CN1053369C

CN1053369C - Medicine for treating thyreoidism

Info

Publication number: CN1053369C
Application number: CN96101871A
Authority: CN
Inventors: 程先敏
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-02-07
Filing date: 1996-02-07
Publication date: 2000-06-14
Anticipated expiration: 2016-02-07
Also published as: CN1156598A

Abstract

The present invention discloses a drug for treating hyperthyroidism. A medicament is prepared from seaweed, laminaria, spica prunellae, phyllosticta mahoniae, edible tulip, forsythia fruit, gypsum, costus root, angelica tail, root of straight ladybell and radix ophiopogonis as raw materials in the proportion of weight portion with a conventional production method. The Chinese patent medicine has the characteristics of stable drug property, conspicuous curative effect, short curative course and no toxic side effect and also has obvious curative effect on simple goiter and nodular thyroid.

Description

The hyperthyroidism ball

The present invention relates to a kind of medicine for the treatment of thyroid disease, particularly relating to what treat hyperthyroidism and simple goiter is the Chinese patent medicine that raw material is made with the Chinese herbal medicine.

Hyperthyroidism (hyperthyroidism) is because a kind of syndrome that thyroid function is too high, thyroid hormone secretion too much causes.Clinically, hyperthyroidism disease is commonly encountered diseases, frequently-occurring disease, and the medicine of treatment is also a lot, but effect is all not too satisfied.Effect mainly is Western medicine methylthiouracil and thiamazole preferably.The mechanism of these two kinds of medicines all is to suppress the iodide oxo, thereby stop the iodate of tyrosine, thyroxine is synthesized be subjected to obstacle, thereby disease is eased, but through clinical verification, these two kinds of medicine stabilities are poor, the treatment disease can only temporarily be stablized the state of an illness, and relief of symptoms is bad during patient's fashion, easily repeatedly, can not play the radical cure effect.If life-time service has stronger toxic and side effects again, use methylthiouracil that erythra can take place, the reaction of serious toxicities such as agranulocytosis, toxic hepatic disease.And the side effect of thiamazole also is that serious agranulocytosis untoward reaction is arranged, show as low grade fever, dry pharynx, weak, body of the tongue is light red, tongue Bai Shaojin, arteries and veins table count accurately unable etc.

China's patent gazette on February 16th, 94 disclosed a kind of " thyroidism capsule and preparation method thereof ", application number is 93111059.9, this Chinese patent medicine preparation adopts the wine Serpentis to take off the composition with the Ovum Gallus domesticus album side of closing.Because this two flavors medicine does not have hard masses softening and resolving, the effect of the removing blood stasis of regulating the flow of vital energy, so clinical effectiveness is not ideal.

The purpose of this invention is to provide a kind of treat hyperthyroidism and simple goiter big be the Chinese patent medicine of raw material with the Chinese herbal medicine, the characteristics of this medicine are that medicine is stable, short treating period, have no side effect, evident in efficacy.

Solution of the present invention is based on motherland's medical science to pathogenetic understanding of hyperthyroidism disease and Therapeutic Principle, motherland's medical science thinks that primary disease mainly is because the stagnation of QI, damp-phlegm, gastric is hot and suffocating, phlegm-fire gathers or direct stimulation, emotion pent-up, strongly fragrant and fire-transformation, the heart-yin consumption is hindered, due to the knot in the expectorant stasis of blood, the cervical region meridians that stagnate.Thereby adopt the Chinese herbal medicine of hard masses softening and resolving, removing heat-phlegm, the removing blood stasis of regulating the flow of vital energy, YIN nourishing yin nourishing.From the treasure-house of motherland's medical science, adopting Sargassum, the Thallus Laminariae (Thallus Eckloniae) of treatment hyperthyroidism disease is principal agent, be ministerial drug, be adjuvant drug with Spica Prunellae, Folium Mahoniae, Pseudobulbus Cremastrae Seu Pleiones, Fructus Forsythiae, Gypsum Fibrosum with Radix Aucklandiae (Radix Vladimiriae), Radix Angelicae Sinensis, and be messenger drug with Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis.

