CN105379749B - A kind of long-acting, less toxic, efficient Pesticidal combination - Google Patents

Abstract

The present invention provides a kind of Pesticidal combinations of high-efficiency low-toxicity, the composition includes methoprene and at least one nicotinic insecticide, and pass through the synergistic effect of methoprene and nicotinic insecticide, expand the controlling object and application field of insecticide, the different existing forms in each stage of pest whole life cycle can be effectively controlled, while improving the effective rate of utilization of insecticide, reduce the drug cost of peasant, extend the service life of chemical pesticide, delaying drug resistance generates.

Description

A kind of long-acting, less toxic, efficient Pesticidal combination

Technical field

The present invention relates to a kind of less toxic, long-acting, efficient Pesticidal combinations, more particularly it relates to methoprene With the composition of one or more nicotinic insecticides, for preventing and treating termite, health, storage and crop pests.

Background technique

Methoprene is the insect growth regulator, IGR occurred the 1970s, juvenoid.As a kind of biology Insecticide, effect are to control the growth and development of pest, prevent larva that cannot become adult from becoming pupa or pupa, generate physiology and appearance On variation, inhibit its growth and development, being allowed to cannot mature and natural death.It is acted on since its mechanism of action is different from the past The conventional pesticides of nervous system have toxicity low, and pollution is few, influence the advantages that small, and this kind ofization to natural enemy and beneficial organism Conjunction object is identical as the intracorporal hormonal action of insect or structure is similar, so generally being difficult to generate resistance, can kill to traditional desinsection The resistant pest of agent, therefore it is known as " third generation pesticide ".

Methoprene is nuisanceless new pesticide, effective to Lepidoptera, Diptera, coleoptera, Homoptera various insects, such as grey The pests such as fly, mosquito, ant, flea, beetle, powder snout moth's larva, booklice.The ovum that methoprene is produced to Larva and newly is effective, acts on Larva makes it mortality occur in the abnormal stage, acts on the ovum or female insect newly produced, shows as ovicidal activity, causes Larvae deformity, but methoprene does not have effect to the ovum and male imago after for 24 hours, and quick-acting is poor, generally after administration 1 to 2 Death could occur in all days, and the peak mortality phase could occur in 3 to 4 all days.Methoprene has very strong volatility, holding indoors The effect phase is very long, is currently used primarily in the prevention and treatment of storage pest and sanitary insect pest, but due to its volatile characteristic, outdoor and light It is more volatile according to condition, cause it to be difficult to maintain high effective pesticidal concentration on the position of application, before guaranteeing insecticidal activity It puts, needs to greatly improve the dosage of unit area, shorten medication cycle, also make methoprene in outdoor locations such as field-crops Use be restricted.

Nicotinic insecticide be the 1980s mid-term successfully developed by Bayer A.G, the insecticides Have the characteristics that the novel mode of action, selection strong toxicity, efficiently, wide spectrum and good to Environmental compatibility, mechanism of action is mainly Insect nerve system nicotinic acetylcholine enzyme acceptor is controlled by selectivity, blocks the normal biography of insect CNS It leads, paralysis and then death occurs so as to cause pest, the pests such as Homoptera, coleoptera, Diptera and Lepidoptera can be effectively prevented.

Summary of the invention

The object of the present invention is to provide a kind of less toxic, long-acting, efficient Pesticidal combination and its preparations.

It is a further object of the present invention to provide a kind of for preventing termite, health, storage and the composition of crop pests And its preparation.

The technical solution that the present invention realizes that above-mentioned purpose is taken is as follows:

The composition includes methoprene and one or more kinds of nicotinic insecticides.

By the synergistic effect of methoprene and nicotinic insecticide, expand the controlling object and application field of insecticide, energy The different existing forms in each stage of enough effective control pest whole life cycles, while improving the effective use of insecticide Rate reduces the drug cost of peasant, extends the service life of chemical pesticide, and delaying drug resistance generates.

The methoprene and nicotinic insecticide mass ratio are 0.00002~50000: 1, preferably 0.0005~2000: 1, Particularly preferred 0.005~100: 1, further preferred 0.01~25: 1.

