CN104940720A - Traditional Chinese medicine pills for preventing and treating contrast-induced nephropathy and preparation method thereof - Google Patents

Abstract

The invention discloses traditional Chinese medicine pills for preventing and treating contrast-induced nephropathy. The traditional Chinese medicine pills are prepared from the following main raw materials in weight proportion: 1-5 parts of flueggea suffruticosa, 2-6 parts of prepared common monkshood daughter root, 4-10 parts of Chinese yam, 3-8 parts of cornus officinalis, 2-4 parts of coix seed, 1-3 parts of polyporus, 6-10 parts of ginseng, 1-5 parts of curculigo capitulata, 10-20 parts of fructus ligustri lucidi, 5-15 parts of angelica sinensis, 4-10 parts of circium japonicum, 10-20 parts of kelp, 7-18 parts of semen raphani, 6-14 parts of cuscuta chinensis, 8-19 parts of astragalus membranaceus and 5-7 parts of cinnamomum cassia. The traditional Chinese medicine pills have an obvious effect on contrast-induced nephropathy symptoms, not only have the effects of reinforcing the kidney and inducing diuresis, but also can regulate visceral dysfunction of the contrast-induced nephropathy fundamentally, and have good recover and conditioning effects on patients with dispiritedness caused by long illness and fatigue. According to the traditional Chinese medicine pills, most common local medicinal materials are selected and used, so that the cost is low and the economical burden of patients is relieved.

Description

A kind of medicine pill preventing and treating radiographic contrast nephropathy and preparation method thereof

Technical field

The invention belongs to traditional Chinese medicine field, especially relate to a kind of can the medicine pill preventing and treating radiographic contrast nephropathy and preparation method thereof.

Background technology

Along with extensively carrying out of modern shadowgraph technique, radiographic contrast nephropathy (CAN) receives the concern of nephropathy worker day by day.CAN refers to the hurried decline of renal function caused by contrast agent.Conventional contrast agent is generally hypertonicity, and amount of iodine, up to 37%, is not absorbed by renal tubules by glomerular filtration with original shape in vivo, and during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.The contrast agent that the cause of disease is commonly used is hypertonicity, and do not absorbed by renal tubules by glomerular filtration with original shape in vivo, during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.It is below easily cause the risk factor of renal damage and possible risk factor: 1. original renal insufficiency; 2. with the diabetes of renal insufficiency; 3. congestive heart failure; 4. nephrotic syndrome; 5. liver cirrhosis companion renal function injury; 6. hypovolemia or dehydration; 7. multiple myeloma; 8. apply other nephrotoxic drugs simultaneously; 9. multiple radiocontrast medium person is accepted in a short time; 10. hypercalcemia.

Clinical manifestation: person's serum creatinine raised usually in 24 hours to accept contrast agent, and 96 hours peakings, return to basic value after general 7 ~ 10 days.But also have report, renal function declined in Progressive symmetric erythrokeratodermia in 1 ~ 3 week, then returned to basic value.Can there is oliguria in more than 60% CAN patient, have resistance to diuretic in early days, also has non-oliguria person.Most patients renal function can clear-cutting forestland, and 10% need dialysis treatment, and irreversible renal failure person is rare, needs long term maintenance to dialyse.There is renal cells, cast and various fragment in uroscopy, non-specific in urinating as seen, uncorrelated with change in renal function.Urate crystal is common, and even visible Citric acid calcium crystallization, High-grade Proteinuria is uncommon.Have the Most patients of acute tubular necrosis, renal sodium excretion is often greater than 40mmol/L, and fractional excretion of sodium (FENa) is greater than 1%; But have 1/3 acute renal failure person renal sodium excretion lower than 20mmol/L, oliguria person's fractional excretion of sodium is less than 1%.

In the method for existing treatment chronic renal failure, application publication number CN 103961587 A(application number 201410239679.X) disclose a kind of Chinese medicine preparation for the treatment of radiographic contrast nephropathy, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are: Folium Elaeagni delavayi 34-58 part, Leontopodium leontopodioides (Willd.) Beauv. 32-56 part, Rhizoma Pinelliae 31-55 part, Semen Pharbitidis 31-55 part, Herba stellariae mediae 30-54 part, Lindera megaphylla 29-53 part, Cortex Eucommiae 29-53 part, Herba Scutellariae Barbatae 28-52 part, Semen Benincasae 28-52 part, Fructus Mahoniae 26-50 part, Herba Rorippae 25-49 part, Ptyas Korros 25-49 part, Herba Orchidis Latifoliae 23-47 part, Semen Euryales 22-46 part, Herba Eragrostidis pilosae 19-43 part, Herba Artemisiae Annuae 14-38 part.Application publication number CN 104436065 A(application number 201410789077.1) patent discloses a kind of image department treatment or prevention radiographic contrast nephropathy Chinese medicine, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Ainsliaeae ovovatae, Stigma Maydis, Ootheca Mantidis, Rhizoma Curcumae, Radix Rehmanniae, Caulis Clematidis Armandii, Ramulus et folium taxi cuspidatae, Radix Wikstroemae Indicae, Herba Hyperici Patuli, Radix Stephaniae Japonicae, Herba Sedi Multicaulis, Radix Helianthi, Herba Peperomiae Dindygulensis and Radix seu folium cipakessae cinerascentis.

