CN103751240B - A kind of pharmaceutical composition for the treatment of gastritis and enteritis - Google Patents
A kind of pharmaceutical composition for the treatment of gastritis and enteritis Download PDFInfo
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- CN103751240B CN103751240B CN201410013918.XA CN201410013918A CN103751240B CN 103751240 B CN103751240 B CN 103751240B CN 201410013918 A CN201410013918 A CN 201410013918A CN 103751240 B CN103751240 B CN 103751240B
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of gastritis and enteritis.Described pharmaceutical composition is made with the raw material of following weight parts: Pulvis Fumi Carbonisatus 12-24 part, Radix Notoginseng 12-24 part, Indigo Naturalis 9-21 part are active component, overcome the deficiency of existing treatment gastritis and enteritis medicine, provide one to treat gastritis and the good pharmaceutical composition of enteritis effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of gastritis and enteritis.
Background technology
Gastritis, colitis belong to digestive system diseases associated with inflammation.Gastritis is the general designation of stomach lining inflammation.Commonly encountered diseases, can be divided into acute and chronic two classes.What acute gastritis was common is pure and erosive two kinds.The former shows as epigastric discomfort, pain, anorexia and Nausea and vomiting; The latter's digestive tract hemorrhage is main manifestations, has hematemesis and melena.Chronic gastritis can be divided into superficial gastritis, atrophic gastritis and hypertrophic gastritis again usually.Unrestrained property gastritis course of disease delay, most non-evident sympton and sign, the generally indigestion symptom such as rarely seen glutted, pantothenic acid, heating installation, irregularities stomachache after meal.Make a definite diagnosis and main rely on gastroscopy stomach function regulating biopsy of mucous membrane, its morbidity many with unhygienic diet, irregular, the eating and drinking too much at one meal of living, pungent stimulation, the factor such as mental pressure be relevant.People have some setbacks due to drinking and eating irregularly and the seven emotions and the six sensory pleasures, indulge in excessive drinking, and smoke, and long-term edible pungent stimulation food, famine is satisfied excessively to making taste not relax, dyspepsia.Gastritis aggravation just can develop into antral gastritis, gastric ulcer, gastric mucosa come off, gastrorrhagia, make whole gastrointestinal function general disturbance, people become become thin, tired out, therefore a lot of patient can cancerate into cancer, thus thoroughly lose work, viability, make family all suffer huge loss with society, gastritis is harm people ' s health and the disease of not easily treating.
Enteritis is generally the general name of gastroenteritis, enteritis and the colitis caused by antibacterial, virus, fungus and parasite etc.Enteritis is different by course of disease length, is divided into acute and chronic two classes.Enteritis patients is diarrhoea, mucopurulent bloody stool, stomachache, tenesmus etc.Diarrhoea degree weight differs, the lighter's defecation every day 3-4 time, or alternating diarrhea and constipation occurs; Severe one can often 1-2 hour once, even there is fecal incontinence.Some patients can have nocturnal diarrhea and (or) postprandial diarrhea, and the daily factor of enteritis that causes is many, and especially edible unclean food causes acute enteritis.Vomiting, diarrhoea severe patient, can have dehydration, acidosis, even body gram etc., have a strong impact on work and the life of people.
At present, treatment gastritis and enteritis are main mainly with Western medicine, take medicine, have an injection, infuse, coloclysis is its main method.Western medicine is that some play the medicine of anti-inflammatory analgetic effect mostly, mostly choice for use antibiotic therapy, such as adjoin croak acid, gentamycin, amikacin, erythromycin, chloromycetin etc., the different azoles of compound sulfonamide methyl, tetracycline etc., these medicines can treat inflammation preferably, but abuse of antibiotics causes the drug resistance of various antibacterial to strengthen, the pathogenic power of antibacterial is larger, causes much new disease not have effective Drug therapy.The western medicine time is long, can only symptom management, and long-term taking Western medicine not only has side effects, and Western medicine is cured the symptoms, not the disease more.The obvious Chinese medicine of therapeutic effect is not had at present when treating gastritis and enteritis yet.Publication number is the Chinese patent of CN102764361A, disclose a kind of healthy medicated wine for the treatment of gastritis, enteritis and spraining, make with the jowar wine of 55 degree brewed one week after treatment by Radix Arctii, Fructus Rosae Normalis, Radix Notoginseng, XUESANQI, Ganoderma, but there is the single problem of dosage form.
