CN105687673A - Medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine - Google Patents
Medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine Download PDFInfo
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- CN105687673A CN105687673A CN201610170934.9A CN201610170934A CN105687673A CN 105687673 A CN105687673 A CN 105687673A CN 201610170934 A CN201610170934 A CN 201610170934A CN 105687673 A CN105687673 A CN 105687673A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
Abstract
The invention discloses a medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine. The medicament is prepared from the following raw materials in parts by weight: 52-71 parts of Hupeh fritillary bulb, 41-63 parts of longan aril, 38-55 parts of soapberry, 32-48 parts of processed rhizoma arisaematis, 26-38 parts of callicarpa macrophylla, 22-36 parts of manchurian lilac bark, 15-30 parts of folium sennae, 11-26 parts of okusa, 0.3-0.9 part of fluorouracil, 0.5-1.3 parts of tegafur and 0.1-0.8 part of mitomycin. Compared with treatment based on single traditional Chinese medicine or western medicine, the medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine has a better curative effect, and is capable of improving the efficacy of Chinese herbal medicinal ingredients and western medicine to the greatest extent, giving play to complementation and promotion effects and improving the medical effect.
Description
Technical field
The present invention relates to the medicine of a kind of therapy of combining Chinese and Western medicine gastric cancer。
Background technology
Gastric cancer is the malignant tumor that digestive system is common, is universally acknowledged persistent ailment, and the healthy of people and life in serious threat。There is no the name of disease of gastric cancer in Chinese medicine, it is discussed and is separately documented in the diseases such as " gastric abscess ", " regurgitation ", " cancer of the esophagus ", " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ", " gathering ", " abdominal mass "。" Medical Treasures of the Golden Chamber " is called: " eating in the morning but vomiting out in the evening, vomiting out in the morning what eaten at last night, indigested food stagnated in the stomach, name says regurgitation。" pathogenic factor of gastric cancer, clinical picture more have a detailed description by Golden Mirror of Medicine: " and three sun accumulation of heats, call stomach, small intestinal, large intestine, and three mansion accumulation of heats do not dissipate, and burn refining body fluid ... cardia dries up, then the road including water paddy in is narrow, thus food can not under, for dysphagia also；Pylorus dry up, then release corruption road narrow, therefore eat counter go out, for regurgitation of food from the stomach also。"
The traditional Chinese medical science thinks that chronic dietary does not save, disorder of emotion, overstrain internal injury or being invaded by exogenous pathogen, cause body zang-fu differentiation malfunction, imbalance between YIN and YANG, occur that a series of pathological changes such as stagnant stopped up by food stagnation, the stagnation of QI, blood stasis, expectorant knot, evil poison, ultimately result in abdominal mass, form cancerous protuberance。The pathogenesis of gastric cancer is with weakness of the spleen and stomach for this, and the stagnation of QI, blood stasis, expectorant are solidifying, mark become by poison。From the angle of doctor trained in Western medicine, gastric cancer is derived from the malignant tumor of gastric epithelial, accounts for the 3rd of whole malignant tumor, accounts for the first place of malignant tumor of digestive tract, account for the 95% of stomach malignancy, is the commonly encountered diseases of a kind of serious threat human body health and lives。
Summary of the invention
The technical problem to be solved is: provide the pharmaceutical preparation of the therapy of combining Chinese and Western medicine gastric cancer that a kind of cure rate is high。
For solving above-mentioned technical problem, the technical solution used in the present invention is:
The medicine of therapy of combining Chinese and Western medicine gastric cancer provided by the invention, is made up of the raw material of following weight portion:
Wherein Chinese medicinal material includes: Hupeh Fritillary Bulb 52-71 part, Arillus Longan 41-63 part, Fructus Sapindi Mukouossi 38-55 part, Rhizoma Arisaematis (processed) 32-48 part, Folium Callicarpae Macrophyllae 26-38 part, Cortex Syingae Amurensis 22-36 part, Folium Sennae 15-30 part, DACAO 11-26 part。
Western medicine medicine includes: fluorouracil 0.3-0.9 part, ftorafur 0.5-1.3 part, mitomycin 0.1-0.8 part。
