CN105403716B - Fixing device cooperating on micro-fluidic chip observation and micro-fluidic chip observation system - Google Patents
Fixing device cooperating on micro-fluidic chip observation and micro-fluidic chip observation system Download PDFInfo
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- CN105403716B CN105403716B CN201510939735.5A CN201510939735A CN105403716B CN 105403716 B CN105403716 B CN 105403716B CN 201510939735 A CN201510939735 A CN 201510939735A CN 105403716 B CN105403716 B CN 105403716B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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Abstract
The application discloses a fixing device cooperating on micro-fluidic chip observation; the fixing device includes a bracket, a two-dimensional mobile platform, a reflective mirror, a supporting board and a chip fixture; the two-dimensional mobile platform is connected to the bracket and can drive the bracket to move in a two-dimensional plane, the supporting board and the reflective mirror are arranged on the bracket, the supporting board is provided with a light transmitting groove, the reflective mirror corresponds to the underface of the light transmitting groove, and the chip fixture is arranged on the upper surface of the supporting plate. The fixing device cooperates with a stereoscopic microscope to observe a small-size to-be-tested target on a micro-fluidic chip, and with the 'reflective mirror-micro-fluidic chip-detection lens' relative positions, experimental results are convenient to observe. Through two-dimensional movement, searching of the target detected object in the experimental process is facilitated, a personal error is avoided, and the device is simple and portable.
Description
Technical field
The invention belongs to microfluidic art, a kind of dress for being easy to observe micro-structural on micro-fluidic chip is specifically provided
Put.
Background technology
Microfluidic chip technology (Microfluidics) is biology, chemistry, the sample preparation of medical analysis process, anti-
Should, separate, detection etc. basic operation unit be integrated on one piece of chip of micro-meter scale, be automatically performed analysis overall process.Due to
It in the great potential in the field such as biology, chemistry, medical science, have been developed as a biology, chemistry, medical science, fluid, electronics,
The brand-new research field of the subject crossings such as material, machinery.
Microflow control technique is few due to the consumption of its reagent, and the reaction time is fast, detects the features such as flux is high, and the system integration is strong,
It is widely used in scientific research field.But the micron-sized size of its key structure, greatly challenge is brought to observation process.Due to
Micro-fluidic chip experimentation generally needs stereomicroscope cooperation to be observed, and stereomicroscope does not configure adjustable load substantially
Thing platform and light source.Current researcher is often using regulation micro-fluidic chip, the method to find observed object manually.Micron
The target of level usually needs the long period just to find, and regulation error is larger manually, and detection target difficult to realize is located to be seen
Survey at central region, micro-fluidic chip is fixed without objective table and fixing device in addition, micro-fluidic chip easily produces position
Move, influence is produced on observation.
Microfluidic chip structure is observed using stereomicroscope, is often required to by means of external light source, more particularly at a high speed
It is different if not fixing the position of " light source-micro-fluidic chip-detector lens ", it is necessary to borrow halogen light source etc. during shooting
The contrast of the photo that experimental stage shoots is entirely different, and difficulty is caused for image batch processing, causes later stage reality repeatedly
Test image processing process.
The content of the invention
It is an object of the invention to provide it is a kind of coordinate micro-fluidic chip observation fixing device, can ligand regard it is micro-
Target microcosmic to be measured on mirror observation micro-fluidic chip..
To achieve the above object, the present invention provides following technical scheme：
The embodiment of the present application discloses a kind of fixing device for coordinating micro-fluidic chip to observe, including support, two-dimensional movement
Platform, reflective mirror, supporting plate and chip fixture, the two-dimensional movement platform are connected to the support and the support can be driven to exist
Moved in two dimensional surface, the supporting plate and reflective mirror are installed on the support, light tank, institute are offered in the supporting plate
Underface of the reflective mirror corresponding to the light tank is stated, the chip fixture is installed on the upper surface of the supporting plate.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the chip fixture includes two phases
To the support bar for setting, two support bars are connected respectively positioned at the both sides of the light tank between two support bars
There are locating support and outer limited block, the locating support and outer limited block are respectively positioned at the two ends of the support bar, the positioning
Inner limited block is provided between support and outer limited block, the inner limited block is slided on the support bar, the inner limited block and
Spring is provided between the outer limited block, is formed between the inner limited block and locating support and is used to carry out micro-fluidic chip
The space of clamping.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the two ends difference of the inner limited block
It is sheathed on the support bar.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the spring housing is located at the support
On bar.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the support includes being located at the branch
Base plate below fagging, is supported by column between the base plate and supporting plate, the reflective mirror is fixed on the upper table of the base plate
Face, the two-dimensional movement platform is fixed on the lower surface of the base plate.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the column is double threaded screw.
