CN105343497A - Pharmaceutical composition for treating chronic gastritis - Google Patents
Pharmaceutical composition for treating chronic gastritis Download PDFInfo
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- CN105343497A CN105343497A CN201510702179.XA CN201510702179A CN105343497A CN 105343497 A CN105343497 A CN 105343497A CN 201510702179 A CN201510702179 A CN 201510702179A CN 105343497 A CN105343497 A CN 105343497A
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Abstract
The invention relates to a pharmaceutical composition for treating chronic gastritis and a preparation method thereof. The pharmaceutical composition is prepared from Radix scutellariae, Poria cocos, calcined Concha arcae, Radix paeoniae rubra, Radix paeoniae alba, Tangerine peel, Radix ophiopogonis, Magnolia officinalis, Codonopsis pilosula and Murraya paniculata, and dosage forms include hard capsules, tablets and granules. The pharmaceutical composition has good effect on treating chronic gastritis and is low in adverse reaction occurrence rate, high in patient compliance and more suitable for being used to treat chronic gastritis clinically.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation for the treatment of chronic gastritis and preparation method thereof.
Background technology
Chronic gastritis is digestive system common frdquently encountered disease, belongs to motherland's medical science " gastric abscess " category.Chronic gastritis is the gastric mucosa chronic inflammatory disease that the various cause of disease causes, the cause of disease many smooth with eating and drinking without temperance, feelings will, have a liking for tobacco and wine, emptiness of spleen and stomach is relevant, fall ill comparatively general and increase along with the increase at age, patient is along with abdominal distention, belch, the early symptom such as full, can be there is the ill symptomses such as anemia and finally cause comparatively serious symptoms in some patients, serious threat patient body is healthy.Clinical treatment many employings western medicine, comparatively large and can not radical curing of disease to patient's body injury, along with treatment by Chinese herbs discovery clinically and use, treatment by Chinese herbs chronic gastritis be in clinical extensive popularization.
Summary of the invention
Goal of the invention of the present invention is to provide new Chinese medicine of a kind of chronic gastritis and preparation method thereof, to solve the problem that existing medicine can not treat chronic gastritis very well.
Drug regimen raw material of the present invention is by weight ratio: Radix Scutellariae, Poria, forge Concha Arcae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Radix Codonopsis, Folium Et Cacumen Murrayae.
Drug regimen raw material of the present invention is by weight ratio: Radix Scutellariae 15 parts, 15 parts, Poria, forge Concha Arcae 15 parts, Radix Paeoniae Rubra 14 parts, the Radix Paeoniae Alba 14 parts, Pericarpium Citri Reticulatae 13 parts, Radix Ophiopogonis 13 parts, Cortex Magnoliae Officinalis 12 parts, Radix Codonopsis 12 parts, Folium Et Cacumen Murrayae 12 parts.
Above-mentioned raw materials makes hard capsule, tablet, granule by the method that pharmaceutics accepts.
Preferred particulates agent.
The preparation method of above pharmaceutical composition is: get the mixing of above pharmaceutical composition crude drug, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, and clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, dried cream powder is broken, adds proper auxiliary materials, makes corresponding dosage form.
Adjuvant in the present invention can be acceptable any excipient or carrier on pharmaceutics.
Radix Scutellariae: heat clearing and damp drying, removing heat from blood are antiabortive, removing toxic substances.Modern pharmacy research proves, Radix Scutellariae has antibacterial action, has inhibitory action to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, staphylococcus, hemolytic vessel used to hold grain at the imperial sacrifice coccus, Diplococcus pneumoniae, diphtheria corynebacterium etc.Radix Scutellariae also has antivirus action, and in vitro tests has copied inhibitory action to hepatitis B virus DNA.
Poria: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Modern pharmacy research proves, Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Forge Concha Arcae: expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.Modern pharmacy research proves, forges Concha Arcae and is rich in calcium carbonate, in energy and gastric acid, alleviates stomach pain.
