CN1709275A - Use of flavone substance or triterpene compound for treating thyreoidism - Google Patents
Use of flavone substance or triterpene compound for treating thyreoidism Download PDFInfo
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Abstract
The present invention relates to a flavone substance or triterpenes compound and its application for curing hyperthyroidism disease. It is made up by using flavone substance or triterpenes compound and adding auxiliary material, the described flavone substance or triterpenes is extracted from Chinese medicinal material drynaria root. Its cure rate is high, and therapeutic effect is reliable.
Description
Technical field: the present invention is the application on the treatment hyperthyroidism disease of a kind of Flavonoid substances or triterpenoid compound, Flavonoid substances that particularly from Rhizoma Drynariae, extracts or triterpenoid compound be used for the treatment of hyperthyroidism disease with and the method for preparation, belong to medicine
Technical field.
Background technology: hyperthyroidism is hyperthyroidism just, and it is a kind of very common clinically endocrinopathy.Be meant by a variety of causes to cause thyroid function to strengthen that thyroid hormone secretion too much or increase a series of hypermetabolism syndromes and the high excited symptom and the eye symptom of multisystems such as the organism nervous system that caused, blood circulation, digestive system cardiovascular system because of thyroxin (T3, T4) level in blood.Hyperthyroid patient mainly shows as clinically: nervous, tachycardia, To Be Protected from Heat, hyperhidrosis, bulimia, become thin, weight loss, fatigue and weak and emotion is emotional, irascible temperament, insomnia, absent-minded, exophthalmos, hands tremor of the tongue are trembled, goiter or enlargement, women can have menoxenia even amenorrhea, the male can have sexual impotence or breast development etc.Thyromegaly is symmetry, and the patient who also has is the asymmetry enlargement, and goiter or enlargement meeting move up and down along with swallowing, and also some hyperthyroid patient has thyroid nodule.The eye that causes during hyperthyroidism changes, and a class is a benign exophthalmos, patient's exophthalmos, eye gaze or present terrified expression in the eyes; Another kind is a malignant exophthalmos, can change by benign exophthalmos and form, malignant exophthalmos patient Chang You keeps in dark place, sheds tears, diplopia, visual deterioration, eye swell and ache, twinge, foreign body sensation etc. is arranged, because the eyeball height is outstanding, make the eyes can not be closed, conjunctiva, cornea expose and cause that hyperemia, edema, cornea fester etc., even blind.Owing to hyperthyroidism can cause the infringement of multiple internal organs such as the heart, liver, kidney and bring out multiple complications, very big to the patient body infringement, so hyperthyroidism one should be adopted the reasonable method treatment after diagnosing immediately.The method for the treatment of hyperthyroidism at present clinically mainly contains internal medicine, operation, iodine-131 and treatment by Chinese herbs.Medical treatment comprises the life treatment of antithyroid drug treatment, auxiliary treatment and reinforcement nutrition etc.Antithyroid drug is based on thiourea, effect is suppress thyroxin synthetic, the method is the main method in the medical treatment, usually the medicine of taking has thiamazole, propylthiouracil sheet, thyroxine etc., though certain recent inhibition effect is arranged, can only take stopgap measures and can't effect a permanent cure, easily recurrence after the drug withdrawal, and take Western medicine for a long time and easily produce toxic and side effects, bigger to hemopoietic organ, liver, kidney, immunocyte infringement, even cause leukemia and bad sequela such as carcinogenic easily; And operative treatment excises very few easy recurrence, has cut many and can cause complication such as first is low, so want the strict operation indication of grasping.Iodine-131 isotope therapy method, simple and convenient, the cure rate height, but also may cause hypothyroidism.In view of present situation, be badly in need of a kind of effectively, Time of Administration is short, side effect is little pharmaceutical preparation.
Summary of the invention:
The objective of the invention is to: provide a kind of Flavonoid substances or triterpenoid compound treatment on the hyperthyroidism disease application and from Rhizoma Drynariae, extract the method for Flavonoid substances or triterpenoid compound, the present invention points out: Flavonoid substances or triterpenoid compound can be used for the treatment of hyperthyroidism disease; Effective ingredient such as Flavonoid substances that particularly extracts from Rhizoma Drynariae or triterpenoid compound have effective therapeutic effect and effective, stable curative effect, short, the safe without toxic side effect of Time of Administration to hyperthyroidism disease.
