CN105381326A - 一种复方黄栌锌口服液及其制备方法 - Google Patents
一种复方黄栌锌口服液及其制备方法 Download PDFInfo
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- CN105381326A CN105381326A CN201510795127.1A CN201510795127A CN105381326A CN 105381326 A CN105381326 A CN 105381326A CN 201510795127 A CN201510795127 A CN 201510795127A CN 105381326 A CN105381326 A CN 105381326A
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Abstract
本发明公开的是一种复方黄栌锌口服液及其制备方法,所述复方黄栌锌口服液主要是由主料和辅料制备而成,所述主料包括以下成分:补锌剂、黄栌根、络石果、葛藟、荠菜子、还筒子、香石藤果、扁担杆、山豆花、刺龙牙;所述辅料包括以下成分:龙须草、乌饭树、松蘑、小扁草、补血草、薏苡叶、赖氨酸、天门冬氨酸、谷维素、月桂酸酯、牛磺酸、复合维生素、乳酸亚铁、矫味剂。本发明复方黄栌锌口服液制备工艺简单,成本低,服用方便,具有强筋壮骨、活血止痛、健脾益气、补益气血、增强免疫力的功效,同时补充钙、锌、维生素、氨基酸等营养物质,综合调理和改善患者身体状况,增加骨骼密度和强度,加速受伤骨骼的康复,促进儿童健康成长。
Description
技术领域
本发明涉及骨科用药技术领域,具体是涉及一种复方黄栌锌口服液及其制备方法。
背景技术
骨折、骨创伤等骨伤是儿科常见的骨科疾病,儿童处于生长阶段,自我保护意识不强,在玩耍时很容易摔跤、扭伤等,不注意治疗就容易导致骨骼发育畸形等,临床中对骨伤的治疗,主要是中、西医两种治疗方法,西医采用手术方式治疗。中医注重身体的综合治疗,对受伤部位的组织进行活血化淤,通络止痛,同时对骨伤进行修复治疗,最后可以达到理想的治疗效果。中药治疗骨伤具有一定的优势,但目前公开的技术,普遍存在疗效长、药效慢等缺点。
最佳的治疗方法应该是中西医结合,通过手术等接合和矫正受伤骨头之后,再用中药进行调理,效果最佳。但市售的强筋壮骨药大多为药酒或针对中老年的,适合儿童的主要是一些单纯的补钙或补血用品。因此,本发明致力于研制出一种适用于儿童的强筋壮骨药,加速受伤骨骼的康复。
发明内容
本发明解决的第一个技术问题是提供一种复方黄栌锌口服液,是专门适用于儿童的强筋壮骨药,能够加速受伤骨骼的康复。
本发明解决的第二个技术问题是提供一种复方黄栌锌口服液及其制备方法。
为解决上述第一个技术问题,本发明所采用的技术方案如下:
一种复方黄栌锌口服液,是由主料和辅料制备而成,所述主料包括以下成分:补锌剂、黄栌根、络石果、葛藟、荠菜子、还筒子、香石藤果、扁担杆、山豆花、刺龙牙;所述辅料包括以下成分:龙须草、乌饭树、松蘑、小扁草、补血草、薏苡叶、赖氨酸、天门冬氨酸、谷维素、月桂酸酯、牛磺酸、复合维生素、乳酸亚铁。
进一步地,所述主料各成分的重量份为:补锌剂2~5份、黄栌根30~60份、络石果30~50份、葛藟28~50份、荠菜子25~45份、还筒子24~40份、香石藤果20~40份、扁担杆20~36份、山豆花20~36份、刺龙牙20~30份;所述辅料各成分的重量份为:龙须草9~15份、乌饭树9~15份、松蘑8~15份、补血草5~15份、薏苡叶4~10份、小扁草2~4份、赖氨酸1~2份、天门冬氨酸1~2份、谷维素1~1.5份、月桂酸酯0.8~2份、牛磺酸0.5~1.5份、复合维生素0.4~2份、乳酸亚铁0.4~1.2份。