Preferably, in the above-mentioned fixing device for coordinating micro-fluidic chip observation, the regulation of the two-dimensional movement platform
Precision is micron order.
Accordingly, disclosed herein as well is a kind of micro-fluidic chip observation system, including：
Described fixing device；
Microscope, correspondence is positioned at the top of the light tank.
Compared with prior art, the advantage of the invention is that：
1. fixing device of the present invention coordinates the target to be measured of small size on stereomicroscope observation micro-fluidic chip；
2. by the two-dimensional movement platform that configures, single degree of regulation is micron order to the present invention, solve adjust manually it is micro-
The problem for wasting time and energy of fluidic chip；
3. the present invention is fixed by configuring reflective mirror, position, coordinates external light source, solves the high-speed camera intensity of light source not
The problem of foot；
4. " reflective mirror-micro-fluidic chip-detector lens " position is relatively fixed, and the photo background of acquisition is consistent, Neng Goujin
Row batch processing；
5. apparatus of the present invention are easy to use, cheap, and scalability is extremely strong.
Brief description of the drawings
In order to illustrate more clearly of the embodiment of the present application or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments described in application, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawings can also be obtained according to these accompanying drawings.
The stereochemical structure that Fig. 1 show the fixing device in the specific embodiment of the invention coordinating micro-fluidic chip to observe is illustrated
Figure；
Fig. 2 show the side view of the fixing device in the specific embodiment of the invention coordinating micro-fluidic chip to observe.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, detailed retouching is carried out to the technical scheme in the embodiment of the present invention
State, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the present invention
In embodiment, the every other implementation that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
Ginseng Fig. 1 and Fig. 2 shown in, coordinate micro-fluidic chip observation fixing device, including support 1, two-dimensional movement platform 2,
Reflective mirror 3, supporting plate 4 and chip fixture 5, two-dimensional movement platform 2 be connected to support 1 and can driving arm 1 in two dimensional surface
Mobile, supporting plate 4 and reflective mirror 3 are installed on support 1, and light tank 401 is offered in supporting plate 4, and reflective mirror 3 corresponds to printing opacity
The underface of groove 401, chip fixture 5 is installed on the upper surface of supporting plate 4.
In the technical scheme, two-dimensional movement platform is XY axle precise mobile platforms, and XY axles precise mobile platform can be real
Existing X, the Y-axis free degree；In a preferred embodiment, its stroke：±12.5mm；Rail types：V-type decussation roller guide rail；It is minimum
Scale:10um；Precision：0.01mm.
Further, chip fixture 5 includes two support bars 501 being oppositely arranged, and two support bars 501 are located at thoroughly respectively
The both sides of light groove 401, are connected with locating support 502 and outer limited block 503 between two support bars 501, locating support 502 and outer
Limited block 503 positioned at the two ends of support bar 501, is provided with inner limited block 504 respectively between locating support 502 and outer limited block 503,
Inner limited block 504 is slided on support bar 501, and spring 505, inner limited block are provided between inner limited block 504 and outer limited block 503
The space for being used to be clamped to micro-fluidic chip 6 is formed between 504 and locating support 502.The two ends of inner limited block 504 point
It is not sheathed on support bar 501.Spring 505 is sheathed on support bar 501.
In the technical scheme, by compressible inner limited block 504, can be by micro-fluidic chip clamping in inner limited block
And locating support between.
The order of " outer limited block-spring-inner limited block " during assembling, is first according to, said structure is in turn mounted to branch
On strut, support bar group is attached in the circular hole at locating support two ends, then by 4 Positioning screws by locating support and support
Structural support plate is fixed together, and micro-fluidic chip is positioned between inner limited block and corresponding locating support, by two
Stop screw fixes the position of the position of outer limited block, outer limited block limited spring and inner limited block, so as to play fixed miniflow
Control the purpose of chip.
It should be noted that the material and connected mode of chip fixture are not limited to the technical scheme, as long as chip can be reached
Fixture and supporting structure relative position are constant, and can fix the position of micro-fluidic chip.
