CN105362089A - Whitening moisturizing cream and preparation method thereof - Google Patents
Whitening moisturizing cream and preparation method thereof Download PDFInfo
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- CN105362089A CN105362089A CN201510904323.8A CN201510904323A CN105362089A CN 105362089 A CN105362089 A CN 105362089A CN 201510904323 A CN201510904323 A CN 201510904323A CN 105362089 A CN105362089 A CN 105362089A
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- component
- emollient cream
- solution
- whitening
- papain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2377/00—Characterised by the use of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/16—Applications used for films
Abstract
The invention discloses a whitening moisturizing cream and a preparation method thereof. The cream comprises a component A, a component B and a component C. In percent by total weight of the cream, the component A includes deionized water 75-78%, a thickener 0.38-0.4%, a stabilizer 0.1-0.15%, a moisturizer 8-9%, and an emulsifying agent 0.05-0.1%; the component B includes hyaluronic acid with high molecular weight 0.04% and hyaluronic acid with low molecular weight 0.13%; the component C includes ethylene glycol 2-3%, an oil 6-9%, a papain biological membrane 0.05-2%, and propylene glycol 4-5%. The whitening moisturizing cream containing the papain biological membrane is stable and safe and nonirritating to human bodies and has the effects such as whitening, age defying and moisture supplementing and locking.
Description
Technical field
The present invention relates to cosmetics of everyday use field, specifically relate to a kind of whitening emollient cream and preparation method thereof.
Background technology
Enzyme is a kind of macromolecular substances with biology catalytic activity, can make that chemical reaction is single-minded efficiently to carry out, so have broad application prospects on daily chemical industry.It is numerous in variety that whitening emollient cream commercially available at present adds enzyme, has superoxide dismutase (SOD), Chymosin, coenzyme Q10 etc.
Enzyme has single-minded efficient, reaction temperature and non-stimulated advantage, but it has stricter requirement to the temperature of environment, pH value.If do not control temperature and pH value well, work efficiency and the effect of enzyme can be reduced.In the day-to-day cosmetic course of processing, enzyme easily because technological operation is improper or environmental condition is not controlled well, causes structural deterioration, thus loses activity.This limits the development of enzyme in daily use chemicals industry to a certain extent.
Summary of the invention
The object of the invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of whitening emollient cream and preparation method thereof, this emollient cream keeps the biological activity of papain, and whitening moisturizing effect is good.
In order to achieve the above object, following technical scheme is adopted:
A kind of whitening emollient cream, this emollient cream comprises component A, B component and C component, and by emollient cream overall weight percent, component A is deionized water 75-78%, thickening agent 0.38-0.4%, stabilizing agent 0.1-0.15%, wetting agent 8-9%, emulsifying agent 0.05-0.1%; B component is macromole hyaluronic acid 0.04%, micromolecule hyaluronic acid 0.13%; Component C comprises ethylene glycol 2-3%, oils and fats 6-9%, papain biomembrane 0.05-0.2%, propylene glycol 4-5%.
Described papain biomembrane is prepared by the following method:
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 1-4% polyamide solution and mass concentration is the papain solution of 0.2-0.4%, polyamide solution and papain solution is mixed with the volume ratio of 1:1-1:5; Above-mentioned mixed solution 100-200 μ L is coated in quartz plate on the surface by microsyringe; On quartz plate, drip 100-150 μ L inorganic salt solution again, and a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.
Preferably, described inorganic salt solution is the one in sulfate liquor, chlorate solution, citrate solution, and concentration is 8 × 10
-3m.
Preferably, described thickening agent is one or more in hydroxyethyl-cellulose, Acritamer 940, carbomer U21.
Preferably, described emulsifying agent is Tween60; Stabilizing agent is methyl hydroxybenzoate.
Preferably, described wetting agent is one or more in glycerol, propylene glycol, 1,3 butylene glycol.
Preferably, described oils and fats is one or more in iso-octyl palmitate, methyl-silicone oil DC-200, methyl-silicone oil DC1403.
Further, described component C also comprises the triethanolamine 0.3-0.4% by emollient cream overall weight percent, antiseptic 0.4-0.5%.
