CN104138591A - Compound Chinese herbal extracting solution for preventing and treating rabbit coccidiosis and preparation method thereof - Google Patents
Compound Chinese herbal extracting solution for preventing and treating rabbit coccidiosis and preparation method thereof Download PDFInfo
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- CN104138591A CN104138591A CN201410343807.5A CN201410343807A CN104138591A CN 104138591 A CN104138591 A CN 104138591A CN 201410343807 A CN201410343807 A CN 201410343807A CN 104138591 A CN104138591 A CN 104138591A
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Abstract
The invention provides a compound Chinese herbal extracting solution for preventing and treating rabbit coccidiosis and a preparation method of the compound Chinese herbal extracting solution. The compound Chinese herbal extracting solution is composed of, by weight, 25 parts of Artemisia apiacea, 15 parts of common carpesium fruits, 15 parts of rhizoma zingiberis, 15 parts of tumion seeds, 15 parts of costus roots, 10 parts of coptis roots, 10 parts of Chinese teasel roots, 5 parts of grapeleaf anemone and 5 parts of greater bunet roots. The preparation method of the compound Chinese herbal extracting solution comprises the steps that the original medicinal materials are weighed according to the weight ratio and mixed, and water extraction is performed for the first time, wherein the amount of added water is 12 times that of the original medicinal materials, the water extraction is performed after the original medicinal materials are soaked for 120 minutes, extraction time is 2 hours, and filtration is performed; (2) water extraction is performed for the second time, wherein the amount of added water is 6 times that of the original medicinal materials, extraction time is 1.5 hours, and filtration is performed; (3) filtrates of two times are merged and concentrated to the weight being 0.8 time the weight of the original medicinal materials.
Description
Technical field
The present invention relates to livestock and poultry parasite medical treatment technical field, refer to especially
oneplant compound Chinese medicinal herb extract of control rabbit coccidiosis and preparation method thereof.
Background technology
Coccidiosis is to the most serious a kind of parasitic disease of rabbit keeping harm.Coccidiosis can reach 40～80% to the case fatality rate of rabbit, China every year for the expense of coccidiostat up to several hundred million units.Up to now, the Main Means of control coccidiosis still depends on the chemical prevention of anticoccidial drug.Due to anticoccidial drug, the such as life-time service such as diclazuril, clopidol, coccidiosis produces drug resistance to medicine and has become unavoidable serious problems, and at present commercially available any anticoccidial chemical medicine, using after certain hour, all can cause the drug resistance of coccidiosis.Therefore find a kind of medicine that should not produce drug resistance to coccidiosis, become the matter of utmost importance of the current control of people coccidiosis.
Chinese herbal medicine kind is a lot, and the composition of every kind of Chinese herbal medicine is all very complicated, often contains again plurality of active ingredients in a kind of Chinese herbal medicine, several functions, and after Chinese herbal medicine composition compound recipe, composition is more complicated.So coccidiosis is not easy it to produce drug resistance.In addition, Chinese herbal medicine is pure natural substance, safe through the Chinese herbal medicine coccidiostat of selected prescription.But at present Chinese herbal medicine anticoccidial drug majority be powder, although powder is easily processed and preservation, use more conveniently, to sneak into feedstuff and both can make curative and also can make preventive drug, large usage quantity, generally will account for 1%～5% of forage volume.General therapeutic consumption is high, and need take a couple of days continuously; Though preventive dose is low, to sneak into feedstuff and take continuously for a long time, cost is higher.
Summary of the invention
For above-mentioned present situation, the invention provides a kind of formula and processing method thereof of compound Chinese medicinal herb extract of preventing and treating rabbit coccidiosis, said preparation can fast, effectively be controlled rabbit coccidiosis, and using dosage is low and with low cost.