Hyperthyroidism, abbreviate " hyperthyroidism " as, it is the autoimmune disease that is caused by immunologic function disorder, main pathological change is to stimulate the thyroid cell secretory function hyperfunction by the autoimmune globulin antibody, produce too much thyroxin, the thyroid function inspection can find that thyroid iodine uptake increases thyroxin in the blood (TT3, TT4, FT3, FT4, rT3) level obviously increases.Hyperthyroidism can be caused by multiple reason, modal is diffuse toxic goiter and hyperthyroidism, secondly be many nodositas toxic goiter and hyperthyroidism and toxic thyroid adenoma, diffuse toxic goiter wherein, also claim exophthalmic goiter, the Graves disease, it is in the hyperthyroidism modal one type, whole approximately hyperthyroidism patients' 90%, diffuse toxic goiter is a kind of organ specificity autoimmune disease, it is because due to the immune dysfunction, different fully with the cause of disease of other types hyperthyroidism, immune dysfunction can cause and produce multiple thyroid autoantibody in the body, and the zest immunoglobulin that wherein the most important thing is to have excited thyroid effect is thyroid stimulating antibody (TSAb).It can stimulate thyromegaly, stimulates thyroid to produce a large amount of thyroxins, causes the sings and symptoms of a series of hyperthyroidisms then.And many nodositas toxic goiter claims nodositas hyperthyroidism, Plummer disease, is a kind of hyperthyroidism that takes place on shape adenoncus basis, many nodositas field, betides the patient of original existing many for many years knot book goiters usually.Its cause of disease is with the Graves disease, generally occurring first gram symptom more than 40 years old, is big than the age of onset of diffuse goiter.Women's sickness rate is than male's height, and the most of onsets of primary disease are slow, and the state of an illness is also lighter, and symptom portion is obvious, and early stage mistaken diagnosis easily or fail to pinpoint a disease in diagnosis needs to the hospital system inspection just diagnosable clear and definite.
Flavonoid substances or triterpenoid compound generally are present in Semen sojae atricolor, Semen Ginkgo, the Radix Astragali, Rhizoma Drynariae or the like food plant, the Chinese medicinal plant, and the technical method of comparative maturity is arranged for their extraction; Those of ordinary skill need not spend creative work and just can extract; Modern technologies even can also carry out chemosynthesis are because their chemical molecular formula is clearer and more definite.And prior art shows: Flavonoid substances or triterpenoid compound generally are to be used for the treatment to cardiovascular and cerebrovascular disease, the treatment of gynaecopathia; Up to the present, do not see the report for the treatment of hyperthyroidism disease with Flavonoid substances or triterpenoid compound as yet; The report of particularly using the Flavonoid substances that from the Chinese crude drug Rhizoma Drynariae, extracts or triterpenoid compound to treat hyperthyroidism disease.
The inventor experimental results show that, Flavonoid substances or triterpenoid compound have the effect that suppresses thyroid stimulating antibody, prevent to stimulate thyromegaly, avoid stimulating thyroid to produce a large amount of thyroxins, and alleviate the hyperthyroidism symptom by suppressing beta-receptor, but do not influence the normal secretion of thyroxin, can suppress thyroxine (T4) around metaplasia be active higher trilute (T3), thereby reach the purpose of treatment hyperthyroidism.
Serum thyrotropin receptor antibody (TRAb) is closely related with the morbidity of various autoimmune thyroid disease, is the important indicator of these diseases of clinical diagnosis.TRAb can be divided into thyroid stimulating antibody (TSAb) on function and thyroid stimulates blocking antibody (TSBAb), can combine with different loci on the thyrotropin receptor molecule to produce the different biological effect.Wherein TSAb can cause the generation of Graves disease (diffuse goiter) patient's hyperthyroidism and diffuse goiter.
