CN105372439A - Female reproductive tract microecology evaluation and detection system - Google Patents
Female reproductive tract microecology evaluation and detection system Download PDFInfo
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- CN105372439A CN105372439A CN201510869124.8A CN201510869124A CN105372439A CN 105372439 A CN105372439 A CN 105372439A CN 201510869124 A CN201510869124 A CN 201510869124A CN 105372439 A CN105372439 A CN 105372439A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Abstract
The present invention discloses a female reproductive tract microecology evaluation and detection system. The system includes a full-automatic intelligent stainer, a vaginitis automatic detection workstation, a morphology full-automatic microscopic detection platform, a computer, an input device and an output device. The full-automatic intelligent stainer is used for automatic staining on a sample of vaginal secretions; the vaginitis automatic detection workstation is used for biochemical detection on preformed enzymes and metabolites in the vaginal secretions to obtain the functional assessment result data; the morphology full-automatic microscopic detection platform is connected to the computer and used for the detection of a smear formed after staining by the full- automatic intelligent stainer, and the morphology full-automatic microscopic detection platform detects and analyzes the visible components in the vaginal secretions to obtain morphological pattern data; the computer is used for controlling the full-automatic intelligent stainer, the vaginitis automatic detection workstation, the morphology full-automatic microscopic detection platform, the input device and the output device; the computer is equipped with application software and pathological knowledge base; and the input device is connected to the computer.
Description
Technical field
The present invention relates to clinical medicine inspection technology field, evaluate detection system in particular to a kind of Lower Female Genital Tract Tiny ecosystem.
Background technology
Lower Female Genital Tract is open cavity, and be Tiny ecosystem district important in human body, lactobacillus accounts for more than 95% of vagina endoparasitism bacterium under normal circumstances, with dominant bacterias such as lactobacilluss for main composition Tiny ecosystem homestat.In vagina, the lactobacillus of normal presence plays key effect to maintenance vagina normal flora.Glycogen in vagina squamous cell becomes lactic acid through the action breaks of lactobacillus, what make vagina is partially formed weak acid environment, the undue growth of other bacterial parasites can be suppressed, secrete hydrogen peroxide, bacteriocin etc. simultaneously and suppress pathogenic microorganisms growth, thus maintain the balance of microecology in vaginas environment.
At present, there is the problem that cure rate is low and recurrence rate is high in the disease caused due to vagina infection clinically, cause the main cause of this phenomenon to be that clinician is usually eager to treat, and first do not determine pathogenic microorganism, this is the modal reason causing Endodontic failure.
Vaginal fluid conventional sense (being called for short leukorrhea conventional) is a current widely used important medical inspection project clinically, and the method for carrying out vaginal fluid conventional sense is clinically divided into two kinds:
The first utilizes microscopical morphology humidity strip Microscopical Method For Detection, the method directly can observe the visible component situation of vaginal fluid, the situation of the miscellaneous bacterias such as vaginal fluid normal bacteria, trichomonad, fungi and epithelial cell and leucocyte pyocyte can be found, but can not find the bacteria resistance function of normal dominant bacteria, cannot distinguish the pathogenic of miscellaneous bacteria and cannot distinguish miscellaneous bacteria is aerobic bacteria or anaerobion, the pathogenic etc. of fungi also cannot be differentiated.
Another kind utilizes biochemical method to carry out the detection of dry chemical enzyme to vaginal fluid, the method is mainly through detecting the index such as preformation enzyme and metabolin of normal dominant bacteria and pathogenic bacteria, the function assessment situation of vagina normal bacteria and pathogenic bacteria can be detected, but the method is poor to trichomonad, fungal test result reliability, specificity is also poor, cannot cleanliness be reflected, and because artificial interpretation subjectivity is strong, workload large, thus can detection speed be affected.
At present, clinically adopt above-mentioned a kind of wherein method to carry out the detection of vaginal fluid, the result of detection not system, comprehensive, easily causes mistaken diagnosis and fails to pinpoint a disease in diagnosis, being unfavorable for clinical treatment more.
In sum, there is the problems such as detection efficiency is low, testing result poor reliability in the vaginal fluid detection system used at present.
Summary of the invention
The invention provides a kind of Lower Female Genital Tract Tiny ecosystem and evaluate detection system, in order to solve the problems such as low, the testing result poor reliability of detection efficiency that current vaginal fluid detection system exists.
