CN116577926B - Controllable batch automatic glass slide loading microscan - Google Patents
Controllable batch automatic glass slide loading microscan Download PDFInfo
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- CN116577926B CN116577926B CN202310853115.4A CN202310853115A CN116577926B CN 116577926 B CN116577926 B CN 116577926B CN 202310853115 A CN202310853115 A CN 202310853115A CN 116577926 B CN116577926 B CN 116577926B
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- driving
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- 239000011521 glass Substances 0.000 title claims description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 73
- 239000000463 material Substances 0.000 claims description 57
- 238000007599 discharging Methods 0.000 claims description 44
- 230000005540 biological transmission Effects 0.000 claims description 20
- 238000005096 rolling process Methods 0.000 claims description 19
- 230000000149 penetrating effect Effects 0.000 claims description 13
- 239000003638 chemical reducing agent Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000000926 separation method Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 8
- 238000005192 partition Methods 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 abstract description 13
- 238000006073 displacement reaction Methods 0.000 abstract description 7
- 238000010586 diagram Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- CJRQAPHWCGEATR-UHFFFAOYSA-N n-methyl-n-prop-2-ynylbutan-2-amine Chemical compound CCC(C)N(C)CC#C CJRQAPHWCGEATR-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006264 polyurethane film Polymers 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G29/00—Rotary conveyors, e.g. rotating discs, arms, star-wheels or cones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G47/00—Article or material-handling devices associated with conveyors; Methods employing such devices
- B65G47/74—Feeding, transfer, or discharging devices of particular kinds or types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/26—Stages; Adjusting means therefor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/32—Micromanipulators structurally combined with microscopes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P40/00—Technologies relating to the processing of minerals
- Y02P40/50—Glass production, e.g. reusing waste heat during processing or shaping
- Y02P40/57—Improving the yield, e-g- reduction of reject rates
Abstract
The invention relates to the technical field of slide scanning detection instruments, in particular to a controllable batch automatic slide loading microscopic scanner, which comprises a scanning microscope and a displacement driving mechanism, wherein the microscopic scanner is arranged at the output end of the displacement driving mechanism; a bearing driving piece is arranged below the scanning microscope; the invention can improve the priority of temporarily added slide samples, and realize the aim that a microscopic scanner can carry out differential treatment according to different priorities of the slide samples.
Description
Technical Field
The invention relates to the technical field of slide scanning detection instruments, in particular to a controllable batch automatic slide loading microscanning instrument.
Background
Slide sample detection is a common biological detection method, typically by observing certain specific areas of the sample with a microscope and performing quantitative analysis.
Aiming at the problem of low scanning detection efficiency of the current microscope, the patent: CN112965233a discloses a microscopic scanner capable of automatically loading slides in batches, which comprises a slide box loading module, a slide box moving module, a slide scanning module, a visual identification module and a slide box recycling module, wherein the slide box loading module is used for loading slide boxes, the slide box moving module comprises a multifunctional pushing mechanism and a slide box moving mechanism which push slides in the horizontal direction, the slide moving mechanism and the multifunctional pushing mechanism push the slides into the slide scanning module for scanning detection, the visual identification module is used for carrying out image acquisition and numbering on the module to be scanned, and the slide box recycling module is used for collecting the scanned slides.
However, this patent still has the problem that the sequencing of the slides is fixed during the batch detection of the slide samples, but some sudden important cases may occur during the detection, the slide samples of these cases need to be scanned quickly, otherwise the patient condition is delayed to cause life hazards, but the normal case samples queued before the important cases cause time delay to them, so that the slide samples of the important cases delay the detection scan.
Disclosure of Invention
Therefore, the invention aims to provide a controllable batch automatic slide loading microscan, so as to solve the technical problem that the microscan in the prior art cannot control the detection sequence of batch slides.