The preparation method of above-mentioned whitening emollient cream, comprises following preparation process:
(1) component A is added in pot, be heated to 80-90 DEG C, high-speed stirred homogeneous dispersion 10-15min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) if component C is not containing triethanolamine and antiseptic, then when cooling to below 55-65 DEG C, add component C, high-speed stirred is uniformly dispersed, 30-40 DEG C of discharging; If containing triethanolamine and antiseptic in component C, then cool to less than 55-65 DEG C, add other component except triethanolamine, antiseptic in component C, high speed homogenization is even; Cool to 45 DEG C, add triethanolamine, dispersed with stirring is even; Add antiseptic again, 30-40 DEG C of discharging.
Papain is the bio protease extracted from papaya milk.Raw material sources pure natural, easily to obtain.Papain, as sulfydryl endopeptidase, has hydrolysis ability and plastein function to albumen, polypeptide, ester etc.Papain has skin care whitening, blood circulation promoting and improves the effect of skin quality.
The present invention is directed to current cosmetics and add the problem of enzyme at the easy inactivation of the course of processing, propose a kind of new inorganic salt crosslinked polyamide investment, prepare papain biomembrane, and apply it in whitening emollient cream.
Beneficial effect of the present invention:
(1) and macromole polyamide embedding crosslinked by inorganic salt, effective raising dissociates the stability of papain, improve the whitening emollient cream course of processing to the damaged condition of enzyme, keep the biological activity of enzyme, reduce enzyme loss, reduce and add cost, easily store, technique is simple, operation is controlled continuously.
(2) be separated with whitening emollient cream system through immobilized papain, reduce some soda acid compositions of white body to the impact of enzymatic activity, allow enzyme keep the reaction condition of the best;
(3) the papain biomembrane prepared has the advantage of biocompatibility, biodegradability, little to skin irritation, nontoxic.
(4) containing the biomembranous whitening emollient cream of papain, stability and safety, non-stimulated to human body, and have whitening, defying age, moisturizing lock water effect.
Accompanying drawing explanation
Fig. 1 is that embodiment 1 papain biomembrane SEM schemes;
Fig. 2 is that experimental example papain biomembrane SEM schemes.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1
A kind of whitening emollient cream, this emollient cream comprises component A, B component and C component, by emollient cream overall weight percent, component A is deionized water 78.23%, hydroxyethyl-cellulose 0.1%, Acritamer 940 0.3%, methyl hydroxybenzoate 0.1%, glycerol 3%, propylene glycol 2%, 1,3-butanediol 3%, Tween600.05%; B component is macromole hyaluronic acid 0.04%, micromolecule hyaluronic acid 0.13%; Component C is ethylene glycol 2%, iso-octyl palmitate 3%, methyl-silicone oil DC-2004%, papain biomembrane 0.05%, propylene glycol 4%.
Described papain biomembrane is prepared by the following method:
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 2% polyamide solution and mass concentration is the papain solution of 0.25%, polyamide solution and papain solution is mixed with the volume ratio of 1:1; Above-mentioned mixed solution 100 μ L is coated in quartz plate on the surface by microsyringe; On quartz plate, drip 125 μ L concentration is again 8 × 10
-3the sulfate liquor of M, and a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.Prepared biomembrane morphosis as shown in Figure 1.
Above-mentioned sulfate liquor, is preferably metabisulfite solution, potassium sulfate solution, calcium sulphate soln or Adlerika etc.
The preparation method of above-mentioned whitening emollient cream, comprises following preparation process:
(1) component A is added in pot, be heated to 85 DEG C, high-speed stirred homogeneous dispersion 12min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) cool to less than 55 DEG C, add component C and make its high speed homogenization even, 35 DEG C of dischargings.
Embodiment 2
A kind of whitening emollient cream, this emollient cream comprises component A, B component and C component, by emollient cream overall weight percent, component A is deionized water 76.05%, hydroxyethyl-cellulose 0.1%, carbomer U210.28%, methyl hydroxybenzoate 0.12%, glycerol 5%, propylene glycol 4%, Tween600.08%; B component is macromole hyaluronic acid 0.04%, micromolecule hyaluronic acid 0.13%; Component C is ethylene glycol 3%, iso-octyl palmitate 6%, papain biomembrane 0.2%, propylene glycol 5%.
Described papain biomembrane is prepared by the following method:
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 4% polyamide solution and mass concentration is the papain solution of 0.2%, polyamide solution and papain solution is mixed with the volume ratio of 1:3; Above-mentioned mixed solution 100 μ L is coated in quartz plate on the surface by microsyringe; It is 8 × 10 that quartz plate drips 120 μ L concentration
-3the chlorate solution of M, and a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.