In order to achieve the above object, the invention provides a kind of Lower Female Genital Tract Tiny ecosystem and evaluate detection system, it comprises: fully-automatic intelligent dyeing instrument, vaginitis automatic testing station, the full-automatic micro-detection platform of morphology, computing machine, input equipment and output device, wherein
Described fully-automatic intelligent dyeing instrument is used for automatically dyeing to vaginal fluid sample, and being formed can for the smear of clear detection;
Described vaginitis automatic testing station is connected with described computing machine, for carrying out biochemistry detection to the preformation enzyme in vaginal fluid and metabolin, to obtain a function assessment result data;
The full-automatic micro-detection platform of described morphology is connected with described computing machine, for detecting the smear via being formed after described fully-automatic intelligent dyeing instrument dyeing, analyze to carry out detection to the visible component in vaginal fluid, to obtain a morphology graph data, described visible component at least comprises: leucocyte, spore, mycelia, trichomonad, male/female property escherichia coli, male/female property dialister bacterium and positive cocci;
Described computing machine is for controlling described fully-automatic intelligent dyeing instrument, described vaginitis automatic testing station, the full-automatic micro-detection platform of described morphology, described input equipment and described output device, described computer-internal is provided with an application software and a pathology knowledge base, and described application software is used for described function assessment result data and described morphology graph data and described pathology knowledge base to compare the diagnostic result obtaining patient;
Described input equipment is connected with described computing machine, for the data information of patient is inputed to computing machine;
Described output device is connected with described computing machine, for exporting the diagnostic result of patient.
In one embodiment of this invention, described fully-automatic intelligent dyeing instrument comprises front end print frame, tail end sample rack, conveyer, slide pusher and spray equipment, described spray equipment comprises multiple feeding device, multiple nozzle, multiple waste collecting device and drying unit, wherein
Described front end print frame and described tail end sample rack are separately positioned on the two ends of described conveyer, described front end print frame is for placing for carrying out the multiple slides dyeed, described tail end sample rack is for placing the multiple slides after having dyeed, multiple slide is horizontal stacking and places on described front end print frame and described tail end sample rack, and the spacing between every two adjacent slides is a setting value, described front end print frame is connected with a lead screw motor respectively with described tail end sample rack, for described front end print frame, lead screw motor is for driving the print frame lifting of described front end, to make to be positioned at uppermost slide and described conveyer is contour, for described tail end sample rack, lead screw motor is for driving the lifting of described tail end sample rack, with make to be positioned at uppermost vacant position and described conveyer contour,
Described conveyer is provided with multiple screens and convolution connecting rod, described conveyer is inner for the multiple slides on the print frame of described front end being sent to described spray equipment, and the multiple described slide dyeed is sent to described tail end sample rack, described convolution connecting rod moves on described conveyer for driving slide, described convolution connecting rod often rotates a circle and namely drives slide to move a screens towards described tail end sample rack, each screens bottom is equipped with an angle adjustment lever, angle adjustment lever is for adjusting the angle of inclination of the slide in screens, on the left of slide He on the right side of slide, a dyeing liquor can be sprayed towards slide respectively to make nozzle,
Described slide pusher is for pushing to multiple screens of described conveyer respectively by the multiple slides on the print frame of described front end, described slide pusher often pushes a slide, and described conveyer all drives the slide on it to move a screens towards described tail end sample rack;
Described spray equipment is for being fixed the sample on multiple described slide, first dye, mordant dyeing, decolour and redye, wherein, described feeding device, described nozzle, described waste collecting device, the number of described angle adjustment lever is all identical with the number of screens, a kind of dyeing liquor is contained with in each feeding device, multiple feeding device is arranged on the bottom of described spray equipment, each feeding device is all connected with one of them nozzle by a water influent pipeline, multiple nozzle is separately positioned on the top of the multiple screens in described conveyer, for towards slide jet dyeing liquid, multiple waste collecting device is arranged on the bottom of multiple screens, for collecting the waste liquid after dyeing, described drying unit is arranged on the bottom of described spray equipment, for the multiple slides after dyeing are dried.
In one embodiment of this invention, the automatic testing station of described vaginitis comprises safety screen, sample rack, shank, mechanical arm, reagent card storage rack, needle remover, constant temperature conveyer and detection module, wherein,
Described safety screen is arranged on the outside at the automatic testing station of described vaginitis in surrounding shape, for the protection of the safety of the automatic testing station of described vaginitis and operating personnel;
Described sample rack is arranged on the central authorities at the automatic testing station of described vaginitis, for depositing sample and syringe needle;
Described shank inside is provided with microsyringe, and described shank is connected with the bottom of described mechanical arm;
The operation that described mechanical arm carries out extracting syringe needle for controlling described shank and unloads syringe needle;
The reagent card used when described reagent card storage rack is for depositing detection;
Described needle remover is used for unloading and collects useless syringe needle;
Described constant temperature conveyer is used for carrying out incubation when detecting to reagent card, and after incubation completes, reagent card is sent to described detection module;
Described detection module is connected with described computing machine, for detecting the reagent card after incubation, a color sensor is provided with in described detection module, described color sensor is used for carrying out color developing detection to described reagent card and drawing function assessment result data after identifying, and exports described function assessment result data to described computing machine.
