CN105663399A - Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese medicine composition for treating gastric cancer and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 55-69 parts of buddleja officinalis, 50-68 parts of Indian adenosma, 41-57 parts of common cissampelos herb, 36-48 parts of erycibe obtusifolia benth, 33-46 parts of medulla stachyuri, 25-41 parts of fructus malvae, 21-36 parts of semen nigellae, 12-23 parts of cynomorium songaricum and 11-18 parts of herba hyperici perforate. In the invention, the adopted traditional Chinese medicines are reasonably collocated and can relieve the clinical symptoms of various types of gastric cancer, reduce the toxic and side effects of radiotherapy and chemotherapy, increase the treatment rate and prolong the survival time.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating gastric cancer.
Background technology
Gastric cancer is the malignant tumor that digestive system is common, is universally acknowledged persistent ailment, and the healthy of people and life in serious threat. There is no the name of disease of gastric cancer in Chinese medicine, it is discussed and is separately documented in the diseases such as " gastric abscess ", " regurgitation ", " cancer of the esophagus ", " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ", " gathering ", " abdominal mass ". " Medical Treasures of the Golden Chamber " is called: " eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night, indigested food stagnated in the stomach, name says regurgitation. " pathogenic factor of gastric cancer, clinical picture more have a detailed description by Golden Mirror of Medicine: " and three sun accumulation of heats, call stomach, small intestinal, large intestine, and three mansion accumulation of heats do not dissipate, and burn refining body fluid ... cardia dries up, then the road including water paddy in is narrow, thus food can not under, for dysphagia also; Pylorus dry up, then release corruption road narrow, therefore eat counter go out, for regurgitation of food from the stomach also. "
The traditional Chinese medical science thinks that chronic dietary does not save, disorder of emotion, overstrain internal injury or being invaded by exogenous pathogen, cause body zang-fu differentiation malfunction, imbalance between YIN and YANG, occur that a series of pathological changes such as stagnant stopped up by food stagnation, the stagnation of QI, blood stasis, expectorant knot, evil poison, ultimately result in abdominal mass, form cancerous protuberance. The pathogenesis of gastric cancer is with weakness of the spleen and stomach for this, and the stagnation of QI, blood stasis, expectorant are solidifying, mark become by poison. From the angle of doctor trained in Western medicine, gastric cancer is derived from the malignant tumor of gastric epithelial, accounts for the 3rd of whole malignant tumor, accounts for the first place of malignant tumor of digestive tract, account for the 95% of stomach malignancy, is the commonly encountered diseases of a kind of serious threat human body health and lives.
Summary of the invention
The technical problem to be solved is: provide the Chinese medicinal composition preparation of the treatment gastric cancer that a kind of cure rate is high.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
The Chinese medicine composition for the treatment of gastric cancer provided by the invention, it is made up of the raw material of following weight portion: Flos Buddlejae 55-69 part, Herba Adenosmae 50-68 part, Herba Cissampelotis pareiae 41-57 part, Caulis Erycibes 36-48 part, Medulla Stachyuri (Medulla Helwingiae) 33-46 part, Fructus Malvae 25-41 part, Semen Nigellae 21-36 part, Herba Cynomorii 12-23 part, Herba Hyperici Monogyni 11-18 part.
Preferably, the Chinese medicine of the present invention is made up of the raw material of Chinese medicine of following weight portion: Flos Buddlejae 61 parts, Herba Adenosmae 59 parts, Herba Cissampelotis pareiae 49 parts, Caulis Erycibes 42 parts, Medulla Stachyuri (Medulla Helwingiae) 40 parts, Fructus Malvae 36 parts, Semen Nigellae 30 parts, Herba Cynomorii 19 parts, Herba Hyperici Monogyni 16 parts.
Preferably, the present invention also provides for a kind of method preparing Chinese medicine composition, it is characterised in that comprise the following steps:
(1) take Flos Buddlejae, Herba Adenosmae, Herba Cissampelotis pareiae add distilled water immersion 4-9 hour, extract volatile oil with volatile oil extractor, dry acquirement volatile oil with anhydrous magnesium sulfate, then use hydroxypropylβ-cyclodextrin inclusion, prepare clathrate, and clathrate and medicinal residues are standby.