In sum, treat gastritis and enteritis and need the little Chinese medicine composition of a kind of effective, instant effect, side effect badly.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency overcoming existing treatment gastritis and enteritis medicine, provides one to treat gastritis and the good pharmaceutical composition of enteritis effect.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summary, is made up of the raw material of following weight parts:
Pulvis Fumi Carbonisatus 12-24 part, Radix Notoginseng 12-24 part, Indigo Naturalis 9-21 part.
Preferably, it is made up by weight of following raw materials according:
Pulvis Fumi Carbonisatus 15-21 part, Radix Notoginseng 15-21 part, Indigo Naturalis 12-18 part.
More preferably, it is made up by weight of following raw materials according:
Pulvis Fumi Carbonisatus 18 parts, Radix Notoginseng 18 parts, Indigo Naturalis 15 parts.
The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage form such as capsule, granule, pill, tablet, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.
The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine preparing treatment gastritis and enteritis.
The traditional Chinese medical science is thought, incoordination between the liver and stomach holds the pathologic basis that the criminal's of trembling with fear stomach is gastritis under the arm, and insufficiency of the spleen rushing down is the pathologic basis of enteritis, incoordination between the liver and stomach, insufficiency of the spleen rushing down cause QI and blood to block, and pyretic toxicity knot is poly-makes the mistake of interior table support, transporting mistake department, thus cause stomach, intestinal mucosa layer impaired, thus cause gastritis and enteritis.Therefore the present invention is the basic rule for the treatment of with heat-clearing and toxic substances removing, strengthening spleen, tonifying kidney, depressed liver-energy dispersing and QI regulating, stomach warming pain relieving, bowel relieving intestinal stasis relieving.
In pharmaceutical composition prescription of the present invention:
Pulvis Fumi Carbonisatus, another name below the moon black at the bottom of dirt, tobacco ash, Fu Yue China and Mexico, pan ink, stove volume inking, still in ink, chimney under ash, black, the still of chimney, the bottom of a pan is black, pan ground coal, stove volume ink, still coal, still Tai, the bottom of a pan ash, stove bituminous coal, stove coal, the soot on the bottom of a pan.Source: medical material Ji Yuan: for investing the black flue dust in the bottom of a pan or chimney after Caulis et Folium Oryzae, wheat straw, weeds burning.Latin plant animal mineral name: FuligoPlantae.Gather and store: scraping in the bottom of a pan or chimney of burning faggot, sieving decontamination with dusting cover, put in bottle and use.Character: character identification is Powdered, or is bonded to fine granularity, i.e. the powdered of hands sth. made by twisting.Black.Body is light, and matter is thin like frost, enters water then floating and disperse.That touches touches with one's hand, without greasy feeling.Feeble QI, lightly seasoned micro-pungent.With darkish complexion, body is light, matter is thin, free from admixture person is good.Chemical analysis: main containing carbon granules.Nature and flavor: bitter, pungent, warm in nature.Gui Jing: liver, lung, stomach warp.Function cures mainly: hemostasis, removing food stagnancy, sterilizing powdered medicine fire, main haematemesis, epistaxis, have blood in stool, metrorrhagia, leukorrhagia, food stagnation, dysentery, jaundice, laryngopharynx swelling and pain, aphtha of the mouth and tongue, ecthyma, white bareheaded skin ulcer, traumatic hemorrhage.