The present invention is achieved by the following scheme:
A kind of compound Chinese medicinal herb extract of preventing and treating rabbit coccidiosis is to be by Herba Artemisiae Annuae, Fructus Carpesii, Rhizoma Zingiberis, Semen Torreyae, the Radix Aucklandiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Herba anemones vitifoliae and Radix Sanguisorbae 9 taste Chinese herbal medicine weight proportion scopes: 5 parts of 25 parts of Herba Artemisiae Annuaes, 15 parts of Fructus Carpesiis, 15 parts of Rhizoma Zingiberiss, 15 parts of Semen Torreyaes, 15 parts of the Radix Aucklandiae, 10 parts of Rhizoma Coptidis, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba anemones vitifoliaes and Radix Sanguisorbaes.
In the prescription of this invention, the pharmacology situation of each component is:
Herba Artemisiae Annuae: be the aerial parts of feverfew Herba Artemisiae annuae, clearing away heat and cooling blood, contains arteannuin, amaroid and volatilization wet goods medicinal ingredient, and Herba Artemisiae Annuae have powerful protozoacide effect.According to the literature, Herba Artemisiae Annuae to coccidiosis zygoblast and first and second in generation schizont there is certain inhibitory action.
Fructus Carpesii: be the fruit of feverfew Radix Carpesii.Phytomorph is " Radix Carpesii " bar in detail.Nature and flavor: toil, flat, poisonous.Function: parasite killing.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: acrid in the mouth, hot in nature; Return spleen, stomach, the heart, lung meridian.Function: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Semen Torreyae: this product is the dry mature seed of taxaceae plant Chinese torreya Torreya grandis Fort..Nature and flavor: sweet, flat; Return lung, stomach, large intestine channel.Function: killing insect and eliminating accumulation, moistening dryness for relaxing bowels.For ancylostome, ascarid, taeniasis, abdominal pain due to worm stagnation, constipation.
The Radix Aucklandiae: this product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Nature and flavor: pungent, bitter, temperature; Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Function: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C. Y. Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..Nature and flavor: hardship, cold; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle.
Radix Et Rhizoma Rhei: this product is polygonum rheum palmatum Rheum palmatum L.Nature and flavor: hardship, cold.Gui Jing: return spleen, stomach, large intestine, liver, pericardium channel.Function: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea.
Herba anemones vitifoliae: Ranunculaceae thimbleweed Herba anemones vitifoliae Anemone vitifolia Buch.-Ham., is used as medicine with root.Nature and flavor: hardship, cold.Slightly poisonous.Function: dispel the wind, dissipating blood stasis, dampness removing, anthelmintic.
Radix Sanguisorbae: be the dry root of rosaceous plant Radix Sanguisorbae Sanguisorba officinalis L. or Radix Sanguisorbae Sanguisorba off icinalis L.var.longifolia (Bert.) the Yu et Li that comes into leaves.Nature and flavor: bitter, acid, puckery, is slightly cold.Function: cooling blood for hemostasis, removing toxic substances sore.
The preparation method of the compound Chinese medicinal herb extract of this invention is: (1) takes crude drug according to the weight proportion of above-mentioned each crude drug and mixes, water extraction first, amount of water is crude drug 12 times, soaks water extraction after 120 minutes, extraction time is 2 hours, filtration; (2) secondary water extraction, amount of water is crude drug 6 times, extraction time is 1.5 hours, filters; (3) merge twice filtrate, and be concentrated into 0.8 times of weight of crude drug.
Compound Chinese medicinal herb extract of the present invention has the following advantages: (1) pure Chinese medicinal preparation, and the property of medicine is gentle, to intestinal mucosa nonirritant; (2) quick control rabbit coccidiosis, repairs intestinal mucosa; (3) spice administration, consumption is little, and per kilogram feedstuff medication 1ml, is used in conjunction 5 days; (4) efficacy stability, effect is lasting; (5) use continuously, do not produce drug resistance.