Preferably, the medicine of the present invention is made up of the raw material of following weight portion: Hupeh Fritillary Bulb 63 parts, Arillus Longan 52 parts, Fructus Sapindi Mukouossi 46 parts, Rhizoma Arisaematis (processed) 41 parts, Folium Callicarpae Macrophyllae 32 parts, Cortex Syingae Amurensis 29 parts, Folium Sennae 20 parts, DACAO 13 parts, fluorouracil 0.6 part, ftorafur 0.9 part, mitomycin 0.4 part。
The present invention also provides for a kind of method preparing described medicine, it is characterised in that comprising the following steps: that Chinese medicine is after sterilizing and cleaning, putting into pulverizer, to be crushed to 300 orders standby；Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
Preferably, the nt wt net weight of the medicine that every capsules is built-in is 1 gram, and the using method of medicine is: oral, twice on the one, one time one。
Clinical verification:
1, case selection
200 example patients are all diagnosed as gastric cancer through fibergastroscope and histopathological examination。
2, diagnostic criteria
With reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard:
(1) symptom: gastric cancer lacks specific clinical symptoms；Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, Nausea and vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely occur in the different phase in gastric cancer generation evolution, but all without specificity。
(2) sign: gastric cancer lacks specificity sign；Early gastric cancer often without obvious sign, late gastric cancer or likely occur that epigastrium lump, rectum front touch the sign such as swollen thing, supraclavicular lymph nodes enlargement when there is metastasis focus。
(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high, can be accurately positioned the position of tumor by fibergastroscopy, it is possible to simultaneously obtain tissue specimen to complete pathological biopsy。Nearly all patient diagnosed as gastric cancer through upper digestive tract contrast examination is required for accepting fibergastroscopy and pathological biopsy again to make a definite diagnosis。Therefore, should directly select gastroscope replaces upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer。
(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without calm and be widely used。But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy。Should can not carry out the medical institutions of fibergastroscopy or to tolerating the gastroscopic patient inspection method selected as diagnosing gastric cancer。
(5) histodiagnosis: histopathologic diagnosis is the determination diagnosis basis of gastric cancer, before implementing various oncotherapy means, should obtain pathological diagnosis foundation as far as possible。
(6) computed tomographic venography (CT): computed tomographic venography has value in evaluating the extent of disease of gastric cancer, metastases in local lymph node situation and metastasis situation etc., should as the first-selected inspection method of preoperative staging of gastric carcinoma。
(7) diagnosis: the diagnosis of gastric cancer cannot rely on merely the clinical data such as medical history, sings and symptoms to be established。The conventional application method such as upper digestive tract radiography and fibergastroscopy establishes the clinical diagnosis of gastric cancer clinically, should prefered method using the latter as diagnosis。The foundation of making a definite diagnosis of gastric cancer is histopathological examination result。
3, Therapeutic Method:
Oral, twice on the one, one time one。
The course for the treatment of: 30 days be a course for the treatment of, the 2-5 course for the treatment of need to be taken。
4, efficacy assessment standard
Record tumor size, B ultrasonic, CT examination result before and after treatment；All patients routine examination blood, urine, stool routine, hepatic and renal function and electrocardiogram, observe reaction in therapeutic process, efficacy evaluation is according to RECIST solid tumor the standard of curative effect evaluation:
Complete incidence graph (CR): all foci disappearances, occurs without new focus, tumor markers is down to normally, and at least maintains 4 weeks；
Partial rcsponse (PR): the most major diameter sum of tumor reduces >=more than 30%, and at least maintains 4 weeks；
Pathological changes stablizes (SD): tumor maximum diameter sum reduces and do not reach PR, or increase does not reach PD；
Lesion growth (PD): maximum diameter increases >=20%, or new focus occurs；But the division of former focus is not very interior。
With CR+PR for effectively (RR)。