Radix Paeoniae Rubra: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Modern pharmacy research proves, Radix Paeoniae Rubra can antithrombotic, antiplatelet aggregation, blood fat reducing, arteriosclerosis, scavenging activated oxygen etc.
The Radix Paeoniae Alba: blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.Modern pharmacy research proves, the Radix Paeoniae Alba has the effects such as calmness, spasmolytic, antiinflammatory, antiulcer, raising immunity, anoxia enduring.
Pericarpium Citri Reticulatae: in regulating qi-flowing for strengthening spleen, tune.Modern pharmacy research proves that volatile oil contained by Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal tract, can the secretion of facilitating digestion liquid, gets rid of pneumatosis in intestinal tube, also has the effect such as defying age, antioxidation.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire.Modern pharmacy research proves, Radix Ophiopogonis containing multiple steroid saponin, Radix Ophiopogonis Saponin A, B, C, D, glycoside unit is ruscogenin, separately containing ophiopogonin B ', C ', D ', glycoside unit is diosgenin; Still containing multiple flavone compound, as methyl flavanone A, B Radix Ophiopogonis, Radix Ophiopogonis flavanone A, ophiopogonone A, B, methyl ophiopogonone A, B etc., have calmness, improve immunity, fatigue-resisting function.
Cortex Magnoliae Officinalis: warming the middle warmer and descending qi, drying dampness to eliminate phlegm, relievings asthma.Modern pharmacy research proves, Cortex Magnoliae Officinalis, containing magnolol, iso-agnolol, huge curarine, containing machilol in volatile oil, has resisting pathogenic microbes effect, pest-resistant effect etc.
Radix Codonopsis: containing polysaccharide, phenols, sterol, volatile oil, vitamin B1, B2, the necessary aminoacid of multiple human body, scutellarein glucosid, Saponin and Alkaloid, trace element etc.Excitation is had, energy enhancing body resistance to nervous system; There is Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduce the effects such as pepsin activity; A rabbit erythrocyte, hemoglobin can be made to increase and to have castering action to the leukopenia caused by chemotherapy, radiotherapy; Can peripheral vessels be expanded and reduce blood pressure, adrenergic boosting can be suppressed again.
Folium Et Cacumen Murrayae: promoting flow of QI and blood, expelling wind and removing dampness.Modern pharmacy research proves, Folium Et Cacumen Murrayae has the effects such as analgesia.
In order to show that medicine of the present invention has therapeutic effect to chronic gastritis, invention has been following clinical trial:
1. data and method
1.1 physical data
The 98 routine Patients with Chronic Gastritis that my institute accepts for medical treatment, man 50 example, female 48 example, patient age 25-75 year, 58.7 years old mean age, course of disease 2-23, average course of disease 8.3 years.Draft standard observe patient disease symptom according to " internal medicine ", patient's abdominal part is all along with tenderness symptom, and the symptoms such as feed postemphasis abdominal part burning pain, glutted, epigastric discomfort, the symptom such as belch, pantothenic acid appears in 48 routine patients.Carry out ultrasound diagnosis to all patients, patient is all without important device matter diseases such as liver and gall.Patient is divided at random medicine group of the present invention and matched group, be respectively 49 examples, two groups of patient ages, sex and state of an illness compare, P > 0.05, and no significant difference can compare.
1.2 method
Give matched group patient the western medicine of routine, every bu 3 oral cisapride sheet 5mg, medicine is all being taken before the meal, and three take Compound Allantoin sheet 2 after 2 ~ 3h after the meal.Medicine group of the present invention adopts embodiment 1 granule, and every day three times, each two bags, two groups of patients treat 4 weeks all continuously.The relatively untoward reaction of two groups of patient outcomes and appearance.