更进一步地,所述主料各成分的重量份为:补锌剂3.5份、黄栌根45份、络石果40份、葛藟39份、荠菜子35份、还筒子32份、香石藤果30份、扁担杆28份、山豆花28份、刺龙牙25份;所述辅料各成分的重量份为:龙须草12份、乌饭树12份、松蘑11.5份、补血草10份、薏苡叶7份、小扁草3份、赖氨酸1.5份、天门冬氨酸1.5份、谷维素1.25份、月桂酸酯1.4份、牛磺酸1份、复合维生素1.2份、乳酸亚铁0.8份。
所述复合维生素是由维生素B2、维生素B9、维生素D3、维生素E按照1:1:5:2的比例组成。
进一步地,所述补锌剂为甘草锌、葡萄糖酸锌或乳酸锌中的任意一种。
为解决上述第二个技术问题,本发明所采用的技术方案如下:
一种复方黄栌锌口服液的制备方法,其特征在于,包括以下步骤:
A.按配比将黄栌根、络石果、荠菜子、还筒子、香石藤果、山豆花、龙须草、乌饭树、松蘑、补血草、薏苡叶混合后研磨粉碎至50目,得混合粉末;
B.向步骤A中所得的混合粉末中加入其质量8~10倍的蒸馏水,浸泡3~6小时,100~110℃煎煮1~2小时,收集滤液,再次加入混合粉末质量4~6倍的蒸馏水,100~110℃煎煮0.5~1小时,收集滤液,合并两次滤液,冷却至30℃以下后,静置,固液分离,然后将上清液进行浓缩,得浓缩液;向所得浓缩液中加入无水乙醇,冷却到6~10℃静置,固液分离后,上清液除去乙醇,然后调节pH值至5.5~6.0,即得提取液a,待用;
C.按配比将葛藟、扁担杆、刺龙牙、小扁草混合洗净,用50°的白酒按1∶5的重量比密封浸泡10~15天后,过滤,得到浸提液;浸提液采用离心分离机进行离心,离心机转速控制在5000r/min,离心时间20min,弃去沉淀,得到提取液b,待用;
D.将提取液a和提取液b合并,0~10℃冷藏,将冷藏液加0.25%的助滤剂硅藻土、石墨粉或活性炭,在1.5~2.0Mpa的压力下,使用孔径为13.0~15.0μm的多管道束式微孔滤膜进行过滤,获得澄清的药液;
E.向步骤D所得澄清的药液中加入0.1~0.3%矫味剂、1~3%防腐剂,采用超声技术搅拌均匀,加蒸馏水到按生产标准所规定的量,进行灌装、封口、灭菌、冷却、灯检、包装,灭菌采用蒸汽灭菌,灭菌温度为120~130℃,时间20~30min。
进一步地,所述矫味剂为蛋白糖、阿斯巴甜、甜菊苷、蔗糖、香精或山梨醇或其任意组合,矫味剂可改善药物口感,便于服用。
进一步地,所述防腐剂为山梨酸,可以防止药物变质,延长保质期。
用法与用量:口服,每次10~15mL,每日两次,一周为一个疗程。
与现有技术相比,本发明的有益效果是:本发明复方黄栌锌口服液具有强筋壮骨、活血止痛、健脾益气、补益气血、增强免疫力的功效,同时补充钙、锌、维生素、氨基酸等营养物质,综合调理患者吸收机能,整体改善患者身体状况,增加骨骼密度和强度,加速受伤骨骼的康复,促进儿童健康成长。本发明复方黄栌锌口服液制备工艺简单,成本低,服用方便,填补了现有技术的空白。
具体实施方式
实施例1:
一种复方黄栌锌口服液,是由主料和辅料制备而成,所述主料按重量份计包括以下成分:补锌剂2份、黄栌根30份、络石果30份、葛藟28份、荠菜子25份、还筒子24份、香石藤果20份、扁担杆20份、山豆花20份、刺龙牙20份;所述辅料按重量份计包括以下成分:龙须草9份、乌饭树9份、松蘑8份、补血草5份、薏苡叶4份、小扁草2份、赖氨酸1份、天门冬氨酸1份、谷维素1份、月桂酸酯0.8份、牛磺酸0.5份、复合维生素0.4份、乳酸亚铁0.4份。
其中,所述复合维生素是由维生素B2、维生素B9、维生素D3、维生素E按照1:1:5:2的比例组成。所述补锌剂为甘草锌、葡萄糖酸锌或乳酸锌中的任意一种。
本复方黄栌锌口服液的制备方法为:
A.按配比将黄栌根、络石果、荠菜子、还筒子、香石藤果、山豆花、龙须草、乌饭树、松蘑、补血草、薏苡叶混合后研磨粉碎至50目,得混合粉末;