(2) take Caulis Erycibes, Medulla Stachyuri (Medulla Helwingiae), Fructus Malvae, add 75% ethanol extraction 2-6 time, each 1 hour, merge medicinal liquid, stand 24 hours, standby.
(3) after taking the medicinal residues mixing of Semen Nigellae, Herba Cynomorii, Herba Hyperici Monogyni and step (1), then the ethanol adding the water of gross weight 3-7 times and the 70% of 0.5-1 times decocts 1.5-3h, double, merges the extracting solution of twice.
(4) taking the supernatant of step (2), (3), decompression recycling ethanol, be concentrated into 55 DEG C-65 DEG C, density is the extractum of 1.01-1.06, and concentrate drying makes powder.
(5) by the powder mix homogeneously of the clathrate of step (1), (4).
Preferably, in step (1) weight of distilled water be Flos Buddlejae, Herba Adenosmae, 3-6 times of Herba Cissampelotis pareiae gross weight, temperature is 40-70 degree Celsius.
Preferably, the mixed Chinese medicine of step (5) loads capsule, and the nt wt net weight of built-in Chinese medicine is 1 gram, and the using method of Chinese medicine is: oral, three times on the one, one time one.
Beneficial effects of the present invention:
The Chinese medicine good absorbing effect of the present invention, safety is high, has heat-clearing and toxic substances removing, inducing diuresis to remove edema, a pharmacological action enriched blood of regulating the flow of vital energy, and is conducive to patient to alleviate condition of illness in time.
Chinese medicine used by the present invention, collocation rationally, can alleviate the clinical symptoms of all kinds gastric cancer, alleviates the toxicity of Radiotherapy chemotherapy, improves treatment rate, extends life span.
The present invention compared with prior art, has good active anticancer, and can use as cancer therapy drug; And Chinese medicine composition of the present invention preparation is simple, and raw material is easy to get, and is suitable to popular use, has good application prospect.
Detailed description of the invention
Embodiment 1
The Chinese medicine composition of the treatment gastric cancer that the present embodiment provides, is made up of the raw material of following weight: Flos Buddlejae 61 parts, Herba Adenosmae 59 parts, Herba Cissampelotis pareiae 49 parts, Caulis Erycibes 42 parts, Medulla Stachyuri (Medulla Helwingiae) 40 parts, Fructus Malvae 36 parts, Semen Nigellae 30 parts, Herba Cynomorii 19 parts, Herba Hyperici Monogyni 16 parts.
The method preparing above-mentioned Chinese medicine composition, comprises the following steps:
((1) takes Flos Buddlejae, Herba Adenosmae, Herba Cissampelotis pareiae add distilled water immersion 6 hours, extracts volatile oil with volatile oil extractor, dries acquirement volatile oil with anhydrous magnesium sulfate, then use hydroxypropylβ-cyclodextrin inclusion, prepares clathrate, and clathrate and medicinal residues are standby.
(2) take Caulis Erycibes, Medulla Stachyuri (Medulla Helwingiae), Fructus Malvae, add 75% ethanol extraction 4 times, each 1 hour, merge medicinal liquid, stand 24 hours, standby.
(3) after taking the medicinal residues mixing of Semen Nigellae, Herba Cynomorii, Herba Hyperici Monogyni and step (1), then the ethanol adding the water of gross weight 5 times and the 70% of 0.5-1 times decocts 2h, double, merges the extracting solution of twice.
(4) taking the supernatant of step (2), (3), decompression recycling ethanol, be concentrated into 60 DEG C, density is the extractum of 1.03, and concentrate drying makes powder.
(5) by the powder mix homogeneously of the clathrate of step (1), (4).
In step (1) weight of distilled water be Flos Buddlejae, Herba Adenosmae, 5 times of Herba Cissampelotis pareiae gross weight, temperature is 60 degrees Celsius.