The present invention constitutes like this: Flavonoid substances or triterpenoid compound are used for the treatment of hyperthyroidism disease; Also can with Flavonoid substances be used for the treatment of hyperthyroidism disease after triterpenoid compound mixes.
Concrete: as to add any preparation that suitable adjuvant is made in the suitable medical treatment with flavanone material in the Flavonoid substances and the tetracyclic triterpenoid in the triterpenoid compound and be used for the treatment of hyperthyroidism disease.
The present invention uses naringin, Rhizoma Drynariae total flavones and He Pa-22 (29)-alkene, 17betaH-Hop-21(22)-ene, He Pa-22-alcohol, fern-9 (11)-alkene, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-ethyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3-ketone, n-dotriacontane acid and cupreol, new bear's weed glycosides, protocatechuic acid, succinic acid, Fern-7-ene., bracken-3-alkene, stigmasterol, campesterol, ring jackfruit steryl acetate, ring Rhizoma Polypodiodis Nipponicae sterol olefin(e) acid acetas, the cyclolaudenol acetas, 9,10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas; 22(29)-Hopene, (+)-Hopan-22-ol, Cyclolaudenol., ring Radix Cannabis alcohol, Cyclolaudnone, 25-alkene-cyclic-ahltin alcohol, 25-alkene-cyclic-ahltin ketone, 24-alkene-cyclic-ahltin alcohol, 24-alkene-Huan Er court of a feudal ruler ketone, 5-stigmastene-3-alcohol, 5-stigmastene-3-ketone, 2-amyl furan, caproic acid, cis-Epoxydihydrolinalool, trans-Epoxydihydrolinalool, aldehyde C-9, nonenyl aldehyde, sad, n-nonanoic acid, 2, the 4-decadienal, 6-ten diketone, copaene, capric acid, n-tetradecane, 6,10-dimethyl-hendecanone, the a-curcumene, Pentadecane, 4-hexyl-2,5-dihydro-2,5-dioxy furan acetic acid, β-bisabolence, kowtow the crust terpene, (-)-Cadina-1,3,5-triene, dodecylic acid, hexadecane, n-heptadecane, n-octadecane, six hydrogen farnesene acetone, AI3-36122,16 methyl carbonates, AI3-28404, hexadecanoic acid comprises its derivant, and one or more chemical compounds with similar chemical constitution add adjuvant and are made into pharmaceutical preparation and are used for the treatment of hyperthyroidism disease.
Described Flavonoid substances or triterpenoid compound extract from Chinese crude drug, or obtain by chemosynthesis.
The inventor thinks: Flavonoid substances and triterpenoid compound extract the better effects if of treatment hyperthyroidism from Rhizoma Drynariae.
Also can be used for the treatment of hyperthyroidism if from the Radix Astragali or other medicinal plants, extract the chemical compound of similar structures certainly.
Flavonoid substances or triterpenoid compound prepare like this: the weighting raw materials Rhizoma Drynariae, unhairing is made only, clean, section decocts with water 1～3 time, add for the first time 8～12 times of water gagings, soaked 2～4 hours, decocted 1～3 hour, add 6～9 times of water gagings for the second time, decocted 1～2 hour, collecting decoction filters, and the survey relative density was 1.06～1.25 clear paste when filtrate was concentrated into 60 ℃, dry, pulverize, mixing promptly obtains effective extract, adopt conventional method to extract Flavonoid substances and triterpenoid compound the effective extract that obtains, add the adjuvant that needs then, be prepared into required preparation according to conventional method.
Specifically: weighting raw materials material Rhizoma Drynariae, unhairing is made only, clean, section decocts with water 2 times, adds 10 times of water gagings for the first time, soaked 3 hours, decocted 2 hours, and added 8 times of water gagings for the second time, decocted 1.5 hours, collecting decoction, filter, the survey relative density was 1.22 clear paste when filtrate was concentrated into 60 ℃, drying, pulverize, mixing promptly obtains extract, further extract chemical constituent by conventional method: Flavonoid substances and triterpenoid compound add the adjuvant that needs with Flavonoid substances and the triterpenoid compound that obtains, be prepared into required preparation according to conventional method.
