CN105362886A - Preparation for treating acute leukemia and preparation method - Google Patents
Preparation for treating acute leukemia and preparation method Download PDFInfo
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- CN105362886A CN105362886A CN201510867036.4A CN201510867036A CN105362886A CN 105362886 A CN105362886 A CN 105362886A CN 201510867036 A CN201510867036 A CN 201510867036A CN 105362886 A CN105362886 A CN 105362886A
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Abstract
The invention discloses a preparation for treating acute leukemia. The preparation is prepared from, by mass, 6-12 parts of Pollen typhae, 2-7 parts of Alpinia katsumadai, 8-13 parts of sowthistle tasselflower herb, 5-10 parts of Excoecaria acerifclia, 9-13 parts of Capsella bursapastoris, 6-11 parts of Fructus polygoni orientalis, 8-14 parts of Changnienia amoena chien, 5-12 parts of Rhizoma sparganii, 7-13 parts of Celosia flower, 9-14 parts of Desmodium pulchellum, 6-13 parts of Rhizoma arundinis, 4-10 parts of Cladonia alpestris, 7-12 parts of Bidens alba and 6-10 parts of root of dwarf flowering cherry. The preparation is reasonable, precise and appropriate in composition, has efficacy of cooling and stopping blood, clearing heat for detoxification, tonifying qi and nourishing yin, warming and nourishing spleen and kidney and vanquishing toxin and resisting cancer, is stable in treatment effect, can effectively improve living quality and prolong life and can realize less proneness to recurrence after acute leukemia is healed.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of preparation and method for making for the treatment of acute leukemia.
Background technology
Acute leukemia is modal is acute lymphoblastic leukemia, accounts for 80% of acute leukemia, and sickness rate is 6/100000ths, and onset peak is between 3-7 year, and boy's sickness rate, a little more than girl, also can betide adult.Acute lymphoblastic leukemia is a kind of Progressive symmetric erythrokeratodermia malignant disease, it is characterized by a large amount of to be similar to lymphoblastic neocyte, and these cells can find in blood, bone marrow, lymph node, spleen and other organ.Along with social environmental pollution is day by day serious, the excessive finishing in house, the excessive use of agriculture chemical, causing acute leukemia sickness rate sharply increases.
The inducement of most of case it be unclear that, by 2012, medical circle generally believed that leukemia morbidity principal element comprises: 1. Family genetic factors, and chromosomal abnormality plays certain effect in the generating process of acute leukemia, comprise trisomy 21 syndrome, many and leukemia is concurrent.2. environmental factors, mainly comprises: radiation factor, chemical drugs factor etc.Research shows, ill reason rank the top three of acute lymphoblastic leukemia infant: house ornamentation pollution, father and mother's smoking, drink, and according to investigation, moving in the ill probability that new clothes repair the house in half a year increases by 4.76 times.If parents are in conceived the first half, just cigarette is not from hands always, and wine is not from mouth, and so the ill probability of child increases by 3.93 times and 3.1 times respectively.3. infective agent, hepatitis A virus infection, immunity inoculation, animal contact history, medicinal application history (as chloromycetin), seasonal variations etc.4. immunodeficiency, the sickness rate of congenital immune deficiency person lymphoid malignancies increases.
