CN105327230A - Medicine for treating eczema and preparation method thereof - Google Patents
Medicine for treating eczema and preparation method thereof Download PDFInfo
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- CN105327230A CN105327230A CN201510836558.8A CN201510836558A CN105327230A CN 105327230 A CN105327230 A CN 105327230A CN 201510836558 A CN201510836558 A CN 201510836558A CN 105327230 A CN105327230 A CN 105327230A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a medicine for treating eczema and a preparation method thereof, which belong to the field of medicine. The medicine for treating the eczema is mainly prepared from the following traditional Chinese medicine raw materials in parts by weight: 30 to 200 parts of garden burnet, 10 to 200 parts of cortex dictamni, 30 to 200 parts of tribulus terrestris, 50 to 200 parts of fructus cnidii, 20 to 300 parts of broom cypress fruits and 20 to 300 parts of radix stemonae. The medicine for treating the eczema has a good effect of treating the eczema, and the eczema can be cured within a short time; compared with existing other medicines, the medicine has the advantages of no toxic or side effect, convenience in use, low cost and the like, and the eczema can be quickly and effectively treated. The preparation method of the medicine comprises the step of soaking the garden burnet, the cortex dictamni, the tribulus terrestris, the fructus cnidii, the broom cypress fruits and the radix stemonae with alcohol, and effective active components obtained by soaking are high. The preparation method of the medicine has the advantages of simple process, easiness in control and low production cost and is suitable for mass production.
Description
Technical field
The present invention relates to field of medicaments, in particular to a kind of medicament for the treatment of eczema and preparation method thereof.
Background technology
Eczema is a kind of common allergic skin inflammation, with erythra multiformity, symmetrical, violent pruritus, recurrent exerbation, easily develop into chronic for feature, any age, any position, any season can be betided.Eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill is as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes, endocrine disturbance, infection, dysbolism etc., and exopathogenic factor such as living environment, climate change, food etc. all can affect the generation of eczema.The cause of disease is complicated brings certain difficulty to primary disease treatment.Eczema is divided into damp-heat syndrome and blood-deficiency and wind-dry disease by the traditional Chinese medical science clinically, the general pruritus of damp-heat syndrome, papular type with antipruritic antibacterial be main treatment, blood-deficiency and wind-dry disease antipruriticly to moisturize, clearing away heat-damp and promoting diuresis treats.
In existing technology, the medicine for the treatment of eczema is a lot, utilizes Chinese medicine to treat, general treatment is long for the course for the treatment of, DeGrain, and trouble of boiling medicine for a long time, to drink medicine painful again, western medicine often adopts hormone or immunosuppressant to treat, although the short time can eliminate symptom, a drug withdrawal is recurrence just, the dosage that next time, treatment needed can be increasing, may cause the toxicity of medicine, hormone relies on phenomenon, cures the symptoms, not the disease, the state of an illness easily recurs, very inadvisable.
As: patent " a kind of medicine for the treatment of the eczema " (application number: CN201510251391 of Fenghua Kechuang science service company limited, the applying date: 2015.05.14, publication number: CN104825921A, publication date: 2015.08.12) disclose a kind of Chinese medicine of external curing eczema, its raw material components comprises: Indigo Naturalis 20 ~ 30 parts, Periostracum Serpentis 5 ~ 10 parts, Calamina 10 ~ 20 parts, dried Alumen 10 ~ 20 parts, 5 ~ 10 parts, sulfur, Borneolum Syntheticum 10 ~ 20 parts, Caulis Spatholobi 5 ~ 15 parts, Fructus Cnidii 5 ~ 10 parts, Radix Sophorae Flavescentis 5 ~ 10 parts, Folium Artemisiae Argyi 15 ~ 30 parts, Semen Coicis 15 ~ 30 parts, artificial Calculus Bovis 10 ~ 20 parts.
