CN105394748A - 从营养方面改善葡萄糖控制和胰岛素作用的方法和组合物 - Google Patents
从营养方面改善葡萄糖控制和胰岛素作用的方法和组合物 Download PDFInfo
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109528734A (zh) * | 2019-01-24 | 2019-03-29 | 华纳时代健康科技（武汉）股份有限公司 | 一种复合营养组合物及其制备方法 |
| CN116473125A (zh) * | 2022-01-17 | 2023-07-25 | 内蒙古伊利实业集团股份有限公司 | 一种缓释碳水组合物以及应用 |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| WO2009135959A1 (es) * | 2008-05-07 | 2009-11-12 | Katry Inversiones, S.L. | Producto alimenticio para la nutrición por vía enteral u oral del paciente diabético |
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| SG10201901259RA (en) | 2009-02-24 | 2019-03-28 | Ritter Pharmaceuticals Inc | Prebiotic formulations and methods of use |
| EP2411033B1 (en) | 2009-03-24 | 2015-03-04 | Universiti Putra Malaysia | Anti-diabetic nutraceutical composition from palm leaf extract |
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| WO2012161670A2 (en) | 2010-04-07 | 2012-11-29 | Incube Labs, Llc | Method for treating diabetes and other glucose regulation disorders using stem cells |
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| CN114631628A (zh) * | 2020-12-15 | 2022-06-17 | 中国科学院上海营养与健康研究所 | 一种增加血液fgf21浓度的方法 |
| CN114794487A (zh) * | 2021-01-22 | 2022-07-29 | 中国科学院上海营养与健康研究所 | 一种治疗糖尿病的方法 |
| CN113785915A (zh) * | 2021-08-05 | 2021-12-14 | 中山大学 | 一种甜味敏感的食物配方及其动物模型的构建方法 |
| CN113521277A (zh) * | 2021-08-27 | 2021-10-22 | 四川力量科技有限公司 | 一种康复糖尿病的产品及其制备方法 |
| CN116549428B (zh) * | 2023-06-20 | 2025-05-16 | 郑州大学 | 4-羟基异亮氨酸的新用途 |
| WO2026038577A1 (ja) * | 2024-08-15 | 2026-02-19 | 太陽化学株式会社 | 飲食品摂取後の血中アミノ酸または消化管ホルモン濃度制御用組成物 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776887A (en) * | 1995-10-16 | 1998-07-07 | Bristol-Myers Squibb Company | Diabetic nutritional product having controlled absorption of carbohydrate |
| EP0898900A2 (en) * | 1997-06-23 | 1999-03-03 | Societe Des Produits Nestle S.A. | Composition and method for providing nutrition to diabetics |
| US5886037A (en) * | 1996-11-20 | 1999-03-23 | N.V. Nutricia | Nutritional composition for the treatment of hypertriglyceridaemia and hyperchylomicronaemia |
| US6140304A (en) * | 1988-09-28 | 2000-10-31 | Eicotech Corporation | Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia |
| CN101897947A (zh) * | 2001-09-07 | 2010-12-01 | 明治乳业株式会社 | 控制血糖水平的营养组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8317248D0 (en) * | 1983-06-24 | 1983-07-27 | Wyeth John & Brother Ltd | Fat compositions |
| CA2173780A1 (en) * | 1995-06-01 | 1996-12-02 | Randy Grote | Method for providing nutrition in a variety of compositional forms |
| DK0780055T3 (da) * | 1995-10-27 | 2003-03-24 | Nestle Sa | Nærende kaffesammensætning |
| US5932258A (en) * | 1998-04-06 | 1999-08-03 | The Iams Company | Composition and process for improving glucose metabolism in companion animals |
| JP2000264844A (ja) * | 1999-01-11 | 2000-09-26 | Otsuka Pharmaceut Factory Inc | 腎疾患患者用栄養組成物 |