At present, the medicine for the treatment of acute leukemia is a lot, publication number CN104983895A(application number 201510454083.6) patent document discloses a kind of oral medicinal herb decoction for the treatment of acute leukemia, it is made up of the raw material of following weight proportioning: Herba Kalimeridis pill 15 grams, Caulis Kadsurae Longipedunculatae 15 grams, Radix seu Caulis Schisandrae Sinensis 15 grams, Herba Agrimoniae 15 grams, Radix Cirsii Japonici 12 grams, 12 grams, Radix Rubiae, Herba Portulacae 15 grams, Herba Scutellariae Barbatae 12 grams, Caulis Sargentodoxae 15 grams, 20 grams, the Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 15 grams, 10 grams, Radix Glycyrrhizae.Publication number CN103432527A(application number 201310387486.4) patent document discloses a kind of medicine for the treatment of acute leukemia and preparation method thereof, it is made up of the crude drug in following weight range: Rhizoma Anemarrhenae 8-15 gram, Rhizoma Pinelliae 8-16 gram, Radix Rehmanniae 10-20 gram, Radix Glycyrrhizae 8-15 gram, Radix Sophorae Flavescentis 8-15 gram, Herba Agrimoniae 10-20 gram, Rhizoma Paridis 25-35 gram, Rhizoma Arisaematis 25-35 gram, Radix Astragali 25-35 gram, Radix Pseudostellariae 15-25 gram, Rhizoma Polygonati 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Rhizoma Curcumae 25-35 gram, Fructus Forsythiae 10-20 gram, Poria 8-15 gram, Radix Ophiopogonis 15-25 gram, Eupolyphaga Seu Steleophaga 15-25 gram, Herba Ecliptae 15-20 gram, Fructus Ligustri Lucidi 10-20 gram.Publication number CN104306667A(application number 201410678245.X) patent document discloses a kind of mixing Chinese medicine for the treatment of acute leukemia, combine by the mass ratio of each Chinese medicine below: 12 parts, Gypsum Fibrosum, the Rhizoma Anemarrhenae 10 parts, 10 parts, the Radix Rehmanniae, Cornu rhinocerotis 8 parts, Radix Scrophulariae 10 parts, Radix Scutellariae 8 parts, Flos Lonicerae 15 parts, Fructus Forsythiae 10 parts, Rhizoma Acori Graminei 10 parts, Radix Ginseng 8 parts, Radix Rehmanniae 10 parts, Radix Notoginseng 3 parts, Colla cornus cervi 10 parts, Fructus Lycii 10 parts.
At present, treat leukemia and mainly contain the method such as chemotherapy, bone marrow transplantation.Chemotherapy is the leukemic Main Means of western medical treatment, although effect is very fast, toxic and side effects is large, and modal side effect has bone marrow depression (showing as leukocyte, thrombocytopenia); Intestines and stomach reaction (as Nausea and vomiting, inappetence etc.); Various infection (as pulmonary infection); Immunosuppressant etc., and easily recur, medical expense is expensive.Bone marrow transplantation distribution type success rate is too low, and somewhat expensive, general family can not accept.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of preparation for the treatment of acute leukemia, reasonable recipe, compatibility is precise and appropriate, there is cooling blood for hemostasis, heat-clearing and toxic substances removing, supplementing QI and nourishing YIN, warming and recuperating the spleen and kidney, relieve internal heat anticancer effect, stable curative effect, can effectively make the life better quality, extending life, and can reach more and not easily recur.Another object of the present invention is just to provide the preparation method of the preparation of above-mentioned treatment acute leukemia.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from: Pollen Typhae 6-12 part; Semen Alpiniae Katsumadai 2-7 part; Herba Emiliae 8-13 part; Plantula Excoecariae Acerifoliae 5-10 part; Flos Capsellae 9-13 part; Fructus Polygoni Orientalis 6-11 part; Changuienia amoena Chien 8-14 part; Rhizoma Sparganii 5-12 part; Flos Celosiae 7-13 part; Ramulus et Folium Phyllodii Pulchelli 9-14 part; Rhizoma Arundinis Donacis 6-13 part; Cladonia alpestris (L.) Rabenh. 4-10 part; Spend Herba Bidentis Bipinnatae 7-12 part in vain; Radix Pruni Japonicae 6-10 part.
The preparation for the treatment of acute leukemia, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Pollen Typhae 8-10 part; Semen Alpiniae Katsumadai 4-6 part; Herba Emiliae 10-12 part; Plantula Excoecariae Acerifoliae 7-9 part; Flos Capsellae 10-12 part; Fructus Polygoni Orientalis 8-10 part; Changuienia amoena Chien 10-12 part; Rhizoma Sparganii 8-10 part; Flos Celosiae 9-11 part; Ramulus et Folium Phyllodii Pulchelli 11-13 part; Rhizoma Arundinis Donacis 9-11 part; Cladonia alpestris (L.) Rabenh. 6-8 part; Spend Herba Bidentis Bipinnatae 9-11 part in vain; Radix Pruni Japonicae 7-9 part.