1.3 efficacy determination
Recovery from illness: clinical symptoms disappears completely or substantially, through gastroscopy, body of gland recovers normal, and stomach mucosa inflammation disappears.Effective: clinical symptoms alleviates to some extent, alleviate to some extent through the life of gastroscopy discovery intestinalization, body of gland pathological changes, local inflammation etc.Invalid: patient clinical symptom without significant change, gastroscopy and pathologic finding no significant difference.Effective percentage equals remarkable effective percentage and adds effective percentage.
1.4 statistical significance
This clinical data studying all patients all adopts SPSS17.0 statistics software processes, and measurement data adopts t inspection, and between group, contrast adopts χ
2inspection, P < 0.05 has statistical significance for difference.
2. result
Medicine group of the present invention and matched group effective percentage and untoward reaction rate difference have statistical significance, specifically in table 1.
Table 1 liang group patient outcomes and untoward reaction are compared (n, %)
Note: compared with matched group, * P < 0.05
Above clinical trial illustrates, medicine of the present invention has the effect of good treatment chronic gastritis, and adverse reaction rate is low, and patient compliance is good, is more suitable for the clinical treatment for chronic gastritis.
Specific embodiment
Embodiment 1 Radix Scutellariae 150g, Poria 150g, forge Concha Arcae 150g, Radix Paeoniae Rubra 140g, Radix Paeoniae Alba 140g, Pericarpium Citri Reticulatae 130g, Radix Ophiopogonis 130g, Cortex Magnoliae Officinalis 120g, Radix Codonopsis 120g, Folium Et Cacumen Murrayae 120g
The preparation method of granule of the present invention: get the mixing of above pharmaceutical composition crude drug, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, dried cream powder is broken, adds amylum pregelatinisatum 1000g, sodium carboxymethyl cellulose 500g, mixes 80 mesh sieves, adds suitable quantity of water and granulates, 60 DEG C of drying under reduced pressure, granulate, is distributed into 1000 bags, obtains final product.
Embodiment 2 Radix Scutellariae 150g, Poria 150g, forge Concha Arcae 150g, Radix Paeoniae Rubra 140g, Radix Paeoniae Alba 140g, Pericarpium Citri Reticulatae 130g, Radix Ophiopogonis 130g, Cortex Magnoliae Officinalis 120g, Radix Codonopsis 120g, Folium Et Cacumen Murrayae 120g
The preparation method of hard capsule of the present invention: get the mixing of above pharmaceutical composition crude drug, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, and clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, dried cream powder is broken, incapsulates, and to obtain final product.
Embodiment 3 Radix Scutellariae 150g, Poria 150g, forge Concha Arcae 150g, Radix Paeoniae Rubra 140g, Radix Paeoniae Alba 140g, Pericarpium Citri Reticulatae 130g, Radix Ophiopogonis 130g, Cortex Magnoliae Officinalis 120g, Radix Codonopsis 120g, Folium Et Cacumen Murrayae 120g
The preparation method of Tablets: get the mixing of above pharmaceutical composition crude drug, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, and clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, dried cream powder is broken, add starch, Pulvis Talci and Magnesium Stearate proper quantity, granulate, tabletted, coating, to obtain final product.
Claims (5)
1. treat a pharmaceutical composition for chronic gastritis, it is characterized in that according to parts by weight, the raw material making this pharmaceutical composition active component is: Radix Scutellariae, Poria, forge Concha Arcae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Ophiopogonis, Cortex Magnoliae Officinalis, Radix Codonopsis, Folium Et Cacumen Murrayae.
2. the pharmaceutical composition for the treatment of chronic gastritis as claimed in claim 1, it is characterized in that according to parts by weight, the raw material making this pharmaceutical composition active component is: Radix Scutellariae 15 parts, 15 parts, Poria, forge Concha Arcae 15 parts, Radix Paeoniae Rubra 14 parts, the Radix Paeoniae Alba 14 parts, Pericarpium Citri Reticulatae 13 parts, Radix Ophiopogonis 13 parts, Cortex Magnoliae Officinalis 12 parts, Radix Codonopsis 12 parts, Folium Et Cacumen Murrayae 12 parts.