Embodiment 2
The Chinese medicine composition of the treatment gastric cancer that the present embodiment provides, is made up of the raw material of following weight: Flos Buddlejae 69 parts, Herba Adenosmae 68 parts, Herba Cissampelotis pareiae 57 parts, Caulis Erycibes 48 parts, Medulla Stachyuri (Medulla Helwingiae) 46 parts, Fructus Malvae 41 parts, Semen Nigellae 36 parts, Herba Cynomorii 23 parts, Herba Hyperici Monogyni 18 parts.
The method preparing above-mentioned Chinese medicine composition, comprises the following steps:
(1) take Flos Buddlejae, Herba Adenosmae, Herba Cissampelotis pareiae add distilled water immersion 9 hours, extract volatile oil with volatile oil extractor, dry acquirement volatile oil with anhydrous magnesium sulfate, then use hydroxypropylβ-cyclodextrin inclusion, prepare clathrate, and clathrate and medicinal residues are standby.
(2) take Caulis Erycibes, Medulla Stachyuri (Medulla Helwingiae), Fructus Malvae, add 75% ethanol extraction 6 times, each 1 hour, merge medicinal liquid, stand 24 hours, standby.
(3) after taking the medicinal residues mixing of Semen Nigellae, Herba Cynomorii, Herba Hyperici Monogyni and step (1), then the ethanol adding the water of gross weight 7 times and the 70% of 0.5-1 times decocts 3h, double, merges the extracting solution of twice.
(4) taking the supernatant of step (2), (3), decompression recycling ethanol, be concentrated into 65 DEG C, density is the extractum of 1.06, and concentrate drying makes powder.
(5) by the powder mix homogeneously of the clathrate of step (1), (4).
In step (1) weight of distilled water be Flos Buddlejae, Herba Adenosmae, 6 times of Herba Cissampelotis pareiae gross weight, temperature is 70 degrees Celsius.
Embodiment 3
The Chinese medicine composition of the treatment gastric cancer that the present embodiment provides, is made up of the raw material of following weight: Flos Buddlejae 55 parts, Herba Adenosmae 50 parts, Herba Cissampelotis pareiae 41 parts, Caulis Erycibes 36 parts, Medulla Stachyuri (Medulla Helwingiae) 33 parts, Fructus Malvae 25 parts, Semen Nigellae 21 parts, Herba Cynomorii 12 parts, Herba Hyperici Monogyni 11 parts.
The method preparing above-mentioned Chinese medicine composition, comprises the following steps:
(1) take Flos Buddlejae, Herba Adenosmae, Herba Cissampelotis pareiae add distilled water immersion 4 hours, extract volatile oil with volatile oil extractor, dry acquirement volatile oil with anhydrous magnesium sulfate, then use hydroxypropylβ-cyclodextrin inclusion, prepare clathrate, and clathrate and medicinal residues are standby.
(2) take Caulis Erycibes, Medulla Stachyuri (Medulla Helwingiae), Fructus Malvae, add 75% ethanol extraction 2 times, each 1 hour, merge medicinal liquid, stand 24 hours, standby.
(3) after taking the medicinal residues mixing of Semen Nigellae, Herba Cynomorii, Herba Hyperici Monogyni and step (1), then the ethanol adding the water of gross weight 3 times and the 70% of 0.5-1 times decocts 1.5h, double, merges the extracting solution of twice.
(4) taking the supernatant of step (2), (3), decompression recycling ethanol, be concentrated into 55 DEG C, density is the extractum of 1.01, and concentrate drying makes powder.
(5) by the powder mix homogeneously of the clathrate of step (1), (4).
In step (1) weight of distilled water be Flos Buddlejae, Herba Adenosmae, 3 times of Herba Cissampelotis pareiae gross weight, temperature is 40 degrees Celsius.
Clinical verification:
1, case selection
200 example patients are all diagnosed as gastric cancer through fibergastroscope and histopathological examination.
2, diagnostic criteria
With reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard:
(1) symptom: gastric cancer lacks specific clinical symptoms; Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, Nausea and vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely occur in the different phase in gastric cancer generation evolution, but all without specificity.
(2) sign: gastric cancer lacks specificity sign; Early gastric cancer often without obvious sign, late gastric cancer or likely occur that epigastrium lump, rectum front touch the sign such as swollen thing, supraclavicular lymph nodes enlargement when there is metastasis focus.