In one embodiment of this invention, the full-automatic micro-detection platform of described morphology comprises base, auto-focusing platform, object lens, objective table, camera and Electric Appliance Cabinet, wherein,
Described auto-focusing platform is arranged on the top of described object lens, for controlling described object lens auto-focusing;
Described objective table is positioned at immediately below described object lens, for placing the smear after described fully-automatic intelligent dyeing instrument dyeing;
Described camera is connected with described object lens and described Electric Appliance Cabinet, for gathering the image in the described object lens visual field;
Described Electric Appliance Cabinet comprises a control chip, described control chip is connected with described computing machine, described control chip carries out scanner uni collection for controlling described camera to the image in the described object lens visual field, the image collected is sent to described computing machine by described camera, the image collected carries out processing and obtains described morphology graph data by described computing machine further, and is saved in the storer in described computing machine by described morphology graph data further.
In one embodiment of this invention, described front end print frame and described tail end sample rack comprise motor rack, lead screw motor, guide frame, many guide poles, slide frame and cylindrical magnetic irons, wherein,
Described motor rack is positioned at the bottom of described front end print frame or described tail end sample rack, and described motor rack is placed with described lead screw motor;
Described guide frame is arranged on described motor rack top, and described guide frame inner vertical is provided with many guide poles, and described guide pole is connected with described lead screw motor, and described lead screw motor vertically rises for driving many guide poles or declines;
Described slide frame is arranged on many guide pole tops, and the described slide frame left and right sides is respectively arranged with a loading plate, and inside two described loading plates, correspondence is provided with multiple convex tongue, and convex tongue is for carrying slide;
Described cylindrical magnetic iron is arranged on the side of described motor rack, for described front end print frame or described tail end sample rack are absorbed and fixed at precalculated position.
In one embodiment of this invention, described slide pusher comprises motor rack, stepper motor, rotating shaft, contiguous block, slide push rod, guide rail and guide rail slide block, wherein,
Described motor rack is arranged on the bottom of described slide pusher, and described motor rack is placed with described stepper motor;
Described rotating shaft is arranged on described motor rack top, and described rotating shaft comprises a first end and one second end, and described first end is connected with described stepper motor, and described contiguous block is arranged on described second end, and described contiguous block is connected with described slide push rod;
Described guide rail is arranged on the bottom of described slide push rod, and described guide rail is provided with guide rail slide block, and described slide push rod moves along described guide rail under the drive of described contiguous block, to be pushed on described conveyer by described front-end samples frame by slide successively.
In one embodiment of this invention, described input equipment comprises scanner and mouse-keyboard, wherein, described scanner is connected with described computing machine respectively by a USB interface with mouse-keyboard, described scanner is for scanning the bar code corresponding with each sample, and described bar code at least comprises following information: patient age, name and test item.
In one embodiment of this invention, described output device is printer, and described printer is for printing the diagnostic result of patient.
In one embodiment of this invention, described function assessment result data comprises the biochemical function characteristic of normal bacteria, miscellaneous bacteria and pathogenic microorganisms in vaginal fluid.
In one embodiment of this invention, described morphology graph data comprises normal bacteria, epithelial cell, miscellaneous bacteria, pathogenic microorganisms and leukocytic form and quantity thereof.
The present invention by leukorrhea secretion is carried out morphology microscopy and normal bacteria, pathogenic bacteria preformation zymogram, metabolite profile function assessment detect and Synchronization Analysis, make morphologic detection result and biochemical function testing result be combined with each other, mutually make up, avoid imperfect, not comprehensively and not system and the mistaken diagnosis caused or fail to pinpoint a disease in diagnosis due to one-sided testing result.The present invention can accurate evaluation microecology in vaginas, finds all common vaginitis and causes the various pathogenic microorganismss of vagina infection.The present invention relative to conventional detection devices have simple to operate, go out analysis report advantage faster, more complete analysis result can be provided for clinician, substantially increase clinic diagnosis efficiency.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the fully-automatic intelligent dyeing instrument in the present invention;
Fig. 2 is the structural representation of the conveyer in the present invention;
Fig. 3 is the structural representation of the angle adjustment lever in the present invention;
Fig. 4 is the structural representation at the automatic testing station of vaginitis in the present invention;
Fig. 5 is the structural representation of the full-automatic micro-detection platform of the morphology in the present invention;
Fig. 6 is the structural representation of the front end print frame in the present invention;
Fig. 7 is the structural representation of the slide pusher in the present invention;
Fig. 8 is the combination schematic diagram of front end print frame in the present invention and slide pusher.