Prescription of the present invention is (consumption is a weight portion):

Sargassum 20-30 part, Thallus Laminariae (Thallus Eckloniae) 20-30 part, Spica Prunellae 10-20 part, Folium Mahoniae 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Fructus Forsythiae 10-20 part, Gypsum Fibrosum 20-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-10 part, Radix Angelicae Sinensis 10-12 part, Radix Adenophorae (Radix Glehniae) 20-30 part, Radix Ophiopogonis 10-20 part.

The optimization formula of preparation medicine of the present invention is:

Sargassum 25-30 part, Thallus Laminariae (Thallus Eckloniae) 25-30 part, Spica Prunellae 10-15 part, Folium Mahoniae 10-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Fructus Forsythiae 15-20 part, Gypsum Fibrosum 25-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-9 part, Radix Angelicae Sinensis 10-12 part, Radix Adenophorae (Radix Glehniae) 25-30 part, Radix Ophiopogonis 15-20 part.

The raw material of above-mentioned prescription can be prepared into various pharmaceutically acceptable dosage form according to the conventional method in this area, for example can make tablet, capsule, powder, pill, electuary etc.

Part be pulverized, be sieved, claim to the raw material of above-mentioned prescription can according to the method for traditional production powder or pill, perhaps refined honey ball, and method is simple, and is with low cost.

The Chinese patent medicine of making by above-mentioned each pharmaceutical formulation is because of being principal agent with the Sargassum, the Thallus Laminariae (Thallus Eckloniae) that contain iodine, but heat clearing away soft junction, the knot that reduces phlegm, the fistula tumor of loosing, and the iodine that surpasses physiological amount can stop the synthetic and release action of thyroxin in the body indirectly; Spica Prunellae, Folium Mahoniae, Pseudobulbus Cremastrae Seu Pleiones, Fructus Forsythiae, Gypsum Fibrosum are ministerial drug altogether, have the effect of heat-clearing and toxic substances removing, diffusing fistula stagnation of QI, medicinal powder for relieving pain knot; Radix Aucklandiae (Radix Vladimiriae), Radix Angelicae Sinensis are adjuvant drug, are aided with monarch, all medicines of minister, the effect that can have looses stagnates gas, transfers all gas, broken stagnant blood, foster fresh blood; Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis are messenger drug, are used for suitable YIN nourishing YIN nourishing and the production of body fluid promoting.

Show through clinical trial 42 examples, take this medicine instant effect, short treating period is promptly felt symptom in 3-7 days after generally taking medicine and is taken a favorable turn, and symptom fades away after more than ten day, and heavier person's one wheat harvesting period of the state of an illness is almost recovered, and cure rate can reach 97.6%.And this curative effect of medication is stable, and no repeatability is without any side effects again.Big and nodositas thyroid also has obvious curative effects to this medicine to simple goiter.

The clinical experiment case report is as follows:

1, the hole * *, woman, 38 years old, the workman of boiler factory, Changzhi County.Come to go to a doctor on June 15th, 86.The main suit: vexed, uncomfortable in chest, fat, blush, bulimia, red tip of the tongue, yellow fur are thick, rapid pulse, heart rate are accelerated, 100 times/minute, neck is thick, exophthalmos, general weakness, the Bethune International Peace Hospital, Changzhi is diagnosed as hyperthyroidism, but therapeutic effect is not obvious.Chinese medical discrimination is: the stagnation of QI is condensed and fire-transformation, the vigorous and pent-up of phlegm-fire.Control suitable hard masses softening and resolving, magical effect hyperthyroidism spirit ball is taken in the yin nourishing of regulating the flow of vital energy, and day clothes three times were clearly better after seven days, and appetite reduces, and whole body feels that effectively heart beating is slowed down, disappearance uncomfortable in chest, and neck constriction obviously alleviates, and eyeball is comfortable, the dizzy dai channel of arteries and veins.Principle according to motherland's medical science " is imitated the not side of change " continued to take this medicine more than 20 day, and appetite is normal, the thick and constriction complete obiteration of neck, and things are as usual.

