prevent diabetes the effects such as complication.
Fructus Jujubae: spleen reinforcing, nourish blood, calm the nerves, regulating menstruation, go delicate fine and smooth, the liver heat removing and eyesight improving of constipation, resolving depression, reduce wrinkle, skin, lung moistening spleen invigorating, be applicable to that Liver and kidney two is empty, feeling dizzy caused by asthenia of essence and blood, the disease such as insomnia forgetfulness, emission, pneumonia in aged, sclerosis of blood vessels patient takes for a long time can life lengthening.
The present invention with spleen reinforcing, calm the nerves, inducing diuresis for treating stranguria syndrome, eliminating stasis to stop pain, raising immunity is the rule for the treatment of, multiple medical material combination is collaborative, be mainly used in invigorating spleen to remove dampness, eliminating impediment antidiarrheal, clearing away heat and discharging pus, abdominalgia with intestinal abscess, with controlling insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung breath with cough, and has significant therapeutic effect to infantile dyspepsia.
Clinical observation:
(1) clinical data
The present inventor in 2009 so far, carries out clinical observation treatment, 1 ~ 7 years old age to 296 routine infantile dyspepsia patients.
(2) Therapeutic Method
Oral, three times on the one, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 ~ 3 day, and severe case serve on 5 ~ 10 days and can fully recover.
(3) clinical effectiveness
Clinical cure 236 example (79.73%), effective 37 examples (12.50%), effective 19 examples (6.42%), invalid 4 examples (1.35%), total effective rate is 98.65%.
The present invention prepares simply, good absorbing effect, and duration of efficacy is long, evident in efficacy, has no side effect, and safety is high, and production cost is low, is conducive to sufferer and alleviates condition of illness in time.
(4) detailed description of the invention
Embodiment 1:
Get Medulla Tetrapanacis 10 grams, Semen Abutili grass 10 grams, CORTEX ZINGIBERIS RHIZOMAE 15 grams, Semen Phaseoli 15 grams, Exocarpium Benincasae 10 grams, Semen Coicis 10 grams, Rhizoma Dioscoreae Septemlobae 11 grams, Herba Dianthi 10 grams, Rhizoma Polygoni Cuspidati 10 grams, 10 grams, Rhizoma Curcumae Longae, Herba Selaginellae 10 grams, Flos Albiziae 11 grams, Fructus Crataegi 10 grams, Radix Gentianae 10 grams, Rhizoma Dioscoreae 10 grams, 10 grams, Radix Glycyrrhizae, 10 grams, Fructus Jujubae, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 2:
Get Medulla Tetrapanacis 20 grams, Semen Abutili grass 16 grams, CORTEX ZINGIBERIS RHIZOMAE 19 grams, Semen Phaseoli 18 grams, Exocarpium Benincasae 18 grams, Semen Coicis 17 grams, Rhizoma Dioscoreae Septemlobae 19 grams, Herba Dianthi 17 grams, Rhizoma Polygoni Cuspidati 20 grams, 19 grams, Rhizoma Curcumae Longae, Herba Selaginellae 20 grams, Flos Albiziae 21 grams, Fructus Crataegi 18 grams, Radix Gentianae 17 grams, Rhizoma Dioscoreae 19 grams, 12 grams, Radix Glycyrrhizae, 18 grams, Fructus Jujubae, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.
Embodiment 3:
Get Medulla Tetrapanacis 25 grams, Semen Abutili grass 20 grams, CORTEX ZINGIBERIS RHIZOMAE 25 grams, Semen Phaseoli 23 grams, Exocarpium Benincasae 23 grams, Semen Coicis 21 grams, Rhizoma Dioscoreae Septemlobae 21 grams, Herba Dianthi 22 grams, Rhizoma Polygoni Cuspidati 23 grams, 23 grams, Rhizoma Curcumae Longae, Herba Selaginellae 24 grams, Flos Albiziae 25 grams, Fructus Crataegi 23 grams, Radix Gentianae 22 grams, Rhizoma Dioscoreae 25 grams, 15 grams, Radix Glycyrrhizae, 23 grams, Fructus Jujubae, above-mentioned raw materials is cleaned up, plays powder mixing, make powder or pill.
Usage and dosage: oral, three times on the one, each 2 ~ 5g, one after each meal.

Claims (3)

1. treat a Chinese medicine composition for infantile dyspepsia, it is characterized by, be made up of the raw material of following parts by weight: Medulla Tetrapanacis 10-25 gram, Semen Abutili grass 10-20 gram, CORTEX ZINGIBERIS RHIZOMAE 15-25 gram, Semen Phaseoli 15-23 gram, Exocarpium Benincasae 10-23 gram, Semen Coicis 10-21 gram, Dioscorea septemloba Thunb. Pi 11-21 gram, Herba Dianthi 10-22 gram, Rhizoma Polygoni Cuspidati 10-23 gram, Rhizoma Curcumae Longae 10-23 gram, Herba Selaginellae 10-24 gram, Flos Albiziae 11-25 gram, Fructus Crataegi 10-23 gram, Radix Gentianae 10-22 gram, Rhizoma Dioscoreae 10-25 gram, Radix Glycyrrhizae 10-15 gram, Fructus Jujubae 10-23 gram.
2. a kind of Chinese medicine composition for the treatment of infantile dyspepsia according to claim 1, is characterized by, be made up of the raw material of following parts by weight: Medulla Tetrapanacis 10 grams, Semen Abutili grass 10 grams, CORTEX ZINGIBERIS RHIZOMAE 15 grams, Semen Phaseoli 15 grams, Exocarpium Benincasae 10 grams, Semen Coicis 10 grams, Dioscorea septemloba Thunb. Pi 11 grams, Herba Dianthi 10 grams, Rhizoma Polygoni Cuspidati 10 grams, 10 grams, Rhizoma Curcumae Longae, Herba Selaginellae 10 grams, Flos Albiziae 11 grams, Fructus Crataegi 10 grams, Radix Gentianae 10 grams, Rhizoma Dioscoreae 10 grams, 10 grams, Radix Glycyrrhizae, 10 grams, Fructus Jujubae.
3. a kind of Chinese medicine composition for the treatment of infantile dyspepsia according to claim 1 and 2, is characterized in that: described Chinese medicine is powder or pill.
CN201510926165.6A 2015-12-15 2015-12-15 Traditional Chinese medicine composition for treating dyspepsia of children Pending CN105412875A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236894A (en) * 2016-10-25 2016-12-21 徐俊杰 A kind of Chinese medicinal granule treating infantile dyspepsia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
岳勇涛等: "小儿腹泻证治5 则", 《安徽中医临床杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236894A (en) * 2016-10-25 2016-12-21 徐俊杰 A kind of Chinese medicinal granule treating infantile dyspepsia

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Application publication date: 20160323