The preparation for the treatment of acute leukemia, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from
:pollen Typhae 9 parts; Semen Alpiniae Katsumadai 5 parts; Herba Emiliae 11 parts; Plantula Excoecariae Acerifoliae 8 parts; Flos Capsellae 11 parts; Fructus Polygoni Orientalis 9 parts; Changuienia amoena Chien 11 parts; Rhizoma Sparganii 9 parts; The Flos Celosiae 10 parts; Ramulus et Folium Phyllodii Pulchelli 12 parts; Rhizoma Arundinis Donacis 10 parts; Cladonia alpestris (L.) Rabenh. 7 parts; Spend Herba Bidentis Bipinnatae 10 parts in vain; Radix Pruni Japonicae 8 parts.
Present invention also offers the preparation method preparation of above-mentioned treatment acute leukemia being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the preparation powder of described treatment acute leukemia, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, takes out, dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate, is concentrated into the thick paste that relative density (55 DEG C) is 1.32-1.35, dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(6) by Pollen Typhae, step (1) gained medicated powder and step (5) gained medicated powder mix homogeneously, sterile packaged.
The preparation method of the preparation of above-mentioned treatment acute leukemia, step (1) preferably yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 15 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the preparation decoction of described treatment acute leukemia, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, stir 3-5 minute clockwise, leave standstill 5-7 hour, cross 160-200 order drainage screen, obtain decoction.
The preparation method of the preparation of above-mentioned treatment acute leukemia, the consumption of the preferred Mel of step (2) is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality.
Instructions of taking: each 15-20ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 15 days courses for the treatment of.
The preparation method of the preparation pill of described treatment acute leukemia, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, clockwise stirring 3-5 minute, leave standstill 5-7 hour, cross 160-200 order drainage screen, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 15 days courses for the treatment of.
The preparation method of the formulation tablet of described treatment acute leukemia, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) joined by Pollen Typhae in step (5) gained filtrate, clockwise stir 3-5 minute, leave standstill 5-7 hour, cross 160-200 order drainage screen, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.
The preparation method of the preparation granules agent of described treatment acute leukemia, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, clockwise stirring 3-5 minute, leave standstill 5-7 hour, cross 160-200 order drainage screen, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, (consumption of preferred simple syrup is the 5%-7% of thick paste quality to add simple syrup, the consumption being more preferably simple syrup is 6% of thick paste quality), mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 15 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, invention formulation reasonable recipe, compatibility is precise and appropriate, has cooling blood for hemostasis, heat-clearing and toxic substances removing, supplementing QI and nourishing YIN, warming and recuperating the spleen and kidney, relieve internal heat anticancer effect, stable curative effect, can effectively make the life better quality, extending life, and can reach more and not easily recur.
2, invention formulation adopts the preparation of pure natural medical material, and all meticulous compatibility forms, and drug effect is lastingly powerful, and quality of medicinal material is superior, safe and reliable, does not injure the intestines and stomach, can not produce drug dependence, have no side effect.
3, invention formulation is evident in efficacy through clinical trial display, and treatment acute leukemia has obvious curative effect.
4, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from (getting 80g for every part): Pollen Typhae 6 parts; Semen Alpiniae Katsumadai 2 parts; Herba Emiliae 8 parts; Plantula Excoecariae Acerifoliae 5 parts; Flos Capsellae 9 parts; Fructus Polygoni Orientalis 6 parts; Changuienia amoena Chien 8 parts; Rhizoma Sparganii 5 parts; The Flos Celosiae 7 parts; Ramulus et Folium Phyllodii Pulchelli 9 parts; Rhizoma Arundinis Donacis 6 parts; Cladonia alpestris (L.) Rabenh. 4 parts; Spend Herba Bidentis Bipinnatae 7 parts in vain; Radix Pruni Japonicae 6 parts.