2, Song * *, the man, 35 years old, vocational middle school taught in the Changzhi County.On March 21st, 87 went to a doctor.Main suit: through seeking medical advice in many ways, fail to respond to any medical treatment, listen other people to tell about and the diagnosis and treatment cardinal symptom of coming, cardiopalmus, hyperhidrosis, thirsty, hunger sensation is strong, eyeball is obviously outstanding, it is weak to become thin, the cervical region both sides are thick, and heart rate 114 times/minute is with hand tremor, polyphagia, thready and rapid pulse, red tongue, the little Huang of tongue.Through peaceful hospital diagnosis is " hyperthyroidism disease ", and blood pressure is normal, and strongly fragrant gas is heavier.Chinese medical discrimination is a hepatic depression, and phlegm-fire coagulates.Control suitable dispersing liver-energy, it is strongly fragrant to reduce phlegm, softening the hard mass, and the heat clearing away eliminating stagnation, the side is surplus with the magical effect hyperthyroidism spirit ball moon for oral administration, and symptomatology disappears, and recovers normally to give a lesson, and is multiple so far.

3, the king * *, the woman, 34 years old is that town shop complete primary school teacher Korea Spro is closed in the territory, Changzhi County.Readme binocular distending pain, the cardiopalmus spontaneous perspiration, polyorexia, emaciated physique, the enlargement of cervical region both sides, the sick several months, lassitude, once southeast, Shanxi examination in hospital was diagnosed as " hyperthyroidism ".The thyroid auscultation has tangible vascular murmur, and basal metabolism is+38%, heart rate 115 times/minute, blood pressure 110/80mm mercury column.Came to go to a doctor in 20th in 87 years JIUYUE.The traditional Chinese medical science is thought: depressedly do not relax, I am because of due to feeling blue for a long time.Method of treatment: dispersing the stagnated live-QI to relieve the stagnation of QI, and blood, hard masses softening and resolving.Take magical effect hyperthyroidism spirit ball, one time one ball, day clothes three balls.Two examine: continued to take this medicine on October 2nd, 87, and sx, body weight is gradually multiple, and the binocular distension syndrome disappears, and spirit is preferable, the cardiopalmus doing well,improving, appetite is normal, and tongue face is normal, and the tongue arteries and veins takes a turn for the better, and usefulness side is constant.Three examine: on October 15th, 87, the enlargement of cervical region both sides disappears, and spontaneous perspiration is eliminated, and is strong from head to foot, the body constitution full recovery, and normal teaching, not multiple so far.

4, journey * *, the woman, 40 years old is that north, Changzhi County is Nan Lingtou village, the township peasant diagnosis and treatment of coming on May 3 in 95 year.Patient's cardiopalmus, irritability, hyperhidrosis that To Be Protected from Heat is of long duration.Conscious myasthenia of limbs near month, appetite increases, and healthy enough to enjoy food and drinks, cardiopalmus increases the weight of.Check: eyeball is felt sleepy sore, and thyroid is anthorisma, and thready and rapid pulse, heart rate are 127 times/minute, the little Huang of thick fur, and body of the tongue is light red, floating and large pulse and count, the tip of the tongue is light red, takes Western medicine orally always and does not imitate, and comes to seek medical advice, and requires Chinese traditional treatment.According to dialectical: the thin irritability of patient's shape, long-term strongly fragrant gas forms, and the liver-fire bar reaches, so that depression of liver-QI, the cohesion fistulization; Deficiency of heart-yin thanks to causes shortness of breath and palpitation; The kidney failing to nourish the liver, so that excessive rising of liver-YANG.Magical effect hyperthyroidism spirit ball for oral administration seven days.Spirit is seen and is shaken during further consultation, and all disease opinions move back, and cardiopalmus is also slow, but heart rate is still about 100 times/minute, and the ancestor is imitated more not square principle, advises the former medicine of clothes constant, continuous clothes ten days.On May 20th, 95, the commentaries on classics of all having got better of all diseases, fistula is swollen not obvious, the weak disappearance of cardiopalmus, so drug withdrawal, multiple so far, all are normal.