B.向步骤A中所得的混合粉末中加入其质量8倍的蒸馏水,浸泡3小时,100℃煎煮1小时,收集滤液,再次加入混合粉末质量4倍的蒸馏水,100℃煎煮0.5小时,收集滤液,合并两次滤液,冷却至30℃以下后,静置,固液分离,然后将上清液进行浓缩,得浓缩液;向所得浓缩液中加入无水乙醇,冷却到6℃静置,固液分离后,上清液除去乙醇,然后调节pH值至5.5,即得提取液a,待用;
C.按配比将葛藟、扁担杆、刺龙牙、小扁草混合洗净,用50°的白酒按1∶5的重量比密封浸泡10天后,过滤,得到浸提液;浸提液采用离心分离机进行离心,离心机转速控制在5000r/min,离心时间20min,弃去沉淀,得到提取液b,待用;
D.将提取液a和提取液b合并,0℃冷藏,将冷藏液加0.25%的助滤剂硅藻土,在1.5Mpa的压力下,使用孔径为13.0μm的多管道束式微孔滤膜进行过滤,获得澄清的药液;
E.向步骤D所得澄清的药液中加入0.1%矫味剂、1%防腐剂,采用超声技术搅拌均匀,加蒸馏水到按生产标准所规定的量,进行灌装、封口、灭菌、冷却、灯检、包装,灭菌采用蒸汽灭菌,灭菌温度为120℃,时间20min。其中,所述矫味剂为蛋白糖、阿斯巴甜、甜菊苷、蔗糖、香精或山梨醇或其任意组合,矫味剂可改善药物口感,便于服用。所述防腐剂为山梨酸,可以防止药物变质,延长保质期。
实施例2:
一种复方黄栌锌口服液,是由主料和辅料制备而成,所述主料按重量份计包括以下成分:补锌剂3.5份、黄栌根45份、络石果40份、葛藟39份、荠菜子35份、还筒子32份、香石藤果30份、扁担杆28份、山豆花28份、刺龙牙25份;所述辅料按重量份计包括以下成分:龙须草12份、乌饭树12份、松蘑11.5份、补血草10份、薏苡叶7份、小扁草3份、赖氨酸1.5份、天门冬氨酸1.5份、谷维素1.25份、月桂酸酯1.4份、牛磺酸1份、复合维生素1.2份、乳酸亚铁0.8份。
其中,所述复合维生素是由维生素B2、维生素B9、维生素D3、维生素E按照1:1:5:2的比例组成。所述补锌剂为甘草锌、葡萄糖酸锌或乳酸锌中的任意一种。
本复方黄栌锌口服液的制备方法为:
A.按配比将黄栌根、络石果、荠菜子、还筒子、香石藤果、山豆花、龙须草、乌饭树、松蘑、补血草、薏苡叶混合后研磨粉碎至50目,得混合粉末;
B.向步骤A中所得的混合粉末中加入其质量9倍的蒸馏水,浸泡4.5小时,105℃煎煮1.5小时,收集滤液,再次加入混合粉末质量5倍的蒸馏水,105℃煎煮0.75小时,收集滤液,合并两次滤液,冷却至30℃以下后,静置,固液分离,然后将上清液进行浓缩,得浓缩液;向所得浓缩液中加入无水乙醇,冷却到8℃静置,固液分离后,上清液除去乙醇,然后调节pH值至5.8,即得提取液a,待用;
C.按配比将葛藟、扁担杆、刺龙牙、小扁草混合洗净,用50°的白酒按1∶5的重量比密封浸泡12.5天后,过滤,得到浸提液;浸提液采用离心分离机进行离心,离心机转速控制在5000r/min,离心时间20min,弃去沉淀,得到提取液b,待用;
D.将提取液a和提取液b合并,5℃冷藏,将冷藏液加0.25%的助滤剂石墨粉,在1.75Mpa的压力下,使用孔径为14.0μm的多管道束式微孔滤膜进行过滤,获得澄清的药液;
E.向步骤D所得澄清的药液中加入0.2%矫味剂、2%防腐剂,采用超声技术搅拌均匀,加蒸馏水到按生产标准所规定的量,进行灌装、封口、灭菌、冷却、灯检、包装,灭菌采用蒸汽灭菌,灭菌温度为125℃,时间25min。其中,所述矫味剂为蛋白糖、阿斯巴甜、甜菊苷、蔗糖、香精或山梨醇或其任意组合,矫味剂可改善药物口感,便于服用。所述防腐剂为山梨酸,可以防止药物变质,延长保质期。
实施例3:
