CN105327284B - 一种治疗儿童髋关节滑膜炎的外用药及其制备方法 - Google Patents

一种治疗儿童髋关节滑膜炎的外用药及其制备方法 Download PDF

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CN105327284B
CN105327284B CN201510864939.7A CN201510864939A CN105327284B CN 105327284 B CN105327284 B CN 105327284B CN 201510864939 A CN201510864939 A CN 201510864939A CN 105327284 B CN105327284 B CN 105327284B
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梁延琛
肖肖
杨晶
毛存华
吕浩
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Affiliated Hospital of Shandong University of Traditional Chinese Medicine
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Abstract

本发明提供了一种治疗儿童髋关节滑膜炎的外用药及其制备方法，它是用下述重量份的中药原料制成的药剂，透骨草13‑17份、片姜黄5‑9份、海桐皮5‑9份、红花5‑9份、马钱子5‑7份、土鳖虫5‑7份、紫花地丁5‑9份、土贝母5‑9份、鳝鱼7‑9份。制备方法是将上述药物煎煮将滤液沉淀，取上清液至三效蒸发器中浓缩得到膏状物；将鳝鱼焙研过筛后置入膏状物内搅拌，得到治疗儿童髋骨关节滑膜炎的外用药；将外用药置入敷料层正面，外用药采用剥离层覆盖，粘结层与敷料层反面相连，粘接层上涂敷粘接剂，得到敷贴外用药。本发明能够解决现有技术的不足，使用特别方便，使用时将剥离层去掉，外用药面向患处，粘结层两端直接贴在皮肤上。