According to existing chemical synthesising technology, synthetic Flavonoid substances and triterpenoid compound are not the thing of a difficulty, so adopt synthetic method or the Flavonoid substances and the triterpenoid compound that extract all can be used for the treatment of hyperthyroidism disease from plants such as other Chinese crude drugs.
Flavonoid substances or triterpenoid compound are the main chemical compositions of Chinese herbal medicine Rhizoma Drynariae, Rhizoma Drynariae is rhizome such as pteridophyta liquid medicine Os Draconis section plant Mongolian oak Herba pteridii latiusculi, drynaria baronii Diels, Semen Nelumbinis Rhizoma Zingiberis Recens Mongolian oak Herba pteridii latiusculi, precipice Rhizoma Zingiberis Recens, the close net Herba pteridii latiusculi of light and Davalliaceae plant Da Ye Rhizoma Drynariae, Rhizoma Drynariae, be perennial herb, high 20～40cm.Leaf two types, the trophophyll withered yellow, keratin, oval, pinniform is shallow to be split, and undercoat is arranged below, stockless, the storied base portion at the spore petiole of imbricate; The sporophyll green; Oblong, the pinniform drastic crack, 7～13 pairs of slivers, wide 2～3cm, the cripetura of base portion sliver becomes the ear shape; Petiole is short, and wing is arranged.The sporangiorus circle is born in the cross point of built-in scun, each 2～4 row in the Zhong Mai both sides, uncovered.Summer spore phase.Grow nonparasitically upon another plant on trunk, rock.Main product Hubei, Zhejiang.The nature and flavor hardship, temperature, go into liver, kidney channel, has the kidney invigorating, invigorate blood circulation, hemostatic effect, tradition be used to suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, odontoseisis, fall wink frustrate, the treatment of diseases such as muscles and bones folding wound, but the treatment that is used in hyperthyroidism still belongs to the first time.
Because Flavonoid substances of the present invention or triterpenoid compound mainly obtain by extracting in the Chinese crude drug Rhizoma Drynariae, therefore compare with the Western medicine chemical drugs that prior art is used, its toxicity, side effect is little, take safety, instant effect, not bounce-back recurrence, and compare with the iodine-131 isotope therapy method that prior art is used, it can not influence and cause going down of thyroid function, the cure rate height, therefore compared with prior art, preparation of the present invention has advantages such as cure rate height, determined curative effect, safety non-toxic, economical rationality.
The problem of need explaining is: the inventor has found that when carrying out some other medical material performance study, experiment Flavonoid substances or triterpenoid compound can have the effect of treatment hyperthyroidism disease, particularly extract Flavonoid substances or triterpenoid compound with Rhizoma Drynariae, be used for the treatment to hyperthyroidism disease, effect is relatively good.
Pharmacodynamic study:
Experimental example: to the influence of experimental hyperthyroidism rat
Get 50 of ♂ SD rats, body weight 197 ± 32g divides 5 groups at random.Take temperature after (anus temperature), irritate stomach (ig) administration respectively, every day 1 time, 14d continuously.In administration 3d, the 2nd～5 group of difference ig thyroid tablet 60mg/kg, matched group gives equal-volume water, every day 1 time, 11d continuously.In administration 7d, measure amount of drinking water every day, calculate its drinking-water index.10d takes temperature once more in administration.1h after the last administration, lumbar injection pentobarbital sodium 40mg/kg anesthesia links with BL 310 microcomputer type biological function experimental systems, traces standard I I lead electrocardiogram; At last, abdominal aortic blood is surveyed T4 content.The result shows that hyperthyroidism health group is significantly resisted the increase of T4 content and amount of drinking water, and makes it be tending towards normal level; Rising to body temperature also has tangible antagonism.