Patent " a kind of medicine for the treatment of rheumatism and accumulateing toxin type chronic the eczema " (application number: CN201510234810 of Zhao Zhenrong, the applying date: 2015.05.11, publication number: CN104815037A, publication date: 2015.08.05) disclose a kind of medicine for the treatment of rheumatism and accumulateing toxin type chronic eczema, its raw material components comprises: Scorpio, Spina Gleditsiae, Fructus Gleditsiae Abnormalis, the Fructus Kochiae, Cortex Dictamni, Semen Phaseoli, Radix Astragali, Radix Angelicae Sinensis, Caulis Spatholobi, Herba Agrimoniae, Foliumet Ramulus Evodiae, Folium Eucalypti Robustae, Herba pronephrii triphylli, Adeps Marmotae bobak, Radix araliae chinensis (Cortex Araliae Chinensis); In described external used medicine, each raw medicinal material is: Radix Sophorae Flavescentis, Fructus Tribuli, Flos Sophorae, Radix Et Rhizoma Rhei, silkworm excrement, Herba Violae, Herba crotalariae albidae, Rhizoma Smilacis, Rhizoma Smilacis Glabrae, sulfur, Periostracum Cicadae, the Radix Paeoniae Alba, Herba Gelsemii Elegantis, Cortex Pterocaryae Stenopterae, Herba Plumbagellae Micranthae, Ramulus et Folium Flueggeae Virosae.
Patent " one treats dermopathic the herbal composite " (application number: CN201510264720 of Hunan University of Traditional Chinese Medicine, the applying date: 2015.05.22, publication number: CN104800700A, publication date: 2015.07.29) disclose one and treat dermopathic herbal composite, its raw material components comprises: Radix Et Rhizoma Rhei 5 ~ 8 parts, Radix Scutellariae 5 ~ 8 parts, Cortex Phellodendri 7 ~ 12 parts, Cortex Dictamni 10 ~ 15 parts, Rhizoma Smilacis Glabrae 7 ~ 12 parts, Bombyx Batryticatus 3 ~ 5 parts, Radix Arnebiae (Radix Lithospermi) 5 ~ 8 parts, Fructus Arctii 8 ~ 12 parts, Flos Chrysanthemi Indici 3 ~ 5 parts, the Fructus Kochiae 8 ~ 15 parts, Radix Saposhnikoviae 5 ~ 7 parts.
Patent " a kind of medicine for the treatment of the infantile eczema " (application number: CN201510278949 of Fan Hengyin, the applying date: 2015.05.27, publication number: CN104815184A, publication date: 2015.08.05) disclose a kind of medicine for the treatment of infantile eczema, its raw material components comprises: Radix Campylotropis Macrocarpae 80 ~ 100 parts, Rauvolfia verticillata 70 ~ 100 parts, Cortex Alni sibiricae 60 ~ 90 parts, Herba Salviae Plebeiae 70 ~ 100 parts, Amur Adonis Herb 50 ~ 80 parts, Viola arcuata 60 ~ 90 parts, Semen Cassiae 50 ~ 80 parts, Herba Silenes conoideae 50 ~ 70 parts, the Herba Blumeae Laciniatae 50 ~ 80 parts, Herba Briggsiae Chienii 50 ~ 80 parts, Radix seu Folium Cinnamomi angustifolii 30 ~ 60 parts, Semen Raphani 30 ~ 60 parts, Herba rungiae pectinatae 30 ~ 60 parts, thin,tough silk hair chrysanthemum 30 ~ 60 parts, Herba Cirrohopetali Andersonii 30 ~ 60 parts, Radix Cacaliae Ainsliaeflorae 30 ~ 50 parts, Conyza canadensis (L.) Cronq. 30 ~ 50 parts, Herba Hydrocotyles 20 ~ 50 parts, Flos Musellae Lasiocarpae 20 ~ 50 parts and 10 ~ 30 parts, Radix Glycyrrhizae.
Patent " a kind of Chinese medicine for the treatment of the eczema " (application number: CN201510235472 of Li Wenfeng, the applying date: 2015.05.11, publication number: CN104784250A, publication date: 2015.07.22) disclose a kind of Chinese medicine for the treatment of eczema, its raw material components comprises: dried Alumen, Realgar, Talcum, Gypsum Fibrosum Preparatum, Radix Glycyrrhizae, Borneolum Syntheticum, Oleum sesami.
