CN105343617A - Traditional Chinese medicine composition for treating hyperthyroidism - Google Patents
Traditional Chinese medicine composition for treating hyperthyroidism Download PDFInfo
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- CN105343617A CN105343617A CN201510864240.0A CN201510864240A CN105343617A CN 105343617 A CN105343617 A CN 105343617A CN 201510864240 A CN201510864240 A CN 201510864240A CN 105343617 A CN105343617 A CN 105343617A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hyperthyroidism. The composition is prepared from oysters, turtle shells, rehmannia roots, radix ophiopogonis, radix pseudostellariae, radix asparagi, codonopsis pilosula, astragalus membranaceus, poria cocos, atractylodes macrocephala koidz, yam, radix paeoniae alba, semen boitae, spina date seeds, schisandra chinensis, fleece-flower roots, paeonia suffruticosa, cornus officinalis, glossy privet fruit, zhebeinine, rhizoma anemarrhenae, cornu bubali, radix bupleuri, scutellaria baicalensis, cape jasmine, elephantopus scaber, blighted wheat, chrysanthemum, fructus lycii, concha haliotidis, gastrodia elata, uncaria, mulberry, semen celosiae, semen cassiae and liquorice. The traditional Chinese medicine composition has functions of tonifying yin and qi, eliminating phlegm by cooling, resolving hard lump, calming liver and suppressing yang and extinguishing wind and relieving pruritus. The composition is mainly used for treating hyperthyroidism, thyromegaly, qi deficiency, palpitation, weakness, fever, sweat, tachycardia, dizziness and tremor.
Description
Technical field
The present invention relates to tcm field, specifically, relate to a kind of Chinese medicine composition for the treatment of hyperthyroidism.
Background technology
Hyperthyroidism is called for short " hyperthyroidism ", is due to the too much thyroxin of thyroid synthesis release, causes the hyperfunction and sympathetic activation of organism metabolism, causes cardiopalmus, perspiration, feed and the just secondary disease increasing and lose weight.Most of patients also usually has the symptoms such as expophthalmos, blepharoedema, visual deterioration simultaneously.Thyroxin enhances metabolism, and promotes body redox reaction, and hypermetabolism needs body to increase feed; Gastrointestinal activity strengthens, and occurs just secondary increasing; Although feed increases, oxidation reaction strengthens, and human body energy consumption increases, and patients loses weight; Heat production increase performance To Be Protected from Heat perspire, there is low grade fever in few patients; Thyroxin increases stimulation sympathetic activation, clinical manifestation cardiopalmus, tachycardia, insomnia, responsive to surrounding, anxious state of mind, even anxiety.Hyperthyroid patient does not obtain appropriate therapeutic for a long time, can cause and become thin and hyperthyroid heart disease.Patient becomes thin and usually easily suffers from acute infectious disease and infect and to disable or dead.Hyperthyroid heart disease causes cardiac dilatation, arrhythmia, atrial fibrillation and heart failure, patient disability, even dead.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of hyperthyroidism.
In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of hyperthyroidism, it comprises the material of following weight parts: Concha Ostreae 30 parts, Carapax Trionycis 15 parts, 15 parts, the Radix Rehmanniae, Radix Ophiopogonis 12 parts, Radix Pseudostellariae 12 parts, Radix Asparagi 12 parts, Radix Codonopsis 30 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Dioscoreae 30 parts, the Radix Paeoniae Alba 15 parts, Semen Platycladi 15 parts, Semen Ziziphi Spinosae 30 parts, Fructus Schisandrae Chinensis 10 parts, the Radix Polygoni Multiflori 30 parts, Cortex Moutan 10 parts, Fructus Corni 15 parts, Fructus Ligustri Lucidi 20 parts, Bulbus Fritillariae Thunbergii 10 parts, the Rhizoma Anemarrhenae 10 parts, Cornu Bubali 10 parts, Radix Bupleuri 15 parts, Radix Scutellariae 15 parts, Fructus Gardeniae 15 parts, Elephantopus scaber L. 10 parts, Fructus Tritici Levis 30 parts, Flos Chrysanthemi 15 parts, Fructus Lycii 15 parts, Concha Haliotidis 30 parts, 10 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, 20 parts, Fructus Mori, Semen Celosiae 10 parts, Semen Cassiae 30 parts and 10 parts, Radix Glycyrrhizae.
Preferably; the Chinese medicine composition for the treatment of hyperthyroidism of the present invention also comprises the material of following weight parts: 6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [b] [Isosorbide-5-Nitrae] oxazine-3 (4H)-one of 0.5 part.
More preferably, described Chinese medicine composition can be tablet, dispersible tablet, powder or unguentum.