As can be seen here: Chinese medicine prevention radiographic contrast nephropathy clinical symptoms, protection residual renal function, delays PD, postpones the time must dialysed with renal transplantation, is more and more subject to the attention of domestic and international medical circle.Nephropathy belongs to Chinese medicine obstruction and rejection, edema, the categories such as poison, asthenia of drowning, Chinese medicine thinks that with the passing of time this disease delays or exopathogen invasion and attack, overstrain internal injury, cause function deficient, turbid damp is stopped over, three Jiao of being jammed, ascending or descending movement of vital Qi is not normal, though the state of an illness is critical, syndrome is complicated, and deficiency in origin and excess in superficiality runs through course of disease main pathogenesis all the time.Deficiency in origin is based on spleen kidney yang (gas) void, and mark is real in turbid damp, noxious water, blood stasis, and strengthening vital QI to eliminate pathogenic factors is answered in treatment.

Summary of the invention

For the present situation of the medicine deficiency of existing control radiographic contrast nephropathy, an object of the present invention is to provide a kind of medicine pill preventing and treating radiographic contrast nephropathy fast and effectively, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.

Another object of the present invention is just to provide the preparation method of above-mentioned medicine pill.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Prevent and treat a medicine pill for radiographic contrast nephropathy, take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 1-5 part, Radix Aconiti Lateralis Preparata 2-6 part, Rhizoma Dioscoreae 4-10 part, Fructus Corni 3-8 part, Semen Coicis 2-4 part, Polyporus 1-3 part, Radix Ginseng 6-10 part, great Ye Rhizoma Curculiginis 1-5 part, Fructus Ligustri Lucidi 10-20 part, Radix Angelicae Sinensis 5-15 part, Radix Cirsii Japonici 4-10 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Raphani 7-18 part, Semen Cuscutae 6-14 part, Radix Astragali 8-19 part, Cortex Cinnamomi 5-7 part.

Prevent and treat a medicine pill for radiographic contrast nephropathy, preferred scheme, take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 2-4 part, Radix Aconiti Lateralis Preparata 3-5 part, Rhizoma Dioscoreae 6-8 part, Fructus Corni 5-7 part, Semen Coicis 2.5-3.5 part, Polyporus 1.5-2.5 part, Radix Ginseng 7-9 part, great Ye Rhizoma Curculiginis 2-4 part, Fructus Ligustri Lucidi 13-18 part, Radix Angelicae Sinensis 8-13 part, Radix Cirsii Japonici 6-8 part, Thallus Laminariae (Thallus Eckloniae) 13-18 part, Semen Raphani 10-15 part, Semen Cuscutae 8-12 part, Radix Astragali 12-17 part, Cortex Cinnamomi 5.5-6.5 part.

Prevent and treat a medicine pill for radiographic contrast nephropathy, better preferred scheme, take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 3 parts, Radix Aconiti Lateralis Preparata 4 parts, Rhizoma Dioscoreae 7 parts, Fructus Corni 6 parts, Semen Coicis 3 parts, Polyporus 2 parts, Radix Ginseng 8 parts, great Ye Rhizoma Curculiginis 3 parts, Fructus Ligustri Lucidi 15 parts, Radix Angelicae Sinensis 10 parts, Radix Cirsii Japonici 7 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Semen Raphani 12 parts, Semen Cuscutae 10 parts, the Radix Astragali 14 parts, Cortex Cinnamomi 6 parts.

The preparation process of above-mentioned control radiographic contrast nephropathy medicine pill is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 1-3 hour, obtains wine Cortex Cinnamomi and Polyporus, is placed in by wheat bran in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, stir-fry 3-8 minute repeatedly, ceases fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 80-120 mesh sieve stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer with Semen Raphani, heating 10-20 minute, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 5-10 minute slowly, take out and dry in the air cool to room temperature, it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, stir-fry 2-6 minute repeatedly, dries in the air to room temperature, and it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 50-70 minute with 50-70 DEG C, be placed in marmite and decoct with water 20-50 minute, water consumption is 2-4 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 5-10 minute and add Mel, rapid stirring becomes thick paste, thick paste is dried 10-30 minute, obtain drying object, drying object is made circle according to the preparation for processing of pill, packs and get final product.