一种复方黄栌锌口服液,是由主料和辅料制备而成,所述主料按重量份计包括以下成分:补锌剂5份、黄栌根60份、络石果50份、葛藟50份、荠菜子45份、还筒子40份、香石藤果40份、扁担杆36份、山豆花36份、刺龙牙30份;所述辅料按重量份计包括以下成分:龙须草15份、乌饭树15份、松蘑15份、补血草15份、薏苡叶10份、小扁草4份、赖氨酸2份、天门冬氨酸2份、谷维素1.5份、月桂酸酯2份、牛磺酸1.5份、复合维生素2份、乳酸亚铁1.2份。
其中,所述复合维生素是由维生素B2、维生素B9、维生素D3、维生素E按照1:1:5:2的比例组成。所述补锌剂为甘草锌、葡萄糖酸锌或乳酸锌中的任意一种。
本复方黄栌锌口服液的制备方法为:
A.按配比将黄栌根、络石果、荠菜子、还筒子、香石藤果、山豆花、龙须草、乌饭树、松蘑、补血草、薏苡叶混合后研磨粉碎至50目,得混合粉末;
B.向步骤A中所得的混合粉末中加入其质量10倍的蒸馏水,浸泡6小时,110℃煎煮2小时,收集滤液,再次加入混合粉末质量6倍的蒸馏水,110℃煎煮1小时,收集滤液,合并两次滤液,冷却至30℃以下后,静置,固液分离,然后将上清液进行浓缩,得浓缩液;向所得浓缩液中加入无水乙醇,冷却到10℃静置,固液分离后,上清液除去乙醇,然后调节pH值至6.0,即得提取液a,待用;
C.按配比将葛藟、扁担杆、刺龙牙、小扁草混合洗净,用50°的白酒按1∶5的重量比密封浸泡15天后,过滤,得到浸提液;浸提液采用离心分离机进行离心,离心机转速控制在5000r/min,离心时间20min,弃去沉淀,得到提取液b,待用;
D.将提取液a和提取液b合并,10℃冷藏,将冷藏液加0.25%的助滤剂活性炭,在2.0Mpa的压力下,使用孔径为15.0μm的多管道束式微孔滤膜进行过滤,获得澄清的药液;
E.向步骤D所得澄清的药液中加入0.3%矫味剂、3%防腐剂,采用超声技术搅拌均匀,加蒸馏水到按生产标准所规定的量,进行灌装、封口、灭菌、冷却、灯检、包装,灭菌采用蒸汽灭菌,灭菌温度为130℃,时间30min。其中,所述矫味剂为蛋白糖、阿斯巴甜、甜菊苷、蔗糖、香精或山梨醇或其任意组合,矫味剂可改善药物口感,便于服用。所述防腐剂为山梨酸,可以防止药物变质,延长保质期。
临床治疗案例:
杨某某,女,7岁,上体育课时摔倒,导致左脚脚踝扭伤,剧烈疼痛,不能站立行走,随后肿胀,青紫色,入医院检查后,诊断为中度扭伤,冷敷处理,24小时后,开始服用本发明实施例1制备的复方黄栌锌口服液,一个疗程后,肿胀消退,青紫色淤血也消失,疼痛大大减轻,继续服用一个疗程后,基本无痛感,可正常站立行走。同时,对医院收治的同样程度受伤的患者,不使用本发明复方黄栌锌口服液进行辅助治疗,恢复时间相对来说要长2周。
闫某某,男,11岁,在马路上行走时不小心被摩托车撞伤,导致左腿胫骨骨折,局部疼痛、肿胀,入医院经X线检查平片见胫腓骨上有断裂,诊断为胫骨上段闭合性骨折,经接骨复位并打石膏固定后两天,开始服用本发明实施例2制备的复方黄栌锌口服液,一个疗程后,疼痛减轻,继续服用一个疗程后,局部肿胀感消失,连续服用5个疗程后,已基本无不适感,经X线检查发现,骨骼已经愈合,8周后,可以活动,第10周的时候,已经完全康复。同时,对医院收治的同样程度受伤的患者,不使用本发明复方黄栌锌口服液进行辅助治疗,恢复时间相对来说要长4至6周。
李某某,男,12岁,因打架导致左手上臂扭伤,无法伸直,肿胀、酸痛,入院后,经X线检查,上臂肱骨有裂缝,为不完全骨折,接骨复位并固定后3天,开始服用本发明实施例3制备的复方黄栌锌口服液,一个疗程后,酸痛感大大减轻,继续服用一个疗程后,手臂肿胀全消,连续服用4个疗程后,已基本无不适感,经X线检查发现,骨骼已经愈合,7周后,可以活动,第9周的时候,已经完全康复。同时,对医院收治的同样程度受伤的患者,不使用本发明复方黄栌锌口服液进行辅助治疗,恢复时间相对来说要长3至5周。