Description

一种治疗儿童髋关节滑膜炎的外用药及其制备方法
技术领域
本发明涉及中药，是一种治疗儿童髋关节滑膜炎的外用药及其制备方法。
背景技术
儿童髋关节滑膜炎多发于4-10岁的儿童，多为单侧发病。主要症状为：髋部、膝部不同程度疼痛，髋关节活动受限，重者伴有跛行。实验室检查血中白细胞升高，以中性粒细胞升高为主。X线片检查关节腔内积液，关节囊肿胀膨大、关节间隙增宽、无明显骨质异常。由于此病患者为儿童，主要采用热外敷，对于出现患肢屈曲畸形采用牵拉治疗，但是这些方法临床见效不快，并易反复发作，而此病迁延期不能超过3个月，否则易发展为髋关节骨关节炎，重者出现股骨头缺血性坏死。现有技术中的药物主要为中药，但是，由于儿童的耐受性及药效等原因，口服药的疗效见效较慢，并易带来其它不良反应；外用药的不足是使用方法复杂、显效慢、治愈率较低。
发明内容
本发明的目的是提供一种治疗儿童髋关节滑膜炎的外用药及其制备方法。它能够解决现有技术的不足。
本发明为实现上述目的，通过以下技术方案实现：一种治疗儿童髋关节滑膜炎的外用药，它是用下述重量份的中药原料制成的药剂，透骨草13-17份、片姜黄5-9份、海桐皮5-9份、红花5-9份、马钱子5-7份、土鳖虫5-7份、紫花地丁5-9份、土贝母5-9份、鳝鱼7-9份。
所述的一种治疗儿童髋关节滑膜炎的外用药，它是用下述重量份的中药原料制成的药剂，透骨草13份、片姜黄5份、海桐皮5份、红花5份、马钱子5份、土鳖虫5份、紫花地丁5份、土贝母5份、鳝鱼7份。
所述的一种治疗儿童髋关节滑膜炎的外用药，它是用下述重量份的中药原料制成的药剂，透骨草17份、片姜黄9份、海桐皮9份、红花9份、马钱子7份、土鳖虫7份、紫花地丁9份、土贝母9份、鳝鱼9份。
所述的一种治疗儿童髋关节滑膜炎的外用药组合物，它是用下述重量份的中药原料制成的药剂，透骨草15份、片姜黄7份、海桐皮7份、红花7份、马钱子6份、土鳖虫6份、紫花地丁7份、土贝母7份、鳝鱼8份。
所述的一种治疗儿童髋关节滑膜炎的外用药的制备方法步骤如下：
①按重量份取：透骨草13-17份、片姜黄5-9份、海桐皮5-9份、红花5-9份、马钱子5-7份、土鳖虫5-7份、紫花地丁5-9份、土贝母5-9份备用；
②煎煮：按所用中药原料总量的6倍水浸泡40-50分钟，武火煮沸、文火煮1-2小时，取第一遍滤液备用，药渣中加入中药原料总量的3倍水，煮2-3小时，取第二遍滤液备用；
③将第一遍滤液和第二遍滤液合并沉淀24小时，取上清液至三效蒸发器中浓缩至相对密度为0.9-1.2（36℃检测）,得到膏状物；
④按重量份取鳝鱼7-9份焙研过200目筛后置入步骤③中的膏状物内，常温下搅拌30-40分钟，得到治疗儿童髋骨关节滑膜炎的外用药；
⑤将步骤④中的外用药置入敷料层正面，外用药采用剥离层覆盖，粘结层与敷料层反面相连，粘接层上涂敷粘接剂，剥离层两端分别与粘结层相连，粘结层的长度和宽度大于敷料层，得到敷贴外用药。所述粘结层上涂覆的粘结剂是芦荟胶。
本发明所述的外用药的中药原料的透骨草用于祛湿活血、活血止痛；片姜黄用于破血行气、祛风疗痹；海桐皮用于祛风湿、通经络；红花用于活血通脉、散瘀止痛；马钱子用于散结消肿、通络止痛；土鳖虫用于破血祛瘀、续筋接骨；紫花地丁用于去热解毒、凉血消肿；鳝鱼用于补虚损、除风湿、强筋骨；土贝母用于散结解毒，排痈消肿。上述各药组合，具有活血化瘀、祛风湿痹症，散瘀消肿止痛等功效。
本发明所述外用药临床资料显示，治疗显效快，使用2天后均有明显好转，有效率为100%。临床病例52例，年龄4-11岁，男性39例，女性13例，左髋发病患者23例，右髋患者发病26例，双髋发病患者3例，发病到就诊时间病程最短为3天，最长为57天。按照本发明所述的外用药使用方法，使用1天后症状有好转的为5例，使用2天后症状有好转的为47例；使用本发明外用药6天，治愈患者为31例，使用10天治愈患者为9例，使用14天治愈患者为9例，有1例患者使用了21天治愈，1例患者使用了29天治愈，1例患者未愈。疾病治疗评判标准：采用《中医病症诊断疗效标准》有关小儿髋关节滑膜炎的疗效标准以无坡行、步行不痛、下蹲正常、“4”字试验和旋转屈髋试验阴性、下肢等长，无复发者为治愈；以症状减轻、体征改善、仍有轻度跛行或愈后复发者为好转，以症状、体征元改善者为未愈。
疾病诊断标准：儿童呼吸道感染后、髋关节创伤或过度活动等原因导致其急性发病，出现髋部、膝部不同程度疼痛，髋关节活动受阴并伴有跛行。实验室检查：血中白细胞略高，以中性粒细胞升高为主，X线片检查：关节腔内积液，关节囊肿胀膨大，关节间隙增宽，未见明显骨质异常。
典型病例：李晓华，男，9岁，住山东省济南市平阴县，左侧髋部开始疼痛已10天，近日疼痛加重，跛行。医院X线检查，关节囊肿胀膨大。按照本发明方法使用本发明外用药1天后疼痛减轻，使用6天，疼痛、跛行症状消失，下蹲正常，“4”字试验和旋转屈髋试验阴性，下肢等长。跟踪观察12个月无复发。
用本发明方法制备的外用药，直接敷在患处，外用药的长宽尺寸有多个型号，根据不同患者的需要获取不同型号。本发明的外用药使用特别方便，使用时将剥离层去掉，外用药面向患处，粘结层两端直接贴在皮肤上。本发明所述外用药一天敷贴2次，贴在患处，每次一贴，敷贴4-6小时，两次敷贴间隔6-8小时。
具体实施方式
本发明所述外用药是用下述重量份的中药原料制成的药剂，透骨草13-17份、片姜黄5-9份、海桐皮5-9份、红花5-9份、马钱子5-7份、土鳖虫5-7份、紫花地丁5-9份、土贝母5-9份、鳝鱼7-9份。
本发明所述外用药是用下述重量份的中药原料制成的药剂，还可用透骨草13份、片姜黄5份、海桐皮5份、红花5份、马钱子5份、土鳖虫5份、紫花地丁5份、土贝母5份、鳝鱼7份。
本发明所述外用药是用下述重量份的中药原料制成的药剂，还可用透骨草17份、片姜黄9份、海桐皮9份、红花9份、马钱子7份、土鳖虫7份、紫花地丁9份、土贝母9份、鳝鱼9份。
本发明所述外用药是用下述重量份的中药原料制成的药剂，还可用透骨草15份、片姜黄7份、海桐皮7份、红花7份、马钱子6份、土鳖虫6份、紫花地丁7份、土贝母7份、鳝鱼8份。
本发明所述的一种治疗儿童髋关节滑膜炎的外用药组合物的制备方法，步骤如下：
①按重量份取：透骨草13-17份、片姜黄5-9份、海桐皮5-9份、红花5-9份、马钱子5-7份、土鳖虫5-7份、紫花地丁5-9份、土贝母5-9份备用；
②煎煮：按所用中药原料总量的6倍水浸泡40-50分钟，武火煮沸、文火煮1-2小时，取第一遍滤液备用，药渣中加入中药原料总量的3倍水，煮2-3小时，取第二遍滤液备用；
③将第一遍滤液和第二遍滤液合并沉淀24小时，取上清液至三效蒸发器中浓缩至相对密度为0.9-1.2（36℃检测）,得到膏状物；
④按重量份取鳝鱼7-9份焙研过200目筛后置入步骤③中的膏状物内，常温下搅拌30-40分钟，得到治疗儿童髋骨关节滑膜炎的外用药；
⑤将步骤④中的外用药置入敷料层正面，外用药采用剥离层覆盖，粘结层与敷料层反面相连，粘接层上涂敷粘接剂，剥离层两端分别与粘结层相连，粘结层的长度和宽度大于敷料层，得到敷贴外用药。所述粘结层上涂覆的粘结剂优选芦荟胶。敷料层为3-4层无纺布构成，粘结层上开设数个通孔。粘结层、敷料层、剥离层采用公知方法连在一起。本发明上述方法制备的外用药，易使外用药直接贴敷在患处，不会产生移动、不影响患者日常活动，易使药物在较长时间内直接作用于患处。