Observational technique: mid-term effects observes the symptoms alleviation situation, life quality after 5 courses for the treatment of of treatment, Patients after Chemotherapy detection after end of chemotherapy 3 weeks；Late result is substantially carried out the investigation of life span。
Remission status: fatigue and asthenia, lustreless complexion, loss of appetite often occurs in gastric cancer, defecate uncomfortable, glutted after food, the symptom such as nausea and vomiting, score in various degree according to these Symptoms, and calculating integral value, after treatment, symptom average product score value is improvement than more than 1/3 person that declines before treatment。
Life quality: evaluate with muscle power situation scoring kamofsky standard, improves more than 10 points for improving, and declines less than 10 points for declining, and before and after treatment, change is divided into constant less than 10。
5, therapeutic outcome
After treating 5 courses for the treatment of, in 200 example patients, 165 example complete incidence graph therein, it is possible to kept in touch by phone or network mode and patient household or sufferers themselves, to follow the tracks of and follow up a case by regular visits to 2 years half, muscle power is normal。21 example partial rcsponses, can complete normal life substantially。10 example pathological changes are stable。4 example lesion growth。
Beneficial effects of the present invention:
The present invention uses therapy of combining Chinese and Western medicine than the generally simple traditional Chinese medical science and western medical treatment effect more preferably, it is possible to improves effect of Chinese medicine ingredients and Western medicine to greatest extent, plays complementary and castering action, improve medicinal effects。
Good absorbing effect, safety is high, has heat-clearing and toxic substances removing, inducing diuresis to remove edema, a pharmacological action enriched blood of regulating the flow of vital energy, and is conducive to patient to alleviate condition of illness in time。
Chinese medicine used by the present invention, collocation rationally, can alleviate the clinical symptoms of all kinds gastric cancer, alleviates the toxicity of Radiotherapy chemotherapy, improves treatment rate, extends life span。
Detailed description of the invention
Embodiment 1
The medicine of the therapy of combining Chinese and Western medicine gastric cancer that the present embodiment provides, it is made up of the raw material of following weight: Hupeh Fritillary Bulb 63 grams, Arillus Longan 52 grams, Fructus Sapindi Mukouossi 46 grams, Rhizoma Arisaematis (processed) 41 grams, Folium Callicarpae Macrophyllae 32 grams, Cortex Syingae Amurensis 29 grams, Folium Sennae 20 grams, DACAO 13 grams, fluorouracil 0.6 gram, ftorafur 0.9 gram, mitomycin 0.4 gram。
The method of the medicine that preparation is described, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby；Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。The nt wt net weight of the medicine that every capsules is built-in is 1 gram, and the using method of medicine is: oral, twice on the one, one time one。
Embodiment 2
The medicine of the therapy of combining Chinese and Western medicine gastric cancer that the present embodiment provides, it is made up of the raw material of following weight: Hupeh Fritillary Bulb 52 grams, Arillus Longan 41 grams, Fructus Sapindi Mukouossi 38 grams, Rhizoma Arisaematis (processed) 32 grams, Folium Callicarpae Macrophyllae 26 grams, Cortex Syingae Amurensis 22 grams, Folium Sennae 15 grams, DACAO 11 grams, fluorouracil 0.3 gram, ftorafur 0.5 gram, mitomycin 0.1 gram。
The method of the medicine that preparation is described, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby；Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。The nt wt net weight of the medicine that every capsules is built-in is 1 gram, and the using method of medicine is: oral, twice on the one, one time one。
Embodiment 3
The medicine of the therapy of combining Chinese and Western medicine gastric cancer that the present embodiment provides, it is made up of the raw material of following weight: Hupeh Fritillary Bulb 71 grams, Arillus Longan 63 grams, Fructus Sapindi Mukouossi 55 grams, Rhizoma Arisaematis (processed) 48 grams, Folium Callicarpae Macrophyllae 38 grams, Cortex Syingae Amurensis 36 grams, Folium Sennae 30 grams, DACAO 26 grams, fluorouracil 0.9 gram, ftorafur 1.3 grams, mitomycin 0.8 gram。
The method of the medicine that preparation is described, comprises the following steps: that Chinese medicine is after sterilizing and cleaning, and putting into pulverizer, to be crushed to 300 orders standby；Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。The nt wt net weight of the medicine that every capsules is built-in is 1 gram, and the using method of medicine is: oral, twice on the one, one time one。