Description of reference numerals: 1-fully-automatic intelligent dyeing instrument; 11-front end print frame; 111-motor rack; 112-lead screw motor; 113-guide frame; 114-guide pole; 115-slide frame; 1151-loading plate; The convex tongue of 1152-; 116-cylindrical magnetic iron; 12-tail end sample rack; 13-conveyer; 131-screens; 132-circles round connecting rod; 133-angle adjustment lever; 14-slide pusher; 141-motor rack; 142-stepper motor; 143-rotating shaft; 144-contiguous block; 145-slide push rod; 146-guide rail; 147-guide rail slide block; A-microslide; 15-spray equipment; 151-nozzle; The automatic testing station of 2-vaginitis; 21-sample rack; 22-shank; 23-mechanical arm; 24-reagent card storage rack; 25-needle remover; 26-constant temperature conveyer; 27-detection module; The full-automatic micro-detection platform of 3-morphology; 31-base; 32-auto-focusing platform; 33-object lens; 34-objective table; 35-Electric Appliance Cabinet.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not paying the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Fig. 1 is the structural representation of the fully-automatic intelligent dyeing instrument in the present invention, Fig. 2 is the structural representation of the conveyer in the present invention, Fig. 3 is the structural representation of the angle adjustment lever in the present invention, as shown in FIG. 1 to 3, Lower Female Genital Tract Tiny ecosystem provided by the invention is evaluated detection system and is comprised: fully-automatic intelligent dyeing instrument 1, vaginitis automatic testing station 2, the full-automatic micro-detection platform 3 of morphology, computing machine, input equipment and output device, wherein
Fully-automatic intelligent dyeing instrument 1 is for automatically dyeing to vaginal fluid sample, and being formed can for the smear of clear detection;
The automatic testing station 2 of vaginitis is connected with computing machine, for carrying out biochemistry detection to the preformation enzyme in vaginal fluid and metabolin, to obtain a function assessment result data;
The full-automatic micro-detection platform 3 of morphology is connected with computing machine, for detect dye via fully-automatic intelligent dyeing instrument 1 after formed smear, analyze to carry out detection to the visible component in vaginal fluid, to obtain a morphology graph data, visible component at least comprises: leucocyte, spore, mycelia, trichomonad, male/female property escherichia coli, male/female property dialister bacterium and positive cocci;
Computing machine is for controlling fully-automatic intelligent dyeing instrument 1, vaginitis automatic testing station 2, the full-automatic micro-detection platform 3 of morphology, input equipment and output device, computer-internal is provided with an application software and a pathology knowledge base, and application software is used for function assessment result data and morphology graph data and pathology knowledge base to compare the diagnostic result obtaining patient;
Input equipment is connected with computing machine, for the data information of patient is inputed to computing machine;
Output device is connected with computing machine, for exporting the diagnostic result of patient.
Be illustrated in figure 1 the structural representation of the fully-automatic intelligent dyeing instrument in the present invention, fully-automatic intelligent dyeing instrument 1 comprises front end print frame 11, tail end sample rack 12, conveyer 13, slide pusher 14 and spray equipment 15, spray equipment 15 comprises multiple feeding device (not shown), multiple nozzle 151, multiple waste collecting device (not shown) and drying unit (not shown), wherein
Front end print frame 11 and tail end sample rack 12 are separately positioned on the two ends of conveyer 13, front end print frame 11 is for placing for carrying out the multiple slides dyeed, tail end sample rack 12 is for placing the multiple slides after having dyeed, multiple slide is horizontal stacking and places on front end print frame 11 with tail end sample rack 12, and the spacing between every two adjacent slides is a setting value, front end print frame 11 is connected with a lead screw motor respectively with tail end sample rack 12, for front end print frame 11, lead screw motor is for driving front end print frame 11 lifting, with make to be positioned at uppermost slide and conveyer contour, for tail end sample rack 12, lead screw motor is for driving tail end sample rack 12 lifting, with make to be positioned at uppermost vacant position and conveyer contour,
Conveyer 13 is provided with multiple screens 131 and convolution connecting rod 132, be illustrated in figure 2 the structural representation of the conveyer in the present invention, conveyer 13 is inner for the multiple slides on front end print frame 11 being sent to spray equipment 15, sample is fixed in spray equipment 15 inside, first dye, mordant dyeing, decolouring, the series of steps such as to redye, and the multiple slides dyeed are sent to tail end sample rack 12, convolution connecting rod 131 moves on conveyer 13 for driving slide, convolution connecting rod 131 often rotates a circle and namely drives slide to move a screens 131 towards tail end sample rack 12, each screens 131 bottom is equipped with an angle adjustment lever 133, be illustrated in figure 3 the angle adjustment lever structural representation in the present invention, angle adjustment lever 133 is for adjusting the angle of inclination of the slide in screens 131, on the left of slide He on the right side of slide, a dyeing liquor can be sprayed towards slide respectively to make nozzle 151,