The preparation method of above-mentioned medicine pill, 1. step adds yellow wine, slightly stewing 1.5-2.5 hour (preferably adding yellow wine, slightly stewing 2 hours).

The preparation method of above-mentioned medicine pill, 1. step drops into wine Cortex Cinnamomi and Polyporus, and stir-fry 5-7 minute (preferably drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 6 minutes) repeatedly.

The preparation method of above-mentioned medicine pill, 2. step is placed on food steamer, heating 13-18 minute, slightly within stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate to dry slowly and (be preferably placed on food steamer for 6-9 minute, heat 15 minutes, slightly within stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 7 minutes slowly).

The preparation method of above-mentioned medicine pill, 3. step drops into the crude drug handled well, and stir-fry 3-5 minute repeatedly, dries in the air to room temperature (preferably drop into the crude drug handled well, repeatedly stir-fry 4 minutes, dry in the air to room temperature).

The preparation method of above-mentioned medicine pill, step is 4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 55-65 minute with 55-65 DEG C, be placed in marmite and decoct with water 30-40 minute, water consumption is that the 2.5-3.5 of crude drug gross weight is doubly (preferably by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 60 minutes with 60 DEG C, be placed in marmite and decoct with water 35 minutes, water consumption is 3 times of crude drug gross weight).

The preparation method of above-mentioned medicine pill, 5. step fully stirs after 6-9 minute and adds Mel, and rapid stirring becomes thick paste, is dried by thick paste 15-25 minute (preferably fully stir after 8 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 20 minutes).

Using method: for making medicine pill of the present invention reach optimum therapeuticing effect, every day three times, half an hour takes after breakfast, lunch and dinner, gets 1-3 grain at every turn, uses warm water delivery service.

This medicine pill, to the Be very effective of radiographic contrast nephropathy symptom, not only has effect of the kidney invigorating, diuresis, and can also nurse one's health the viscera function disorder of radiographic contrast nephropathy from root, cause lethargy for prolonged illness, look tired person has good recovery and opsonic action.The local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.

The pharmacological effect of each crude drug is respectively:

Cacumen Securinegae Suffruticosae: base is former: be browse or the root of Euphorbiaceae Suffrutescent Securinega Twig platymiscium Suffrutescent Securinega Twig.Composition: Herb contains alkaloid: Securinine, Suffrutescent Securinega Twig alkali.Containing dihydrosecurinine in leaf, securinol A, B, securinol C picrate, Bie Securinine, Securinine; Also containing phenolic constituent: Herba Euphorbiae Helioscopiae tannin B and the nor-Bergeninum of 11-O-galloyl.Containing gallic acid etc. in stem.The property of medicine: pungent, bitter, tepor, slightly poisonous.Function cures mainly: expelling wind and activating blood circulation, the strong muscle of kidney tonifying.Cure mainly lumbago due to pathogenic wind-dampness, sexual impotence, dizzy, tinnitus, deaf, facial paralysis, poliomyelitis sequela.

Radix Aconiti Lateralis Preparata: excess of YIN due to YANG-insufficiency, real cold with pseudo-heat.Overabundance of YANG leading to deficiency of YIN, real heat with pseudo-cold and anemia of pregnant woman all prohibit clothes.Radix Aconiti Lateralis Preparata dietary function: Radix Aconiti Lateralis Preparata acrid in the mouth, sweet, hot in nature; Poisonous; GUIXIN, spleen, kidney channel; Gas hero row is loose, can rise and can fall, and walks and does not keep and have that to mend fire supporing yang, the cold dehumidifying of green bristlegrass, pain relieving cures mainly YANG-depletion for de-, cold extremities faint pulse, sexual impotence cold womb, cold limbs has a headache, YIN-fire sore throat, trusted subordinate's cold type of pain, vomiting and diarrhoea chronic dysentery, cold junction constipation, YIN-cold edema, cold long-pending hernia abdominal mass, yang deficiency diseases caused by exogenous pathogenic factor, anemofrigid-damp arthralgia, apoplexy contraction is anxious, and carbuncle of yin nature skin ulcer is leaked.

