CN105395698A - Traditional Chinese medicine composition for treating stomach cancer - Google Patents

Traditional Chinese medicine composition for treating stomach cancer Download PDF

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Publication number
CN105395698A
CN105395698A CN201511006815.1A CN201511006815A CN105395698A CN 105395698 A CN105395698 A CN 105395698A CN 201511006815 A CN201511006815 A CN 201511006815A CN 105395698 A CN105395698 A CN 105395698A
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China
Prior art keywords
parts
chinese medicine
traditional chinese
treatment
gastric cancer
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CN201511006815.1A
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Chinese (zh)
Inventor
王璐
许璟
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Qingdao Changanda Pharmaceutical Co Ltd
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Qingdao Changanda Pharmaceutical Co Ltd
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Priority to CN201511006815.1A priority Critical patent/CN105395698A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Abstract

The invention discloses a traditional Chinese medicine composition for treating a stomach cancer. The traditional Chinese medicine composition is prepared from, by weight, 31-46 parts of flos magnoliae, 21-30 parts of Chinese waxgourd peels, 13-24 parts of radix physochlainae, 10-19 parts of tortoise-shell glue, 5-14 parts of cortex ailanthi, 9-16 parts of sapium sebiferum, 2-8 parts of ginseng leaves and 1-8 parts of folium isatidis. The traditional Chinese medicine preparation used for the adjuvant therapy of the stomach cancer can improve the effect of the traditional Chinese medicine components to the maximum extent, complementation and promotion effects are exerted, and the medicinal effect is improved.