The preparation method of the preparation powder of above-mentioned treatment acute leukemia, step is as follows:
(1) be placed in glass container by Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh., add yellow wine and mix thoroughly (consumption is 25% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass), moistening 3 hours, puts in tank, airtight, Steam by water bath 35 minutes, takes out, dry, pulverize, cross 160 mesh sieves;
(2) Radix Pruni Japonicae is diced, add Mel (consumption is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 3 hours, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 4 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry fast 18 minutes, take out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 4 minutes, add step (3)-(4) gains, continue decoction 35 minutes, add step (2) gains, continue decoction twice, each decoction 18 minutes, filter, merging filtrate, being concentrated into relative density is 1.34(55 DEG C) thick paste, dry, pulverize, cross 160 mesh sieves;
(6) by Pollen Typhae, step (1) gained medicated powder and step (5) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 15 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2the preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): Pollen Typhae 12 parts; Semen Alpiniae Katsumadai 7 parts; Herba Emiliae 13 parts; Plantula Excoecariae Acerifoliae 10 parts; Flos Capsellae 13 parts; Fructus Polygoni Orientalis 11 parts; Changuienia amoena Chien 14 parts; Rhizoma Sparganii 12 parts; The Flos Celosiae 13 parts; Ramulus et Folium Phyllodii Pulchelli 14 parts; Rhizoma Arundinis Donacis 13 parts; Cladonia alpestris (L.) Rabenh. 10 parts; Spend Herba Bidentis Bipinnatae 12 parts in vain; Radix Pruni Japonicae 10 parts.
The preparation method of the preparation decoction of above-mentioned treatment acute leukemia, step is as follows:
(1) be placed in glass container by Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh., add yellow wine and mix thoroughly (consumption is 25% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass), moistening 3 hours, puts in tank, airtight, Steam by water bath 35 minutes, takes out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 3 hours, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 4 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry fast 18 minutes, take out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 4 minutes, add step (3)-(4) gains, continue decoction 35 minutes, add step (1)-(2) gains, continue decoction twice, each decoction 17 minutes, filters, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, stir 4 minutes clockwise, leave standstill 6 hours, cross 180 order drainage screens, obtain decoction.
Instructions of taking: each 20ml, every day 3 times, 15 days courses for the treatment of.
model case oneopen XX, man, 9 years old, people from Linyi.Without there is persistent fever 38.5 DEG C-39.0 DEG C under obvious inducement, originally think it has been cat fever, infusion treatment is without obviously alleviating after 3 days, and companion's systemic pain, weak, the state of an illness increases the weight of gradually, so remove examination in hospital, routine blood test is abnormal: RBC1.12*10
12/ L, WBC12.6*10
9/ L, Hb4g, former grain 34%, early kinetochore 27%, middle kinetochore 11.6%, bone marrow smear: granulocyte active proliferation, myeloblast is more, and the increase and decrease of red system is low, and platelet is rare.Be diagnosed as acute leukemia, after treatment two weeks, effect is not remarkable.
Take after the present invention treats 2 courses for the treatment of of preparation decoction (embodiment 2) of acute leukemia, patient mental is clearly better, and body temperature has returned to normally, and systemic pain, the disease such as weak are obviously alleviated.After continuing to take 2 courses for the treatment of, all malaise symptoms disappear, and check that all index is normal.Tracing observation is so far without recurrence.
embodiment 3the preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Pollen Typhae 8 parts; Semen Alpiniae Katsumadai 4 parts; Herba Emiliae 10 parts; Plantula Excoecariae Acerifoliae 7 parts; Flos Capsellae 10 parts; Fructus Polygoni Orientalis 8 parts; Changuienia amoena Chien 10 parts; Rhizoma Sparganii 8 parts; The Flos Celosiae 9 parts; Ramulus et Folium Phyllodii Pulchelli 11 parts; Rhizoma Arundinis Donacis 9 parts; Cladonia alpestris (L.) Rabenh. 6 parts; Spend Herba Bidentis Bipinnatae 9 parts in vain; Radix Pruni Japonicae 7 parts.
The preparation method of the preparation pill of above-mentioned treatment acute leukemia, step is as follows:
(1) be placed in glass container by Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh., add yellow wine and mix thoroughly (consumption is 25% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass), moistening 3 hours, puts in tank, airtight, Steam by water bath 35 minutes, takes out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 3 hours, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 4 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry fast 18 minutes, take out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 4 minutes, add step (3)-(4) gains, continue decoction 35 minutes, add step (1)-(2) gains, continue decoction twice, each decoction 18 minutes, filters, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, stir 4 minutes clockwise, leave standstill 6 hours, cross 180 order drainage screens, be condensed into the thick paste that relative density is 1.20, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 15 days courses for the treatment of.
embodiment 4the preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): Pollen Typhae 10 parts; Semen Alpiniae Katsumadai 6 parts; Herba Emiliae 12 parts; Plantula Excoecariae Acerifoliae 9 parts; Flos Capsellae 12 parts; Fructus Polygoni Orientalis 10 parts; Changuienia amoena Chien 12 parts; Rhizoma Sparganii 10 parts; The Flos Celosiae 11 parts; Ramulus et Folium Phyllodii Pulchelli 13 parts; Rhizoma Arundinis Donacis 11 parts; Cladonia alpestris (L.) Rabenh. 8 parts; Spend Herba Bidentis Bipinnatae 11 parts in vain; Radix Pruni Japonicae 9 parts.