Based on the above purpose, the invention provides a controllable batch automatic slide loading microscopic scanner, which comprises a scanning microscope, a bearing driving piece for bearing the slide, and a discharging and conveying mechanism for recycling the slide; the material distribution control mechanism is used for controlling a slide sorting mode and conveying the slide to the bearing driving piece and comprises an upper tray frame and a lower tray frame, wherein the interiors of the upper tray frame and the lower tray frame are hollow, a first feeding hole is formed in the top surface of the upper tray frame, a first discharging hole and a second discharging hole are formed in the bottom surface of the upper tray frame, the first feeding hole and the second discharging hole are coaxially arranged, a second feeding hole and a third feeding hole are formed in the top surface of the lower tray frame, a third discharging hole is formed in the bottom surface of the lower tray frame, the second feeding hole and the third discharging hole are coaxially arranged, a first carrying tray and a second carrying tray are respectively arranged in the interiors of the upper tray frame and the lower tray frame, the structures of the first carrying tray and the second carrying tray are consistent, and two first containing holes are symmetrically formed in the first carrying tray;
an intermittent conveying mechanism is arranged between the upper tray frame and the lower tray frame, a feeding end and a discharging end of the intermittent conveying mechanism respectively correspond to the first discharging hole and the second feeding hole, and the intermittent conveying mechanism is used for batch intermittent conveying of the glass slides in the first discharging hole to the inside of the lower tray frame;
the material distributing control mechanism also comprises a material distributing driver, and the material distributing driver is used for controlling the glass slide to move to a feeding end or a discharging end of the intermittent conveying mechanism;
the material distribution driver comprises a material distribution converter, the material distribution converter is arranged between the upper tray frame and the lower tray frame, the material distribution converter is positioned between the second discharging hole and the third feeding hole, and the material distribution converter is used for conveying the glass slide positioned in the second discharging hole to the inside of the lower tray frame;
the material distributing driver also comprises a driving control mechanism which is arranged at the top of the upper tray frame and is in transmission connection with the first carrying tray and the second carrying tray;
the driving control mechanism comprises a driving rod, the driving rod is a spline shaft, spline sleeves are fixedly arranged on the first carrying disc and the second carrying disc, the driving rod is in sliding connection with the spline sleeves on the first carrying disc, a second linear driver for controlling the driving rod to longitudinally move is arranged on the upper disc frame, the driving rod is separated from the spline sleeves on the second carrying disc in the upward moving process of the driving rod, a double-shaft stepping motor is further arranged on the upper disc frame, and the first output end of the double-shaft stepping motor is in transmission connection with the spline sleeves on the first carrying disc;
the lower disc frame is provided with a locking rod, the locking rod is in sliding connection with the lower disc frame, the locking rod is in elastic connection with the lower disc frame through a first elastic element, the locking rod is used for fixing the second carrying disc, and the spring normally pushes the locking rod to extend into the second carrying disc.
Preferably, the intermittent conveying mechanism comprises a first sheet passing cylinder, two ends of the first sheet passing cylinder are fixedly connected with an upper tray frame and a lower tray frame respectively, the first sheet passing cylinder is coaxially arranged with a first discharging hole and a second feeding hole, a belt wheel set is arranged on the first sheet passing cylinder, a driving belt is wound on the belt wheel set, a plurality of partition plates for supporting glass slides are arranged on the driving belt at equal intervals, a rotary driver is arranged on the upper tray frame, and the output end of the rotary driver is in transmission connection with the belt wheel set.
Preferably, the material distribution converter comprises a second passing barrel, the second passing barrel is arranged between the upper disc frame and the lower disc frame, the second passing barrel, the second discharging hole and the third feeding hole are coaxially arranged, a slide carrier is arranged in the second passing barrel, the slide carrier is slidably connected with the second passing barrel, a first linear driver is arranged at the bottom of the lower disc frame, and the output end of the first linear driver is connected with the slide carrier.
Preferably, the bearing driving piece comprises a rotating disk, three second containing holes are formed in the rotating disk, a fixed disk is arranged at the bottom of the rotating disk, the rotating disk is rotatably arranged on the fixed disk, two penetrating holes are formed in the fixed disk, the two penetrating holes are respectively a detecting part and a blanking part of the bearing driving piece, the penetrating holes of the detecting part are positioned below the scanning microscope, the penetrating holes of the detecting part are positioned above the conveying part of the unloading conveying mechanism, the rotating disk is in transmission connection with a double-shaft stepping motor of the distributing driver, a supporting piece for supporting a slide is arranged at the bottom of the rotating disk and is positioned at the positions of the three second containing holes, and when any one of the second containing holes of the rotating disk is positioned at the blanking part of the bearing driving piece, the supporting piece stops supporting the slide.
Preferably, a speed reducer is arranged on the second output end of the double-shaft stepping motor, the output end of the speed reducer is in transmission connection with the rotating disc through a linkage rod, and the linkage rod rotates one third of a circle when the second output end of the double-shaft stepping motor rotates for half a circle.
Preferably, the bearing piece comprises a sliding block, a path of which the diameter line on the rotating disk coincides with the diameter line of the second accommodating hole is a separation line, the sliding blocks are symmetrically arranged along the separation line, a second elastic element is arranged on the sliding block, and the two sliding blocks are mutually close to each other in a normal state of the second elastic element;
the sliding block is provided with a rolling shaft, the rolling shaft is rotatably provided with a roller, the outer surface of the roller is attached with flexible materials, the bottom of the rotating disk is provided with a connecting piece, the connecting piece is in sliding connection with the rotating disk, the sliding direction is a separation line, the connecting piece is provided with rolling bodies, the rolling bodies are rolling balls, and the connecting piece is in transmission connection with the two sliding blocks through a connecting rod;
the fixing disc is provided with a convex block, the top point of the convex block is close to the axis of the fixing disc, and when the rolling bodies of the connecting piece are contacted to the top point of the convex block, the two rolling shafts are in an open state and are separated from the support of the slide.