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。
Claims (7)
1.一种复方黄栌锌口服液,其特征在于,是由主料和辅料制备而成,所述主料包括以下成分:补锌剂、黄栌根、络石果、葛藟、荠菜子、还筒子、香石藤果、扁担杆、山豆花、刺龙牙;所述辅料包括以下成分:龙须草、乌饭树、松蘑、小扁草、补血草、薏苡叶、赖氨酸、天门冬氨酸、谷维素、月桂酸酯、牛磺酸、复合维生素、乳酸亚铁。
2.如权利要求1所述的一种复方黄栌锌口服液,其特征在于,其特征在于,所述主料各成分的重量份为:补锌剂2~5份、黄栌根30~60份、络石果30~50份、葛藟28~50份、荠菜子25~45份、还筒子24~40份、香石藤果20~40份、扁担杆20~36份、山豆花20~36份、刺龙牙20~30份;所述辅料各成分的重量份为:龙须草9~15份、乌饭树9~15份、松蘑8~15份、补血草5~15份、薏苡叶4~10份、小扁草2~4份、赖氨酸1~2份、天门冬氨酸1~2份、谷维素1~1.5份、月桂酸酯0.8~2份、牛磺酸0.5~1.5份、复合维生素0.4~2份、乳酸亚铁0.4~1.2份。
3.如权利要求2所述的一种复方黄栌锌口服液,其特征在于,所述主料各成分的重量份为:补锌剂3.5份、黄栌根45份、络石果40份、葛藟39份、荠菜子35份、还筒子32份、香石藤果30份、扁担杆28份、山豆花28份、刺龙牙25份;所述辅料各成分的重量份为:龙须草12份、乌饭树12份、松蘑11.5份、补血草10份、薏苡叶7份、小扁草3份、赖氨酸1.5份、天门冬氨酸1.5份、谷维素1.25份、月桂酸酯1.4份、牛磺酸1份、复合维生素1.2份、乳酸亚铁0.8份。
4.如权利要求1至3任意一项所述的一种复方黄栌锌口服液,其特征在于,所述补锌剂为甘草锌、葡萄糖酸锌或乳酸锌中的任意一种。
5.所述如权利要求1至4任意一项所述的一种复方黄栌锌口服液的制备方法,其特征在于,包括以下步骤:
A.按配比将黄栌根、络石果、荠菜子、还筒子、香石藤果、山豆花、龙须草、乌饭树、松蘑、补血草、薏苡叶混合后研磨粉碎至50目,得混合粉末;
B.向步骤A中所得的混合粉末中加入其质量8~10倍的蒸馏水,浸泡3~6小时,100~110℃煎煮1~2小时,收集滤液,再次加入混合粉末质量4~6倍的蒸馏水,100~110℃煎煮0.5~1小时,收集滤液,合并两次滤液,冷却至30℃以下后,静置,固液分离,然后将上清液进行浓缩,得浓缩液;向所得浓缩液中加入无水乙醇,冷却到6~10℃静置,固液分离后,上清液除去乙醇,然后调节pH值至5.5~6.0,即得提取液a,待用;
C.按配比将葛藟、扁担杆、刺龙牙、小扁草混合洗净,用50°的白酒按1∶5的重量比密封浸泡10~15天后,过滤,得到浸提液;浸提液采用离心分离机进行离心,离心机转速控制在5000r/min,离心时间20min,弃去沉淀,得到提取液b,待用;
D.将提取液a和提取液b合并,0~10℃冷藏,将冷藏液加0.25%的助滤剂,在1.5~2.0Mpa的压力下,使用孔径为13.0~15.0μm的多管道束式微孔滤膜进行过滤,获得澄清的药液;
E.向步骤D所得澄清的药液中加入0.1~0.3%矫味剂、1~3%防腐剂,采用超声技术搅拌均匀,加蒸馏水到按生产标准所规定的量,进行灌装、封口、灭菌、冷却、灯检、包装,灭菌采用蒸汽灭菌,灭菌温度为120~130℃,时间20~30min。
6.所述如权利要求5所述的一种复方黄栌锌口服液的制备方法,其特征在于,所述矫味剂为蛋白糖、阿斯巴甜、甜菊苷、蔗糖、香精或山梨醇或其任意组合。
7.所述如权利要求5所述的一种复方黄栌锌口服液的制备方法,其特征在于,所述防腐剂为山梨酸。
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