Radix Notoginseng, have another name called Radix Notoginseng, Radix Notoginseng, Herba Senecionis Chrysanthemoidis, blood mountain grass, June drench, Sedum spectabile Boreau, the famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Radix Notoginseng is a jewel in Chinese crude drug, records in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." Radix Notoginseng belongs to Araliaceae herbaceos perennial.Nature and flavor: sweet in the mouth; Micro-hardship; Warm in nature.Gui Jing: return Liver Channel; Stomach warp.Function: hemostasis; Loose blood; Analgesic therapy, dissipating blood stasis stops blooding, and desilting bolt stops blooding, blood pressure lowering, reducing swelling and alleviating pain.
Indigo Naturalis is the dry pigment in dicotyledon medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf.Nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly: epidemic febrile disease intenseness of heat, macule, haematemesis, spitting of blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer are swollen, erysipelas, snake bite and insect sting.
The pure Chinese medicine composition of pharmaceutical composition of the present invention, occurs that every dysfunction of organ works in the dyspepsia that three kinds of Material synthesis cause the exedens hemorrhage of the intestines and stomach or suppurative gastroenteritis symptom, body.This pharmaceutical composition has the effect of anti-inflammation hemostasia evacuation of pus removing the necrotic tissue and promoting granulation, also has facilitating digestion effect, bactericidal effect simultaneously.Unusual antiviral therapy effect is had to body inner virus.This pharmaceutical composition be inventor in long-term practice to the result that TCM Recipe art is developed meticulously in conjunction with modern crafts, have fabulous effect to the persistent ailment such as gastritis, enteritis.
Detailed description of the invention
With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiments.
Embodiment 1
Pulvis Fumi Carbonisatus 120g, Radix Notoginseng 240g, Indigo Naturalis 210g.
Take above each raw material by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decoct 1.5 hours, second time adds 8 times of water gagings, decocts 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.
Embodiment 2
Pulvis Fumi Carbonisatus 240g, Radix Notoginseng 120g, Indigo Naturalis 90g.
Above each raw material is taken by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decocts 1.5 hours, and second time adds 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add appropriate cane sugar powder, technique makes granule routinely.
Embodiment 3
Pulvis Fumi Carbonisatus 150g, Radix Notoginseng 210g, Indigo Naturalis 120g.
Take above each raw material, decoct with water twice, first time adds 8 times of water gagings, decocts 2 hours, and second time adds 6 times of water gagings, decocts 1.5 hours, collecting decoction, filters, obtains decoction.
Embodiment 4
Pulvis Fumi Carbonisatus 210g, Radix Notoginseng 150g, Indigo Naturalis 180g.
Take above each raw material, clean and dry, co-grinding crosses 80 mesh sieves, adds making pellets by mixing medical powder with honey, obtains pill.
Embodiment 5
Pulvis Fumi Carbonisatus 180g, Radix Notoginseng 180g, Indigo Naturalis 150g.
Above each raw material is taken by proportional quantity, decoct with water twice, first time adds 7 times of water gagings, decocts 1.5 hours, second time adds 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, filtrate be concentrated into when relative density is 1.30(70 DEG C survey) extractum, add the magnesium stearate adjuvant of conventional amount used, technique makes tablet routinely, specification 0.5g/ sheet.
Experimental example: pharmaceutical composition of the present invention is to the clinical efficacy of gastritis and enteritis
Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 5.
Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.
1, case and method
2008-2013, connect control patient 120 example, male 62 example, women 58 example, the age 18-68 year, wherein gastritis sufferer 56 example, enteritis patient 48 example, have simultaneously gastritis, enteritis patient 16 example.
Gastritis diagnostic criteria: upper abdomen dull pain, loss of appetite, post-prandial fullness, dyspepsia, acid regurgitation.
Enteritis diagnostic criteria: diarrhoea, people is just in water sample, and whole body generates heat, and dehydration, loses weight, Abdeminal pain, nausea and vomiting.Containing pus, blood and mucus in feces, every day 2-4 time, severe patient can reach 10-15 time, weak all over, and lower limb is aching and limp, stomachache, and after defecation, stomachache subtracts.