3. the pharmaceutical composition for the treatment of chronic gastritis as claimed in claim 1 or 2, is characterized in that described pharmaceutical composition is capsule, tablet, granule.
4. the pharmaceutical composition for the treatment of chronic gastritis as claimed in claim 1 or 2, it is characterized in that the method for making of described pharmaceutical composition is as follows: get the mixing of described pharmaceutical composition crude drug, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, and dried cream powder is broken, add proper auxiliary materials, make corresponding dosage form.
5. the pharmaceutical composition for the treatment of chronic gastritis as claimed in claim 4, it is characterized in that the method for making of described pharmaceutical composition is as follows: get Radix Scutellariae 150g, Poria 150g, forge Concha Arcae 150g, Radix Paeoniae Rubra 140g, Radix Paeoniae Alba 140g, Pericarpium Citri Reticulatae 130g, Radix Ophiopogonis 130g, Cortex Magnoliae Officinalis 120g, Radix Codonopsis 120g, Folium Et Cacumen Murrayae 120g, above pharmaceutical composition crude drug mixing, be ground into 10 ~ 20 order coarse granules, add 60% ethanol 6 times (volume), with the continuous 60 DEG C of extractions of microwave assisted extraction methods three times, extract carries out centrifugalize, clean immersion is concentrated into the thick paste that relative density is 1.20 ~ 1.30, vacuum drying, dried cream powder is broken, add amylum pregelatinisatum 1000g, sodium carboxymethyl cellulose 500g, mixed 80 mesh sieves, add suitable quantity of water to granulate, 60 DEG C of drying under reduced pressure, granulate, be distributed into bag.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510702179.XA CN105343497A (en) | 2015-10-21 | 2015-10-21 | Pharmaceutical composition for treating chronic gastritis |
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| CN201510702179.XA CN105343497A (en) | 2015-10-21 | 2015-10-21 | Pharmaceutical composition for treating chronic gastritis |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524520A (en) * | 2008-03-06 | 2009-09-09 | 北京中科仁和科技有限公司 | Chinese medicinal composition for resisting chronic gastritis and preparation method thereof |
| CN102106971A (en) * | 2010-11-02 | 2011-06-29 | 吕奎荣 | Chinese medicinal oral administration decoction for treating chronic gastritis |
| CN102397516A (en) * | 2010-09-09 | 2012-04-04 | 姜富春 | Chinese medicinal composition for treating chronic gastritis |
| CN102671172A (en) * | 2012-05-18 | 2012-09-19 | 河北省电力公司职业技术培训中心 | Traditional Chinese medicine capsule for treating intestines and stomach diseases |
-
2015
- 2015-10-21 CN CN201510702179.XA patent/CN105343497A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524520A (en) * | 2008-03-06 | 2009-09-09 | 北京中科仁和科技有限公司 | Chinese medicinal composition for resisting chronic gastritis and preparation method thereof |
| CN102397516A (en) * | 2010-09-09 | 2012-04-04 | 姜富春 | Chinese medicinal composition for treating chronic gastritis |
| CN102106971A (en) * | 2010-11-02 | 2011-06-29 | 吕奎荣 | Chinese medicinal oral administration decoction for treating chronic gastritis |
| CN102671172A (en) * | 2012-05-18 | 2012-09-19 | 河北省电力公司职业技术培训中心 | Traditional Chinese medicine capsule for treating intestines and stomach diseases |
Non-Patent Citations (2)
| Title |
|---|
| 孔文霞等: "胃炎舒治疗慢性胃炎75例疗效观察", 《四川中医》 * |
| 张惠强: "慢性胃炎中医辨证与用药规律的临床探析", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
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Application publication date: 20160224 |
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