The invention has the beneficial effects that:
according to the controllable batch automatic slide loading microscopic scanner provided by the invention, the slide is driven to sequentially pass through the second discharging hole, the second passing barrel and the third feeding hole by the slide carrier of the material distribution converter, and finally positioned in the lower tray frame, the output end of the driving control mechanism drives the second slide tray in the lower tray frame to rotate, the second slide tray drives the slide to move to the third discharging hole of the lower tray frame by the first containing hole, and the slide positioned in the third discharging hole directly falls to the feeding part of the bearing driving piece, so that the priority of a temporarily added slide sample can be improved, the purpose that the microscopic scanner can perform differential treatment according to different priorities of slide samples is realized, and the tedious procedure of taking out a large number of slides in an arrangement state is avoided.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only of the invention and that other drawings can be obtained from them without inventive effort for a person skilled in the art.
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a schematic perspective view of a second embodiment of the present invention.
Fig. 3 is a schematic perspective view of a material distributing control mechanism and an intermittent conveying mechanism according to the present invention.
Fig. 4 is a schematic diagram of a partially exploded structure of the feed control mechanism of the present invention.
Fig. 5 is a schematic diagram showing a partially exploded structure of the feed control mechanism according to the present invention.
Fig. 6 is a top view of the feed control mechanism of the present invention.
Fig. 7 is a sectional view taken along the direction A-A of fig. 6.
Fig. 8 is a sectional view in the direction B-B of fig. 6.
Fig. 9 is an enlarged view at C of fig. 8.
Fig. 10 is a schematic perspective view of a carrying drive member, a feed control mechanism and an intermittent conveying mechanism according to the present invention.
Fig. 11 is a schematic perspective exploded view of the bearing driving member of the present invention.
Fig. 12 is a schematic partial structure of the carrier driving member of the present invention.
The reference numerals in the figures are:
1-a scanning microscope;
2-a displacement driving mechanism;
3-a carrier drive; 3 a-rotating disc; 3a 1-a second accommodation hole; 3 b-a fixed disk; 3b 1-a through hole; 3b 2-bump; 3 c-backing support; 3c 1-a slider; 3c 2-a second elastic element; 3c 3-roller; 3c 4-connector; 3c 5-rolling elements; 3c 6-connecting rod; 3 d-reducer; 3d 1-a linkage rod;
4-a discharging and conveying mechanism;
5-a material distribution control mechanism; 5 a-upper tray rack; 5a 1-a first feed hole; 5a 2-a first discharge hole; 5a 3-a second discharge hole; 5a 4-a first tray; 5 b-a lower tray rack; 5b 1-a second feed aperture; 5b 2-a third feed hole; 5b 3-a third discharge hole; 5b 4-a second tray; 5 c-a first receiving hole;
6-intermittent conveying mechanism; 6 A-A first wafer passing cylinder; 6 b-a belt pulley group; 6 c-a transmission belt; 6 d-separator; 6 e-a rotary drive;
7-a material distributing driver; 7 A-A split converter; 7a 1-a second sheet passing barrel; 7a 2-slide; 7a 3-a first linear drive; 7 b-a drive control mechanism; 7b 1-a drive rod; 7b 2-spline housing; 7b 3-a second linear drive; 7b 4-biaxial stepper motor; 7b 5-locking lever; 7b 6-first elastic element.
Detailed Description
The present invention will be further described in detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent.
It is to be noted that unless otherwise defined, technical or scientific terms used herein should be taken in a general sense as understood by one of ordinary skill in the art to which the present invention belongs. The terms "first," "second," and the like, as used herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", etc. are used merely to indicate relative positional relationships, which may also be changed when the absolute position of the object to be described is changed.
As shown in fig. 1 to 7, a controllable batch automatic slide loading microscopic scanner includes a scanning microscope 1 for scanning slides, the scanning microscope 1 is connected with a background computer, and a displacement driving mechanism 2, the microscopic scanning microscope is disposed at an output end of the displacement driving mechanism 2, the displacement driving mechanism 2 is used for driving the scanning microscope 1 to perform position movement, thereby controlling position change of an input end of the microscopic scanning microscope, and the displacement driving mechanism 2 is specifically a horizontal sliding table module but not limited thereto.
A carrying drive 3 for carrying a slide is arranged below the scanning microscope 1, and the scanning microscope 1 is used for scanning the slide on the carrying drive 3.
A discharge conveying mechanism 4 is arranged below the bearing driving member 3, the discharge conveying mechanism 4 is used for recycling the slide unloaded by the bearing driving member 3, and the discharge conveying mechanism 4 is a belt conveyor but is not limited to the belt conveyor.