Description

A kind of Chinese medicine composition for the treatment of gastric cancer
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of gastric cancer.
Background technology
Gastric cancer is modal malignant tumor, and sickness rate occupies the first place of whole body malignant tumor, and mortality rate is first of common cancer, though motherland's medical science is without gastric cancer name of disease, in conjunction with disease analysis, this disease belongs to gastric abscess, regurgitation, the cancer of the esophagus, and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times disease is long-pending waits category.Its pathogenesis mostly is unhygienic diet, transformation failure of spleen, phlegm and qi stasis, and pyretic toxicity blood stasis gathers in bulk and sends out this disease.Should with dispersing the stagnated liver-QI for regulating the stomach, sending down the abnormal ascending QI pain relieving in treatment, heat clearing away cold expelling is main.。This disease can take radical operation to cure in early days, but still lacks effective treatment means for middle and advanced stage patient, at present, Therapeutic Method still based on excision, combined with chemotherapy, radiotherapy and immunotherapy, but all do not reach ideal effect, and medical expense is expensive.Treatment by Chinese herbs cancer more and more comes into one's own.Adopt Chinese traditional treatment cancer, generally from entirety, both considered topical therapeutic, and took again the method for the body resistance strengthening and constitution consolidating, and had important effect for the local symptom and overall health of patients improving patient; Treatment side effect is little.Therefore, need a kind of evident in efficacy in clinical treatment, the Chinese medicine preparation of the treatment gastric cancer that side effect is less, economic.
Summary of the invention
Technical problem to be solved by this invention is: provide all deficiencies overcoming prior art, a kind of Chinese medicine composition for the treatment of gastric cancer.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of Chinese medicine composition for the treatment of gastric cancer provided by the invention, is made up of the raw material of Chinese medicine of following weight portion: Flos Magnoliae 31-46 part, Exocarpium Benincasae 21-30 part, Radix Physochlainae 13-24 part, Colla Plastri Testudinis 10-19 part, Cortex Ailanthi 5-14 part, Cortex Sapii Radicis 9-16 part, Folium Ginseng 2-8 part, Folium Isatidis 1-8 part.
Preferably, Chinese medicine provided by the invention is made up of the raw material of Chinese medicine of following weight portion: Flos Magnoliae 40 parts, Exocarpium Benincasae 26 parts, Radix Physochlainae 18 parts, Colla Plastri Testudinis 16 parts, Cortex Ailanthi 10 parts, Cortex Sapii Radicis 11 parts, Folium Ginseng 6 parts, Folium Isatidis 5 parts.
Usage and dosage: above-mentioned raw materials, is simmered in water after boiling with high heat 30 minutes after 30 minutes with warm water soaking again, taking liquid 150 milliliters, then add water and two to decoct, filter after twice medicinal liquid mixing, take at twice.Twice daily, one after each meal.
The course for the treatment of: 20 days be a course for the treatment of, the 2-5 course for the treatment of need be taken.
Clinical verification:
1, case selection
83 routine patients with gastric cancer.
Treat aforementioned 93 routine patients, make a definite diagnosis through hospital above county level x-ray canel barium meal contrast examination and gastroscope typing and histocytology pathologic finding, wherein early stage patient (tumor is at 1-3cm) 18 example, account for 19.36%, patient in mid-term (tumor is at 3.1-5cm) 44 is routine, account for 47.3%, patients with terminal (tumor is greater than more than 5cm) 31 example, account for the inappetence that 33.33% clinical manifestation all has weight not wait, upper limb is uncomfortable, the pernicious condition of illness such as to become thin, most of patients has long-term feeling sick, regurgitation, stomachache and gastric ulcer case history, small number of patients also has agnogenic hematemesis, the symptoms such as melena.
2, diagnostic criteria
With reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard: (1) symptom: gastric cancer lacks specific clinical symptoms; Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, Nausea and vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely appear at the different phase in gastric cancer generation evolution, but all without specificity.(2) sign: gastric cancer lacks specificity sign; Early gastric cancer often without obvious sign, late gastric cancer or likely there is epigastrium lump when there is metastasis focus, rectum front touches the sign such as swollen thing, supraclavicular lymph nodes enlargement.(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high, can the position of accurate positioning tumor by fibergastroscopy, can obtain tissue specimen to complete pathological biopsy simultaneously.Nearly all patient being diagnosed as gastric cancer through upper digestive tract contrast examination needs to accept fibergastroscopy and pathological biopsy to make a definite diagnosis again.Therefore, gastroscope should be directly selected to replace upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer.(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without the need to calm and be widely used.But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy.Should can not carry out the medical institutions of fibergastroscopy or select as the inspection method of diagnosing gastric cancer gastroscopic patient cannot be tolerated.(5) histodiagnosis: histopathologic diagnosis is the determination diagnosis basis of gastric cancer, before the various oncotherapy means of enforcement, should obtain pathological diagnosis foundation as far as possible.(6) computed tomographic venography (CT): computed tomographic venography has value evaluating in the extent of disease of gastric cancer, metastases in local lymph node situation and metastasis situation etc., should as the first-selected inspection method of preoperative staging of gastric carcinoma.(7) diagnose: the diagnosis of gastric cancer cannot rely on merely the clinical data such as medical history, sings and symptoms to be established.Conventional method such as application upper digestive tract radiography and fibergastroscopy etc. establishes the clinical diagnosis of gastric cancer clinically, should using the latter as the prefered method diagnosed.Gastric cancer make a definite diagnosis according to being histopathological examination result.
3, Therapeutic Method:
Above-mentioned raw materials, simmers in water after boiling with high heat 30 minutes after 30 minutes with warm water soaking again, taking liquid 150 milliliters, then adds water and two to decoct, and filters, take after twice medicinal liquid mixing at twice.Twice daily, one after each meal.
The course for the treatment of: 15 days be a course for the treatment of, the 2-5 course for the treatment of need be taken.
4, efficacy assessment standard
By the unified national critical treatment malignant tumor efficacy assessment standard demonstration formulated of " up-to-date domestic and international disease treatment standard " level Ministry of Public Health.Cure: after treatment, symptom and the objective determination positive levy disappearance, and recover certain work capacity, Continuous Observation more than 3 years, without recidivist.Clinical cure: after treatment, the positive sign of symptom and objective determination disappears substantially, and tumor regression half or over half, recovers certain work capacity, Continuous Observation half a year to one is year without recidivist.Effective: after curing, cardinal symptom disappears, focus reduces or stablizes, and within Continuous Observation 2-6 month, does not develop.Therapeutic outcome:
5, therapeutic outcome
In the 83 routine patients observed, cure 32 examples, clinical cure 24 example, effective 24 examples, invalid 3 examples.Through observing the most elder's medication of tumor block extinction time 149 days, the shortest person's medication 80 days, average administration time is 108 days.
Beneficial effect of the present invention: adopt the auxiliary treatment Chinese medicine preparation for gastric cancer disclosed in this invention, can improve effect of Chinese medicine ingredients to greatest extent, plays complementary and castering action, improves medicinal effects.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition for the treatment of gastric cancer that the present embodiment provides, is made up of the raw material of Chinese medicine of following weight portion: Flos Magnoliae 40 parts, Exocarpium Benincasae 26 parts, Radix Physochlainae 18 parts, Colla Plastri Testudinis 16 parts, Cortex Ailanthi 10 parts, Cortex Sapii Radicis 11 parts, Folium Ginseng 6 parts, Folium Isatidis 5 parts.
Usage and dosage: above-mentioned raw materials, is simmered in water after boiling with high heat 30 minutes after 30 minutes with warm water soaking again, taking liquid 150 milliliters, then add water and two to decoct, filter after twice medicinal liquid mixing, take at twice.Twice daily, one after each meal.
The course for the treatment of: 20 days be a course for the treatment of, the 2-5 course for the treatment of need be taken.
Model case:
Case 1: journey, man, 77 years old.Gastral cavilty portion pain medical history many decades, the pain increased recently, loss of appetite, because to become thin and melena increases the weight of gradually.Take medicine of the present invention to control after after 5 courses for the treatment of, symptom complete incidence graph, life quality significantly improves.After continue again 4 courses for the treatment of of taking medicine.Follow up a case by regular visits to so far, life is normal.Case 2: the Qin, man, 61 years old, belch, acid regurgitation water, epigastric discomfort, more than epigastric oppression block main cause feed choking feeling half a year, companion's stomachus cardiacus and lesser gastric curvature side thickened stomach wall, after row interventional therapy 1 time, patients diet's choking feeling was without improvement.After taking 5 courses for the treatment of of Chinese medicine of the present invention, feed choking feeling takes a turn for the better, and stomachache, abdominal distention obviously alleviate.Patient adheres to 6 courses for the treatment of of taking medicine, and Effect of follow-up visit by telephone diet is normal, and body weight increases.Case 3: Feng, female, 57 years old, Nausea and vomiting, epigastrium distension pain is accompanied, capsule Space-occupying lesions shadow between liver stomach, considers the occupy-place of gastric antrum portion, multiple low-density shadow in liver, consider metastatic tumor, after taking 5 courses for the treatment of of Drug therapy of the present invention, stomachache, abdominal distention take a turn for the better, and the sense of discomfort such as Nausea and vomiting, acid regurgitation disappears substantially.Continue to take 5 courses for the treatment of, follow up a case by regular visits to food-intake and increase, life is normal.