Rhizoma Dioscoreae: invigorating spleen and reinforcing stomach.Aid digestion: contained by Rhizoma Dioscoreae can diastatic diastase, be 3 times of content in Radix Raphani, edible during flatulence, there is the effect of facilitating digestion, can remove malaise symptoms, be conducive to improving taste digestive and absorptive functions, be the good merchantable brand of the medicine-food two-purpose of flat tonifying the spleen and stomach simply; Kidney nourishing and replenishing vital essence: Rhizoma Dioscoreae contains mucoprotein, the material such as amylase, saponin, free amino acid, polyphenol oxidase, and content comparatively horn of plenty, having tonic effect, is the good merchantable brand of the rehabilitation tonic after being ill, has the effect of strong body, kidney nourishing and replenishing vital essence; Lung benefiting cough-relieving: Rhizoma Dioscoreae contains saponin, lymphatic temperament, has lubrication, moist effect, thus can lung benefiting gas, support lung yin, the disease for the treatment of deficiency of the lung phlegmatic cough chronic cough; Prevention cardiovascular diseases: Rhizoma Dioscoreae is fatty hardly, and the contained mucoprotein lipidosis that can prevent cardiovascular system, prevents tremulous pulse from hardening prematurely.Rhizoma Dioscoreae contains saponin can reduce cholesterol and triglyceride, is improved effect to the disease such as hypertension and hyperlipidemia; Life lengthening: Rhizoma Dioscoreae can increase T lymphocytes in human body, strengthens immunologic function, delaying cell aging; Anti-hepatic coma: the choline contained by Rhizoma Dioscoreae is the transmitter substance relevant with learning and memory---the material base of acetylcholine, research finds that Rhizoma Dioscoreae has sedation, can resist hepatic coma; Defatting beauty: Rhizoma Dioscoreae contains various trace elements, abundant vitamin and mineral, and especially the content of potassium is higher, institute's heat content is relatively low again, often eats, and has the effect of defatting beauty.

Fructus Corni: liver and kidney tonifying; Convergence is solid de-.Cure mainly and have a dizzy spell; Deafness and tinnitus; Soreness of the waist and knees; Emission and spermatorrhea; Frequent micturition; Fructus Corni incessant sweating due to debility; Woman uterine bleeding; Interior-heat is quenched one's thirst; Warming the liver the kidney invigorating, except a wind cutting, only menorrhagia, controls senile frequent micturition.

Semen Coicis: Semen Coicis, Chinese medicine, another name Semen Coicis, NLIUGU, Semen Coicis, the Fructus Sapindi Mukouossi.For the kernel of grass Semen Coicis Coix lacryma-jobi L. var. meyuan (Romen.) Stapf.There is spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.For effect of edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.

Polyporus: economic worth: edible when sporophore children is tender, taste is very delicious.Its underground sclerotium black, various shapes are famous Chinese medicine, have diuresis to harness the river swollen effect.Containing polyporusum bellatus (glucan), test anticancer.

Radix Ginseng: effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Cure mainly: weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.

Great Ye Rhizoma Curculiginis: another name the earth palm fibre, monkey back of the body towel, monkey packet header, bamboo Ganoderma.Flavor efficacy nature and flavor are bitter, puckery, flat.Function moistening the lung and resolving phlegm, relieving cough and asthma, calm spleen invigorating, tonifying the kidney to consolidate the essence.Be applicable to dyspnea and cough due to deficiency of the kidney, soreness of waist and knee joint, leucorrhea, seminal emission.

The Radix Astragali: the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.

Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

Radix Cirsii Japonici: having another name called horse Ji, wild thorn dish, thatch mustard, is aerial parts or the root of Compositae artichoke plant Radix Cirsii Japonici.The property of medicine: sweet in the mouth, slightly cool in nature.Composition: fresh leaf contains pectolinarin; Root contains volatile oil component aplotaxene, Rhizoma Cyperi alkene, Flos Caryophylli alkene.Find according to modern pharmacological research, this medical instrument has effect of hemostasis, blood pressure lowering, the detumescence of antibacterial, clots absorbing, and for spitting blood, spitting of blood, epistaxis, has blood in stool, hematuria, and skin infection swells and ache, nephritis, eczema etc.