The upper part of the bearing driving piece 3 is provided with a material distribution control mechanism 5, the material distribution control mechanism 5 comprises an upper tray frame 5a and a lower tray frame 5b, the upper tray frame 5a and the lower tray frame 5b are hollow, the top surface of the upper tray frame 5a is provided with a first material inlet hole 5a1, the bottom surface of the upper tray frame 5a is provided with a first material outlet hole 5a2 and a second material outlet hole 5a3, the first material inlet hole 5a1 and the second material outlet hole 5a3 are coaxially arranged, the top surface of the lower tray frame 5b is provided with a second material inlet hole 5b1 and a third material inlet hole 5b2, the bottom surface of the lower tray frame 5b is provided with a third material outlet hole 5b3, the inner parts of the upper tray frame 5a and the lower tray frame 5b are respectively provided with a first material carrying tray 5a4 and a second material carrying tray 5b4, the first material carrying tray 5a4 and the second material carrying tray 5b4 are consistent in structure, and the first material carrying tray 5a4 is provided with two material carrying trays 5c and 5c are symmetrically arranged.
An intermittent conveying mechanism 6 is arranged between the upper tray frame 5a and the lower tray frame 5b, a feeding end and a discharging end of the intermittent conveying mechanism 6 respectively correspond to the first discharging hole 5a2 and the second feeding hole 5b1, and the intermittent conveying mechanism 6 is used for batch intermittent conveying of the slides in the first discharging hole 5a2 to the inside of the lower tray frame 5 b.
The intermittent conveying mechanism 6 comprises a first passing barrel 6a, two ends of the first passing barrel 6a are fixedly connected with an upper tray frame 5a and a lower tray frame 5b respectively, the first passing barrel 6a is coaxially arranged with a first discharging hole 5a2 and a second feeding hole 5b1, gaps are symmetrically formed in the first passing barrel 6a, belt wheel sets 6b are arranged at the gaps, each belt wheel set 6b consists of two synchronous wheels, a driving belt 6c is wound on each belt wheel set 6b, the driving belt 6c is a synchronous belt, a plurality of partition plates 6d for supporting glass slides are arranged on the driving belt 6c at equal intervals, a rotary driver 6e is arranged on the upper tray frame 5a, the rotary driver 6e is a servo motor, and the output end of the rotary driver 6e is in transmission connection with the belt wheel sets 6 b.
The material distributing control mechanism 5 further comprises a material distributing driver 7, the material distributing driver 7 comprises a material distributing converter 7a, the material distributing converter 7a is arranged between the upper tray frame 5a and the lower tray frame 5b, the material distributing converter 7a is positioned between the second discharging hole 5a3 and the third feeding hole 5b2, the material distributing converter 7a is used for conveying the glass slide positioned in the second discharging hole 5a3 to the inner part of the lower tray frame 5b, the material distributing converter 7a comprises a second through-piece cylinder 7a1, the second through-piece cylinder 7a1 is arranged between the upper tray frame 5a and the lower tray frame 5b, the second through-piece cylinder 7a1 is coaxially arranged with the second discharging hole 5a3 and the third feeding hole 5b2, a slide piece 7a2 is arranged in the second through-piece cylinder 7a1, the slide piece 7a2 is in sliding connection with the second through-piece cylinder 7a1, a first linear driver 7a3 is arranged at the bottom of the lower tray frame 5b, and the output end of the first linear driver 7a3 is not connected with the first linear driver 7a3 or the push rod 3.
The material distributing driver 7 further comprises a driving control mechanism 7b, the driving control mechanism 7b is arranged on the upper top of the upper tray frame 5a, and the driving control mechanism 7b is in transmission connection with the first carrying tray 5a4 and the second carrying tray 5b 4.
Specifically, in the normal state, the worker places the slide on the slide 7a2 of the distribution converter 7a through the first feed hole 5a1 of the upper tray 5a, at this time, the slide is located in the upper tray 5a and in the first accommodating hole 5c of the first slide tray 5a4, the driving control mechanism 7b starts to work, the output end of the driving control mechanism 7b drives the first slide tray 5a4 in the upper tray 5a to rotate, the first slide tray 5a4 drives the slide to move to the first discharge hole 5a2 of the upper tray 5a through the first accommodating hole 5c, the inner surfaces of the upper tray 5a and the lower tray 5b are attached with flexible materials, and abrasion to the slide in the process of driving the slide to rotate can be avoided through the flexible materials, and the flexible materials are specifically polyurethane: polyurethane is a soft polymer and can be coated with a polyurethane film on the surface to reduce the movement friction.
