CN105378053B - 成分分析装置、药效分析装置和分析方法 - Google Patents

成分分析装置、药效分析装置和分析方法 Download PDF

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Publication number
CN105378053B
CN105378053B CN201480040060.4A CN201480040060A CN105378053B CN 105378053 B CN105378053 B CN 105378053B CN 201480040060 A CN201480040060 A CN 201480040060A CN 105378053 B CN105378053 B CN 105378053B
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container
amount
liver cell
medicament
buffer solution
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CN105378053A (zh
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高桥亮介
神田胜弘
清水佑辅
市川久词
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/20—Heating or cooling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201480040060.4A 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法 Active CN105378053B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201710860736.XA CN107513550B (zh) 2013-11-29 2014-11-26 成分分析方法
CN201710862144.1A CN107677779B (zh) 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法

Applications Claiming Priority (3)

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JP2013-246906 2013-11-29
JP2013246906A JP6087264B2 (ja) 2013-11-29 2013-11-29 成分分析装置、薬効分析装置、及び分析方法
PCT/JP2014/081135 WO2015080106A1 (ja) 2013-11-29 2014-11-26 成分分析装置、薬効分析装置、及び分析方法

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CN201710862144.1A Division CN107677779B (zh) 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法
CN201710860736.XA Division CN107513550B (zh) 2013-11-29 2014-11-26 成分分析方法

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CN201710862144.1A Active CN107677779B (zh) 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法
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CN201710860736.XA Active CN107513550B (zh) 2013-11-29 2014-11-26 成分分析方法

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US (3) US9880153B2 (enExample)
EP (3) EP3272852B1 (enExample)
JP (1) JP6087264B2 (enExample)
CN (3) CN105378053B (enExample)
WO (1) WO2015080106A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087264B2 (ja) 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法
JP6758026B2 (ja) 2015-04-17 2020-09-23 株式会社日立ハイテク 成分分析装置、薬剤成分分析装置、成分分析方法及び薬剤成分分析方法
JP6582070B2 (ja) * 2018-01-22 2019-09-25 株式会社日立ハイテクノロジーズ 分析方法
US20220113299A1 (en) * 2019-02-26 2022-04-14 Hitachi High-Tech Corporation Method of dynamics analysis for compound in cell
WO2021014519A1 (ja) * 2019-07-22 2021-01-28 株式会社日立ハイテク 試薬キット
WO2023084648A1 (ja) * 2021-11-10 2023-05-19 株式会社日立ハイテク 薬剤相互作用解析方法

Citations (6)

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US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
WO2000055355A2 (en) * 1999-03-17 2000-09-21 University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
CN1284127A (zh) * 1997-12-02 2001-02-14 Y·K·谭 模拟的生物溶解和吸收系统
CN102272288A (zh) * 2009-01-08 2011-12-07 株式会社日立制作所 动物肝细胞的培养方法
EP2471908A1 (en) * 2009-08-26 2012-07-04 The University of Tokyo Method for culture of hepatocytes
WO2012121261A1 (ja) * 2011-03-10 2012-09-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｏａｔｐ１ｂ１の輸送活性を促進又は阻害する化合物をスクリーニングするための方法、及びｏａｔｐ１ｂ１発現量を測定するための方法

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JPH08503610A (ja) 1992-11-25 1996-04-23 メルク エンド カンパニー インコーポレーテッド 肝モデル
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
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US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
AR035231A1 (es) * 2002-03-11 2004-05-05 Ypf S A Un equipo para analizar el crecimiento de microorganismos y procedimiento para cuantificar la concentracion de microorganismos
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
CN1284127A (zh) * 1997-12-02 2001-02-14 Y·K·谭 模拟的生物溶解和吸收系统
WO2000055355A2 (en) * 1999-03-17 2000-09-21 University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
CN102272288A (zh) * 2009-01-08 2011-12-07 株式会社日立制作所 动物肝细胞的培养方法
EP2471908A1 (en) * 2009-08-26 2012-07-04 The University of Tokyo Method for culture of hepatocytes
WO2012121261A1 (ja) * 2011-03-10 2012-09-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｏａｔｐ１ｂ１の輸送活性を促進又は阻害する化合物をスクリーニングするための方法、及びｏａｔｐ１ｂ１発現量を測定するための方法

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Also Published As

Publication number Publication date
EP3712245A1 (en) 2020-09-23
EP3712245B1 (en) 2022-05-11
CN107513550A (zh) 2017-12-26
WO2015080106A1 (ja) 2015-06-04
CN105378053A (zh) 2016-03-02
US9880153B2 (en) 2018-01-30
US10684276B2 (en) 2020-06-16
JP6087264B2 (ja) 2017-03-01
EP3272852A1 (en) 2018-01-24
JP2015105842A (ja) 2015-06-08
US20180106783A1 (en) 2018-04-19
CN107677779B (zh) 2020-06-12
US20160209403A1 (en) 2016-07-21
EP3023489A1 (en) 2016-05-25
EP3023489B1 (en) 2017-11-01
EP3023489A4 (en) 2016-09-21
CN107677779A (zh) 2018-02-09
US11789013B2 (en) 2023-10-17
US20200249223A1 (en) 2020-08-06
CN107513550B (zh) 2022-06-21
EP3272852B1 (en) 2020-03-18

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