Group dosage (g/kg) body temperature value added (℃) drinking-water index (ml/100g) heart rate (inferior min) T4 content (nmol/L)
Contrast 0 11 ± 0.13 9.60 ± 2.08 382 ± 44 35.61 ± 6.70
Model 0 64 ± 0.32 13.23 ± 2.47 478 ± 31 61.25 ± 12.81
Thiamazole 0.015 0.31 ± 0.38 10.80 ± 1.69 441 ± 21 41.10 ± 13.15
Naringin 16.0 0.36 ± 0.41 10.09 ± 2.88 465 ± 32 40.18 ± 14.32
Rhizoma Drynariae total flavones 16.0 0.35 ± 0.29 10.12 ± 1.54 462 ± 22 40.27 ± 12.08
Rhizoma Drynariae triterpene 16.0 0.36 ± 0.75 10.10 ± 2.09 464 ± 19 40.32 ± 11.37
After above-mentioned experimental results show that, the inventor also carries out some human trials among a small circle; The process evidence: effect, the particularly inventor that Flavonoid substances or triterpenoid compound situation have the treatment hyperthyroidism disease extract Flavonoid substances or triterpenoid compound with Rhizoma Drynariae, and be apparent in view to the therapeutic effect of hyperthyroidism disease; General effective percentage reaches more than 88%; And there is not toxic and side effects; The inventor has once proposed number of patent application to State Intellectual Property Office and is for this reason: 200410022546.3, title is the patent application of " application and the preparation thereof of Rhizoma Drynariae in the treatment hyperthyroidism "; The research that the inventor still is being correlated with at present; Can why Flavonoid substances or triterpenoid compound produce such effect? do whether all Flavonoid substances or triterpenoid compound all have this effect? do Flavonoid substances in those plants or triterpenoid compound just have such curative effect? whether synthetic has therapeutic effect or the like accurately really, all is problems of research.
Technical study:
Decocting in water, alcohol extraction process research:
Purpose: be the influence of investigation water extraction and alcohol extracting method to active chemical content in the Rhizoma Drynariae.
Method: adopt the content of active chemical in the 752 spectrophotometry samples, so that relatively Different Extraction Method is to the influence of active chemical proposition amount in the Rhizoma Drynariae.
Conclusion: be more or less the same with active chemical content and alcohol extracting method in the water extraction Rhizoma Drynariae, from economical and practical angle, the present invention adopts water extraction.
Technological parameter research:
According to the character of the medicine of respectively distinguishing the flavor of in the side, determined medical material water absorption rate 137.1%, soak time 3 hours; Adopt orthogonal test that extraction process by water is carried out preferably, with amount of water, decoction number of times, decocting time is the investigation factor, the factor significance size order that the result influences extraction effect is amount of water B＞decoction number of times D＞decocting time C, wherein amount of water has the greatest impact, and The results of analysis of variance is consistent with the intuitive analysis conclusion.Optimum process condition is B
3D
2C
2, technology is defined as: add 10 times of amounts of water, soaked 3 hours, decoct 2 times, decocted 2 hours for the first time, add 8 times of amounts of water for the second time, decocted 1.5 hours.The condition checking is three batches in view of the above, and result and orthogonal test basically identical illustrate that process stabilizing is feasible.
Above-mentioned preparation method is not limited to preparation of the present invention; Because the method for Flavonoid substances or triterpenoid compound of extracting can also be conventional prior art; Not adding the professor professional and technical personnel just can implement.
Concrete embodiment:
Embodiments of the invention 1: weighting raw materials material Rhizoma Drynariae is some, and unhairing is made only, cleans, section decocts with water 2 times, adds 10 times of water gagings for the first time, soaked 3 hours, decocted 2 hours, add 8 times of water gagings for the second time, decocted 1.5 hours, collecting decoction filters, the survey relative density was 1.22 clear paste when filtrate was concentrated into 60 ℃, and drying is pulverized, mixing adopts prior art therefrom to extract naringin again; Take by weighing naringin medicated powder 100g, adding and medicated powder ratio are 1: 1.2 microcrystalline Cellulose, and the mixing that sieves adds suitable quantity of water and makes soft material, and through the extruder sieve plate, aperture 0.9mm is extruded into fine strip shape, extrudes rotating speed 100rmin
-1, put in the spheronizator, regulate rotating speed 1000rmin
-1And round as a ball time 8min, make granule round as a ball fully, take out micropill in 50 ℃ of drying 3～4h, spray adds Lignum Dalbergiae Odoriferae oil, after the screening, carries out coating with 18～24 purpose micropills, and Opadry 2 is a coating material, and coating adopts top spray method: nozzle diameter 1mm, fluidisation air quantity 100m
3/ h, 55 ℃ of inlet temperature, 35 ℃ of bed body temperature degree, atomizing pressure 0.15MPa, hydrojet speed 15mL/min, diameter be the micropill of 2.5mm, this product oral, three times on the one, each 10.