Model case:
Case 1: Wang, man, 69 years old。Epigastrium pain, abdominal distention 1 year, with melena, time have gastric antrum uncomfortable in chest, weak uneven to thicken, after peritoneum and para-aortic lymph node enlargement。Diagnosis: Gerontal gastric cancer, give after being admitted to hospital to the ill after Supporting Therapy without taking a turn for the better。Taking after medicine of the present invention controls 4 courses for the treatment of, patient's stomachache, abdominal distention take a turn for the better, disappearance uncomfortable in chest, weak。After continue again 3 courses for the treatment of of taking medicine。Following up a case by regular visits to so far, life is normal。
Case 2: hole, female, 52 years old, stomachache, abdominal distention, feed choking feeling more than 1 year, accompany stomachus cardiacus and lesser gastric curvature side thickened stomach wall。After taking 3 courses for the treatment of of medicine of the present invention, feed choking feeling takes a turn for the better, and stomachache, abdominal distention substantially alleviate。Patient adheres to 5 courses for the treatment of of taking medicine, and follows up a case by regular visits to diet normally, and body weight increases。
Case 3: Huang, man, 41 years old, Nausea and vomiting, epigastrium distension pain was accompanied, capsule Space-occupying lesions shadow between liver stomach, and after taking 5 courses for the treatment of of Drug therapy of the present invention, stomachache, abdominal distention take a turn for the better, and the sense of discomfort such as Nausea and vomiting, acid regurgitation disappears。Continuing to take 3 courses for the treatment of, follow up a case by regular visits to food-intake and increase, life is normal。
Case 4: Zhao, female, 52 years old, patient's readme: occurred that gastral cavilty portion was uncomfortable without obvious inducement before 4 months, have a dull ache, once take the Drug therapys such as motilium, have no improvement, after in certain hospital's row gastroscopy, diagnose as cardia adenocarcinoma of stomach。By the agency of starts to take medicine of the present invention subsequently, takes pain relief after 2 courses for the treatment of, and appetite take a favorable turn sign, and after continuing to take 3 courses for the treatment of, above-mentioned symptom disappears, after consolidating 2 courses for the treatment of of medication, and drug withdrawal, do not recur so far。
Claims (3)
1. the medicine of therapy of combining Chinese and Western medicine gastric cancer, it is characterised in that be made up of the raw material of following weight portion: Hupeh Fritillary Bulb 52-71 part, Arillus Longan 41-63 part, Fructus Sapindi Mukouossi 38-55 part, Rhizoma Arisaematis (processed) 32-48 part, Folium Callicarpae Macrophyllae 26-38 part, Cortex Syingae Amurensis 22-36 part, Folium Sennae 15-30 part, DACAO 11-26 part, fluorouracil 0.3-0.9 part, ftorafur 0.5-1.3 part, mitomycin 0.1-0.8 part。
2. medicine according to claim 1, it is characterised in that be made up of the raw material of Chinese medicine of following weight portion: Hupeh Fritillary Bulb 63 parts, Arillus Longan 52 parts, Fructus Sapindi Mukouossi 46 parts, Rhizoma Arisaematis (processed) 41 parts, Folium Callicarpae Macrophyllae 32 parts, Cortex Syingae Amurensis 29 parts, Folium Sennae 20 parts, DACAO 13 parts, fluorouracil 0.6 part, ftorafur 0.9 part, mitomycin 0.4 part。
3. the method preparing medicine described in any of the above-described claim, it is characterised in that comprise the following steps: that Chinese medicine is after sterilizing and cleaning, putting into pulverizer, to be crushed to 300 orders standby；Western medicine medicine adopts method prepared by modern medicine to make powder, loads capsule with Chinese medicine powder after then mixing。
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610170934.9A CN105687673A (en) | 2016-03-24 | 2016-03-24 | Medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine |
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| CN201610170934.9A CN105687673A (en) | 2016-03-24 | 2016-03-24 | Medicament capable of treating gastric cancer by virtue of combined treatment of traditional Chinese medicine and western medicine |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656554A (en) * | 2012-09-13 | 2014-03-26 | 李树军 | Traditional Chinese medicine for treating tumors and cancers |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656554A (en) * | 2012-09-13 | 2014-03-26 | 李树军 | Traditional Chinese medicine for treating tumors and cancers |
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Application publication date: 20160622 |