The present invention also provides 6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [the b] [purposes of Isosorbide-5-Nitrae] oxazine-3 (4H)-one in the medicine of preparation treatment hyperthyroidism.
Preferably, described medicine can be tablet, dispersible tablet, powder or unguentum
The Chinese medicine composition function for the treatment of hyperthyroidism of the present invention: enriching yin boost qi, removing heat-phlegm, hard masses softening and resolving, suppressing the hyperactive liver and subsiding YANG, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. only scabies.Cure mainly: hyperthyroidism disease, thyromegaly, the deficiency of vital energy.Cardiopalmus, weak, heating hyperhidrosis, heart beating is overrun, dizzy, hand shaking.
Detailed description of the invention
Embodiment:
Take Concha Ostreae 30 grams, Carapax Trionycis 15 grams, 15 grams, the Radix Rehmanniae, Radix Ophiopogonis 12 grams, Radix Pseudostellariae 12 grams, Radix Asparagi 12 grams, Radix Codonopsis 30 grams, the Radix Astragali 30 grams, 15 grams, Poria, the Rhizoma Atractylodis Macrocephalae 15 grams, Rhizoma Dioscoreae 30 grams, the Radix Paeoniae Alba 15 grams, Semen Platycladi 15 grams, Semen Ziziphi Spinosae 30 grams, Fructus Schisandrae Chinensis 10 grams, the Radix Polygoni Multiflori 30 grams, Cortex Moutan 10 grams, Fructus Corni 15 grams, Fructus Ligustri Lucidi 20 grams, Bulbus Fritillariae Thunbergii 10 grams, the Rhizoma Anemarrhenae 10 grams, Cornu Bubali 10 grams, Radix Bupleuri 15 grams, Radix Scutellariae 15 grams, Fructus Gardeniae 15 grams, Elephantopus scaber L. 10 grams, Fructus Tritici Levis 30 grams, Flos Chrysanthemi 15 grams, Fructus Lycii 15 grams, Concha Haliotidis 30 grams, 10 grams, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 grams, 20 grams, Fructus Mori, Semen Celosiae 10 grams, Semen Cassiae 30 grams and 10 grams, Radix Glycyrrhizae, pulverize, cross 100 mesh sieves, mix homogeneously, obtain.
Experimental example
Cleaning grade (SPF) male Wistar rat (Mus 5-6 in the age month, weight 170.0 ± 20.5) is divided into 6 groups: blank group, model group, positive drug group, administration group 1, administration group 2, administration group 3.Often organize 10.
After rat adaptability is fed 1 week, except blank group, by thyroid tablet (trilute (T
3)+thyroxine (T
4)) grind into powder, be made into 40mgmL suspension with normal saline, give model group, positive drug group, administration group 1, administration group 2, administration group 3 five groups of rats, every rat 1mL/ days, gastric infusion, continuous 2 weeks, make Hyperthyroid Model, the normal saline of blank group gavage equivalent.
Modeling, after the 8th day, starts gavage to curative.Blank group, model group give normal saline gavage 1mL/100g body weight; Positive drug group, propylthiouracil 1g adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Administration group 1, the powder 10g of embodiment adds 1000mL normal saline and becomes suspension, gives gavage 1mL/100g body weight; Administration group 2,6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [b] [1 of 0.02g, 4] oxazine-3 (4H)-one add 1000mL normal saline and become suspension, give gavage 1mL/100g body weight; Administration group 3; 6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [b] [1 of powder 5g and 0.01g of embodiment; 4] oxazine-3 (4H)-one add 1000mL normal saline and become suspension, give gavage 1mL/100g body weight.Once a day,
After 21st day, with urethane, intraperitoneal anesthesia is carried out to rat, cut abdominal cavity, expose ventral aorta, and carry out ligation, then carry out ventral aorta puncture with 5mL syringe, extract arterial blood about 3 ~ 5mL, finally put to death rat.Six groups of blood are carried out labelling, on centrifuge after the centrifugal 10min of 2000r/min, gets supernatant, employing is put the method for exempting from and is measured its T
3, T
4, operate according to test kit description.The results are shown in following table.