The nicotinic insecticide is selected from imidacloprid, Acetamiprid, Diacloden, Nitenpyram, dinotefuran, clothianidin, thiophene worm Quinoline, paichongding, cycloxaprid, imidaclothiz, sulfoxaflor, pyrrole worm nitrile, flonicamid.

The nicotinic insecticide is more preferably from Nitenpyram, thiacloprid, paichongding, cycloxaprid, imidaclothiz, fluorine pyridine Worm amine nitrile, pyrrole worm nitrile, flonicamid.

Composition provided by the invention further may include oil component, be selected from vegetable oil, animal oil, mineral oil, essence It is oily and other, wherein the vegetable oil be selected from peanut oil, soya-bean oil, linseed oil, castor oil, sunflower oil, sesame oil, tea-seed oil, Coconut oil, rosin base oil etc., the animal oil are selected from lard, butter, sheep oil etc..The oil component is further selected from gasoline, bavin Oil, paraffin, kerosene etc..

The mass ratio of the composition and oil component is 0.0001~1000, preferably 0.001~100: 1, particularly preferably 0.001~80: 1.

Composition provided by the invention further may include alcohols, be selected from ethylene glycol, glycerine, polyethylene glycol 200, poly- second Glycol 400, polyethylene glycol-800, Macrogol 600.

The ratio of the composition and alcohol component is 0.0001~1000, preferably 0.001~100: 1, particularly preferably 0.001~80: 1.

The invention also includes a kind of less toxic, long-acting and efficient Pesticidal combination preparations.By effective quantity above-mentioned composition and The combination of other auxiliary elements is made suitable preparation and uses.Wherein the dosage form can be missible oil, suspending agent, solution, powder The preparations such as agent, wettable powder, jelly, granule select suitable dosage form according to actual conditions.

In composition the content and ratio of methoprene and nicotinic insecticide can according to the difference of controlling object and dosage form and Variation, the total content of composition accounts for the 0.001~95% of total formulation weight, preferably 0.01~90% in institute's preparaton, especially excellent Select 0.1~80%.

Wherein the auxiliary element include wetting agent, dispersing agent, disintegrating agent, emulsifier, binder, stabilizer, defoaming agent, One or both of antifreezing agent, preservative, light stabilizer, antioxidant, solvent, encapsulating agent, warning coloration, filler, film forming agent More than.

Wherein, solvent mainly include dimethylbenzene, toluene, chlorobenzene, dichlorotoleune, paraffin, hexamethylene, mineral oil, vegetable oil, One or more of alcohols, acetone, cyclohexanone, methyl iso-butyl ketone (MIBK), dimethylformamide, dimethyl sulfoxide, water etc. Mixture.

Filler includes but is not limited to the days such as kaolin, clay, talcum, chalk, quartz, attapulgite, montmorillonite, diatomite The synthetic minerals powder such as right mineral powder, silica, aluminium oxide, silicate；Calcite, marble, float stone, sepiolite and white clouds The natural rock that stone etc. is crushed and is classified, the particle of the organic substances such as sawdust, coconut husk, corncob and tobacco stem；Ammonium sulfate, sulphur Sour potassium, sodium sulphate, ammonium chloride, potassium chloride, sodium chloride, ammonium hydrogen carbonate, saleratus, sodium bicarbonate, ammonium carbonate, potassium carbonate, carbon Sour sodium, sodium pyrophosphate, tertiary sodium phosphate, precipitated calcium carbonate inorganic salts.

Film forming agent include but is not limited to Arabic gum, acrylic acid polymer, oxidized starch acetic acid vinegar, Macrogol 600, Ethylene-vinyl acetate copolymer, Pioloform, polyvinyl acetal, methyl acrylate-methyl acrylic copolymer, povidone.

Adhesive includes but is not limited to carboxymethyl cellulose (CMC), hydroxypropyl cellulose, polyvinyl alcohol, polyvinyl acetate Ester, natural phospholipid, synthetic phospholipid.

