CN107765020A - Coordinate the fixing device and micro-fluidic chip observation system of micro-fluidic chip observation - Google Patents
Coordinate the fixing device and micro-fluidic chip observation system of micro-fluidic chip observation Download PDFInfo
- Publication number
- CN107765020A CN107765020A CN201710957819.0A CN201710957819A CN107765020A CN 107765020 A CN107765020 A CN 107765020A CN 201710957819 A CN201710957819 A CN 201710957819A CN 107765020 A CN107765020 A CN 107765020A
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- support
- micro
- fluidic chip
- fixing device
- limited block
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optical Elements Other Than Lenses (AREA)
Abstract
This application discloses a kind of fixing device for coordinating micro-fluidic chip observation, including support, two-dimensional movement platform, reflective mirror, supporting plate and chip fixture, the two-dimensional movement platform is connected to the support and the support can be driven to be moved in two dimensional surface, the supporting plate and reflective mirror are installed on the support, light tank is offered in the supporting plate, the reflective mirror corresponds to the underface of the light tank, and the chip fixture is installed on the upper surface of the supporting plate.Fixing device of the present invention coordinates the target to be measured of small size on stereomicroscope observation micro-fluidic chip, the relative position of " reflective mirror micro-fluidic chip detector lens ", facilitates experimental result to observe.By two-dimensional movement, facilitate the searching of target detection thing in experimentation, avoid human error, device is simply portable.
Description
Technical field
The invention belongs to microfluidic art, specifically provides a kind of dress for being easy to observe micro-structural on micro-fluidic chip
Put.
Background technology
Microfluidic chip technology (Microfluidics) is biological, chemical, medical analysis process sample preparation, instead
Should, separation, detection etc. basic operation unit be integrated on the chip of one piece of micro-meter scale, be automatically performed analysis overall process.Due to
It in the great potential in the field such as biology, chemistry, medical science, have been developed as a biology, chemistry, medical science, fluid, electronics,
The brand-new research field of the subject crossings such as material, machinery.
The features such as microflow control technique because the consumption of its reagent is few, the reaction time is fast, detection flux height, and the system integration is strong,
It is widely used in scientific research field.But the micron-sized size of its key structure, great challenge is brought to observation process.Due to
Micro-fluidic chip experimentation usually requires stereomicroscope cooperation and observed, and stereomicroscope does not configure adjustable load substantially
Thing platform and light source.Researcher is often using regulation micro-fluidic chip manually at present, to find the method for observed object.Micron
The target of level usually needs the long period just to find, and regulation error is larger manually, and detection target difficult to realize, which is located at, to be seen
Survey at central region, micro-fluidic chip is fixed without objective table and fixing device in addition, micro-fluidic chip easily produces position
Move, observation is had an impact.
Microfluidic chip structure is observed using stereomicroscope, is often required to by means of external light source, more particularly at a high speed
It is different if the position of unfixed " light source-micro-fluidic chip-detector lens ", it is necessary to borrow halogen light source etc. during shooting
The contrast of the photo of experimental stage shooting is entirely different, causes difficulty for image batch processing, causes the reality of later stage repeatedly
Test image processing process.
The content of the invention
It is an object of the invention to provide it is a kind of coordinate micro-fluidic chip observation fixing device, can ligand regard it is micro-
Microcosmic target to be measured on mirror observation micro-fluidic chip..