Above-mentioned chlorate solution, is preferably sodium chloride solution, Klorvess Liquid, calcium chloride solution or magnesium chloride solution etc.
The preparation method of above-mentioned whitening emollient cream, comprises following preparation process:
(1) component A is added in pot, be heated to 90 DEG C, high-speed stirred homogeneous dispersion 10min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) cool to less than 60 DEG C, add component C and make its high speed homogenization even, 30 DEG C of dischargings.
Embodiment 3
A kind of whitening emollient cream, this emollient cream comprises component A, B component and C component, by emollient cream overall weight percent, component A is deionized water 74.38%, hydroxyethyl-cellulose 0.4%, methyl hydroxybenzoate 0.15%, propylene glycol 6%, 1,3 butylene glycol 2%, Tween600.1%; B component is macromole hyaluronic acid 0.04%, micromolecule hyaluronic acid 0.13%; Component C is ethylene glycol 2%, iso-octyl palmitate 5%, methyl-silicone oil DC14034%, papain biomembrane 0.1%, propylene glycol 5%, triethanolamine 0.3%, antiseptic 0.4%.
Described papain biomembrane is prepared by the following method:
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 3% polyamide solution and mass concentration is the papain solution of 0.25%, polyamide solution and papain solution is mixed with the volume ratio of 1:5; Above-mentioned mixed solution 150 μ L is coated in quartz plate on the surface by microsyringe; It is 8 × 10 that quartz plate drips 100 μ L concentration
-3the citrate solution of M, and a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.
Above-mentioned citrate solution, is preferably sodium citrate solution, potassium citrate solution, calcium citrate solutions or magnesium citrate solution etc.
The preparation method of above-mentioned whitening emollient cream, comprises following preparation process:
(1) component A is added in pot, be heated to 80 DEG C, high-speed stirred homogeneous dispersion 15min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) cool to less than 65 DEG C, add other component except triethanolamine, antiseptic in component C, high speed homogenization is even; Cool to 45 DEG C, add triethanolamine, dispersed with stirring is even; Add antiseptic again, 40 DEG C of dischargings.
Described macromole hyaluronan molecule amount can reach several ten thousand to hundreds of thousands dalton; cannot transdermal, but the ventilative thin film of one deck can be formed at skin surface, make skin smooth moistening; and alien bacteria, dust, ultraviolet intrusion can be intercepted, protection skin is from infringement.Micromolecule hyaluronic acid, molecular weight is low to moderate 1000Da, can transdermal easily, has antiinflammatory, suppresses pathogenic bacteria to produce, keeps the effect that skin is bright and clean.
Experimental example
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 1% polyamide solution and mass concentration is the papain solution of 0.25%, polyamide solution and papain solution is mixed with the volume ratio of 1:1; Above-mentioned mixed solution 150 μ L is coated in quartz plate on the surface by microsyringe; And a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.Prepared biomembrane morphosis as shown in Figure 2.
Papain biomembrane of the present invention is hydrophilic transparent membrane, and size reaches micron level.After adding inorganic salt cross-linking agent, biomembrane is dendritic structure, as Fig. 1.When not adding inorganic salt, obtaining form by SEM observation is overlapping spherical biomembrane, as Fig. 2.
Whitening emollient cream every morning of the present invention and evening smear in face and trick, have firm skin, improve skin quality, the effect of clean whitening thoroughly.Product moistness is strong, uses rear skin not have excitement.
Above; be only the present invention's preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (10)
1. a whitening emollient cream, is characterized in that: this emollient cream comprises component A, B component and C component, by emollient cream overall weight percent, component A is deionized water 74-79%, thickening agent 0.38-0.4%, stabilizing agent 0.1-0.15%, wetting agent 8-9%, emulsifying agent 0.05-0.1%; B component is macromole hyaluronic acid 0.04%, micromolecule hyaluronic acid 0.13%; Component C comprises ethylene glycol 2-3%, oils and fats 6-9%, papain biomembrane 0.05-0.2%, propylene glycol 4-5%.
2. a kind of whitening emollient cream as claimed in claim 1, is characterized in that: described papain biomembrane is prepared by the following method:
Compound concentration is 0.02M, pH is the phosphate buffer solution of 7.0, respectively polyamide and papain are dissolved in phosphate buffer solution, to be mixed with mass concentration be 1-4% polyamide solution and mass concentration is the papain solution of 0.2-0.4%, polyamide solution and papain solution is mixed with the volume ratio of 1:1-1:5; Above-mentioned mixed solution 100-200 μ L is coated in quartz plate on the surface by microsyringe; On quartz plate, drip 100-150 μ L inorganic salt solution again, and a beaker is covered on quartz plate naturally dry film forming, seal for subsequent use.
3. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described inorganic salt solution is the one in sulfate liquor, chlorate solution, citrate solution, and concentration is 8 × 10
-3m.
4. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described thickening agent is one or more in hydroxyethyl-cellulose, Acritamer 940, carbomer U21.
5. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described emulsifying agent is Tween60; Stabilizing agent is methyl hydroxybenzoate.
6. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described wetting agent is one or more in glycerol, propylene glycol, 1,3 butylene glycol.
7. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described oils and fats is one or more in iso-octyl palmitate, methyl-silicone oil DC-200, methyl-silicone oil DC1403.
8. a kind of whitening emollient cream as claimed in claim 2, is characterized in that: described component C also comprises the triethanolamine 0.3-0.4% by emollient cream overall weight percent, antiseptic 0.4-0.5%.
9. a preparation method for the whitening emollient cream as described in any one of claim 2-7, is characterized in that: comprise following preparation process:
(1) component A is added in pot, be heated to 80-90 DEG C, high-speed stirred homogeneous dispersion 10-15min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) cool to less than 55-65 DEG C, add component C and make its high speed homogenization even, 30-40 DEG C of discharging.
10. a preparation method for whitening emollient cream as claimed in claim 8, is characterized in that: comprise following preparation process:
(1) component A is added in pot, be heated to 80-90 DEG C, high-speed stirred homogeneous dispersion 10-15min; Cool to 70 DEG C, add B component and make its high speed homogenization even; (2) cool to less than 55-65 DEG C, add other component except triethanolamine, antiseptic in component C, high speed homogenization is even; Cool to 45 DEG C, add triethanolamine, dispersed with stirring is even; Add antiseptic again, 30-40 DEG C of discharging.
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| CN201510904323.8A CN105362089B (en) | 2015-12-09 | 2015-12-09 | A kind of whitening emollient cream and preparation method thereof |
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| CN105362089B CN105362089B (en) | 2018-02-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110893147A (en) * | 2018-09-12 | 2020-03-20 | 广州赛度检测服务有限公司 | Skin care product for diminishing inflammation and relieving itching and preparation process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59134706A (en) * | 1983-01-19 | 1984-08-02 | Kobayashi Kooc:Kk | Cosmetic |
| CN101489520A (en) * | 2006-05-25 | 2009-07-22 | Wm.雷格利Jr.公司 | Oral compositions providing enhanced tooth stain removal |
| CN102229679A (en) * | 2011-07-20 | 2011-11-02 | 上海相宜本草化妆品有限公司 | Pleurotus nebrodensis polysaccharide-containing moisturizing cosmetic and preparation method thereof |
| CN102250860A (en) * | 2011-04-08 | 2011-11-23 | 华东理工大学 | Separation and purification method and immobilization method of papain, and product thereof |
-
2015
- 2015-12-09 CN CN201510904323.8A patent/CN105362089B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59134706A (en) * | 1983-01-19 | 1984-08-02 | Kobayashi Kooc:Kk | Cosmetic |
| CN101489520A (en) * | 2006-05-25 | 2009-07-22 | Wm.雷格利Jr.公司 | Oral compositions providing enhanced tooth stain removal |
| CN102250860A (en) * | 2011-04-08 | 2011-11-23 | 华东理工大学 | Separation and purification method and immobilization method of papain, and product thereof |
| CN102229679A (en) * | 2011-07-20 | 2011-11-02 | 上海相宜本草化妆品有限公司 | Pleurotus nebrodensis polysaccharide-containing moisturizing cosmetic and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110893147A (en) * | 2018-09-12 | 2020-03-20 | 广州赛度检测服务有限公司 | Skin care product for diminishing inflammation and relieving itching and preparation process thereof |
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Effective date of registration: 20181122 Address after: 363005 Lantian Economic Development Zone, Zhangzhou City, Fujian Province Patentee after: Frog Prince (Fujian) Infant Care Products Co., Ltd. Address before: 363000 Lantian Economic Development Zone, Longwen District, Zhangzhou City, Fujian Province Patentee before: Frog Prince (China) Daily Chemicals Co., Ltd. |
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