CN105407884B - 降低甘油三酯、总胆固醇和低密度脂蛋白血液浓度的方法 - Google Patents

降低甘油三酯、总胆固醇和低密度脂蛋白血液浓度的方法 Download PDF

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Publication number
CN105407884B
CN105407884B CN201480041441.4A CN201480041441A CN105407884B CN 105407884 B CN105407884 B CN 105407884B CN 201480041441 A CN201480041441 A CN 201480041441A CN 105407884 B CN105407884 B CN 105407884B
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compound
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formula
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pharmaceutically acceptable
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CN105407884A (zh
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松田和子
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Medicinova Inc
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Medicinova Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
CN201480041441.4A 2013-07-25 2014-07-23 降低甘油三酯、总胆固醇和低密度脂蛋白血液浓度的方法 Active CN105407884B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361858450P 2013-07-25 2013-07-25
US61/858,450 2013-07-25
PCT/US2014/047797 WO2015013395A1 (en) 2013-07-25 2014-07-23 Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels

Publications (2)

Publication Number Publication Date
CN105407884A CN105407884A (zh) 2016-03-16
CN105407884B true CN105407884B (zh) 2019-04-30

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CN201480041441.4A Active CN105407884B (zh) 2013-07-25 2014-07-23 降低甘油三酯、总胆固醇和低密度脂蛋白血液浓度的方法

Country Status (9)

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US (2) US20150031769A1 (enExample)
EP (1) EP3024454B1 (enExample)
JP (1) JP6363192B2 (enExample)
KR (1) KR102352728B1 (enExample)
CN (1) CN105407884B (enExample)
BR (1) BR112016001400B1 (enExample)
CA (1) CA2917780C (enExample)
ES (1) ES2843511T3 (enExample)
WO (1) WO2015013395A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024522030A (ja) 2021-05-28 2024-06-10 メディシノバ・インコーポレイテッド フェノキシアルキルカルボン酸誘導体、およびトリグリセリドレベルを低下させることにおけるその使用
WO2024117173A1 (ja) 2022-11-30 2024-06-06 花王株式会社 痒みの予防又は改善剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004803A1 (en) * 2004-06-30 2006-01-12 Combinatorx, Incorporated Methods and reagents for the treatment of metabolic disorders
EP1894576A1 (en) * 2005-06-08 2008-03-05 Kowa Company, Ltd. Novel triglyceride reducing agent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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FR2585246A1 (fr) 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
US4788055A (en) 1985-12-09 1988-11-29 Ciba-Geigy Corporation Resinate sustained release dextromethorphan composition
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613689D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US4816264A (en) 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
US4985585A (en) 1988-03-07 1991-01-15 Kyorin Pharmaceutical Co., Ltd. Phenoxyalkylcarboxylic acid derivatives and process for their preparations
US4996047A (en) 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
CA2002492A1 (en) 1988-11-11 1990-05-11 Sandra T. A. Malkowska Pharmaceutical ion exchange resin composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5290812A (en) 1991-01-18 1994-03-01 Kyorin Pharmaceutical Co., Ltd. Phenoxyalkylcarboxylic acid derivatives and process of preparing the same
US7060854B2 (en) 2003-06-24 2006-06-13 Medicinova, Inc. Process for making polymorphic form A of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid
US7064146B2 (en) 2003-06-24 2006-06-20 Medicinova, Inc. Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use
KR20070058381A (ko) * 2004-04-27 2007-06-08 메디시노바, 인크. 염증성 질환 치료용 페녹시알킬카르복실 산 유도체
WO2009002746A1 (en) * 2007-06-22 2008-12-31 Decode Genetics Ehf. Dosing schedules of leukotriene synthesis inhibitors for human therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004803A1 (en) * 2004-06-30 2006-01-12 Combinatorx, Incorporated Methods and reagents for the treatment of metabolic disorders
EP1894576A1 (en) * 2005-06-08 2008-03-05 Kowa Company, Ltd. Novel triglyceride reducing agent

Also Published As

Publication number Publication date
ES2843511T3 (es) 2021-07-19
CA2917780C (en) 2023-01-24
EP3024454A1 (en) 2016-06-01
BR112016001400A8 (pt) 2020-01-14
EP3024454A4 (en) 2017-03-15
WO2015013395A1 (en) 2015-01-29
KR102352728B1 (ko) 2022-01-18
US20150080471A1 (en) 2015-03-19
US20150031769A1 (en) 2015-01-29
CN105407884A (zh) 2016-03-16
EP3024454B1 (en) 2020-10-21
CA2917780A1 (en) 2015-01-29
BR112016001400A2 (pt) 2017-07-25
KR20160034324A (ko) 2016-03-29
JP6363192B2 (ja) 2018-07-25
BR112016001400B1 (pt) 2023-02-28
US9358217B2 (en) 2016-06-07
JP2016525546A (ja) 2016-08-25

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