5, journey * *, the woman, 25 years old is area just outside a city gate, Changzhi County town Han Dian people from village, the individual owner of barber shop went to a doctor in 95 years JIUYUE on the 14th.Readme is nervous unable, and spontaneous perspiration is easily irritated, and easily hungry, eyeball has outstanding slightly, and thyroid is enlargement slightly, heart rate 86 times/minute, and hospital is diagnosed as hyperthyroidism through Changzhi peace.Basal metabolic rate+80-100%.Through taking medicines such as thiamazole and thyroid tablet, off and on, took 1 year, DeGrain, bad during state of an illness fashion, fail to effect a radical cure.According to this disease of comprehensive analysis of the data gained by the four methods of diagnosis, belong to " the expectorant fistula " of the traditional Chinese medical science, promptly phlegm-fire is tied in the neck chap, and fiery upper punch is in binocular, and eyeball has outstanding slightly, disturbs then susceptible to lose temper due to restlessness, easily hungry in the phlegm-fire, becomes thin than in the past.Control when regulate the flow of vital energy, eliminating stagnation, removing heat-phlegm.Through taking magical effect hyperthyroidism spirit ball after ten days, symptom reduces by half, and has stomach not relax slightly.Then advise the patient to take medicine after meal, use Rhizoma Atractylodis Macrocephalae preparata with disease adding, Poria serve on 20, clinical symptom disappearance, and basal metabolism is normal, follows up a case by regular visits to and does not see recurrence.

Embodiment:

Take by weighing raw material by following weight proportion, 15 parts of the Radix Ophiopogonis behind 30 parts of Sargassums, 30 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Spica Prunellaes, 15 parts of Folium Mahoniae, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Fructus Forsythiaes, 25 parts in Gypsum Fibrosum, 8 parts of Radix Aucklandiae (Radix Vladimiriae), 10 parts of Radix Angelicae Sinensis, 25 parts of Radix Adenophorae (Radix Glehniae), the coring; Then with various raw material stoving, pulverize, sieve; Equivalent Mel is heated to boiling point, after a few minutes, add rapidly and be equipped with in the container of medicated powder, stir rapidly, rubbing becomes ball then, every ball 9 grammes per square metres.

Instructions of taking: day clothes three times, one time one ball

Taboo: avoid anxious state of mind, give up alcohol, pungent fry.

Claims

1, a kind of medicine that is used for the treatment of hyperthyroidism and simple goiter, it is characterized in that it is by the following weight proportion raw material medicament of production method preparation routinely, Sargassum 20-30 part, Thallus Laminariae (Thallus Eckloniae) 20-30 part, Spica Prunellae 10-20 part, Folium Mahoniae 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Fructus Forsythiae 10-20 part, Gypsum Fibrosum 20-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-10 part, Radix Angelicae Sinensis 10-12 part, Radix Adenophorae (Radix Glehniae) 20-30 part, Radix Ophiopogonis 10-20 part.

2, the medicine of treatment hyperthyroidism according to claim 1 and simple goiter, it is characterized in that wherein the weight proportion of each raw material is: Sargassum 25-30 part, Thallus Laminariae (Thallus Eckloniae) 25-30 part, Spica Prunellae 10-15 part, Folium Mahoniae 10-15 part, Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Fructus Forsythiae 15-20 part, Gypsum Fibrosum 25-30 part, Radix Aucklandiae (Radix Vladimiriae) 5-9 part, Radix Angelicae Sinensis 10-12 part, Radix Adenophorae (Radix Glehniae) 25-30 part, Radix Ophiopogonis 15-20 part.

3, the medicine of treatment hyperthyroidism according to claim 1 and simple goiter, it is characterized in that wherein the preferred weight proportioning of each raw material is: 30 parts of Sargassums, 30 parts of Thallus Laminariae (Thallus Eckloniae)s, 15 parts of Spica Prunellaes, 15 parts of Folium Mahoniae, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Fructus Forsythiaes, 25 parts in Gypsum Fibrosum, 8 parts of Radix Aucklandiae (Radix Vladimiriae), 10 parts of Radix Angelicae Sinensis, 25 parts of Radix Adenophorae (Radix Glehniae), 15 parts of Radix Ophiopogonis.

4,, it is characterized in that described medicament is powder, pill or electuary according to the medicine of claim 1,2 or 3 described hyperthyroidism and simple goiter.