Slide pusher 14 is for pushing to multiple screens 131 of conveyer 13 respectively by the multiple slides on front end print frame 11, slide pusher 14 often pushes a slide, and conveyer 13 all drives the slide on it to move a screens 131 towards tail end sample rack 12;
Spray equipment 15 is for being fixed the sample on multiple slide, first dye, mordant dyeing, decolour and redye, wherein, feeding device, nozzle 151, the number of angle adjustment lever 133 is all identical with the number of screens 131, a kind of dyeing liquor is contained with in each feeding device, multiple feeding device is arranged on the bottom of spray equipment 15, each feeding device is all connected with one of them nozzle 151 by a water influent pipeline (not shown), multiple nozzle 151 is separately positioned on the top of the multiple screens 131 in conveyer 13, for towards slide jet dyeing liquid, multiple waste collecting device is arranged on the bottom of multiple screens 131, for collecting the waste liquid after dyeing, drying unit is arranged on the bottom of spray equipment 15, for the multiple slides after dyeing are dried.
The gram main flow colouring method of current employing is divided into centrifuge method and dip method two kinds.Centrifuge method speed is slow, and because of its centrifugal chamber casing, no matter place how many microslides, centrifugation time is fixing, so cannot be applied to emergency treatment; Dip method is all dipped into by microslide in color pond to carry out unifying dyeing, and because dyeing liquor need soak a large amount of microslide waste reagent, and Color is general, the many also easy stifled instruments of impurity.
Fully-automatic intelligent dyeing instrument 1 in the present invention make use of unique spray equipment 15 and conveyer 13, can save reagent, interim film releasing in orbit can, with to inspection, be accomplished really can be applied to emergency treatment, speed is fast, evaluates detection system provide speed support for whole genital tract Tiny ecosystem.
Be illustrated in figure 4 the structural representation at the automatic testing station of vaginitis in the present invention, the automatic testing station 2 of vaginitis comprises safety screen (not shown), sample rack 21, shank 22, mechanical arm 23, reagent card storage rack 24, needle remover 25, constant temperature conveyer 26 and detection module 27, wherein
Safety screen is arranged on the outside at the automatic testing station 2 of vaginitis in surrounding shape, for the protection of the safety of the automatic testing station 2 of vaginitis and operating personnel;
Sample rack 21 is arranged on the central authorities at the automatic testing station 2 of vaginitis, for depositing sample and syringe needle;
Shank 22 inside is provided with microsyringe, and shank 22 is connected with the bottom of mechanical arm 23;
The operation that mechanical arm 23 carries out extracting syringe needle for controlling shank 22 and unloads syringe needle;
The reagent card used when reagent card storage rack 24 is for depositing detection;
Needle remover 25 is for unloading and collecting useless syringe needle;
Constant temperature conveyer carries out incubation to reagent card with 26 when in detection, and after incubation completes, reagent card is sent to detection module 27;
Detection module 27 is connected with computing machine, for detecting the reagent card after incubation, a color sensor (not shown) is provided with in detection module 27, color sensor is used for carrying out color developing detection to reagent card and drawing function assessment result data after identifying, and exports function assessment result data to computing machine.
Be illustrated in figure 5 the structural representation of the full-automatic micro-detection platform of morphology in the present invention, the full-automatic micro-detection platform 3 of morphology comprises base 31, auto-focusing platform 32, object lens 33, objective table 34, camera (not shown) and Electric Appliance Cabinet 35, wherein
Auto-focusing platform 32 is arranged on the top of object lens 33, for controlling object lens 33 auto-focusing;
Objective table 34 is positioned at immediately below object lens 33, for placing the smear after fully-automatic intelligent dyeing instrument 1 dyes;
Camera is connected with object lens 33 and Electric Appliance Cabinet 35, for gathering the image in the object lens visual field;
Electric Appliance Cabinet 35 comprises a control chip, control chip is connected with computing machine, control chip carries out scanner uni collection for controlling camera to the image in the object lens visual field, the image collected is sent to computing machine by camera, the image collected carries out processing and obtains morphology graph data by computing machine further, and is saved to by morphology graph data further in the storer in computing machine.