Embodiments of the invention 2: weighting raw materials Rhizoma Drynariae (or Radix Astragali) is some, and unhairing is made only, cleans, section decocts with water 1 time, adds 8 times of water gagings for the first time, soaked 2 hours, decocted 1 hour, decocting liquid filters, and the survey relative density was 1.06 clear paste when filtrate was concentrated into 60 ℃, dry, pulverize, mixing adopts prior art therefrom to extract the Rhizoma Drynariae total flavones again; Take by weighing Rhizoma Drynariae total flavones medicated powder 80g, adding with the medicated powder ratio is 1: 2 steviosin, mix, and tabletting, coating then, Opadry 2 be a coating material, coating employing top spray method promptly gets dispersible tablet, this product oral, three times on the one, each 2.
Embodiments of the invention 3: the weighting raw materials Rhizoma Drynariae is some, and unhairing is made only, cleans, section decocts with water 3 times, adds 12 times of water gagings for the first time, soaked 4 hours, decocted 3 hours, add 9 times of water gagings for the second time, decocted 2 hours, and added 6 times of water gagings for the third time, decocted 1 hour, collecting decoction, filter, the survey relative density was 1.25 clear paste when filtrate was concentrated into 60 ℃, adopted prior art therefrom to extract active substance such as naringin, Rhizoma Drynariae total flavones again; Take by weighing naringin 50g, Rhizoma Drynariae total flavones 150g, He Pa-22 (29)-alkene 1.0g, 17betaH-Hop-21(22)-ene 3.0g, He Pa-22-alcohol 2.0g, 9 (11)-fernene 1.0g, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-ethyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3-ketone, lacceroic acid 2.0g and cupreol 2.0g, new bear's weed glycosides 0.5g, protocatechuic acid 10g, succinic acid 0.8g, Fern-7-ene. 0.9g, bracken-3-alkene 0.5g, stigmasterol 3.0g, campesterol 4.5g, ring jackfruit steryl acetate 0.8g, ring Rhizoma Polypodiodis Nipponicae sterol olefin(e) acid acetas 1.2g, cyclolaudenol acetas 2.0g, 9,10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas 1.0g; 22(29)-Hopene 1.0g, (+)-Hopan-22-ol 1.0g, Cyclolaudenol. 1.0g, ring Radix Cannabis alcohol 2.0g, Cyclolaudnone 2.0g, 25-alkene-cyclic-ahltin alcohol 3.0g, 25-alkene-cyclic-ahltin ketone 2.0g, 24-alkene-cyclic-ahltin alcohol 2.0g, 24-alkene-Huan Er court of a feudal ruler ketone 2.0g, 5-stigmastene-3-alcohol 2.0g, 5-stigmastene-3-ketone 2.0g, 2-amyl furan 2.0g, caproic acid 1.5g, cis-Epoxydihydrolinalool 1.5g, trans-Epoxydihydrolinalool 1.5g, aldehyde C-9 1.2g, nonenyl aldehyde 1.2g, sad 1.6g, n-nonanoic acid 1.5g, 2,4-decadienal 2.0g, 6-ten diketone 2.1g, copaene 1.2g, capric acid 0.2g, n-tetradecane 0.2g, 6,10-dimethyl-hendecanone 0.1g, a-curcumene 0.1g, Pentadecane 0.1g, 4-hexyl-2,5-dihydro-2,5-dioxy furan acetic acid 0.2g, β-bisabolence 0.3g, kowtow crust terpene 0.3g, (-)-Cadina-1,3,5-triene 0.3g, dodecylic acid 0.1g, hexadecane 0.1g, n-heptadecane 0.1g, n-octadecane 0.2g, six hydrogen farnesene acetone 0.1g, AI3-36122 0.1g, 16 methyl carbonate 0.2g, AI3-28404 0.2g, hexadecanoic acid 0.1g, mix, press extractum again: substrate=1: 1.2, add soybean oil, the mixed-matrix of soybean lecithin, heating and melting, mixing gets soft capsule content; The preparation of glue: with gelatin: glycerol: water=1: 0.5: 0.7, getting gelatin adds an amount of distilled water and makes its imbibition, in addition the water of glycerol and remainder is put and be heated to 70～80 ℃ in the glue pot, mix homogeneously, add expansible gelatin and stir, make it to dissolve into uniform glue, in 70 ℃ of insulations 1～2 hour, leave standstill, remove the come-up foam, filter, in encapsulating machine, be pressed into soft capsule with cloth bag, be pressed into soft capsule, put in the drum drying machine and finalize the design, whole ball, drying, make 1000, promptly get soft capsule.