(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high, can be accurately positioned the position of tumor by fibergastroscopy, it is possible to simultaneously obtain tissue specimen to complete pathological biopsy. Nearly all patient diagnosed as gastric cancer through upper digestive tract contrast examination is required for accepting fibergastroscopy and pathological biopsy again to make a definite diagnosis. Therefore, should directly select gastroscope replaces upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer.
(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without calm and be widely used.But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy. Should can not carry out the medical institutions of fibergastroscopy or to tolerating the gastroscopic patient inspection method selected as diagnosing gastric cancer.
(5) histodiagnosis: histopathologic diagnosis is the determination diagnosis basis of gastric cancer, before implementing various oncotherapy means, should obtain pathological diagnosis foundation as far as possible.
(6) computed tomographic venography (CT): computed tomographic venography has value in evaluating the extent of disease of gastric cancer, metastases in local lymph node situation and metastasis situation etc., should as the first-selected inspection method of preoperative staging of gastric carcinoma.
(7) diagnosis: the diagnosis of gastric cancer cannot rely on merely the clinical data such as medical history, sings and symptoms to be established. The conventional application method such as upper digestive tract radiography and fibergastroscopy establishes the clinical diagnosis of gastric cancer clinically, should prefered method using the latter as diagnosis. The foundation of making a definite diagnosis of gastric cancer is histopathological examination result.
3, Therapeutic Method:
Oral, three times on the one, one time one.
The course for the treatment of: 30 days be a course for the treatment of, the 2-5 course for the treatment of need to be taken.
4, efficacy assessment standard
Record tumor size, B ultrasonic, CT examination result before and after treatment; All patients routine examination blood, urine, stool routine, hepatic and renal function and electrocardiogram, observe reaction in therapeutic process, efficacy evaluation is according to RECIST solid tumor the standard of curative effect evaluation:
Complete incidence graph (CR): all foci disappearances, occurs without new focus, tumor markers is down to normally, and at least maintains 4 weeks;
Partial rcsponse (PR): the most major diameter sum of tumor reduces >=more than 30%, and at least maintains 4 weeks;
Pathological changes stablizes (SD): tumor maximum diameter sum reduces and do not reach PR, or increase does not reach PD;
Lesion growth (PD): maximum diameter increases >=20%, or new focus occurs; But the division of former focus is not very interior.
With CR+PR for effectively (RR).
Observational technique: mid-term effects observes the symptoms alleviation situation, life quality after 5 courses for the treatment of of treatment, Patients after Chemotherapy detection after end of chemotherapy 3 weeks; Late result is substantially carried out the investigation of life span.
Remission status: fatigue and asthenia, lustreless complexion, loss of appetite often occurs in gastric cancer, defecate uncomfortable, glutted after food, the symptom such as nausea and vomiting, score in various degree according to these Symptoms, and calculating integral value, after treatment, symptom average product score value is improvement than more than 1/3 person that declines before treatment.
Life quality: evaluate with muscle power situation scoring kamofsky standard, improves more than 10 points for improving, and declines less than 10 points for declining, and before and after treatment, change is divided into constant less than 10.
5, therapeutic outcome
After treating 5 courses for the treatment of, in 200 example patients, 175 example complete incidence graph therein, tracking is followed up a case by regular visits to, and muscle power is normal. 20 example partial rcsponses, can complete normal life substantially. 5 example pathological changes are stable. 0 example lesion growth.
By therapeutic outcome it can be seen that the curative effect highly significant of the Chinese medicine of the present invention.
Model case:
Case 1: Zhang, man, 53 years old. Patient's stomachache, abdominal distention, belong to gastric cancer mid-term. Taking after Chinese medicine composition of the present invention controls 4 courses for the treatment of, patient's stomachache, abdominal distention take a turn for the better, disappearance uncomfortable in chest, weak. After continue again 3 courses for the treatment of of taking medicine. Following up a case by regular visits to so far, life is normal.