Its formula of the said goods is each different, although can reach certain curative effect, these products all can not effect a radical cure eczema, and these product components are complicated, preparation trouble.Therefore be necessary to develop a kind of can the medicament of rapid, effective treatment eczema, and to have no side effect, not easily recur, eczema reached to treating both the principal and secondary aspects of a disease, easy to use, product with low cost.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of medicament for the treatment of eczema, and described medicament can rapid, effective treatment eczema, Be very effective, and have no side effect, and not easily recurs, reaches treating both the principal and secondary aspects of a disease to eczema.
The second object of the present invention is the preparation method of the medicament providing a kind of described treatment eczema, and the method process is simple, and easily control, production cost is low, is applicable to batch production.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Treat a medicament for eczema, make primarily of following raw material of Chinese medicine, by weight, Radix Sanguisorbae 30 ~ 200 parts, Cortex Dictamni 10 ~ 200 parts, Fructus Tribuli 30 ~ 200 parts, Fructus Cnidii 50 ~ 200 parts, the Fructus Kochiae 20 ~ 300 parts, the Radix Stemonae 20 ~ 300 parts.
Specific this several effective active matter of Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae of selecting of the medicament for the treatment of eczema provided by the invention is made, raw material components is simple, the medicament obtained not only has good effect to treatment eczema, just can be almost recovered at short notice, compared with other medicines existing, there is rapid, effective treatment eczema, and have no side effect, easy to use, with low cost.
Wherein, Radix Sanguisorbae, another name Matteuccia struthiopteri, beautiful letter, Fructus Choerospondiatis, bitter, sour, puckery, be slightly cold, there is cooling blood for hemostasis, heat-clearing and toxic substances removing, effect of detumescence sore.
Cortex Dictamni, another name Cortex Dictamni, stereotyped writing cattle, Cortex Argyreiae Seguinii Radicis, the fresh grass of sheep, bitter, salty, cold, have and dispel the wind, dampness, heat clearing away, effect of removing toxic substances, for damp and hot sore, eczema scabies.
Fructus Tribuli, another name thatch (" Book of Songs "), Fructus Tribuli (" Mao Shichuan "), Fructus Tribuli, bypass, drawer people, only row, jackal plumage, rise and push away (" herbal classic "), i.e. Herba chenopodii (" not Lu "), Fructus Atriplicis Sibiricae (" property of medicine opinion "), Du Fructus Tribuli (Holy Benevolent Prescriptions), stop plumage (" detailed outline "), drought grass (" book on Chinese herbal medicine is through separating "), triangle Fructus Tribuli (" book on Chinese herbal medicine is looked for the truth "), three Fructus Gleditsia acupuncture (" will planted by middle traditional Chinese medicines "), anistree thorn (" Qinghai medical material "), puncture frame, wild Pedicellus et Pericarpium Trapae, ground Pedicellus et Pericarpium Trapae (" medicine will is planted in Jiangsu "), hard Fructus Tribuli, Ji Li Follicle radish (" Shandong Chinese medicine "), toil, temperature, property is put down, Fructus Atriplicis Sibiricae is used as diuretic India is among the people.
Fructus Cnidii, calls wild Fructus Foeniculi, Daucus carota L., Serpentis rice, She Li, acrid, bitter, warm, slightly poisonous, returns kidney channel, warming the kidney to activate YANG, dispels the wind, dampness, parasite killing.Find after deliberation, Fructus Cnidii contains antifungal chemical composition.
The Fructus Kochiae, another name broom Seedling, pungent, bitter, cold, return kidney, urinary bladder channel, diuresis, clearing away damp-heat, and have inhibitory action to dermatophytes.
The Radix Stemonae, another name Radix Stemonae, Herba delphinii grandiflori, noisy louse medicine, medicine louse medicine, sweet, bitter, tepor, returns lung meridian, can nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.During in vitro tests Radix Stemonae decoct and the immersion of radix stemonae tuberosae ethanol to various pathogens as streptococcus pneumoniae, beta hemolysis type streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus and dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis, and vibrio cholera, Bacillus tuberculosis etc. have bacteriostasis in various degree.