Claims (9)
1. Flavonoid substances or the triterpenoid compound application on the treatment hyperthyroidism disease is characterized in that: Flavonoid substances or triterpenoid compound are used for the treatment of hyperthyroidism disease.
2. according to the application on the treatment hyperthyroidism disease of the described Flavonoid substances of claim 1 or triterpenoid compound, it is characterized in that: with Flavonoid substances be used for the treatment of hyperthyroidism disease after triterpenoid compound mixes.
3. according to the application on the treatment hyperthyroidism disease of the described Flavonoid substances of claim 2 or triterpenoid compound, it is characterized in that: add any preparation that suitable adjuvant is made in the suitable medical treatment with flavanone material in the Flavonoid substances and the tetracyclic triterpenoid in the triterpenoid compound and be used for the treatment of hyperthyroidism disease.
4. according to claim 1, the application on the treatment hyperthyroidism disease of 2 or 3 described Flavonoid substances or triterpenoid compound, it is characterized in that: it is to use naringin, Rhizoma Drynariae total flavones and He Pa-22 (29)-alkene, 17betaH-Hop-21(22)-ene, He Pa-22-alcohol, fern-9 (11)-alkene, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-ethyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3 β-alcohol, 24-methyl-9,19-ring Pilus Caprae seu Ovis steroid-25-alkene-3-ketone, n-dotriacontane acid and cupreol, new bear's weed glycosides, protocatechuic acid, succinic acid, Fern-7-ene., bracken-3-alkene, stigmasterol, campesterol, ring jackfruit steryl acetate, ring Rhizoma Polypodiodis Nipponicae sterol olefin(e) acid acetas, the cyclolaudenol acetas, 9,10-ring Pilus Caprae seu Ovis steroid-25-enol-3 β-acetas; 22(29)-Hopene, (+)-Hopan-22-ol, Cyclolaudenol., ring Radix Cannabis alcohol, Cyclolaudnone, 25-alkene-cyclic-ahltin alcohol, 25-alkene-cyclic-ahltin ketone, 24-alkene-cyclic-ahltin alcohol, 24-alkene-Huan Er court of a feudal ruler ketone, 5-stigmastene-3-alcohol, 5-stigmastene-3-ketone, 2-amyl furan, caproic acid, cis-Epoxydihydrolinalool, trans-Epoxydihydrolinalool, aldehyde C-9, nonenyl aldehyde, sad, n-nonanoic acid, 2, the 4-decadienal, 6-ten diketone, copaene, capric acid, n-tetradecane, 6,10-dimethyl-hendecanone, the a-curcumene, Pentadecane, 4-hexyl-2,5-dihydro-2,5-dioxy furan acetic acid, β-bisabolence, kowtow the crust terpene, (-)-Cadina-1,3,5-triene, dodecylic acid, hexadecane, n-heptadecane, n-octadecane, six hydrogen farnesene acetone, AI3-36122,16 methyl carbonates, AI3-28404, hexadecanoic acid comprises its derivant, and one or more chemical compounds with similar chemical constitution add adjuvant and are made into pharmaceutical preparation and are used for the treatment of hyperthyroidism disease.