The slide at the first discharging hole 5a2 falls into the first slide passing barrel 6a from the first discharging hole 5a2 of the upper tray 5a, the slide is supported by the partition boards 6d symmetrically distributed in the first slide passing barrel 6a, the belt wheel group 6b is driven by the rotary driver 6e to rotate, the belt wheel group 6b drives the partition boards 6d to descend through the driving belt 6c, the partition boards 6d symmetrically supporting the slide in the first slide passing barrel 6a descend by the distance of one slide after each falling into each slide from the first discharging hole 5a2 of the upper tray 5a, so that a plurality of slide scanning states can be arranged in the first slide passing barrel 6a, the slide at the lowest part of the first passing barrel 6a passes through the second feeding hole 5b1 of the lower tray frame 5b after losing the support of the partition plate 6d in the running process of the transmission belt 6c, the slide entering the lower tray frame 5b through the second feeding hole 5b1 sequentially passes through the first containing hole 5c on the second carrying tray 5b4 and the third discharging hole 5b3 formed on the lower tray frame 5b and then falls on the bearing driving piece 3, the bearing driving piece 3 drives the slide to move to the detection part so as to be positioned below the lens of the scanning microscope 1, and the scanning microscope 1 scans a sample through laser or electron beams to generate a series of image signals, and the image signals are converted into digital signals and stored and processed through a computer so as to obtain a high-resolution and clear image.
The bearing driving piece 3 works again, the bearing driving piece 3 drives the slide after the information collection of the scanning microscope 1 to move to the conveying part of the unloading conveying mechanism 4, and finally the slide conveyed by the unloading conveying mechanism 4 is recovered, so that a round of normal detection flow of the slide sample is completed.
When the slide sample with important cases needs to be collected in advance, a worker places the slide on the slide 7a2 of the distribution converter 7a through the first feed hole 5a1 of the upper tray frame 5a, then the distribution converter 7a starts working, the output end of the linear driver drives the slide 7a2 to descend, the slide 7a2 drives the slide to sequentially pass through the second discharge hole 5a3, the second slide passing cylinder 7a1 and the third feed hole 5b2, finally the slide is positioned in the lower tray frame 5b, then the driving control mechanism 7b starts working, the output end of the driving control mechanism 7b drives the second slide tray 5b4 in the lower tray frame 5b to rotate, the second slide tray 5b4 drives the slide to move to the third discharge hole 5b3 of the lower tray frame 5b through the first accommodating hole 5c, the slide positioned in the third discharge hole 5b3 directly falls onto the bearing driver 3, and the next working process is consistent with the conventional working process.
In order to solve the technical problem that the object carrying discs in the upper disc frame 5a and the lower disc frame 5b can not rotate simultaneously, as shown in fig. 8 and fig. 9, the following preferable technical scheme is provided:
the driving control mechanism 7b comprises a driving rod 7b1, the driving rod 7b1 is a spline shaft, spline sleeves 7b2 are fixedly arranged on the first carrying disc 5a4 and the second carrying disc 5b4, the driving rod 7b1 is in sliding connection with the spline sleeves 7b2 on the first carrying disc 5a4, a second linear driver 7b3 for controlling the driving rod 7b1 to longitudinally move is arranged on the upper disc frame 5a, the second linear driver 7b3 is an air cylinder or an electric push rod, the driving rod 7b1 is separated from the spline sleeves 7b2 on the second carrying disc 5b4 in the upward moving process of the driving rod 7b1, a double-shaft stepping motor 7b4 is further arranged on the upper disc frame 5a, and the first output end of the double-shaft stepping motor 7b4 is in transmission connection with the spline sleeves 7b2 on the first carrying disc 5a4 and is in transmission connection with a bevel gear arranged on the spline sleeve 7b2 through a motor output shaft.
The lower disc frame 5b is provided with a locking rod 7b5, the locking rod 7b5 is a spline shaft, the locking rod 7b5 is in sliding connection with the lower disc frame 5b, the locking rod 7b5 is in elastic connection with the lower disc frame 5b through a first elastic element 7b6, the first elastic element 7b6 is a spring but is not limited to the spring, the locking rod 7b5 is used for fixing the second carrying disc 5b4, the situation that in a normal working state, the second carrying disc 5b4 rotates so that a slide falling from the first passing barrel 6a cannot directly pass through a first accommodating hole 5c in the second carrying disc 5b4, the slide cannot be loaded on the bearing driving piece 3 is avoided, and the locking rod 7b5 is pushed to extend into the inside of a spline sleeve 7b2 in the second carrying disc 5b4 under a spring normal state.
Specifically, in the normal working state, the biaxial stepping motor 7b4 drives the first carrying disc 5a4 to rotate for half a circle through the spline housing 7b2, the first carrying disc 5a4 drives the slide to move to the first discharging hole 5a2 of the upper disc frame 5a through the first accommodating hole 5c, in the non-normal state, the slide 7a2 drives the slide to sequentially pass through the second discharging hole 5a3, the second passing barrel 7a1 and the third feeding hole 5b2, and finally is positioned in the first accommodating hole 5c of the second carrying disc 5b4, at this time, the second linear driver 7b3 drives the driving rod 7b1 to descend, so that the driving rod 7b1 is connected with the spline housing 7b2 on the second carrying disc 5b4, and drives the locking rod 7b5 to descend, so that the second carrying disc 5b4 is restored to the rotatable state, and then the biaxial stepping motor 7b4 drives the second carrying disc 5b4 to complete rotation through the driving rod 7b 1.