The preparation method of the formulation tablet of above-mentioned treatment acute leukemia, step is as follows:
(1) be placed in glass container by Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh., add yellow wine and mix thoroughly (consumption is 25% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass), moistening 3 hours, puts in tank, airtight, Steam by water bath 35 minutes, takes out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 3 hours, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 4 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry fast 18 minutes, take out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 4 minutes, add step (3)-(4) gains, continue decoction 35 minutes, add step (1)-(2) gains, continue decoction twice, each decoction 18 minutes, filters, merging filtrate;
(6) joined by Pollen Typhae in step (5) gained filtrate, stir 4 minutes clockwise, leave standstill 6 hours, cross 180 order drainage screens, being condensed into relative density is 1.20(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.
model case twochapter XX, female, 18 years old, people from Jining City in Shandong Province.Before 4 or five years, dizzy weak without occurring under obvious inducement, often have a fever, infusion treatment there will be again hyperpyrexia symptom after bringing down a fever soon, and the state of an illness increases the weight of gradually, has badly influenced normal study.Occur again that skin is dispersed in petechia in the near future, so go to hospital to carry out detailed inspection: Hb82g/L, reticulocyte 0.5%, WBC:5.4 × 10
9/ L, former juvenile cell 20%, PLT:29*10
9/ L.Be diagnosed as acute leukemia, so the chemotherapy of coming into effect, there is the side effect such as bone marrow depression in period.
Take after the present invention treats 2 courses for the treatment of of formulation tablet (embodiment 4) of acute leukemia, symptom obviously alleviates, and body temperature remains normal, and routine blood test recovers normal.After continuing to take 2 courses for the treatment of, whole skin petechia disappears, and check indices reaches normal level, reaches clinical cure.Later stage follows up a case by regular visits to and learns and do not recur, healthy, has been admitted to university.
embodiment 5the preparation for the treatment of acute leukemia, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Pollen Typhae 9 parts; Semen Alpiniae Katsumadai 5 parts; Herba Emiliae 11 parts; Plantula Excoecariae Acerifoliae 8 parts; Flos Capsellae 11 parts; Fructus Polygoni Orientalis 9 parts; Changuienia amoena Chien 11 parts; Rhizoma Sparganii 9 parts; The Flos Celosiae 10 parts; Ramulus et Folium Phyllodii Pulchelli 12 parts; Rhizoma Arundinis Donacis 10 parts; Cladonia alpestris (L.) Rabenh. 7 parts; Spend Herba Bidentis Bipinnatae 10 parts in vain; Radix Pruni Japonicae 8 parts.
The preparation method of the preparation granules agent of above-mentioned treatment acute leukemia, step is as follows:
(1) be placed in glass container by Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh., add yellow wine and mix thoroughly (consumption is 25% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass), moistening 3 hours, puts in tank, airtight, Steam by water bath 35 minutes, takes out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 3 hours, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 4 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry fast 18 minutes, take out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 4 minutes, add step (3)-(4) gains, continue decoction 35 minutes, add step (1)-(2) gains, continue decoction twice, each decoction 18 minutes, filters, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, clockwise stirring 4 minutes, leave standstill 6 hours, cross 180 order drainage screens, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup (consumption is 6% of thick paste quality), mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 15 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Pollen Typhae: sweet in the mouth, property is put down.Return liver, pericardium channel.For the dry pollen of Typhaceae plant Typha angustifolia Herba Typhae, typha orientalis or congener.There is hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.
Semen Alpiniae Katsumadai: acrid in the mouth, warm in nature.Return spleen, stomach warp.For the dry near mature seed of zingiberaceous plant list Fructus Amomi Rotundus.Have drying damp and strengthening spleen, effect of stomach warming preventing or arresting vomiting.For internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, anorexia.