As preferably, by weight, Radix Sanguisorbae 80 ~ 200 parts, Cortex Dictamni 50 ~ 200 parts, Fructus Tribuli 80 ~ 200 parts, Fructus Cnidii 100 ~ 200 parts, the Fructus Kochiae 100 ~ 300 parts, the Radix Stemonae 100 ~ 300 parts.
As preferably, described medicament also comprises adjuvant.Adjuvant comprises stabilizing agent, antiseptic, penetration enhancer, wetting agent etc.Be easy to make the medicament obtained preserve, stable performance, during use, effect is better.Other materials not affecting drug effect also can as adjuvant.
Present invention also offers the preparation method of described medicament, by described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the lixiviate of Radix Stemonae ethanol, obtain lixiviating solution.
The preparation method of described medicament provided by the invention, that Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and Radix Stemonae alcoholic solution are carried out lixiviate, the effective active composition that lixiviate obtains is high, the method is simple, the medicament effective active composition obtained is high, therapeutic effect is remarkable, and safe without toxic side effect.
As preferably, the mass concentration of described ethanol is 75% ~ 95%.
Under this preferred concentration, the extraction effect of ethanol to the active substance of Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae is better.
As preferably, the total mass ratio of described ethanol and described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, the Radix Stemonae is 2 ~ 8:1.
Under this preferred proportion, the extraction of ethanol to the active substance of Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae is more abundant.
As preferably, described lixiviate is specially: by described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, Radix Stemonae ethanol sealing immersion 12 ~ 90 days; Then use filter screen filtration, the filtrate obtained is described lixiviating solution.
In this preferred version, to carry out preferably to soak time, make Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae active substance be fully extracted out, the utilization rate of Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae is higher.
As preferably, described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, the Radix Stemonae are first pulverized before immersion.
After Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are pulverized, larger with the contact surface of ethanol, the active substance contained by Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae is more easily by ethanol stripping.
As preferably, in immersion process, stir 1 ~ 2 every day, soak 12 ~ 20 days.
As preferably, after immersion completes, elder generation obtains filtrate through coarse filtration, and the medicinal residues that coarse filtration obtains carry out squeezing and obtain residual liquid, and described filtrate and described residual liquid are mixed to get mixed liquor, described mixed liquor is carried out fine straining to obtain fine straining liquid and be described lixiviating solution, the medicament of eczema must be treated.
Compared with prior art, beneficial effect of the present invention is:
(1) medicament for the treatment of eczema provided by the invention, specific this several effective active matter of Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae of selecting is made, the medicament of energy rapid, effective treatment eczema, and have no side effect, not easily recur, eczema reached to treating both the principal and secondary aspects of a disease, easy to use, product with low cost.
(2) in order to increase the effect of medicament, present invention also defines the consumption of each raw material.
(3) preparation method of the medicament for the treatment of eczema provided by the invention, carry out lixiviate with the active cost of alcoholic solution to Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae, spy have selected usage ratio and the concentration range of alcoholic solution, also define the time of lixiviate, the preparation method of the medicament for the treatment of eczema of the present invention, technical process is simple, easily controls, production cost is low, is applicable to batch production.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
Get the chopping of following raw material for subsequent use, Radix Sanguisorbae 30g, Cortex Dictamni 10g, Fructus Tribuli 30g, Fructus Cnidii 50g, Fructus Kochiae 20g, Radix Stemonae 20g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 320g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
Soak after 12 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Embodiment 2
Get the chopping of following raw material for subsequent use, Radix Sanguisorbae 80g, Cortex Dictamni 50g, Fructus Tribuli 80g, Fructus Cnidii 100g, Fructus Kochiae 100g, Radix Stemonae 100g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 1530g alcoholic solution and soak, the concentration of alcoholic solution is 80%;
Soak after 15 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Experimental example 3
Get the chopping of following raw material for subsequent use, Radix Sanguisorbae 120g, Cortex Dictamni 70g, Fructus Tribuli 120g, Fructus Cnidii 130g, Fructus Kochiae 80g, Radix Stemonae 60g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 2320g alcoholic solution and soak, the concentration of alcoholic solution is 90%;
Soak after 18 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Experimental example 4
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 150g, Cortex Dictamni 90g, Fructus Tribuli 140g, Fructus Cnidii 150g, Fructus Kochiae 150g, Radix Stemonae 120g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 4000g alcoholic solution and soak, the concentration of alcoholic solution is 95%;
Soak after 20 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Experimental example 5
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 180g, Cortex Dictamni 120g, Fructus Tribuli 180g, Fructus Cnidii 180g, Fructus Kochiae 200g, Radix Stemonae 200g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 6360g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
Soak after 30 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Experimental example 6
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 200g, Cortex Dictamni 200g, Fructus Tribuli 200g, Fructus Cnidii 200g, Fructus Kochiae 300g, Radix Stemonae 300g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 11200g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
Soak after 50 days, with strainer filtering to remove medicinal residues, obtain lixiviating solution, this lixiviating solution is final obtained medicament.