Antioxidant includes but is not limited to butylhydroxy anisole (BHA), dibutyl hydroxy toluene (BHT), tert-butyl Hydroquinone (TBHQ), propylgallate (PG), ascorbyl palmitate (AP), thiodipropionic acid dilauryl cinnamic acid ester (DLTP), the artificial synthesized class such as 4- hexyl resorcin (4-HR), tocopherol (vitamin E), L-AA (vitamin C), D-araboascorbic acid sodium (sodium isoascorbate), tea polyphenols (TP), Rosmarinus officinalis extract, phytic acid (phytic acid), ginger extract Object.

Light stabilizer includes but is not limited to phenyl salicylate, 3,5- dichlorosalicylic acid phenyl ester, the double 4 (benzene of 4,4 '-isopropylidenes Phenol salicylate), p-t-butylphenyl salicylate, the salicylic acids esters such as p-octylphenyl salicylate, resorcinol list benzene potassium acid The benzoate light stabilizers such as ester, 3,5- di-tert-butyl-4-hydroxybenzoic acid -2,4- 6- di-tert-butyl phenyl ester, UV-2908, N- 539, the cyanoacrylates light stabilizer such as N-35,2,4-DihydroxyBenzophenone (UV-0), 2- hydroxyl -4- methoxyl group hexichol Ketone (UV-9), 2- hydroxyl -4- n-octyloxy-benzophenone (UV-531), 2- hydroxyl -4- (2 '-second are for hexyloxy)-hexichol first The benzophenones such as ketone (UV-242), UV-39, UV-21, UV-207, DOBP, HBBP, UV-P, UV-320, UV-327, UV- 328, the benzotriazoles such as UV-510, UV5411, the nickel compound containings such as NBC, UV-1084, AM-101, UV-3034, light stabilizer 744, the hindered amines such as light stabilizer LA-57, light stabilizer LA-68, light stabilizer LA-63, light stabilizer LA-67.

Wherein the wetting agent, dispersing agent or emulsifier include but is not limited to calcium dodecyl benzene sulfonate, fatty alcohol polyoxy Vinethene, benzene ethylbenzene phenol polyethenoxy ether, lignosulfonates, alkyl phenol polyoxyethylene ether or its phosphate, sulfosuccinate Dioctyl ester sodium salt, alkylnaphthalene sulfonate formaldehyde condensation products, polycarboxylic acid, Ben-zylphenol Polyoxyethyl Ether, fatty alcohol polyoxyethylene ether, Alkyl glycosides, amine alcoxylates, Tea Saponin, coconut oil amide compound, organosilicon, lignosulfonates, dodecyl sulphur Hydrochlorate, dodecyl naphthalene sulfonate, dibutyl naphthalenesulfonic acid salt, naphthalene sulfonate, di-2-ethylhexylphosphine oxide naphthalene sulfonate, polyacrylate.

Wherein the disintegrating agent sodium sulphate, ammonium sulfate, ammonium chloride, chlorination calcium bentonite, starch, cellulose, urea, carbonic acid One or more of sodium, sodium bicarbonate, citric acid, tartaric acid.

The component with synergistic effect, including polyether modified silicon oil, mineral oil, plant can also be added as needed in insecticide Object oil, lecithin and its derivative, Wax dissolving agent, fatty alcohol polyoxyethylene ether (JFC), starch, corn syrup solids, malt paste The carbohydrates such as essence, chitosan, small molecule carbohydrate, chitosan, gelatin, shellac, agar, dextrin, pectin, guar gum, The hydrophilic colloids class such as seaweed glue, carragheen, alginate, lactalbumin, casein, gelatin etc. are one of protein-based or more Kind.

The preparation that composition or composition are prepared is used directly or after solvent dilutes, according to purpose to be achieved and institute The environment at place selects method of administration according to the property of composition, to be sprayed, atomizing, dust, smear, fumigate, spread fertilizer over the fields, dress seed, pour The methods of filling processing pest or its habitat.