| US6440931B1 (en) * | 1999-02-23 | 2002-08-27 | Natural Corporation | Conjugated linoleic acid in treatment and prophylaxis of diabetes |
| US6592863B2 (en) * | 2000-08-22 | 2003-07-15 | Nestec S.A. | Nutritional composition |
| WO2002064809A2 (en) * | 2001-02-09 | 2002-08-22 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| US6605310B2 (en) * | 2001-06-06 | 2003-08-12 | Nestec S.A. | Calorically dense liquid oral supplement |
| DK1643861T3 (da) * | 2003-07-15 | 2011-07-25 | Nestec Sa | Fiber- og kalorierig flydende næringssammensætning til tarmsundhed hos ældre patienter |
| DK1868454T3 (da) * | 2005-04-06 | 2013-04-02 | Nestec Sa | Sammensætning til ernæringsmæssig forbedring af glucosekontrol og insulinvirkning |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6140304A (en) * | 1988-09-28 | 2000-10-31 | Eicotech Corporation | Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia |
| US5776887A (en) * | 1995-10-16 | 1998-07-07 | Bristol-Myers Squibb Company | Diabetic nutritional product having controlled absorption of carbohydrate |
| US5886037A (en) * | 1996-11-20 | 1999-03-23 | N.V. Nutricia | Nutritional composition for the treatment of hypertriglyceridaemia and hyperchylomicronaemia |
| EP0898900A2 (en) * | 1997-06-23 | 1999-03-03 | Societe Des Produits Nestle S.A. | Composition and method for providing nutrition to diabetics |
| CN101897947A (zh) * | 2001-09-07 | 2010-12-01 | 明治乳业株式会社 | 控制血糖水平的营养组合物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528734A (zh) * | 2019-01-24 | 2019-03-29 | 华纳时代健康科技（武汉）股份有限公司 | 一种复合营养组合物及其制备方法 |
| CN116473125A (zh) * | 2022-01-17 | 2023-07-25 | 内蒙古伊利实业集团股份有限公司 | 一种缓释碳水组合物以及应用 |
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| CN101175416A (zh) | 2008-05-07 |
| JP2013100353A (ja) | 2013-05-23 |
| EP1868454B1 (en) | 2013-03-06 |
| SG161234A1 (en) | 2010-05-27 |
| WO2006108008A3 (en) | 2007-01-18 |
| DK1868454T3 (da) | 2013-04-02 |
| US8067359B2 (en) | 2011-11-29 |
| US20110305791A1 (en) | 2011-12-15 |
| AU2010202933A1 (en) | 2010-07-29 |
| BRPI0608610A2 (pt) | 2010-01-19 |
| JP2008535840A (ja) | 2008-09-04 |
| US20080193603A1 (en) | 2008-08-14 |
| RU2421076C2 (ru) | 2011-06-20 |
| MX2007012450A (es) | 2008-02-12 |
| RU2007140731A (ru) | 2009-05-20 |
| HK1113289A1 (en) | 2008-10-03 |
| US8697630B2 (en) | 2014-04-15 |
| IL186005A0 (en) | 2008-01-20 |
| CA2601427A1 (en) | 2006-10-12 |
| AU2006231557A1 (en) | 2006-10-12 |
| WO2006108008A2 (en) | 2006-10-12 |
| EP2241195A1 (en) | 2010-10-20 |
| AU2006231557B2 (en) | 2010-09-09 |
| CA2601427C (en) | 2013-06-11 |
| EP1868454A2 (en) | 2007-12-26 |
| EP2243383A3 (en) | 2011-02-16 |
| ES2419205T3 (es) | 2013-08-19 |
| PT1868454E (pt) | 2013-04-03 |
| EP2243383A2 (en) | 2010-10-27 |
| ZA200707825B (en) | 2009-10-28 |
| JP2015187182A (ja) | 2015-10-29 |
| JP5788631B2 (ja) | 2015-10-07 |
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