Thallus Laminariae (Thallus Eckloniae): base is former: be the thallus of Laminariaceae (Laminariophyceae) Larminaria plant Thallus Laminariae (Thallus Eckloniae) and the black Thallus Laminariae (Thallus Eckloniae) of Alariaceae laminaria, undaria plant Thallus Laminariae.Composition: 1. Thallus Laminariae (Thallus Eckloniae) is containing compound of polysaccharide, and mainly containing three kinds: one is alginate, is alginic acid and sodium, potassium, ammonium, calcium salt etc.; Secondly be that rock algae is according to polysaccharide; Moreover be laminarin etc.2. black Thallus Laminariae (Thallus Eckloniae) is containing alginic acid and sodium salt thereof, laminarin, mannitol, vitamin, halogenide, sulfate, phosphate, iodine and other trace element lamps.3. the full algae of Thallus Laminariae is containing compound of polysaccharide, mainly alginic acid, laminarin and lipopolysaccharide etc.The property of medicine: salty, cold.Return liver, stomach, kidney channel.Function cures mainly: softening and eliminating sputum, inducing diuresis to remove edema.Cure mainly goiter, scrofula, swelling of the scrotum, the cancer of the esophagus, beriberi edema.

Semen Raphani: pungent, sweet, flat.Gui Jing returns lung, spleen, stomach warp.Effect helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.

Semen Cuscutae: base is former: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.

Cortex Cinnamomi: base is former: be dried bark, the branch skin of Lauraceae cinnamon Cortex Cinnamomi.Composition: Cortex cinnamomi japonici (Ramulus Cinnamomi) is containing volatile oil 1.89%-2.06%, and its main component is cinnamic aldehyde, accounts for 52.92%-61.20%, also has acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, ethyl cinnamate, benzaldehyde benzyl ester, benzaldehyde, coumarin etc.The property of medicine: pungent, sweet, heat.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, dyspnea with rapid and short breath of losing heart, all diseases of edema oliguria; Decline of the fire from the gate of life, fire is Gui Yuan not, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, and dispute gruel is broken; Spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain, cold womb is infertile, dysmenorrhea amenorrhea, stomachache of being retarded by silt puerperal; Carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.

Medicine pill of the present invention is based on the principle of Chinese medicine control radiographic contrast nephropathy.The medical material selected all has effect of strengthening spleen, tonifying kidney, diuresis, for radiographic contrast nephropathy symptom, starts with from root, belongs to the prescription for the treatment of both the principal and secondary aspects of a disease.Fabulous therapeutical effect is had to radiographic contrast nephropathy.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1the medicine pill of control radiographic contrast nephropathy, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Cacumen Securinegae Suffruticosae 1 part, Radix Aconiti Lateralis Preparata 2 parts, Rhizoma Dioscoreae 4 parts, Fructus Corni 3 parts, Semen Coicis 2 parts, Polyporus 1 part, Radix Ginseng 6 parts, great Ye Rhizoma Curculiginis 1 part, Fructus Ligustri Lucidi 10 parts, Radix Angelicae Sinensis 5 parts, Radix Cirsii Japonici 4 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Semen Raphani 7 parts, Semen Cuscutae 6 parts, the Radix Astragali 8 parts, Cortex Cinnamomi 5 parts.

The medicine pill of above-mentioned control radiographic contrast nephropathy, preparation process is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 1 hour, obtain wine Cortex Cinnamomi and Polyporus, wheat bran is placed in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 3 minutes, cease fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 80 mesh sieves stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer, heat 10 minutes with Semen Raphani, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 5 minutes slowly, taking-up is dried in the air cool to room temperature, and it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, repeatedly stir-fry 2 minutes, dry in the air to room temperature, it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 50 minutes with 50 DEG C, be placed in marmite and decoct with water 20 minutes, water consumption is 2 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 5 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 10 minutes, obtains drying object, and drying object is made circle according to the preparation for processing of pill, packs and get final product.

model case one:king XX, female, 48 years old, Beijing personage.Autumn in 2013, patient examined, patient's readme: have diabetes, because of angiocardiography, after radiography 35 hours, serum creatinine raised 42% than before radiography, is diagnosed as radiographic contrast nephropathy, with anuria, cardiopalmus, be in a cold sweat and urine examination abnormal etc., follow up a case by regular visits to and start to take medicine pill of the present invention under the suggestion of doctor.

Take the present embodiment 1 gained medicine pill, every day three times, after breakfast, lunch and dinner, half an hour takes, and gets 1 at every turn, uses warm water delivery service.Treat after 3 days, anuria, cardiopalmus and the symptom such as to be in a cold sweat disappear substantially, continue to take to the 7th day, all clinical symptom disappearance, and serum creatinine returns to normal level before radiography, and cure, half a year does not recur.

embodiment 2the medicine pill of control radiographic contrast nephropathy, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Cacumen Securinegae Suffruticosae 5 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Dioscoreae 10 parts, Fructus Corni 8 parts, Semen Coicis 4 parts, Polyporus 3 parts, Radix Ginseng 10 parts, great Ye Rhizoma Curculiginis 5 parts, Fructus Ligustri Lucidi 20 parts, Radix Angelicae Sinensis 15 parts, Radix Cirsii Japonici 10 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Semen Raphani 18 parts, Semen Cuscutae 14 parts, the Radix Astragali 19 parts, Cortex Cinnamomi 7 parts.