Claims (1)

1.一种治疗儿童髋关节滑膜炎的外用药的制备方法，其特征在于：选用下述重量份的中药原料：透骨草15份、片姜黄7份、海桐皮7份、红花7份、马钱子6份、土鳖虫6份、紫花地丁7份、土贝母7份、鳝鱼8份；
按照下述步骤制备：
①按重量份取：透骨草15份、片姜黄7份、海桐皮7份、红花7份、马钱子6份、土鳖虫6份、紫花地丁7份、土贝母7份备用；
②煎煮：按所用中药原料总量的6倍水浸泡40-50分钟，武火煮沸、文火煮1-2小时，取第一遍滤液备用，药渣中加入中药原料总量的3倍水，煮2-3小时，取第二遍滤液备用；
③将第一遍滤液和第二遍滤液合并沉淀24小时，取上清液至三效蒸发器中浓缩至相对密度为0.9-1.2，36℃检测得到膏状物；
④按重量份取鳝鱼8份焙研过200目筛后置入步骤③中的膏状物内，常温下搅拌30-40分钟，得到治疗儿童髋骨关节滑膜炎的外用药；
⑤将步骤④中的外用药置入敷料层正面，外用药采用剥离层覆盖，粘结层与敷料层反面相连，粘接层上涂敷粘接剂，剥离层两端分别与粘结层相连，粘结层的长度和宽度大于敷料层，得到敷贴外用药。
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