Embodiment 7
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 30g, Cortex Dictamni 10g, Fructus Tribuli 30g, Fructus Cnidii 50g, Fructus Kochiae 20g, Radix Stemonae 20g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 320g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
Soak after 90 days, first obtain filtrate through coarse filtration, the medicinal residues that coarse filtration obtains carry out squeezing and obtain residual liquid, and filtrate and residual liquid are mixed to get mixed liquor, mixed liquor are carried out fine straining and obtain fine straining liquid and be lixiviating solution, must treat the medicament of eczema.
Embodiment 8
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 30g, Cortex Dictamni 10g, Fructus Tribuli 30g, Fructus Cnidii 50g, Fructus Kochiae 20g, Radix Stemonae 20g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 320g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
During immersion, every day stirs once, and soak after 20 days, with strainer filtering to remove medicinal residues, obtain filtrate, this filtrate is lixiviating solution, also namely obtains the medicament for the treatment of eczema.
Embodiment 9
Getting following raw material, to make powder for subsequent use, Radix Sanguisorbae 30g, Cortex Dictamni 10g, Fructus Tribuli 30g, Fructus Cnidii 50g, Fructus Kochiae 20g, Radix Stemonae 20g;
Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the Radix Stemonae are added in 320g alcoholic solution and soak, the concentration of alcoholic solution is 75%;
During immersion, every day stirs twice, and soak after 15 days, with strainer filtering to remove medicinal residues, obtain filtrate, this filtrate is lixiviating solution, also namely obtains the medicament for the treatment of eczema.
Experimental example
Repeat embodiment 1-9, obtained abundant medicinal liquid uses to eczema patients, wherein, each embodiment all selects 50 patients to use, and the medicament of corresponding embodiment is all spread upon eczema affected part by each patient, and the every day of each use sooner or later once, continuous use one week, finally adds up the number of different-effect.
Effect is divided into healing, effective and invalid, cures as disease disappears; Effectively obviously alleviate for disease; Invalid is that disease is without significant change.The result obtained is as shown in table 1.
The statistics effect of table 1 eczema patients
| Group | Cure (number) | Effectively (number) | Invalid (number) |
| Embodiment 1 | 47 | 3 | 0 |
| Embodiment 2 | 48 | 2 | 0 |
| Embodiment 3 | 48 | 2 | 0 |
| Embodiment 4 | 50 | 0 | 0 |
| Embodiment 5 | 50 | 0 | 0 |
| Embodiment 6 | 49 | 1 | 0 |
| Embodiment 7 | 49 | 1 | 0 |
| Embodiment 8 | 50 | 0 | 0 |
| Embodiment 9 | 50 | 0 | 0 |
As can be seen from Table 1, the medicament for the treatment of eczema provided by the invention is obvious to the treatment of eczema patients, and all patients use the rear state of an illness to have and take a turn for the better significantly, wherein minimum cure rate 94%, and average cure rate 97%, has the therapeutic effect of highly significant.Find in test, patient takes effect after 1 ~ 2 day in use, and skin pruritus symptom disappears, 5 ~ 7 days eczema transference cures, and skin recovers normal.