In some embodiments
In order to control the scanning microscope 1 to obtain a clearer observation result when light passes through the slide during scanning of the slide, the following preferred technical solutions are provided as shown in fig. 10 to 12.
The bearing driving piece 3 comprises a rotating disc 3a, three second containing holes 3a1 are formed in the rotating disc 3a, a fixed disc 3b is arranged at the bottom of the rotating disc 3a, the rotating disc 3a is rotatably arranged on the fixed disc 3b, the rotating disc 3a and the fixed disc 3b are coaxially arranged, two penetrating holes 3b1 are formed in the fixed disc 3b, the two penetrating holes 3b1 are respectively a detecting part and a blanking part of the bearing driving piece 3, the penetrating holes 3b1 of the detecting part are positioned below the scanning microscope 1, the penetrating holes 3b1 of the detecting part are positioned above the conveying part of the unloading conveying mechanism 4, the rotating disc 3a is in transmission connection with a double-shaft stepping motor 7b4 of the distributing driver 7, particularly, a second output end of the double-shaft stepping motor 7b4 is provided with a speed reducer 3d, an output end of the speed reducer 3d is in transmission connection with the rotating disc 3a through a linkage rod 3d1, the bottom of the rotating disc 3a is provided with a supporting piece 3c used for supporting slides, the supporting piece 3c is respectively positioned at the positions of the three second containing holes 3a1, when any one of the penetrating holes 3a is positioned at the position of the supporting parts 3a, and the supporting part of the falling part 3b is positioned at the position of the supporting part 3b, and the falling part is positioned above the conveying part of the supporting part 3b, and the supporting part is positioned at the position of the supporting part 3 b.
The supporting member 3c includes a sliding block 3c1, a radial line on the rotating disc 3a is a separation line overlapping with a radial line of the second accommodating hole 3a1, the sliding block 3c1 is symmetrically arranged along the separation line, the sliding block 3c1 is provided with a second elastic element 3c2, the second elastic element 3c2 is a spring, but not limited thereto, and the two sliding blocks 3c1 are close to each other in a normal state of the second elastic element 3c 2.
The slide block 3c1 is provided with a roller 3c3, the roller 3c3 is rotatably provided with a roller, a flexible material is attached to the outer surface of the roller for buffering and protecting a slide, the bottom of the rotary disk 3a is provided with a connecting piece 3c4, the connecting piece 3c4 is in sliding connection with the rotary disk 3a, the sliding direction is a separation line, the connecting piece 3c4 is provided with a rolling body 3c5, the rolling body 3c5 is a ball, and the connecting piece 3c4 is in transmission connection with the two slide blocks 3c1 through a connecting rod 3c 6.
The fixed disk 3b is provided with a bump 3b2, the vertex of the bump 3b2 is close to the axis of the fixed disk 3b, and when the rolling body 3c5 of the connecting piece 3c4 contacts the vertex of the bump 3b2, the two rolling shafts 3c3 are in an open state and are separated from supporting the slide.
Specifically, when the slide falls through the third discharge hole 5b3 of the lower tray 5b and is located in the second receiving hole 3a1 of the corresponding rotating disc 3a, the bottom of the glass tray is edge-supported by the two rollers of the bearing member 3c, and then the slide is required to be fed once after the feeding control mechanism 5 finishes one time, the feeding process of the feeding control mechanism 5 is performed through the driving control mechanism 7b, the first output shaft of the dual-shaft stepping motor 7b4 drives the slide plate to rotate for half a turn, and meanwhile, the second output shaft drives the linkage rod 3d1 through the speed reducer 3d to rotate for one third turn, so that the rotating disc 3a rotates for three times, the slide originally located below the third discharge hole 5b3 of the lower tray 5a is moved to the detecting portion, then continues to be moved to the feeding portion in the same manner after the detection is finished, the rotating disc 3c5 of the connecting member 3c4 of the connecting member 3c is pressed by the rolling body 3c5 of the bearing member 3c4 of the bump 3b2 to push the connecting member 3c4 towards the two rollers 3c to move towards the connecting member 3c4 through the speed reducer 3d, and the slide is moved away from the two connecting members 3c4 to the slide conveying mechanism 4.
Those of ordinary skill in the art will appreciate that: the discussion of any of the embodiments above is merely exemplary and is not intended to suggest that the scope of the invention (including the claims) is limited to these examples; the technical features of the above embodiments or in the different embodiments may also be combined within the idea of the invention, the steps may be implemented in any order and there are many other variations of the different aspects of the invention as described above, which are not provided in detail for the sake of brevity.