5. the application on the treatment hyperthyroidism disease according to described Flavonoid substances of claim 1～4 or triterpenoid compound, it is characterized in that: described Flavonoid substances or triterpenoid compound extract from Chinese crude drug, or obtain by chemosynthesis.
6. the application on the treatment hyperthyroidism disease according to Flavonoid substances described in the claim 5 or triterpenoid compound, it is characterized in that: Flavonoid substances and triterpenoid compound extract from Rhizoma Drynariae.
7. the application on the treatment hyperthyroidism disease according to described Flavonoid substances of claim 6 or triterpenoid compound, it is characterized in that: the chemical compound that extracts similar structures from the Radix Astragali or other medicinal plants is used for the treatment of hyperthyroidism.
8. the application on the treatment hyperthyroidism disease as Flavonoid substances as described in the claim 1～7 any or triterpenoid compound, it is characterized in that: Flavonoid substances or triterpenoid compound prepare like this: the weighting raw materials Rhizoma Drynariae, unhairing is made only, clean, section, decoct with water 1～3 time, add 8～12 times of water gagings for the first time, soaked 2～4 hours, decocted 1～3 hour, for the second time add 6～9 times of water gagings, decocted collecting decoction 1～2 hour, filter, the survey relative density was 1.06～1.25 clear paste when filtrate was concentrated into 60 ℃, and drying is pulverized, mixing, promptly obtain effective extract, adopt conventional method to extract Flavonoid substances and triterpenoid compound the effective extract that obtains, add the adjuvant that needs then, be prepared into required preparation according to conventional method.
9. the application on the treatment hyperthyroidism disease according to described Flavonoid substances of claim 8 or triterpenoid compound, it is characterized in that: Flavonoid substances or triterpenoid compound prepare like this: weighting raw materials material Rhizoma Drynariae, unhairing is made only, clean, section, decoct with water 2 times, for the first time add 10 times of water gagings, soaked 3 hours, decocted 2 hours, add for the second time 8 times of water gagings, decocted 1.5 hours, collecting decoction filters, the survey relative density was 1.22 clear paste when filtrate was concentrated into 60 ℃, drying is pulverized mixing, promptly obtain extract, further extract chemical constituent by conventional method: Flavonoid substances and triterpenoid compound add the adjuvant that needs with Flavonoid substances and the triterpenoid compound that obtains, be prepared into required preparation according to conventional method.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005102003749A CN100425230C (en) | 2005-07-06 | 2005-07-06 | Use of flavone substance or triterpene compound for treating thyreoidism |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005102003749A CN100425230C (en) | 2005-07-06 | 2005-07-06 | Use of flavone substance or triterpene compound for treating thyreoidism |
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| CN1709275A true CN1709275A (en) | 2005-12-21 |
| CN100425230C CN100425230C (en) | 2008-10-15 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343617A (en) * | 2015-12-01 | 2016-02-24 | 李朝彬 | Traditional Chinese medicine composition for treating hyperthyroidism |
| CN109503696A (en) * | 2019-01-04 | 2019-03-22 | 云南中烟工业有限责任公司 | A kind of triterpene compound with antibacterial functions and preparation method thereof and the application in electronic cigarette |
| CN112394121A (en) * | 2020-12-25 | 2021-02-23 | 成都普思生物科技股份有限公司 | Method for determining content of synechocystin B in achyranthes bidentata |
-
2005
- 2005-07-06 CN CNB2005102003749A patent/CN100425230C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343617A (en) * | 2015-12-01 | 2016-02-24 | 李朝彬 | Traditional Chinese medicine composition for treating hyperthyroidism |
| CN109503696A (en) * | 2019-01-04 | 2019-03-22 | 云南中烟工业有限责任公司 | A kind of triterpene compound with antibacterial functions and preparation method thereof and the application in electronic cigarette |
| CN112394121A (en) * | 2020-12-25 | 2021-02-23 | 成都普思生物科技股份有限公司 | Method for determining content of synechocystin B in achyranthes bidentata |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100425230C (en) | 2008-10-15 |
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