To achieve the above object, the present invention provides following technical scheme：
The embodiment of the present application disclose it is a kind of coordinate micro-fluidic chip observation fixing device, including support, two-dimensional movement platform,
Reflective mirror, supporting plate and chip fixture, the two-dimensional movement platform are connected to the support and can drive the support in two dimension
Moved in plane, the supporting plate and reflective mirror are installed on the support, and light tank is offered in the supporting plate, described anti-
Light microscopic corresponds to the underface of the light tank, and the chip fixture is installed on the upper surface of the supporting plate.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the chip fixture includes two phases
To the support bar of setting, two support bars are located at the both sides of the light tank respectively, are connected between two support bars
There are locating support and outer limited block, the locating support and outer limited block are located at the both ends of the support bar, the positioning respectively
Inner limited block is provided between support and outer limited block, the inner limited block is slided on the support bar, the inner limited block and
Spring is provided between the outer limited block, formed with being carried out to micro-fluidic chip between the inner limited block and locating support
The space of clamping.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the both ends difference of the inner limited block
It is sheathed on the support bar.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the spring housing is located at the support
On bar.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the support includes being located at the branch
Bottom plate below fagging, is supported by column between the bottom plate and supporting plate, the reflective mirror is fixed on the upper table of the bottom plate
Face, the two-dimensional movement platform are fixed on the lower surface of the bottom plate.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the column is double threaded screw.
Preferably, in the fixing device of above-mentioned cooperation micro-fluidic chip observation, the regulation of the two-dimensional movement platform
Precision is micron order.
Accordingly, disclosed herein as well is a kind of micro-fluidic chip observation system, including：
Described fixing device；
Microscope, it is corresponding positioned at the top of the light tank.
Compared with prior art, the advantage of the invention is that：
1. fixing device of the present invention coordinates the target to be measured of small size on stereomicroscope observation micro-fluidic chip；
2. the present invention, by the two-dimensional movement platform that configures, single degree of regulation is micron order, solve adjust manually it is micro-fluidic
The problem of wasting time and energy of chip；
3. the present invention by configuring reflective mirror, fix by position, coordinate external light source, solve high-speed camera intensity of light source deficiency
Problem；
4. " reflective mirror-micro-fluidic chip-detector lens " position is relatively fixed, the photo background of acquisition is consistent, can be criticized
Amount processing；
5. apparatus of the present invention are easy to use, cheap, scalability is extremely strong.
Brief description of the drawings
, below will be to embodiment or existing skill in order to illustrate more clearly of the embodiment of the present application or technical scheme of the prior art
The required accompanying drawing used is briefly described in art description, it should be apparent that, drawings in the following description are only the application
Described in some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, may be used also
To obtain other accompanying drawings according to these accompanying drawings.
Fig. 1 show the stereochemical structure signal for the fixing device for coordinating micro-fluidic chip observation in the specific embodiment of the invention
Figure；
Fig. 2 show the side view for the fixing device for coordinating micro-fluidic chip observation in the specific embodiment of the invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is described in detail,
Obviously, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained on the premise of creative work is not made,
Belong to the scope of protection of the invention.
Join Fig. 1 and Fig. 2 shown in, coordinate micro-fluidic chip observation fixing device, including support 1, two-dimensional movement platform 2,
Reflective mirror 3, supporting plate 4 and chip fixture 5, two-dimensional movement platform 2 be connected to support 1 and can driving arm 1 in two dimensional surface
Mobile, supporting plate 4 and reflective mirror 3 are installed on support 1, light tank 401 are offered in supporting plate 4, reflective mirror 3 corresponds to printing opacity
The underface of groove 401, chip fixture 5 are installed on the upper surface of supporting plate 4.
In the technical scheme, two-dimensional movement platform is XY axle precise mobile platforms, and XY axles precise mobile platform can be real
Existing X, the Y-axis free degree；In a preferred embodiment, its stroke：±12.5mm；Rail types：V-type decussation roller guide rail；It is minimum
Scale:10um；Precision：0.01mm.
Further, chip fixture 5 includes two support bars 501 being oppositely arranged, and two support bars 501 are respectively positioned at saturating
The both sides of light groove 401, are connected with locating support 502 and outer limited block 503 between two support bars 501, locating support 502 and outer
Limited block 503 is located at the both ends of support bar 501 respectively, and inner limited block 504 is provided between locating support 502 and outer limited block 503,
Inner limited block 504 is slided on support bar 501, and spring 505, inner limited block are provided between inner limited block 504 and outer limited block 503
Formed with the space to be clamped to micro-fluidic chip 6 between 504 and locating support 502.The both ends of inner limited block 504 point
It is not sheathed on support bar 501.Spring 505 is sheathed on support bar 501.