The present invention is intended to embrace all such alternatives, modifications and variances which fall within the broad scope of the appended claims. Therefore, any omission, modification, equivalent replacement, improvement, etc. of the present invention should be included in the scope of the present invention.
Claims (6)
1. The controllable batch automatic slide loading microscopic scanner comprises a scanning microscope (1), and is characterized by further comprising a bearing driving piece (3) for bearing the slide and a discharging and conveying mechanism (4) for recycling the slide; and a material distributing control mechanism (5) for controlling the glass slide sorting mode and conveying the glass slide to the bearing driving piece (3), wherein the material distributing control mechanism (5) comprises an upper tray frame (5 a) and a lower tray frame (5 b), the interiors of the upper tray frame (5 a) and the lower tray frame (5 b) are hollow, a first feeding hole (5 a 1) is formed in the top surface of the upper tray frame (5 a), a first discharging hole (5 a 2) and a second discharging hole (5 a 3) are formed in the bottom surface of the upper tray frame (5 a), the first feeding hole (5 a 1) and the second discharging hole (5 a 3) are coaxially arranged, the top surface of the lower tray frame (5 b) is provided with a second feeding hole (5 b 1) and a third feeding hole (5 b 2), the bottom surface of the lower tray frame (5 b) is provided with a third discharging hole (5 b 3), the second feeding hole (5 b 1) and the third discharging hole (5 b 3) are coaxially arranged, the interiors of the upper tray frame (5 a) and the lower tray frame (5 b) are respectively provided with a first carrying tray (5 a 4) and a second carrying tray (5 b 4), the structures of the first carrying tray (5 a 4) and the second carrying tray (5 b 4) are consistent, and two first containing holes (5 c) are symmetrically formed in the first carrying tray (5 a 4);
an intermittent conveying mechanism (6) is arranged between the upper tray frame (5 a) and the lower tray frame (5 b), a feeding end and a discharging end of the intermittent conveying mechanism (6) respectively correspond to the first discharging hole (5 a 2) and the second feeding hole (5 b 1), and the intermittent conveying mechanism (6) is used for intermittently conveying the glass slides in the first discharging hole (5 a 2) to the inside of the lower tray frame (5 b) in batches;
the material distributing control mechanism (5) also comprises a material distributing driver (7), and the material distributing driver (7) is used for controlling the glass slide to move to the feeding end or the discharging end of the intermittent conveying mechanism (6);
the material distributing driver (7) comprises a material distributing converter (7 a), wherein the material distributing converter (7 a) is arranged between the upper tray frame (5 a) and the lower tray frame (5 b), the material distributing converter (7 a) is positioned between the second discharging hole (5 a 3) and the third feeding hole (5 b 2), and the material distributing converter (7 a) is used for conveying the glass slide positioned in the second discharging hole (5 a 3) to the inside of the lower tray frame (5 b);
the material distributing driver (7) further comprises a driving control mechanism (7 b), the driving control mechanism (7 b) is arranged at the top of the upper tray frame (5 a), and the driving control mechanism (7 b) is in transmission connection with the first carrying tray (5 a 4) and the second carrying tray (5 b 4);
the driving control mechanism (7 b) comprises a driving rod (7 b 1), the driving rod (7 b 1) is a spline shaft, spline sleeves (7 b 2) are fixedly arranged on the first carrying disc (5 a 4) and the second carrying disc (5 b 4), the driving rod (7 b 1) is in sliding connection with the spline sleeves (7 b 2) on the first carrying disc (5 a 4), a second linear driver (7 b 3) for controlling the driving rod (7 b 1) to longitudinally move is arranged on the upper disc frame (5 a), in the upward movement process of the driving rod (7 b 1), the driving rod (7 b 1) is separated from the spline sleeves (7 b 2) on the second carrying disc (5 b 4), a double-shaft stepping motor (7 b 4) is further arranged on the upper disc frame (5 a), and the first output end of the double-shaft stepping motor (7 b 4) is in transmission connection with the spline sleeves (7 b 2) on the first carrying disc (5 a 4);
be provided with locking pole (7 b 5) on chassis frame (5 b), locking pole (7 b 5) and chassis frame (5 b) sliding connection, locking pole (7 b 5) are through first elastic component (7 b 6) and chassis frame (5 b) elastic connection, and locking pole (7 b 5) are used for fixed second year thing dish (5 b 4), and inside spline housing (7 b 2) on pushing locking pole (7 b 5) stretches into second year thing dish (5 b 4) under the spring normal state.