Case 2: Zheng, man, 51 years old, patient's abdominal pain, without obvious rhythmicity, goes hospital diagnosis to find the visible occupying lesion in gastric antrum portion, size 32mm*26mm, diagnoses as gastric cancer.After taking 4 courses for the treatment of of Chinese medicine composition of the present invention, the malaise symptoms such as epigastrium pain, health are tired obtain alleviation in various degree. After continuing to take 2 courses for the treatment of, all malaise symptoms are all eased, and check and find that cancerous cell obtains effective control, without the sign of diffusion. Follow up a case by regular visits to so far, do not spread or shift.
Case 3: Hu, man, 59 years old, patient's epigastrium pain, abdominal distention, heartburn, acid regurgitation accompanied stomachus cardiacus and lesser gastric curvature side thickened stomach wall. After taking 4 courses for the treatment of of Chinese medicine composition of the present invention, feed choking feeling takes a turn for the better, and stomachache, abdominal distention substantially alleviate. Patient adheres to 5 courses for the treatment of of taking medicine, and follows up a case by regular visits to diet normally, and body weight increases.
Case 4: Liu, female, 64 years old, capsule Space-occupying lesions shadow between patient's liver stomach, Nausea and vomiting, epigastrium distension pain accompany, take the present composition treatment 3 courses for the treatment of after, stomachache, abdominal distention take a turn for the better, the sense of discomfort such as Nausea and vomiting, acid regurgitation disappears substantially. Continuing to take 4 courses for the treatment of, follow up a case by regular visits to food-intake and increase, life is normal.
Claims (4)
1. the Chinese medicine composition treating gastric cancer, it is characterized in that, it is made up of the raw material of following weight portion: Flos Buddlejae 55-69 part, Herba Adenosmae 50-68 part, Herba Cissampelotis pareiae 41-57 part, Caulis Erycibes 36-48 part, Medulla Stachyuri (Medulla Helwingiae) 33-46 part, Fructus Malvae 25-41 part, Semen Nigellae 21-36 part, Herba Cynomorii 12-23 part, Herba Hyperici Monogyni 11-18 part.
2. Chinese medicine composition according to claim 1, it is characterised in that be made up of the raw material of Chinese medicine of following weight portion: Flos Buddlejae 61 parts, Herba Adenosmae 59 parts, Herba Cissampelotis pareiae 49 parts, Caulis Erycibes 42 parts, Medulla Stachyuri (Medulla Helwingiae) 40 parts, Fructus Malvae 36 parts, Semen Nigellae 30 parts, Herba Cynomorii 19 parts, Herba Hyperici Monogyni 16 parts.
3. the method preparing Chinese medicine composition described in any of the above-described claim, it is characterised in that comprise the following steps:
(1) take Flos Buddlejae, Herba Adenosmae, Herba Cissampelotis pareiae add distilled water immersion 4-9 hour, extract volatile oil with volatile oil extractor, dry acquirement volatile oil with anhydrous magnesium sulfate, then use hydroxypropylβ-cyclodextrin inclusion, prepare clathrate, and clathrate and medicinal residues are standby;
(2) take Caulis Erycibes, Medulla Stachyuri (Medulla Helwingiae), Fructus Malvae, add 75% ethanol extraction 2-6 time, each 1 hour, merge medicinal liquid, stand 24 hours, standby;
(3) after taking the medicinal residues mixing of Semen Nigellae, Herba Cynomorii, Herba Hyperici Monogyni and step (1), then the ethanol adding the water of gross weight 3-7 times and the 70% of 0.5-1 times decocts 1.5-3h, double, merges the extracting solution of twice;
(4) taking the supernatant of step (2), (3), decompression recycling ethanol, be concentrated into 55 DEG C-65 DEG C, density is the extractum of 1.01-1.06, and concentrate drying makes powder;
(5) by the powder mix homogeneously of the clathrate of step (1), (4).
4. method according to claim 3, it is characterised in that in step (1) weight of distilled water be Flos Buddlejae, Herba Adenosmae, 3-6 times of Herba Cissampelotis pareiae gross weight, temperature is 40-70 degree Celsius.
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| CN201610132378.6A CN105663399A (en) | 2016-03-10 | 2016-03-10 | Traditional Chinese medicine composition for treating gastric cancer and preparation method thereof |
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