The medicine pill of above-mentioned control radiographic contrast nephropathy, preparation process is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 3 hours, obtain wine Cortex Cinnamomi and Polyporus, wheat bran is placed in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 8 minutes, cease fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 120 mesh sieves stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer, heat 20 minutes with Semen Raphani, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 10 minutes slowly, taking-up is dried in the air cool to room temperature, and it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, repeatedly stir-fry 6 minutes, dry in the air to room temperature, it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 70 minutes with 70 DEG C, be placed in marmite and decoct with water 50 minutes, water consumption is 4 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 10 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 30 minutes, obtains drying object, and drying object is made circle according to the preparation for processing of pill, packs and get final product.

embodiment 3the medicine pill of control radiographic contrast nephropathy, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Cacumen Securinegae Suffruticosae 2 parts, Radix Aconiti Lateralis Preparata 3 parts, Rhizoma Dioscoreae 6 parts, Fructus Corni 5 parts, Semen Coicis 2.5 parts, Polyporus 1.5 parts, Radix Ginseng 7 parts, great Ye Rhizoma Curculiginis 2 parts, Fructus Ligustri Lucidi 13 parts, Radix Angelicae Sinensis 8 parts, Radix Cirsii Japonici 6 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Semen Raphani 10 parts, Semen Cuscutae 8 parts, the Radix Astragali 12 parts, Cortex Cinnamomi 5.5 parts.

The medicine pill of above-mentioned control radiographic contrast nephropathy, preparation process is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 1.5 hours, obtain wine Cortex Cinnamomi and Polyporus, wheat bran is placed in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 5 minutes, cease fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 90 mesh sieves stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer, heat 13 minutes with Semen Raphani, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 6 minutes slowly, taking-up is dried in the air cool to room temperature, and it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, repeatedly stir-fry 3 minutes, dry in the air to room temperature, it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 55 minutes with 55 DEG C, be placed in marmite and decoct with water 30 minutes, water consumption is 2.5 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 6 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 15 minutes, obtains drying object, and drying object is made circle according to the preparation for processing of pill, packs and get final product.

model case two:woods XX, man, 50 years old, Chengyang District, Qingdao of Shandong province.Be engaged in accountancy always, have diabetes, because of angiocardiography, after radiography 40 hours, serum creatinine raises 43% than before radiography, is diagnosed as radiographic contrast nephropathy, with anuria, cardiopalmus, be in a cold sweat and urine examination abnormal etc., follow up a case by regular visits to and start to take medicine pill of the present invention under the suggestion of doctor.

Take the present embodiment 3 gained medicine pill, every day three times, after breakfast, lunch and dinner, half an hour takes, and gets 1 at every turn, uses warm water delivery service.Treat after 3 days, anuria, cardiopalmus and the symptom such as to be in a cold sweat disappear substantially, continue to take to the 7th day, all clinical symptom disappearance, and serum creatinine returns to normal level before radiography, and cure, half a year does not recur.

embodiment 4the medicine pill of control radiographic contrast nephropathy, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Cacumen Securinegae Suffruticosae 4 parts, Radix Aconiti Lateralis Preparata 5 parts, Rhizoma Dioscoreae 8 parts, Fructus Corni 7 parts, Semen Coicis 3.5 parts, Polyporus 2.5 parts, Radix Ginseng 9 parts, great Ye Rhizoma Curculiginis 4 parts, Fructus Ligustri Lucidi 18 parts, Radix Angelicae Sinensis 13 parts, Radix Cirsii Japonici 8 parts, Thallus Laminariae (Thallus Eckloniae) 18 parts, Semen Raphani 15 parts, Semen Cuscutae 12 parts, the Radix Astragali 17 parts, Cortex Cinnamomi 6.5 parts.