Herba Emiliae: bitter in the mouth, cool in nature.For the herb of feverfew Herba Duchesneae Indicae.There is heat-clearing and toxic substances removing, effect of dissipating blood stasis for subsidence of swelling.For upper respiratory tract infection, oral ulcer, pneumonia, mastitis, enteritis, bacillary dysentery, urinary tract infection, furuncle carbuncle, eczema, traumatic injury.
Plantula Excoecariae Acerifoliae: bitter in the mouth, pungent, slightly warm in nature.Return spleen, stomach, liver, gallbladder meridian.For the tender young Herb of euphorbia plant grass Lignum Aquilariae Resinatum.There is circulation of qi promoting, removing blood stasis, removing food stagnancy, effect of malaria.For lump in the abdomen, food stagnation, tympanites, jaundice, malaria.
Flos Capsellae: sweet in the mouth, cool in nature.Return large intestine channel.For the inflorescence of crucifer Herba Capsellae.There is cooling blood for hemostasis, effect of clearing away heat-damp and promoting diuresis.For dysentery, metrorrhagia, hematuria, leaf blood, spitting of blood, epistaxis, children's's infantile dyspepsia, leucorrhea with red and white discharge.
Fructus Polygoni Orientalis: salty in the mouth, cold nature.Return liver, stomach warp.For the dry mature fruit of polygonaceae plant smartweed.There is loose Xue Xiao Disorder, effect of removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, goiter swells and ache, and food stagnation does not disappear, stomach institute distending pain.
Changuienia amoena Chien: bitter in the mouth, cold in nature.Another name: band blood Herba Amitostigmatis Gracilis.For pseudobulb and the herb of orchid Herba Changnieniae amoenae.There is heat clearing away, removing heat from blood, effect of removing toxic substances.For cough, sputum mixed with blood, furuncle furuncle.
Rhizoma Sparganii: acrid in the mouth, hardship, property is put down.Return liver, spleen channel.For the dry tuber of Sparganiaceae plant rhizoma scirpi.There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.Yong Yu Disorder trace mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
The Flos Celosiae: bitter in the mouth, cool in nature.For the inflorescence of amaranthaceous plant Herba Celosiae argenteae.Have cooling blood for hemostasis, liver heat removing dehumidifies, effect of improving eyesight.For spitting blood, epistaxis, metrorrhagia, bloody dysentery, stranguria with blood, leucorrhea, conjunctival congestion and swelling pain, the raw cataracta of order.
Ramulus et Folium Phyllodii Pulchelli: lightly seasoned, bitter, property is put down.Return lung, spleen, Liver Channel.For the aerial parts of leguminous plant row Qian Shu.There is heat-clearing and toxic substances removing, expelling wind and promoting diuresis, effect of promoting blood circulation and detumescence.For cold, fever, laryngopharynx swelling and pain, ulcerative gingivitis, rheumatic arthralgia, edema, expands, hepatosplenomegaly, treating swelling and pain by traumatic injury, insect-bite.
Rhizoma Arundinis Donacis: bitter in the mouth, sweet, cold in nature.For the rhizome of grass Arundo donax.There is clearing away heat-fire, relieving restlessness of promoting the production of body fluid, effect of diuresis.For calentura excessive thirst, asthenia hectic fever due to YIN-deficiency, spits blood, pyretic stranguria, dysuria, acute toothache.
Cladonia alpestris (L.) Rabenh.: lightly seasoned, property is put down.Return liver, stomach warp.For the dendrimer of Cladoniaceae plant Herba Cladoniae rangiferinae.Containing black bitter edible plant stain element, usnic acid, perlatolic acid, 2-hydroxyl-4-methoxyl group-6-n-amylbenzene formic acid.There is suppressing the hyperactive liver improving eyesight, effect of blood-arresting catamenia-regulating.For wind-yang and up-boring, have a dizzy spell, migraine, order disease, epistaxis, menstruation is inconsiderate, leucorrhea.
Spend Herba Bidentis Bipinnatae in vain: sweet in the mouth, micro-hardship, property is put down.For feverfew spends the herb of Herba Bidentis Bipinnatae in vain.There is heat-clearing and toxic substances removing, effect of dampness removing jaundice eliminating.For cold, fever, rheumatic arthralgia, jaundice due to damp-heat, carbuncle furuncle.