Further, support 1 includes the base plate 101 below supporting plate, is supported by between base plate 101 and supporting plate 4
Column 102, reflective mirror 3 is fixed on the upper surface of base plate 101, and two-dimensional movement platform 2 is fixed on the lower surface of base plate 101.Column
102 are preferably double threaded screw.
In the technical scheme, column 102 is preferably provided with 4, its rectangular housing of arrangement.
Further, the centre of base plate 101 is machined with multiple internal thread holes 1011, and position and the two dimension of screwed hole are moved
Screw thread hole site correspondence on moving platform, by the cooperation of Positioning screw and nut, realizes between base plate and two-dimensional movement platform
Fixation.
In the technical scheme, the connection of two-dimensional movement platform and support is not limited to the mode of screw positioning, can also adopt
With the mode such as gluing, as long as the relative position of two-dimensional movement platform and supporting structure can be limited.
Further, the corner location of base plate 101 processes 4 internal thread holes 1012, these screwed holes by upper lower nut and
The bottom connection of double threaded screw 102, the top connection supporting plate 4 of double threaded screw 102, by the phase for adjusting double threaded screw and base plate
To position, the purpose of regulating base board and supporting plate spacing is realized.
The corner location of supporting plate 4 is machined with and base plate 101 corresponding 4 internal thread holes 402, the top of double threaded screw 102
Connected through internal thread hole 402 and by location nut 403.In the case where ensureing that groove can support micro-fluidic chip, thoroughly
Light groove 401 can expand as far as possible, be easy to the observation of larger target to be measured.
In the technical scheme, supporting structure integral material is not limited, and can be polymer or metal material.Supporting plate and
The connected mode of base plate is not limited, and is not limited to double threaded screw and is fixed, and can realize that the relative position of integral support structure is constant, up and down
Plate specifically places reflective mirror enough, and the relative distance of supporting plate and base plate can be adjusted most preferably.
The material of base plate and supporting plate can be metal or polymer sheet, or other hard materials, thickness is big
In 5mm, the fixation of processing and screw rod in order to screwed hole.
Further, reflective mirror processes groove by base plate corresponding position, with fixed counter-mirror base, it is necessary to assure
Reflective mirror center line and supporting plate printing opacity groove center line are alignd, and ensure reflective mirror minute surface covering micro-fluidic chip target observation position
Put.
In the technical scheme, the connected mode of reflective mirror and base plate is not limited to locating slot, as long as keeping reflective mirror and branch
The relative position of frame structure is constant, can be by the mechanical structure or gluing between reflective mirror and supporting plate or base plate
Mode realize.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation make a distinction with another entity or operation, and not necessarily require or imply these entities or deposited between operating
In any this actual relation or order.And, term " including ", "comprising" or its any other variant be intended to
Nonexcludability is included, so that process, method, article or equipment including a series of key elements not only will including those
Element, but also other key elements including being not expressly set out, or also include being this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence " including ... ... ", it is not excluded that
Also there is other identical element in the process including the key element, method, article or equipment.
The above is only the specific embodiment of the application, it is noted that for the ordinary skill people of the art
For member, on the premise of the application principle is not departed from, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as the protection domain of the application.
Claims (7)
1. a kind of fixing device for coordinating micro-fluidic chip observation, it is characterised in that including support, two-dimensional movement platform, reflective
Mirror, supporting plate and chip fixture, the two-dimensional movement platform are connected to the support and can drive the support in two dimensional surface
Interior movement, the supporting plate and reflective mirror are installed on the support, and light tank, the reflective mirror are offered in the supporting plate
Corresponding to the underface of the light tank, the chip fixture is installed on the upper surface of the supporting plate, the chip fixture bag
Two support bars being oppositely arranged are included, two support bars are respectively positioned at the both sides of the light tank, two support bars
Between be connected with locating support and outer limited block, the locating support and outer limited block respectively positioned at the two ends of the support bar,
Inner limited block is provided between the locating support and outer limited block, the inner limited block is slided on the support bar, it is described interior
Spring is provided between limited block and the outer limited block, is formed between the inner limited block and locating support and is used to micro-fluidic
The space that chip is clamped.
2. the fixing device that cooperation micro-fluidic chip according to claim 1 is observed, it is characterised in that：The inner limited block
Two ends be sheathed on respectively on the support bar.
3. the fixing device that cooperation micro-fluidic chip according to claim 1 is observed, it is characterised in that：The spring is arranged
In on the support bar.