Be illustrated in figure 6 the structural representation of the front end print frame in the present invention, front end print frame 11 comprises motor rack 111, lead screw motor 112, guide frame 113, many guide poles 114, slide frame 115 and cylindrical magnetic irons 116, wherein,
Motor rack 111 is positioned at the bottom of front end print frame 12, motor rack 111 is placed with lead screw motor 112;
Guide frame 113 is arranged on motor rack 111 top, and guide frame 113 inner vertical is provided with many guide poles 114, and guide pole 114 is connected with lead screw motor 112, and lead screw motor 112 vertically rises for driving many guide poles 114 or declines;
Slide frame 115 is arranged on the top of many guide poles 114, slide frame 115 left and right sides be respectively arranged with a loading plate 1151, two loading plates 1151 inside correspondence be provided with multiple convex tongue 1152, convex tongue 1152 is for carrying slide;
Cylindrical magnetic iron 116 is arranged on the side of motor rack 111, for front end print frame 11 is absorbed and fixed at precalculated position.
The structure of tail end sample rack 12 is identical with front end print frame 11, its difference is, lead screw motor 112 in front end print frame 11 is for driving front end print frame 11 lifting, to make to be positioned at uppermost slide and conveyer 13 is contour, and the lead screw motor 112 in tail end sample rack 12 declines for driving tail end sample rack 12, contour with the vacant position and conveyer 13 that make to be positioned at the superiors.
Be illustrated in figure 7 the structural representation of the slide pusher in the present invention, slide pusher 14 comprises motor rack 141, stepper motor 142, rotating shaft 143, contiguous block 144, slide push rod 145, guide rail 146 and guide rail slide block 147, wherein,
Motor rack 141 is arranged on the bottom of slide pusher 14, motor rack 141 is placed with stepper motor 142;
Rotating shaft 143 is arranged on motor rack 141 top, and rotating shaft 143 comprises first end 1431 and one second end 1432, and first end 1431 is connected with stepper motor 142, and contiguous block 144 is arranged on the second end 1432, and contiguous block 144 is connected with slide push rod 145;
Guide rail 146 is arranged on the bottom of slide push rod 145, guide rail 146 is provided with guide rail slide block 147, and slide push rod 145 moves along guide rail 146 under the drive of contiguous block 144, to be pushed on conveyer 13 by front-end samples frame 11 by slide A successively.
Be illustrated in figure 8 the combination schematic diagram of front end print frame in the present invention and slide pusher, slide in front end print frame 11 pushes on conveyer 13 by slide push rod 145 in slide pusher 14 successively, often push a slide A, lead screw motor in front end print frame 11 drives front end print frame 11 lifting once, with make to be positioned at uppermost slide and conveyer contour, ensure that slide can push on conveyer 13 by slide push rod 145.It can thus be appreciated that what present in Fig. 8 is the schematic diagram that slide push rod 145 pushes last slide.
In the present invention, input equipment can comprise scanner and mouse-keyboard, wherein, scanner is connected with computing machine respectively by a USB interface with mouse-keyboard, scanner is for scanning the bar code corresponding with each sample, and bar code at least comprises following information: patient age, name and test item.In addition, output device can be printer, and printer is for printing the diagnostic result of patient.The present invention also can adopt other input equipments that patient information can be inputted, and other can be adopted can to export the output device of patient diagnosis result, and the present invention is not as limit.
In the present invention, function assessment result data can comprise the biochemical function characteristic of normal bacteria, miscellaneous bacteria and pathogenic microorganisms in vaginal fluid, and morphology graph data can comprise normal bacteria, epithelial cell, miscellaneous bacteria, pathogenic microorganisms and leukocytic form and quantity thereof.
The present invention by leukorrhea secretion is carried out morphology microscopy and normal bacteria, pathogenic bacteria preformation zymogram, metabolite profile function assessment detect and Synchronization Analysis, make morphologic detection result and Tiny ecosystem evaluate testing result to be combined with each other, mutually make up, avoid imperfect, not comprehensively and not system and the mistaken diagnosis that causes or fail to pinpoint a disease in diagnosis due to testing result.The present invention can accurate evaluation microecology in vaginas, finds all common vaginitis and causes the various pathogenic microorganismss of vagina infection.The present invention relative to conventional detection devices have simple to operate, go out analysis report advantage faster, more complete analysis result can be provided for clinician, substantially increase clinic diagnosis efficiency.
One of ordinary skill in the art will appreciate that: accompanying drawing is the schematic diagram of an embodiment, the module in accompanying drawing or flow process might not be that enforcement the present invention is necessary.