The embodiment of the present invention 5, tablet, every day 3 times, each 2, oral; 15d is 1 course for the treatment of, after drug withdrawal 1-3d, can carry out next course for the treatment of, be used in conjunction 4 courses for the treatment of.
2, efficacy determination
Be as the criterion according to clinical symptom disappearance, be divided into recovery from illness, effective, effective, invalid.
Recovery from illness: Clinical symptom and sign disappears, recovers normal.
Effective: the basic or major part of Clinical symptom and sign disappears.
Effective: Clinical symptom and sign is clearly better.
Invalid: Clinical symptom and sign is without improvement.
3, curative effect is summed up
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage |
| Gastritis sufferer 56 | 37 | 8 | 8 | 3 | 94.6% |
| Enteritis patient 48 | 32 | 9 | 4 | 3 | 93.8% |
| Gastritis, enteritis patient 16 | 11 | 2 | 1 | 2 | 87.5% |
Gastritis sufferer is treated, effective percentage 94.6%, treatment enteritis patient, effective percentage 93.8%, treatment gastritis, enteritis patient, effective percentage 87.5% by the embodiment of the present invention 5.
Claims (4)
1. treat a pharmaceutical composition for gastritis and enteritis, it is characterized in that: this pharmaceutical composition be made up of the raw material of following weight parts:
Pulvis Fumi Carbonisatus 12-24 part, Radix Notoginseng 12-24 part, Indigo Naturalis 9-21 part.
2. the pharmaceutical composition for the treatment of gastritis according to claim 1 and enteritis, is characterized in that: this pharmaceutical composition be made up of the raw material of following weight parts:
Pulvis Fumi Carbonisatus 15-21 part, Radix Notoginseng 15-21 part, Indigo Naturalis 12-18 part.
3. the pharmaceutical composition for the treatment of gastritis according to claim 1 and enteritis, is characterized in that: this pharmaceutical composition be made up of the raw material of following weight parts:
Pulvis Fumi Carbonisatus 18 parts, Radix Notoginseng 18 parts, Indigo Naturalis 15 parts.
4. the application of the pharmaceutical composition according to any one of claim 1-3 in the medicine preparing treatment gastritis and enteritis.
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| CN201410013918.XA CN103751240B (en) | 2014-01-13 | 2014-01-13 | A kind of pharmaceutical composition for the treatment of gastritis and enteritis |
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| CN201410013918.XA CN103751240B (en) | 2014-01-13 | 2014-01-13 | A kind of pharmaceutical composition for the treatment of gastritis and enteritis |
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| CN103751240A CN103751240A (en) | 2014-04-30 |
| CN103751240B true CN103751240B (en) | 2016-03-30 |
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| CN1242218A (en) * | 1999-05-20 | 2000-01-26 | 冯学杰 | Traditional Chinese medicine for treating various kinds of acute and chronic gastroenteritis disease |
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Address after: Zhaoping town 546800 the Guangxi Zhuang Autonomous Region Zhaoping County of Hezhou City, Xining Road No. 57 Patentee after: Li Shaohua Address before: 535000 human resources and Social Security Bureau of Qinzhou County, the Guangxi Zhuang Autonomous Region, Lingshan Patentee before: Li Shaohua |
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Effective date of registration: 20181122 Address after: 408300 Yuhe Village, Guixi Street, Dinjiang County, Chongqing Patentee after: Chongqing Zhicaotang Pharmaceutical Co., Ltd. Address before: 546800 57 Xining Road, Zhaoping Town, Zhaoping County, Hezhou, the Guangxi Zhuang Autonomous Region Patentee before: Li Shaohua |
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Address after: 408300 Yuhe Village, Guixi Street, Dinjiang County, Chongqing Patentee after: Chongqing guochengtang Pharmaceutical Co.,Ltd. Address before: 408300 Yuhe Village, Guixi Street, Dinjiang County, Chongqing Patentee before: Chongqing Zhicaotang Pharmaceutical Co.,Ltd. |