Claims (2)

1. treat a Chinese medicine composition for gastric cancer, it is characterized in that, be made up of the raw material of Chinese medicine of following weight portion: Flos Magnoliae 31-46 part, Exocarpium Benincasae 21-30 part, Radix Physochlainae 13-24 part, Colla Plastri Testudinis 10-19 part, Cortex Ailanthi 5-14 part, Cortex Sapii Radicis 9-16 part, Folium Ginseng 2-8 part, Folium Isatidis 1-8 part.
2. Chinese medicine according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine of following weight portion: Flos Magnoliae 40 parts, Exocarpium Benincasae 26 parts, Radix Physochlainae 18 parts, Colla Plastri Testudinis 16 parts, Cortex Ailanthi 10 parts, Cortex Sapii Radicis 11 parts, Folium Ginseng 6 parts, Folium Isatidis 5 parts.
CN201511006815.1A 2015-12-30 2015-12-30 Traditional Chinese medicine composition for treating stomach cancer Withdrawn CN105395698A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101091769A (en) * 2007-07-20 2007-12-26 李文良 Medicine for treating and preventing esophagus cancer and gastric cancer, and preparation method
CN101433575A (en) * 2007-11-13 2009-05-20 蒋爱芳 Chinese sapium bark seed extract and preparation method thereof
CN102133284A (en) * 2011-04-06 2011-07-27 李秋荣 Pain killer for relieving pain of tumor patient
CN102357211A (en) * 2011-04-25 2012-02-22 周琼 Traditional Chinese medicine composition for curing cancers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101091769A (en) * 2007-07-20 2007-12-26 李文良 Medicine for treating and preventing esophagus cancer and gastric cancer, and preparation method
CN101433575A (en) * 2007-11-13 2009-05-20 蒋爱芳 Chinese sapium bark seed extract and preparation method thereof
CN102133284A (en) * 2011-04-06 2011-07-27 李秋荣 Pain killer for relieving pain of tumor patient
CN102357211A (en) * 2011-04-25 2012-02-22 周琼 Traditional Chinese medicine composition for curing cancers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
南京中医药大学: "《中药大辞典（第二版）》", 31 March 2006 *

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Application publication date: 20160316