In the technical scheme, by compressible inner limited block 504, micro-fluidic chip can be clamped in interior limited block
Between locating support.
The order of " outer limited block-spring-inner limited block " during assembling, is first according to, said structure is in turn mounted to branch
On strut, support bar group is attached in the circular hole at locating support both ends, then by 4 positioning screws by locating support and support
Structural support plate is fixed together, and micro-fluidic chip is positioned between inner limited block and corresponding locating support, passes through two
Stop screw fixes the position of the position of outer limited block, outer limited block limited spring and inner limited block, so as to play fixed miniflow
Control the purpose of chip.
It should be noted that the material and connected mode of chip fixture are not limited to the technical scheme, as long as can reach chip
Fixture and supporting structure relative position are constant, and can fix the position of micro-fluidic chip.
Further, support 1 includes the bottom plate 101 below supporting plate, is supported by between bottom plate 101 and supporting plate 4
Column 102, reflective mirror 3 are fixed on the upper surface of bottom plate 101, and two-dimensional movement platform 2 is fixed on the lower surface of bottom plate 101.Column
102 be preferably double threaded screw.
In the technical scheme, column 102 is preferably provided with 4, and it arranges rectangular housing.
Further, the centre of bottom plate 101 is machined with multiple internal thread holes 1011, and position and the two dimension of screwed hole are moved
Screwed hole position correspondence on moving platform, by the cooperation of positioning screw and nut, is realized between bottom plate and two-dimensional movement platform
Fixation.
In the technical scheme, the connection of two-dimensional movement platform and support is not limited to the mode of screw positioning, can also adopt
With the mode such as gluing, as long as two-dimensional movement platform and the relative position of supporting structure can be limited.
Further, the corner location of bottom plate 101 processes 4 internal thread holes 1012, these screwed holes by upper lower nut and
The bottom connection of double threaded screw 102, the top connection supporting plate 4 of double threaded screw 102, by the phase for adjusting double threaded screw and bottom plate
To position, the purpose of regulating base board and supporting plate spacing is realized.
The corner location of supporting plate 4 be machined with bottom plate 101 corresponding to 4 internal thread holes 402, the top of double threaded screw 102
Connected through internal thread hole 402 and by location nut 403.In the case where ensureing that groove can support micro-fluidic chip, thoroughly
Light groove 401 can expand as far as possible, be easy to the observation of larger target to be measured.
In the technical scheme, supporting structure integral material is unlimited, can be polymer or metal material.Supporting plate and
The connected mode of bottom plate is unlimited, is not limited to double threaded screw and fixes, and can realize that the relative position of integral support structure is constant, up and down
Plate specifically places reflective mirror enough, and supporting plate and the relative distance of bottom plate can be adjusted most preferably.
The material of bottom plate and supporting plate can be metal or polymer sheet, or other hard materials, thickness are big
In 5mm, in order to the processing of screwed hole and the fixation of screw rod.
Further, reflective mirror in bottom plate corresponding position by processing groove, with fixed counter-mirror base, it is necessary to assure
Reflective mirror center line and the alignment of supporting plate printing opacity groove center line, and ensure reflective mirror minute surface covering micro-fluidic chip target observation position
Put.
In the technical scheme, the connected mode of reflective mirror and bottom plate is not limited to locating slot, as long as keeping reflective mirror and branch
The relative position of frame structure is constant, can pass through the mechanical structure or gluing between reflective mirror and supporting plate either bottom plate
Mode realize.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation make a distinction with another entity or operation, and not necessarily require or imply and deposited between these entities or operation
In any this actual relation or order.Moreover, term " comprising ", "comprising" or its any other variant are intended to
Nonexcludability includes, so that process, method, article or equipment including a series of elements not only will including those
Element, but also the other element including being not expressly set out, or it is this process, method, article or equipment also to include
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence " including one ... ... ", it is not excluded that
Other identical element in the process including the key element, method, article or equipment also be present.