Radix Pruni Japonicae: bitter in the mouth, acid, cool in nature.Return spleen, stomach warp.For the root of strongly fragrant Lee of rosaceous plant.There is heat clearing away, parasite killing, effect of circulation of qi promoting removing mass.For dental caries pain, fever of children, the stagnation of QI is gathered.
test examplein order to verify that the present invention treats the curative effect of the preparation (embodiment 5) of acute leukemia, do contrast test in August ,-2011 in June, 2008:
General data: screening 270 routine acute leukemic patients, wherein male patient 137 people, female patient 133 people.Be divided into experimental group and matched group two groups (wherein experimental group 170 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: urgency of 1. falling ill, has hemorrhage, anemia, the symptom such as heating and osteodynia.2. breastbone tenderness is often had, lymph node, hepatosplenomegaly.3. peripheral hemogram hemoglobin, platelet count often reduce.4. in bone marrow, nucleated cell quantity significantly increases, and part can be Hypolasia.5. use the inspection such as Wright's staining and peroxidase, staining for glycogen and hematopoietic stem cell In vitro culture, be diagnosed as acute leukemia.
Usage and dosage: experimental group takes the preparation granules agent that the present invention treats acute leukemia, each 1 bag, every day 3 times, 15 days courses for the treatment of.Matched group uses other medicine (as methotrexate, Cyclophosphamide Compound Tablet etc.), wherein, methotrexate: oral adult 5mg-10mg, 1 time on the one, 1-2 time weekly, one the course for the treatment of safe dose 50mg-100mg; For acute lymphoblastic leukemia maintaining treatment, a 15mg-20mg/m
2, once in a week.Cyclophosphamide Compound Tablet: oral, adult usual amounts: one time 1,3-4 time on the one.
Criterion of therapeutical effect: according to " new Chinese medicine clinical guidance principle " and national leukemia control cooperation conference accessory in 1978, leukemia criterion of therapeutical effect (tentative draft), cure: clinical in anemia, hemorrhage, infectious agent leukemiacell infiltration shows; Hemogram hemoglobin G reatT.GreaT.GT 100g/L, total white blood cells > 10*10
9/ L, classifies without juvenile cell, platelet 100-400*10
9/ L; Bone marrow smear is normal; Within at least 2 years, do not recur.Effective: in clinical manifestation, hemogram, bone marrow smear three, to have one or binomial not reach criterion of cure.Invalid: in clinical manifestation, hemogram, bone marrow smear three, all not reach criterion of cure or recidivist in 2 years.
4 courses for the treatment of of medication treatment, observe latter 2 years for the treatment of.Take the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of the preparation of acute leukemia, result is as shown in table 1:
Table 1
As can be seen from Table 1, take the present invention and treat the cure rate of the preparation of acute leukemia up to 71.76%, effective percentage is up to 95.88%; And the cure rate taking other drug only 38%, effective percentage also only has 78%, and inefficiency is up to 22%.So the successful that the present invention treats the preparation of acute leukemia is better than the effect of the medicine of other treatment acute leukemia.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the preparation of acute leukemia, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Pollen Typhae 6-12 part; Semen Alpiniae Katsumadai 2-7 part; Herba Emiliae 8-13 part; Plantula Excoecariae Acerifoliae 5-10 part; Flos Capsellae 9-13 part; Fructus Polygoni Orientalis 6-11 part; Changuienia amoena Chien 8-14 part; Rhizoma Sparganii 5-12 part; Flos Celosiae 7-13 part; Ramulus et Folium Phyllodii Pulchelli 9-14 part; Rhizoma Arundinis Donacis 6-13 part; Cladonia alpestris (L.) Rabenh. 4-10 part; Spend Herba Bidentis Bipinnatae 7-12 part in vain; Radix Pruni Japonicae 6-10 part.
2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Pollen Typhae 8-10 part; Semen Alpiniae Katsumadai 4-6 part; Herba Emiliae 10-12 part; Plantula Excoecariae Acerifoliae 7-9 part; Flos Capsellae 10-12 part; Fructus Polygoni Orientalis 8-10 part; Changuienia amoena Chien 10-12 part; Rhizoma Sparganii 8-10 part; Flos Celosiae 9-11 part; Ramulus et Folium Phyllodii Pulchelli 11-13 part; Rhizoma Arundinis Donacis 9-11 part; Cladonia alpestris (L.) Rabenh. 6-8 part; Spend Herba Bidentis Bipinnatae 9-11 part in vain; Radix Pruni Japonicae 7-9 part.