Typical clinical case:
Clinical example 1: poplar, man, 49 years old, people from Yueqing City, suffered from whole body eczema 5 years, though ground treatment, has no improvement through Shanghai etc., from July, 2014, use the medicament that the embodiment of the present invention is obtained, 2 days take effect, and skin pruritus symptom disappears, and within 7 days, skin recovers normal, from then on relieves the puzzlement of eczema.
Clinical example 2: leaf, female, 51 years old, people from Yueqing City, more than 20 years of eczema are suffered from the many places such as extremity, though through all parts of the country treatment, all could not cure, from August, 2013, use the medicament that the embodiment of the present invention is obtained, 1 day takes effect, and within 2 days, eczema is clearly better, and within 5 days, eczema disappears, and skin recovers normal.
Clinical example 3: Lee, man, 48 years old, people from Yueqing City, more than 10 years of eczema are suffered from double-legged many places, though through various western medicine, all could not cure, from June, 2013, use the medicament that the embodiment of the present invention is obtained, 2 days take effect, and within 4 days, eczema is clearly better, and within 7 days, eczema disappears, and skin recovers normal.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1. treat a medicament for eczema, it is characterized in that, make primarily of following raw material of Chinese medicine, by weight, Radix Sanguisorbae 30 ~ 200 parts, Cortex Dictamni 10 ~ 200 parts, Fructus Tribuli 30 ~ 200 parts, Fructus Cnidii 50 ~ 200 parts, the Fructus Kochiae 20 ~ 300 parts, the Radix Stemonae 20 ~ 300 parts.
2. the medicament for the treatment of eczema according to claim 1, is characterized in that, by weight, and Radix Sanguisorbae 80 ~ 200 parts, Cortex Dictamni 50 ~ 200 parts, Fructus Tribuli 80 ~ 200 parts, Fructus Cnidii 100 ~ 200 parts, the Fructus Kochiae 100 ~ 300 parts, the Radix Stemonae 100 ~ 300 parts.
3. the medicament of the treatment eczema according to any one of claim 1 ~ 2, is characterized in that, described medicament also comprises adjuvant.
4. the preparation method of the medicament described in any one of claim 1 ~ 2, is characterized in that, by described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae and the lixiviate of Radix Stemonae ethanol, obtains lixiviating solution.
5. preparation method according to claim 4, is characterized in that, the mass concentration of described ethanol is 75% ~ 95%.
6. preparation method according to claim 5, is characterized in that, the total mass ratio of described ethanol and described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, the Radix Stemonae is 2 ~ 8:1.
7. preparation method according to claim 5, is characterized in that, described lixiviate is specially: described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, Radix Stemonae ethanol are sealed immersion 12 ~ 90 days; Then use filter screen filtration, the filtrate obtained is described lixiviating solution.
8. preparation method according to claim 7, is characterized in that, described Radix Sanguisorbae, Cortex Dictamni, Fructus Tribuli, Fructus Cnidii, the Fructus Kochiae, the Radix Stemonae are first pulverized before immersion.
9. preparation method according to claim 8, is characterized in that, in immersion process, stirs 1 ~ 2 every day, soaks 12 ~ 20 days.
10. preparation method according to claim 9, it is characterized in that, after immersion completes, elder generation obtains filtrate through coarse filtration, the medicinal residues that coarse filtration obtains carry out squeezing and obtain residual liquid, described filtrate and described residual liquid are mixed to get mixed liquor, described mixed liquor is carried out fine straining to obtain fine straining liquid and be described lixiviating solution, the medicament of eczema must be treated.
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| CN101554463A (en) * | 2009-05-26 | 2009-10-14 | 贵州本草堂药业有限公司 | Drug for treating gynecologic and andrological diseases and preparation method thereof |
| KR20130015340A (en) * | 2011-08-03 | 2013-02-14 | 정의영 | Cream composition for improving atopic dermatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554463A (en) * | 2009-05-26 | 2009-10-14 | 贵州本草堂药业有限公司 | Drug for treating gynecologic and andrological diseases and preparation method thereof |
| KR20130015340A (en) * | 2011-08-03 | 2013-02-14 | 정의영 | Cream composition for improving atopic dermatitis |
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