Composition or preparation of the present invention have splendid absorbability, contact toxicity, stomach toxicity and ovicidal effect aobvious Work feature, composition or preparation through the invention can kill the pest on storage, health and plant (crops), Yi Jibai Ant, red fire ant etc..

Purposes in the storage refers to that composition is applied to grain, seed, tobacco, and particularly preferred storage includes small Wheat, barley, highland barley, rye, oat, soybean, red bean, mung bean, semen viciae fabae, pea, red bean, kidney bean, japonica rice, long-grained nonglutinous rice, glutinous rice, drought Rice, corn, sorghum, buckwheat, chestnut, broomcorn millet, cassava, sweet potato, potato, cotton.

The storage pest can be coleoptera, Lepidoptera, Blattaria, Corrodentia, Thysanoptera and Arachnoidea Acarina, packet Include but be not limited to curculionid class, ancient moth, saw-toothed grain beetle, Cryptolestes pusillus, red flour beetle, gelechiid, Indian meal moth, the thermophilic junket of corruption, pea weevil, Grain peat, lasioderma serricorne beetle, tobacco powder sp, short foot attagenus piceus, Ptinus japonicus, black rice worm, small phycitid.

It is described health on purposes refer to composition be applied to lake, river, marsh, rice field, roadside irrigation canals and ditches, swimming pool, pond, The surface of bucket, livestock (ox, sheep, pig, chicken, horse etc.) and its excrement.

The sanitary insect pest refers mainly to mosquito and fly, the fly include but is not limited to housefly, torsalo, stomach fly, yellow fly, horse botfly, Horn fly, matting huge legendary turtle fly, black fly, deerfly, hippoboscid, tsetse fly, botfly, calliphorid, screwfly, bomb fly, fleece worm；The mosquito include but It is not limited to Aedes aegypti, aedes africanus, white beam yellow-fever mosquito, aedes albopictus, aedes canadensis, Aedes cooki, aedes dorsalis, band and pitches her Mosquito, Aedes harinasutai, Aedes japonicus, intellectual with a senior professional title yellow-fever mosquito, aedes luteocephalus, Mans yellow-fever mosquito, black yellow-fever mosquito, Aedes poicilius, Pori Ni Xiyi Mosquito, Samoa yellow-fever mosquito, aedes scapularis, aedes scutellaris, aedes taeniorhynchus, safe formula yellow-fever mosquito, aedes togoi, aedes triseriatus, Aedes vexans, Vigilance yellow-fever mosquito, rhizome of Chinese monkshood yellow-fever mosquito, anopheles albimanus, anopheles albitarsis, ring grain anopheles, must also anopheles, anopheles aquasalis, Anopheles arabiensis, silver Instep anopheles, small anopheles maculipennis, anopheles bancroftii, anopheles barbirostris barbirostris, anopheles bellator, southern Colombia anopheles, Brazilian anopheles, field are pressed Mosquito, anopheles claviger, anopheles crucians, Anopheles culicifacies, anopheles darlingi, Anopheles donaldi, Fa Shi anopheles, Anopheles fluviatilis, anopheles funestus, Anopheles costalis, anopheles costalis's complex, anopheles hancocki, Anopheles jeyporiensis, slips that anopheles, Anopheles koliensis, anopheles labranchiae labranchiae, thunder Family name anopheles, anopheles leucosphyrus leucosphyrus, Lloyd's anopheles, anopheles maculatus maculatus, anopheles maculipennis, Anopheles melas, Anopheles merus, ring beak culex, two bands Beak culex, culex rubithoracis, culex gelidus, northern house, black palpus culex, Culex quinquefasciatus, beach culex, culex tarsalis, the library Xi Shi Mosquito, Culex tritaeniorhynchus, single mosquito culex, culex vishnui complex, hair text midge, Mansonia indiana, Mansonia uniformis, discoloration squama mosquito.