The medicine pill of above-mentioned control radiographic contrast nephropathy, preparation process is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 2.5 hours, obtain wine Cortex Cinnamomi and Polyporus, wheat bran is placed in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 7 minutes, cease fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 110 mesh sieves stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer, heat 18 minutes with Semen Raphani, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 9 minutes slowly, taking-up is dried in the air cool to room temperature, and it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, repeatedly stir-fry 5 minutes, dry in the air to room temperature, it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 65 minutes with 65 DEG C, be placed in marmite and decoct with water 40 minutes, water consumption is 3.5 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 9 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 25 minutes, obtains drying object, and drying object is made circle according to the preparation for processing of pill, packs and get final product.

embodiment 5the medicine pill of control radiographic contrast nephropathy, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Cacumen Securinegae Suffruticosae 3 parts, Radix Aconiti Lateralis Preparata 4 parts, Rhizoma Dioscoreae 7 parts, Fructus Corni 6 parts, Semen Coicis 3 parts, Polyporus 2 parts, Radix Ginseng 8 parts, great Ye Rhizoma Curculiginis 3 parts, Fructus Ligustri Lucidi 15 parts, Radix Angelicae Sinensis 10 parts, Radix Cirsii Japonici 7 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Semen Raphani 12 parts, Semen Cuscutae 10 parts, the Radix Astragali 14 parts, Cortex Cinnamomi 6 parts.

The medicine pill of above-mentioned control radiographic contrast nephropathy, preparation process is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 2 hours, obtain wine Cortex Cinnamomi and Polyporus, wheat bran is placed in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 6 minutes, cease fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 100 mesh sieves stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer, heat 15 minutes with Semen Raphani, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 8 minutes slowly, taking-up is dried in the air cool to room temperature, and it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, repeatedly stir-fry 4 minutes, dry in the air to room temperature, it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 60 minutes with 60 DEG C, be placed in marmite and decoct with water 35 minutes, water consumption is 3 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 8 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 20 minutes, obtains drying object, and drying object is made circle according to the preparation for processing of pill, packs and get final product.

experimental example: in order to verify the effect of Chinese medicine medicine pill of the present invention (embodiment 5), we have extracted 400 patients and have carried out the experiment of medicine, are equally divided into two groups, experimental group and matched group, experimental group takes gained medicine pill of the present invention, and matched group takes the medicine of other treatment control radiographic contrast nephropathy.

Inclusion criteria: have the one or more of radiographic contrast nephropathy symptom.

Curative effect situation criterion: cure: renal function and serum creatinine recover normal on inspection, oliguria, and the clinical symptoms such as anuria all disappear; Effective: renal function is clearly better on inspection, serum creatinine declines 15% ~ 22%, oliguria, and the clinical symptoms such as anuria obviously alleviate; Effective: renal function takes a turn for the better to some extent on inspection, serum creatinine declines 5% ~ 10%, oliguria, and the clinical symptoms such as anuria alleviate to some extent; Invalid: renal function is without taking a turn for the better or increasing the weight of on inspection, be reduced to 5% or rising under serum creatinine, oliguria, the clinical symptoms such as anuria are without alleviating or increasing the weight of.

We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:

Medicine pill of the present invention cure rate compared with other medicine preventing and treating radiographic contrast nephropathy is high, and total effective rate is 99%, higher than matched group effective percentage by 29%, successful is better than matched group, this invention medicine pill is cheap, ordinary people life-time service, also can not increase health and pecuniary burden.Do not occur a routine side effect profile in clinical experiment, safety is far above the medicine of other control radiographic contrast nephropathy, and instant effect, therapeutic process no pain prevents and treats radiographic contrast nephropathy Chinese medicine the most fast and effectively at present.

Claims (10)

1. prevent and treat a medicine pill for radiographic contrast nephropathy, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 1-5 part, Radix Aconiti Lateralis Preparata 2-6 part, Rhizoma Dioscoreae 4-10 part, Fructus Corni 3-8 part, Semen Coicis 2-4 part, Polyporus 1-3 part, Radix Ginseng 6-10 part, great Ye Rhizoma Curculiginis 1-5 part, Fructus Ligustri Lucidi 10-20 part, Radix Angelicae Sinensis 5-15 part, Radix Cirsii Japonici 4-10 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Raphani 7-18 part, Semen Cuscutae 6-14 part, Radix Astragali 8-19 part, Cortex Cinnamomi 5-7 part.

2. the medicine pill of control radiographic contrast nephropathy according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 2-4 part, Radix Aconiti Lateralis Preparata 3-5 part, Rhizoma Dioscoreae 6-8 part, Fructus Corni 5-7 part, Semen Coicis 2.5-3.5 part, Polyporus 1.5-2.5 part, Radix Ginseng 7-9 part, great Ye Rhizoma Curculiginis 2-4 part, Fructus Ligustri Lucidi 13-18 part, Radix Angelicae Sinensis 8-13 part, Radix Cirsii Japonici 6-8 part, Thallus Laminariae (Thallus Eckloniae) 13-18 part, Semen Raphani 10-15 part, Semen Cuscutae 8-12 part, Radix Astragali 12-17 part, Cortex Cinnamomi 5.5-6.5 part.