| Group | T 3(ng·mL -1) | T 4(ng·mL -1) |
| Blank group | 0.51±0.13 | 35.36±5.29 |
| Model group | 1.92±0.26 | 72.34±7.18 |
| Positive drug group | 1.31±0.15 | 41.53±6.06 |
| Administration group 1 | 1.45±0.12 | 49.63±6.37 |
| Administration group 2 | 1.32±0.11 | 41.08±5.52 |
| Administration group 3 | 1.41±0.15 | 46.52±6.69 |
Claims (5)
1. treat the Chinese medicine composition of hyperthyroidism for one kind, it is characterized in that, it comprises the material of following weight parts: Concha Ostreae 30 parts, Carapax Trionycis 15 parts, 15 parts, the Radix Rehmanniae, Radix Ophiopogonis 12 parts, Radix Pseudostellariae 12 parts, Radix Asparagi 12 parts, Radix Codonopsis 30 parts, the Radix Astragali 30 parts, 15 parts, Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Dioscoreae 30 parts, the Radix Paeoniae Alba 15 parts, Semen Platycladi 15 parts, Semen Ziziphi Spinosae 30 parts, Fructus Schisandrae Chinensis 10 parts, the Radix Polygoni Multiflori 30 parts, Cortex Moutan 10 parts, Fructus Corni 15 parts, Fructus Ligustri Lucidi 20 parts, Bulbus Fritillariae Thunbergii 10 parts, the Rhizoma Anemarrhenae 10 parts, Cornu Bubali 10 parts, Radix Bupleuri 15 parts, Radix Scutellariae 15 parts, Fructus Gardeniae 15 parts, Elephantopus scaber L. 10 parts, Fructus Tritici Levis 30 parts, Flos Chrysanthemi 15 parts, Fructus Lycii 15 parts, Concha Haliotidis 30 parts, 10 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, 20 parts, Fructus Mori, Semen Celosiae 10 parts, Semen Cassiae 30 parts and 10 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of hyperthyroidism according to claim 1; it is characterized in that; also comprise the material of following weight parts: 6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [b] [Isosorbide-5-Nitrae] oxazine-3 (4H)-one of 0.5 part.
3. the Chinese medicine composition for the treatment of hyperthyroidism according to claim 1 and 2, is characterized in that, described Chinese medicine composition can be tablet, dispersible tablet, powder or unguentum.
4.6-(3-(4-(benzyloxy) phenyl) acryloyl group-2H-benzo [the b] [purposes of Isosorbide-5-Nitrae] oxazine-3 (4H)-one in the medicine of preparation treatment hyperthyroidism.
5. purposes according to claim 4, is characterized in that, described medicine can be tablet, dispersible tablet, powder or unguentum.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510864240.0A CN105343617A (en) | 2015-12-01 | 2015-12-01 | Traditional Chinese medicine composition for treating hyperthyroidism |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510864240.0A CN105343617A (en) | 2015-12-01 | 2015-12-01 | Traditional Chinese medicine composition for treating hyperthyroidism |
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| CN105343617A true CN105343617A (en) | 2016-02-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853331A (en) * | 2017-05-08 | 2018-11-23 | 张震 | A kind of Chinese medicine composition and preparation method thereof for treating hyperthyroidism |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709275A (en) * | 2005-07-06 | 2005-12-21 | 陈晨 | Use of flavone substance or triterpene compound for treating thyreoidism |
| KR20060030575A (en) * | 2004-10-06 | 2006-04-11 | (주) 한약마을 | Pharmaceutical composition comprising the complex crude drug extract for preventing and treating hyperthyroidism |
| CN103755659A (en) * | 2014-02-25 | 2014-04-30 | 山东大学 | 6-cinnamon acyl-2H-benzo [b] [1, 4] oxazine-3 (4H)-ketone compound and application thereof |
-
2015
- 2015-12-01 CN CN201510864240.0A patent/CN105343617A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060030575A (en) * | 2004-10-06 | 2006-04-11 | (주) 한약마을 | Pharmaceutical composition comprising the complex crude drug extract for preventing and treating hyperthyroidism |
| CN1709275A (en) * | 2005-07-06 | 2005-12-21 | 陈晨 | Use of flavone substance or triterpene compound for treating thyreoidism |
| CN103755659A (en) * | 2014-02-25 | 2014-04-30 | 山东大学 | 6-cinnamon acyl-2H-benzo [b] [1, 4] oxazine-3 (4H)-ketone compound and application thereof |
Non-Patent Citations (4)
| Title |
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| 张昭原等: "《内分泌系统疾病诊治绝招》", 31 August 2008, 河北科学技术出版社 * |
| 李玉芳: "《甲亢患者的家庭养护》", 31 October 2008, 科学技术文献出版社 * |
| 程时平等: "《难治内科病名医绝技》", 30 April 2012, 华中科学大学出版社 * |
| 高汉森等: "《甲亢中医疗法》", 30 September 2004, 华南理工大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853331A (en) * | 2017-05-08 | 2018-11-23 | 张震 | A kind of Chinese medicine composition and preparation method thereof for treating hyperthyroidism |
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Application publication date: 20160224 |
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