Plant (crops) pest can be Lepidoptera, Diptera, coleoptera, Homoptera, Hymenoptera, Semiptera, Orthoptera, Diptera, Acarina, Anoplura, Siphonaptera, Neuroptera, Collembola, Thysanoptera, including but not limited to striped rice borer, beet night Moth, codling moth, olethreutid, bollworm, cabbage butterfly, diamondback moth, pear psyllid, Bemisia tabaci, scale insect, aphid, thrips, Rice leaf roller, pink bollworm, lopper worm, arrowhead scales, mite, aphid, pine moth, rice leaf roller, plant hopper, green bugs, Grain aphid, rhopalosiphum padi, aleyrodid, thrips, prodenia litura, cabbage caterpillar, flea beetle, bean-pod borer, liriomyza bryoniae, red spider, white spider Spider, pears mesh lice, heart-eating worm, bollworm, black cutworm, grub, Asiatic migrotory locust, mulberry tree spring looper, smaller green leaf hopper, the small greenery of artificial eye Cicada.

The present composition be used as health pest control when, effective dose be 1~2000 gram/ha, preferably 10~ 1000 grams/ha, particularly preferred 20~600 grams/ha.

The present composition be used as storage pest prevent and treat when, effective dose be 1~2000 g kg, preferably 10~ 1000 g kgs, particularly preferred 20~600 g kgs.

The present composition be used as crop pests prevent and treat when, effective dose be 1~2000 gram/ha, preferably 10~ 1000 grams/ha, particularly preferred 20~600 grams/ha.

The present invention by adding methoprene in insecticide so that the Pesticidal combination obtain it is more superior pesticidal Energy.Compared with using single insecticide, due to adding nuisanceless new pesticide methoprene in the present composition, so that group Conjunction object is safer, and the lasting period of methoprene is long, and the two, which is applied in combination, extends action time, reduces spraying times.With use Single methoprene is compared, and due to being added to insecticide in the present composition, can kill ovum, larva, pupa and the adult of pest, So that pest each worm state in its entire history of life is controlled, administration time is unrestricted, reduces spraying times；It can be rapid Target pest is killed, shortening takes effect the phase.The present composition further includes oils and/or alcohol component, is conducive to active constituent Absorption, prevent or slow down the volatilization of methoprene, improve active constituent and maintain high effective desinsection dense on the position of application Degree reduces the dosage of unit area, reduces drug cost；It is anti-that composition of the invention can also be used in the pest on crops It controls, has diffused into the application field of the composition.

Specific embodiment

In this test, the present composition is measured relative to the reactive compound of exclusive use and shows synergistic work Property, and each worm state in the target pest entire history of life is controlled, experimental design composition leaching ovum method test target evil Test, leaf dipping method of egg hatch etc. test target pest larva and adult insecticidal activity is tested.

Ovicidal: reactive compound being used respectively dehydrated alcohol and Tween 80 handle, and it is stand-by to be configured to required drug concentrations, then Ovum card immersion with target pest ovum is wanted after handling in medicament, is transferred under the conditions of suitable temperature and cultivates, through being taken Between after, record hatching ovum number and dead ovum number calculate the death rate.

It kills larva: reactive compound being used respectively dehydrated alcohol and Tween 80 handle, it is stand-by to be configured to required drug concentrations, The erosion object of target pest (such as tobacco leaf, paddy) or living environment (such as dechlorination water) are carried out in the medicament for preparing completion again Processing, then access target pest larva.After required time, the death rate is determined, in terms of %.100% indicates to kill all bodyguards Pest larva；0% indicates that no target pest larva is killed.The identified death rate is substituted into Colby formula.

It kills adult: reactive compound being used respectively dehydrated alcohol and Tween 80 handle, it is stand-by to be configured to required drug concentrations, By the erosion object (such as tobacco leaf, paddy) of target pest with prepare complete medicament in handle, then access target pest at Worm；Either medicament is sprayed onto the closed container equipped with target pest adult, it is normal to raise.After required time, determine dead Rate is died, in terms of %.100% indicates to kill all lasioderma serricorne adults；0% indicates that no lasioderma serricorne adult is killed.It will be identified The death rate substitutes into Colby formula.