3. the medicine pill of control radiographic contrast nephropathy according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cacumen Securinegae Suffruticosae 3 parts, Radix Aconiti Lateralis Preparata 4 parts, Rhizoma Dioscoreae 7 parts, Fructus Corni 6 parts, Semen Coicis 3 parts, Polyporus 2 parts, Radix Ginseng 8 parts, great Ye Rhizoma Curculiginis 3 parts, Fructus Ligustri Lucidi 15 parts, Radix Angelicae Sinensis 10 parts, Radix Cirsii Japonici 7 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Semen Raphani 12 parts, Semen Cuscutae 10 parts, the Radix Astragali 14 parts, Cortex Cinnamomi 6 parts.

4. the preparation method of the control radiographic contrast nephropathy medicine pill according to any one of claim 1-3, is characterized in that: step is as follows:

1. Cortex Cinnamomi and Polyporus are cleaned, be placed in shady and cool ventilation place and dry, after smashing to pieces, put into crock, add yellow wine, slightly stewing 1-3 hour, obtains wine Cortex Cinnamomi and Polyporus, is placed in by wheat bran in dry pot, by sliding for wheat bran parch sharp state, drop into wine Cortex Cinnamomi and Polyporus, stir-fry 3-8 minute repeatedly, ceases fire, sieve removes wheat bran, and the Cortex Cinnamomi good by parch and Polyporus are dried in the air and coolly grind to form smalls to cross 80-120 mesh sieve stand-by;

2. removed the peel by Rhizoma Dioscoreae, together clean, be cut into the block of beans size, be placed on food steamer with Semen Raphani, heating 10-20 minute, within slightly stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 5-10 minute slowly, take out and dry in the air cool to room temperature, it is stand-by to grind to form smalls;

3. Cacumen Securinegae Suffruticosae, Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Radix Ginseng and Thallus Laminariae (Thallus Eckloniae) are cleaned, smash, dryouied by hot pot, drop into the crude drug handled well, stir-fry 2-6 minute repeatedly, dries in the air to room temperature, and it is stand-by to grind to form smalls;

4. by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 50-70 minute with 50-70 DEG C, be placed in marmite and decoct with water 20-50 minute, water consumption is 2-4 times of crude drug gross weight, filters to get filtrate;

5. by step 1.-3. gained smalls and step 4. gained filtrate mix, fully stir after 5-10 minute and add Mel, rapid stirring becomes thick paste, thick paste is dried 10-30 minute, obtain drying object, drying object is made circle according to the preparation for processing of pill, packs and get final product.

5. the preparation method of medicine pill according to claim 4, is characterized in that: 1. step adds yellow wine, slightly stewing 1.5-2.5 hour (preferably adding yellow wine, slightly stewing 2 hours).

6. the preparation method of medicine pill according to claim 4, is characterized in that: 1. step drops into wine Cortex Cinnamomi and Polyporus, and stir-fry 5-7 minute (preferably drop into wine Cortex Cinnamomi and Polyporus, repeatedly stir-fry 6 minutes) repeatedly.

7. the preparation method of medicine pill according to claim 4, it is characterized in that: 2. step is placed on food steamer, heating 13-18 minute, slightly within stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate to dry slowly and (be preferably placed on food steamer for 6-9 minute, heat 15 minutes, slightly within stewing 10 minutes, take out, be laid on the upper little fire of clean iron plate and dry 7 minutes slowly).

8. the preparation method of medicine pill according to claim 4, is characterized in that: 3. step drops into the crude drug handled well, and stir-fry 3-5 minute repeatedly, dries in the air to room temperature (preferably drop into the crude drug handled well, repeatedly stir-fry 4 minutes, dry in the air to room temperature).

9. the preparation method of medicine pill according to claim 4, it is characterized in that: step is 4. by the water soaking 55-65 minute of Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and Radix Astragali 55-65 DEG C, be placed in marmite and decoct with water 30-40 minute, water consumption is that the 2.5-3.5 of crude drug gross weight is doubly (preferably by Fructus Corni, Semen Coicis, great Ye Rhizoma Curculiginis, Radix Angelicae Sinensis, Radix Cirsii Japonici, Semen Cuscutae and the Radix Astragali water soaking 60 minutes with 60 DEG C, be placed in marmite and decoct with water 35 minutes, water consumption is 3 times of crude drug gross weight).

10. the preparation method of medicine pill according to claim 4, it is characterized in that: 5. step fully stirs after 6-9 minute and add Mel, rapid stirring becomes thick paste, thick paste is dried and within 15-25 minute, (preferably fully stirs after 8 minutes and add Mel, rapid stirring becomes thick paste, thick paste is dried 20 minutes).