One of ordinary skill in the art will appreciate that: the module in the device in embodiment can describe according to embodiment and be distributed in the device of embodiment, also can carry out respective change and be arranged in the one or more devices being different from the present embodiment.The module of above-described embodiment can merge into a module, also can split into multiple submodule further.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (10)
1. Lower Female Genital Tract Tiny ecosystem evaluates a detection system, it is characterized in that, comprising: fully-automatic intelligent dyeing instrument, vaginitis automatic testing station, the full-automatic micro-detection platform of morphology, computing machine, input equipment and output device, wherein,
Described fully-automatic intelligent dyeing instrument is used for automatically dyeing to vaginal fluid sample, and being formed can for the smear of clear detection;
Described vaginitis automatic testing station is connected with described computing machine, for carrying out biochemistry detection to the preformation enzyme in vaginal fluid and metabolin, to obtain a function assessment result data;
The full-automatic micro-detection platform of described morphology is connected with described computing machine, for detecting the smear via being formed after described fully-automatic intelligent dyeing instrument dyeing, analyze to carry out detection to the visible component in vaginal fluid, to obtain a morphology graph data, described visible component at least comprises: leucocyte, spore, mycelia, trichomonad, male/female property escherichia coli, male/female property dialister bacterium and positive cocci;
Described computing machine is for controlling described fully-automatic intelligent dyeing instrument, described vaginitis automatic testing station, the full-automatic micro-detection platform of described morphology, described input equipment and described output device, described computer-internal is provided with an application software and a pathology knowledge base, and described application software is used for described function assessment result data and described morphology graph data and described pathology knowledge base to compare the diagnostic result obtaining patient;
Described input equipment is connected with described computing machine, for the data information of patient is inputed to computing machine;
Described output device is connected with described computing machine, for exporting the diagnostic result of patient.
2. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, it is characterized in that, described fully-automatic intelligent dyeing instrument comprises front end print frame, tail end sample rack, conveyer, slide pusher and spray equipment, described spray equipment comprises multiple feeding device, multiple nozzle, multiple waste collecting device and drying unit, wherein
Described front end print frame and described tail end sample rack are separately positioned on the two ends of described conveyer, described front end print frame is for placing for carrying out the multiple slides dyeed, described tail end sample rack is for placing the multiple slides after having dyeed, multiple slide is horizontal stacking and places on described front end print frame and described tail end sample rack, and the spacing between every two adjacent slides is a setting value, described front end print frame is connected with a lead screw motor respectively with described tail end sample rack, for described front end print frame, lead screw motor is for driving the print frame lifting of described front end, to make to be positioned at uppermost slide and described conveyer is contour, for described tail end sample rack, lead screw motor is for driving the lifting of described tail end sample rack, with make to be positioned at uppermost vacant position and described conveyer contour,
Described conveyer is provided with multiple screens and convolution connecting rod, described conveyer is inner for the multiple slides on the print frame of described front end being sent to described spray equipment, and the multiple described slide dyeed is sent to described tail end sample rack, described convolution connecting rod moves on described conveyer for driving slide, described convolution connecting rod often rotates a circle and namely drives slide to move a screens towards described tail end sample rack, each screens bottom is equipped with an angle adjustment lever, angle adjustment lever is for adjusting the angle of inclination of the slide in screens, on the left of slide He on the right side of slide, a dyeing liquor can be sprayed towards slide respectively to make nozzle,
Described slide pusher is for pushing to multiple screens of described conveyer respectively by the multiple slides on the print frame of described front end, described slide pusher often pushes a slide, and described conveyer all drives the slide on it to move a screens towards described tail end sample rack;
Described spray equipment is for being fixed the sample on multiple described slide, first dye, mordant dyeing, decolour and redye, wherein, described feeding device, described nozzle, described waste collecting device, the number of described angle adjustment lever is all identical with the number of screens, a kind of dyeing liquor is contained with in each feeding device, multiple feeding device is arranged on the bottom of described spray equipment, each feeding device is all connected with one of them nozzle by a water influent pipeline, multiple nozzle is separately positioned on the top of the multiple screens in described conveyer, for towards slide jet dyeing liquid, multiple waste collecting device is arranged on the bottom of multiple screens, for collecting the waste liquid after dyeing, described drying unit is arranged on the bottom of described spray equipment, for the multiple slides after dyeing are dried.
3. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, it is characterized in that, the automatic testing station of described vaginitis comprises safety screen, sample rack, shank, mechanical arm, reagent card storage rack, needle remover, constant temperature conveyer and detection module, wherein
Described safety screen is arranged on the outside at the automatic testing station of described vaginitis in surrounding shape, for the protection of the safety of the automatic testing station of described vaginitis and operating personnel;
Described sample rack is arranged on the central authorities at the automatic testing station of described vaginitis, for depositing sample and syringe needle;
Described shank inside is provided with microsyringe, and described shank is connected with the bottom of described mechanical arm;
The operation that described mechanical arm carries out extracting syringe needle for controlling described shank and unloads syringe needle;
The reagent card used when described reagent card storage rack is for depositing detection;
Described needle remover is used for unloading and collects useless syringe needle;
Described constant temperature conveyer is used for carrying out incubation when detecting to reagent card, and after incubation completes, reagent card is sent to described detection module;
Described detection module is connected with described computing machine, for detecting the reagent card after incubation, a color sensor is provided with in described detection module, described color sensor is used for carrying out color developing detection to described reagent card and drawing function assessment result data after identifying, and exports described function assessment result data to described computing machine.
4. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, the full-automatic micro-detection platform of described morphology comprises base, auto-focusing platform, object lens, objective table, camera and Electric Appliance Cabinet, wherein,
Described auto-focusing platform is arranged on the top of described object lens, for controlling described object lens auto-focusing;
Described objective table is positioned at immediately below described object lens, for placing the smear after described fully-automatic intelligent dyeing instrument dyeing;
Described camera is connected with described object lens and described Electric Appliance Cabinet, for gathering the image in the described object lens visual field;
Described Electric Appliance Cabinet comprises a control chip, described control chip is connected with described computing machine, described control chip carries out scanner uni collection for controlling described camera to the image in the described object lens visual field, the image collected is sent to described computing machine by described camera, the image collected carries out processing and obtains described morphology graph data by described computing machine further, and is saved in the storer in described computing machine by described morphology graph data further.
5. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, described front end print frame and described tail end sample rack comprise motor rack, lead screw motor, guide frame, many guide poles, slide frame and cylindrical magnetic irons, wherein,
Described motor rack is positioned at the bottom of described front end print frame or described tail end sample rack, and described motor rack is placed with described lead screw motor;
Described guide frame is arranged on described motor rack top, and described guide frame inner vertical is provided with many guide poles, and described guide pole is connected with described lead screw motor, and described lead screw motor vertically rises for driving many guide poles or declines;
Described slide frame is arranged on many guide pole tops, and the described slide frame left and right sides is respectively arranged with a loading plate, and inside two described loading plates, correspondence is provided with multiple convex tongue, and convex tongue is for carrying slide;
Described cylindrical magnetic iron is arranged on the side of described motor rack, for described front end print frame or described tail end sample rack are absorbed and fixed at precalculated position.
6. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, described slide pusher comprises motor rack, stepper motor, rotating shaft, contiguous block, slide push rod, guide rail and guide rail slide block, wherein,
Described motor rack is arranged on the bottom of described slide pusher, and described motor rack is placed with described stepper motor;
Described rotating shaft is arranged on described motor rack top, and described rotating shaft comprises a first end and one second end, and described first end is connected with described stepper motor, and described contiguous block is arranged on described second end, and described contiguous block is connected with described slide push rod;
Described guide rail is arranged on the bottom of described slide push rod, and described guide rail is provided with guide rail slide block, and described slide push rod moves along described guide rail under the drive of described contiguous block, to be pushed on described conveyer by described front-end samples frame by slide successively.
7. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, it is characterized in that, described input equipment comprises scanner and mouse-keyboard, wherein, described scanner is connected with described computing machine respectively by a USB interface with mouse-keyboard, described scanner is for scanning the bar code corresponding with each sample, and described bar code at least comprises following information: patient age, name and test item.
8. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, described output device is printer, and described printer is for printing the diagnostic result of patient.
9. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, described function assessment result data comprises the biochemical function characteristic of normal bacteria, miscellaneous bacteria and pathogenic microorganisms in vaginal fluid.
10. Lower Female Genital Tract Tiny ecosystem according to claim 1 evaluates detection system, and it is characterized in that, described morphology graph data comprises normal bacteria, epithelial cell, miscellaneous bacteria, pathogenic microorganisms and leukocytic form and quantity thereof.
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| CN201510869124.8A CN105372439A (en) | 2015-12-01 | 2015-12-01 | Female reproductive tract microecology evaluation and detection system |
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| CN116363128A (en) * | 2023-05-31 | 2023-06-30 | 天津医科大学总医院 | Vaginal microecology evaluation model and system for menopausal women |
| CN116363128B (en) * | 2023-05-31 | 2023-08-04 | 天津医科大学总医院 | Vaginal microecology evaluation model and system for menopausal women |
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