2. The controllable batch automatic slide loading microscan of claim 1, wherein the intermittent conveying mechanism (6) comprises a first sheet passing barrel (6 a), two ends of the first sheet passing barrel (6 a) are fixedly connected with an upper tray frame (5 a) and a lower tray frame (5 b) respectively, the first sheet passing barrel (6 a) is coaxially arranged with a first discharging hole (5 a 2) and a second feeding hole (5 b 1) at the same time, a belt wheel group (6 b) is arranged on the first sheet passing barrel (6 a), a driving belt (6 c) is wound on the belt wheel group (6 b), a plurality of partition boards (6 d) for supporting slides are arranged on the driving belt (6 c) at equal intervals, a rotary driver (6 e) is arranged on the upper tray frame (5 a), and the output end of the rotary driver (6 e) is in driving connection with the belt wheel group (6 b).
3. A controllable batch auto-loading slide microscan as claimed in claim 1, wherein the feed-through converter (7 a) comprises a second slide-passing barrel (7 a 1), the second slide-passing barrel (7 a 1) is arranged between the upper tray frame (5 a) and the lower tray frame (5 b), the second slide-passing barrel (7 a 1) is coaxially arranged with the second discharge hole (5 a 3) and the third feed hole (5 b 2), a slide-carrier (7 a 2) is arranged in the second slide-passing barrel (7 a 1), the slide-carrier (7 a 2) is slidably connected with the second slide-passing barrel (7 a 1), a first linear driver (7 a 3) is arranged at the bottom of the lower tray frame (5 b), and the output end of the first linear driver (7 a 3) is connected with the slide-carrier (7 a 2).
4. The controllable batch automatic slide loading microscopic scanner according to claim 1, wherein the carrying driving member (3) comprises a rotating disc (3 a), three second containing holes (3 a 1) are formed in the rotating disc (3 a), a fixed disc (3 b) is arranged at the bottom of the rotating disc (3 a), the rotating disc (3 a) is rotatably arranged on the fixed disc (3 b), two penetrating holes (3 b 1) are formed in the fixed disc (3 b), the two penetrating holes (3 b 1) are respectively a detecting portion and a blanking portion of the carrying driving member (3), the penetrating holes (3 b 1) of the detecting portion are located below the scanning microscope (1), the penetrating holes (3 b 1) of the detecting portion are located above the conveying portion of the unloading conveying mechanism (4), a bearing member (3 c) for supporting slides is arranged at the bottom of the rotating disc (3 a) and is in transmission connection with a double-shaft stepping motor (7 b 4) of the distributing driver (7), and the bearing member (3 c) is located at any position of the second containing holes (3 a) of the detecting portion when the second containing holes (3 a) are located at any position of the carrying portion (3 a) of the carrying driving member (3 c).
5. The controllable batch automatic slide loading microscan of claim 4, wherein a speed reducer (3 d) is arranged on the second output end of the double-shaft stepping motor (7 b 4), the output end of the speed reducer (3 d) is in transmission connection with the rotating disc (3 a) through a linkage rod (3 d 1), and the second output end of the double-shaft stepping motor (7 b 4) rotates for one third of a circle when the linkage rod (3 d 1) rotates for one half of a circle.
6. The controllable batch automatic slide loading microscan of claim 4, wherein the support (3 c) comprises a slide block (3 c 1), the path of the diameter line of the rotating disk (3 a) overlapping the diameter line of the second receiving hole (3 a 1) is a separation line, the slide block (3 c 1) is symmetrically arranged along the separation line, the slide block (3 c 1) is provided with a second elastic element (3 c 2), and the two slide blocks (3 c 1) are close to each other in a normal state of the second elastic element (3 c 2);
the sliding block (3 c 1) is provided with a rolling shaft (3 c 3), the rolling shaft (3 c 3) is rotatably provided with a roller, the outer surface of the roller is attached with a flexible material, the bottom of the rotating disc (3 a) is provided with a connecting piece (3 c 4), the connecting piece (3 c 4) is in sliding connection with the rotating disc (3 a), the sliding direction is a separation line, the connecting piece (3 c 4) is provided with a rolling body (3 c 5), the rolling body (3 c 5) is a ball, and the connecting piece (3 c 4) is in transmission connection with the two sliding blocks (3 c 1) through a connecting rod (3 c 6);
the fixing disc (3 b) is provided with a bump (3 b 2), the top point of the bump (3 b 2) is close to the axis of the fixing disc (3 b), and when the rolling body (3 c 5) of the connecting piece (3 c 4) contacts with the top point of the bump (3 b 2), the two rolling shafts (3 c 3) are in an open state and separate from the support of a slide.
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| CN202310853115.4A CN116577926B (en) | 2023-07-12 | 2023-07-12 | Controllable batch automatic glass slide loading microscan |
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| CN202310853115.4A CN116577926B (en) | 2023-07-12 | 2023-07-12 | Controllable batch automatic glass slide loading microscan |
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| CN116577926B true CN116577926B (en) | 2023-09-12 |
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| WO2006104616A2 (en) * | 2005-03-24 | 2006-10-05 | Siemens Medical Solutions Diagnostics | Carousel system for automated chemical or biological analyzers employing linear racks |
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| CN116577926A (en) | 2023-08-11 |
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