3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Pollen Typhae 9 parts; Semen Alpiniae Katsumadai 5 parts; Herba Emiliae 11 parts; Plantula Excoecariae Acerifoliae 8 parts; Flos Capsellae 11 parts; Fructus Polygoni Orientalis 9 parts; Changuienia amoena Chien 11 parts; Rhizoma Sparganii 9 parts; The Flos Celosiae 10 parts; Ramulus et Folium Phyllodii Pulchelli 12 parts; Rhizoma Arundinis Donacis 10 parts; Cladonia alpestris (L.) Rabenh. 7 parts; Spend Herba Bidentis Bipinnatae 10 parts in vain; Radix Pruni Japonicae 8 parts.
4., according to the preparation method of the arbitrary described preparation powder of claim 1-3, it is characterized in that, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, takes out, dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate, is concentrated into the thick paste that relative density is 1.32-1.35, dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(6) by Pollen Typhae, step (1) gained medicated powder and step (5) gained medicated powder mix homogeneously, sterile packaged.
5. the preparation method of preparation according to claim 4, it is characterized in that: step (1) preferably yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%.
6., according to the preparation method of the arbitrary described preparation decoction of claim 1-3, it is characterized in that, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, stir 3-5 minute clockwise, leave standstill 5-7 hour, cross 160-200 order drainage screen, obtain decoction.
7. the preparation method of preparation according to claim 6, is characterized in that: the consumption of the preferred Mel of step (2) is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality.
8., according to the preparation method of the arbitrary described preparation pill of claim 1-3, it is characterized in that, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, clockwise stirring 3-5 minute, leave standstill 5-7 hour, cross 160-200 order drainage screen, be condensed into the thick paste that relative density is 1.10-1.30, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
9., according to the preparation method of the arbitrary described formulation tablet of claim 1-3, it is characterized in that, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, stir 3-5 minute clockwise, leave standstill 5-7 hour, cross 160-200 order drainage screen, be condensed into the thick paste that relative density is 1.10-1.30, make tablet.
10., according to the preparation method of the arbitrary described preparation granules agent of claim 1-3, it is characterized in that, step is as follows:
(1) Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. are placed in glass container, add yellow wine and mix that (preferred yellow wine consumption is the 20%-30% of Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass thoroughly, be more preferably that yellow wine consumption is Plantula Excoecariae Acerifoliae, Fructus Polygoni Orientalis and Cladonia alpestris (L.) Rabenh. gross mass 25%), moistening 2-4 hour, put in tank, airtight, Steam by water bath 30-40 minute, take out, dry;
(2) Radix Pruni Japonicae is diced, add Mel (consumption of preferred Mel is 6-10 times of Radix Pruni Japonicae quality, and the consumption being more preferably Mel is 8 times of Radix Pruni Japonicae quality) and mix thoroughly, wrap preservative film, leave standstill 2-4 hour, stand-by;
(3) Semen Alpiniae Katsumadai, Rhizoma Sparganii and Rhizoma Arundinis Donacis are cleaned, dry, with soaking in Chinese liquor 2-6 days, take out and drain Chinese liquor, be placed in frying pan, stir-fry 15-20 minute fast, takes out, dry in the air cool, stand-by;
(4) Flos Capsellae and the Flos Celosiae are placed in sterile gauze, tighten, stand-by;
(5) by Herba Emiliae, Changuienia amoena Chien, Ramulus et Folium Phyllodii Pulchelli with spend Herba Bidentis Bipinnatae in vain and be placed in marmite, add water boil 3-5 minute, add step (3)-(4) gains, continue to decoct 30-40 minute, add step (1)-(2) gains, continue decoction twice, each decoction 15-20 minute, filter, merging filtrate;
(6) Pollen Typhae is joined in step (5) gained filtrate, clockwise stirring 3-5 minute, leave standstill 5-7 hour, cross 160-200 order drainage screen, be concentrated into the thick paste that relative density is 1.10.-1.20, (consumption of preferred simple syrup is the 5%-7% of thick paste quality to add simple syrup, the consumption being more preferably simple syrup is 6% of thick paste quality), mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
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