Described above is only the embodiment of the application, it is noted that for the ordinary skill people of the art
For member, on the premise of the application principle is not departed from, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as the protection domain of the application.
Claims (8)
1. a kind of fixing device for coordinating micro-fluidic chip observation, it is characterised in that including support, two-dimensional movement platform, reflective
Mirror, supporting plate and chip fixture, the two-dimensional movement platform are connected to the support and can drive the support in two dimensional surface
Interior movement, the supporting plate and reflective mirror are installed on the support, and light tank, the reflective mirror are offered in the supporting plate
Corresponding to the underface of the light tank, the chip fixture is installed on the upper surface of the supporting plate.
2. the fixing device according to claim 1 for coordinating micro-fluidic chip observation, it is characterised in that：The chip fixture
Including two support bars being oppositely arranged, two support bars are located at the both sides of the light tank, two supports respectively
Locating support and outer limited block are connected between bar, the locating support and outer limited block are located at the two of the support bar respectively
End, is provided with inner limited block, the inner limited block is slided on the support bar, described between the locating support and outer limited block
Spring is provided between inner limited block and the outer limited block, formed with to miniflow between the inner limited block and locating support
The space that control chip is clamped.
3. the fixing device according to claim 2 for coordinating micro-fluidic chip observation, it is characterised in that：The inner limited block
Both ends be sheathed on respectively on the support bar.
4. the fixing device according to claim 2 for coordinating micro-fluidic chip observation, it is characterised in that：The spring is arranged
In on the support bar.
5. the fixing device according to claim 1 for coordinating micro-fluidic chip observation, it is characterised in that：The support includes
Bottom plate below the supporting plate, is supported by column between the bottom plate and supporting plate, the reflective mirror is fixed on described
The upper surface of bottom plate, the two-dimensional movement platform are fixed on the lower surface of the bottom plate.
6. the fixing device according to claim 5 for coordinating micro-fluidic chip observation, it is characterised in that：The column is double
Head screw rod.
7. the fixing device according to claim 1 for coordinating micro-fluidic chip observation, it is characterised in that：The two-dimensional movement
The degree of regulation of platform is micron order.
A kind of 8. micro-fluidic chip observation system, it is characterised in that including：
Any described fixing device of claim 1 to 7；
Microscope, it is corresponding positioned at the top of the light tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710957819.0A CN107765020A (en) | 2017-10-16 | 2017-10-16 | Coordinate the fixing device and micro-fluidic chip observation system of micro-fluidic chip observation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710957819.0A CN107765020A (en) | 2017-10-16 | 2017-10-16 | Coordinate the fixing device and micro-fluidic chip observation system of micro-fluidic chip observation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107765020A true CN107765020A (en) | 2018-03-06 |
Family
ID=61269696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710957819.0A Withdrawn CN107765020A (en) | 2017-10-16 | 2017-10-16 | Coordinate the fixing device and micro-fluidic chip observation system of micro-fluidic chip observation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107765020A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110703070A (en) * | 2019-09-16 | 2020-01-17 | 芜湖德锐电子技术有限公司 | Chip moving assembly |
| WO2022156052A1 (en) * | 2021-01-22 | 2022-07-28 | 中国石油大学(华东) | Microfluidic chip experimental platform having visualization and infrared thermal imaging functions |
-
2017
- 2017-10-16 CN CN201710957819.0A patent/CN107765020A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110703070A (en) * | 2019-09-16 | 2020-01-17 | 芜湖德锐电子技术有限公司 | Chip moving assembly |
| CN110703070B (en) * | 2019-09-16 | 2022-02-11 | 马舍科技(上海)有限公司 | Chip moving assembly |
| WO2022156052A1 (en) * | 2021-01-22 | 2022-07-28 | 中国石油大学(华东) | Microfluidic chip experimental platform having visualization and infrared thermal imaging functions |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180306 |