4. the fixing device that cooperation micro-fluidic chip according to claim 1 is observed, it is characterised in that：The support includes
Base plate below the supporting plate, is supported by column between the base plate and supporting plate, the reflective mirror is fixed on described
The upper surface of base plate, the two-dimensional movement platform is fixed on the lower surface of the base plate.
5. the fixing device that cooperation micro-fluidic chip according to claim 4 is observed, it is characterised in that：The column is double
Head screw rod.
6. the fixing device that cooperation micro-fluidic chip according to claim 1 is observed, it is characterised in that：The two-dimensional movement
The degree of regulation of platform is micron order.
7. a kind of micro-fluidic chip observation system, it is characterised in that including：
Any described fixing device of claim 1 to 6；
Microscope, correspondence is positioned at the top of the light tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510939735.5A CN105403716B (en) | 2015-12-15 | 2015-12-15 | Fixing device cooperating on micro-fluidic chip observation and micro-fluidic chip observation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510939735.5A CN105403716B (en) | 2015-12-15 | 2015-12-15 | Fixing device cooperating on micro-fluidic chip observation and micro-fluidic chip observation system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105403716A CN105403716A (en) | 2016-03-16 |
| CN105403716B true CN105403716B (en) | 2017-05-24 |
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ID=55469325
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510939735.5A Active CN105403716B (en) | 2015-12-15 | 2015-12-15 | Fixing device cooperating on micro-fluidic chip observation and micro-fluidic chip observation system |
Country Status (1)
| Country | Link |
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| CN (1) | CN105403716B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730163B (en) * | 2017-02-21 | 2023-04-14 | 苏州优点优唯医疗科技有限公司 | Infusion controller |
| CN107159636A (en) * | 2017-04-02 | 2017-09-15 | 厦门芯光润泽科技有限公司 | A kind of optical branching-device chip fixture |
| CN109971630B (en) * | 2019-02-18 | 2022-10-25 | 深圳市易赛贝尔科技有限公司 | Nanopore chip clamp |
| CN112916076A (en) * | 2021-01-22 | 2021-06-08 | 中国石油大学(华东) | Micro-fluidic chip experiment platform with visualization and infrared thermal imaging functions |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2733393Y (en) * | 2004-09-21 | 2005-10-12 | 中国科学院力学研究所 | Micro-alignment apparatus for transparent micro-flow control chip assembly |
| CN2742457Y (en) * | 2004-10-13 | 2005-11-23 | 林云才 | Movable work table for microscope |
| CN201532188U (en) * | 2009-10-17 | 2010-07-21 | 山东工商学院 | Laser intelligent detecting instrument for microfluidic chip |
| JP2010266750A (en) * | 2009-05-15 | 2010-11-25 | Olympus Corp | Observation device and observation system |
| CN205193080U (en) * | 2015-12-15 | 2016-04-27 | 苏州汶颢芯片科技有限公司 | Fixing device and micro -fluidic chip observation system that cooperation micro -fluidic chip surveyd |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040008409A1 (en) * | 2002-07-15 | 2004-01-15 | Hung Fu Group Of Companies | Innovative micrometric measuring instrument |
-
2015
- 2015-12-15 CN CN201510939735.5A patent/CN105403716B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2733393Y (en) * | 2004-09-21 | 2005-10-12 | 中国科学院力学研究所 | Micro-alignment apparatus for transparent micro-flow control chip assembly |
| CN2742457Y (en) * | 2004-10-13 | 2005-11-23 | 林云才 | Movable work table for microscope |
| JP2010266750A (en) * | 2009-05-15 | 2010-11-25 | Olympus Corp | Observation device and observation system |
| CN201532188U (en) * | 2009-10-17 | 2010-07-21 | 山东工商学院 | Laser intelligent detecting instrument for microfluidic chip |
| CN205193080U (en) * | 2015-12-15 | 2016-04-27 | 苏州汶颢芯片科技有限公司 | Fixing device and micro -fluidic chip observation system that cooperation micro -fluidic chip surveyd |
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| CN105403716A (en) | 2016-03-16 |
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Address after: 215000 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee after: SUZHOU WENHAO MICROFLUIDIC TECHNOLOGY Co.,Ltd. Address before: 215808 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee before: SUZHOU WENHAO CHIP TECHNOLOGY Co.,Ltd. |
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