Colby calculation formula is as follows:

E=X+Y- (X × Y)/100, wherein

The death rate of the X=when using reactive compound A with the rate of application of m ppm, is expressed as the hundred of untreated control group Divide ratio,

The death rate of the Y=when using reactive compound B with the rate of application of n ppm, is expressed as the hundred of untreated control group Divide ratio,

The death rate of the E=when using reactive compound A and B with the rate of application of m+n ppm, is expressed as untreated control group Percentage.

1 storage pest of embodiment

The insect of the harm storage of table 1 --- ovum test

The insect of the harm storage of table 2 --- larva test

The insect of the harm storage of table 3 --- adult test

The test of 2 sanitary insect pest of embodiment

Table 1 endangers the insect of health --- ovum test

Table 2 endangers the insect of health --- larva test

Table 3 endangers the insect of health --- adult test

3 plant of embodiment (crops) pest

Table 1 endangers the insect of plant --- ovicidal test

Table 2 endangers the insect of plant --- larva test

Table 3 endangers the insect of plant --- kill adult test

The test of 2 sanitary insect pest of embodiment

Table 1 endangers the insect of health --- ovum test

Table 2 endangers the insect of health --- larva test

Table 3 endangers the insect of health --- adult test

Prevention and treatment on 4 ant class pest of embodiment

1 ant class pest of table --- ovicidal test

2 ant class pest of table --- larva test

Claims (13)

1. a kind of low toxicity Efficient insecticidal composition, it is characterised in that including methoprene, nicotinic insecticide, oils and/or alcohol, institute The nicotinic insecticide stated include thiacloprid, paichongding, cycloxaprid, imidaclothiz, sulfoxaflor, in flonicamid extremely Few one kind, wherein methoprene and nicotinic insecticide mass ratio are 0.005~100: 1, and the oils includes vegetable oil, animal At least one of oil, mineral oil, essential oil, the alcohols include polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 800, at least one of Macrogol 600.

2. composition as described in claim 1, it is characterised in that the vegetable oil is selected from peanut oil, soya-bean oil, linseed oil, castor-oil plant At least one of oil, sunflower oil, sesame oil, tea-seed oil, coconut oil, rosin base oil, animal oil are selected from lard, butter, sheep oil At least one of.

3. composition as described in claim 1, it is characterised in that the gross mass and oils of the methoprene and nicotinic insecticide The mass ratio of component is 0.001-100: 1.

4. the composition as described in claim 1, it is characterised in that the gross mass and alcohol group of methoprene and nicotinic insecticide The mass ratio divided is 1:30-1.5: 1.

5. a kind of low toxicity efficient insecticide preparation, it is characterised in that including the composition as described in claim 1-4 any one, with And the acceptable auxiliary agent of pesticide, the quality of the composition account for the 0.001~95% of total formulation weight.

6. preparation as claimed in claim 5, it is characterised in that the auxiliary agent include wetting agent, dispersing agent, disintegrating agent, emulsifier, Binder, stabilizer, defoaming agent, antifreezing agent, preservative, light stabilizer, antioxidant, solvent, encapsulating agent, warning coloration, filler, One or both of film forming agent or more.

7. a kind of method for preventing and treating health, storage or crop pests, it is characterised in that using described in claim 1-6 Pesticidal combination or preparation directly or applied after solvent dilutes, to be sprayed, atomizing, dust, smear, fumigate, spread fertilizer over the fields, mix The processing of the methods of kind and pouring.

8. method as claimed in claim 7, it is characterised in that the storage pest includes coleoptera, Lepidoptera, Blattaria.

9. method as claimed in claim 7, it is characterised in that the sanitary insect pest is mosquito and/or fly.

10. method as claimed in claim 7, it is characterised in that the crop pests include Lepidoptera, Homoptera.

11. such as claim 7 or 9 the methods, it is characterised in that when being used as health pest control, effective dose is 1~ 2000 grams/ha.

12. such as claim 7 or 8 the methods, it is characterised in that when being used as storage pest prevention and treatment, effective dose is 1~ 2000 grams/ha.

13. such as claim 7 or 10 the methods, it is characterised in that when being used as crop pests prevention and treatment, effective dose is 1~ 2000 grams/ha.