Detailed description of the invention
Be below embodiments of the invention, actual use of the present invention is not limited to embodiment.
embodiment 1
Take the 9.6kg mixing altogether of each crude drug according to the weight proportion of the weight ratio 22:13:13:13:13:8:8:3:3 of crude drug Herba Artemisiae Annuae, Fructus Carpesii, Rhizoma Zingiberis, Semen Torreyae, the Radix Aucklandiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Herba anemones vitifoliae, Radix Sanguisorbae, water extraction amount of water is 115.2kg first, soak water extraction after 120 minutes, extraction time is 2 hours, filter, again add 57.6kg water to carry out secondary water extraction, extraction time is 1.5 hours, filter, merge water extraction liquid twice, be concentrated into 7.68kg, make the compound Chinese medicinal herb extract of the treatment rabbit coccidiosis of this invention.
Compound Chinese medicinal herb extract prepared by the above method of application is tested in warren, Baoding, the rabbit generation disease in warren, Baoding in May, 2013, change and be judged as doubtful rabbit coccidiosis according to its epidemiology, clinical symptoms and dissection, add medicine 1ml of the present invention according to per kilogram feedstuff, be used in conjunction 5 days, cure rate has reached 85.89%.
embodiment 2
Adopt preparation method of the present invention to prepare compound Chinese medicinal herb extract, according to crude drug Herba Artemisiae Annuae, Fructus Carpesii, Rhizoma Zingiberis, Semen Torreyae, the Radix Aucklandiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Herba anemones vitifoliae, the weight proportion of the weight ratio 25:15:15:15:15:10:10:5:5 of Radix Sanguisorbae takes the 11.5kg mixing altogether of each crude drug, water extraction amount of water is 138kg first, soak water extraction after 120 minutes, extraction time is 2 hours, filter, again add 69kg water to carry out secondary water extraction, extraction time is 1.5 hours, filter, merge water extraction liquid twice, be concentrated into 9.2kg, make the compound Chinese medicinal herb extract of the treatment rabbit coccidiosis of this invention.
Pure Chinese herbal and crude drugs preparations prepared by the above method of application, in March, 2013 in Nanjing, the ground such as Wujin, Changzhou and Beijing amounts to 6 warrens and carried out clinical trial, 1211 rabbits that amount to that suffer from coccidiosis are treated, add medicine 1ml of the present invention according to per kilogram feedstuff, be used in conjunction 5 days, wherein after 912 rabbit medications, the 3rd day dysentery symptom obviously alleviate, within the 4th day, feces recovers normal substantially, separately there are 93 sick rabbits to occur being clearly better after 3 days in medication, treat after 5 days, improvement rate has reached 82.99%.
embodiment 3
Adopt preparation method of the present invention to prepare compound Chinese medicinal herb extract, according to crude drug Herba Artemisiae Annuae, Fructus Carpesii, Rhizoma Zingiberis, Semen Torreyae, the Radix Aucklandiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Herba anemones vitifoliae, the weight proportion of the weight ratio 28:17:17:17:17:12:12:7:7 of Radix Sanguisorbae takes the 13.4kg mixing altogether of each crude drug, water extraction amount of water is 160.8kg first, soak water extraction after 120 minutes, extraction time is 2 hours, filter, again add 80.4kg water to carry out secondary water extraction, extraction time is 1.5 hours, filter, merge water extraction liquid twice, be concentrated into 10.72kg, make the compound Chinese medicinal herb extract of the treatment dog bacterial diarrhea of this invention.
Compound Chinese medicinal herb extract prepared by the above method of application, in April, 2013 in Nanjing, the ground such as Zhenjiang and Yancheng amounts to 8 warrens and carried out clinical trial, the 1359 routine sick rabbits that amount to that suffer from coccidiosis are treated, add medicine 1ml of the present invention according to per kilogram feedstuff and feed, coordinate fluid infusion, antiphlogistic treatment simultaneously.Be used in conjunction 5 days, through statistics, wherein have all favourable prognosises of 1187 examples, effective percentage has reached 87.34%.
Comprehensive above visible, the compound Chinese medicinal herb extract of this invention has comparatively desirable therapeutic effect to the coccidiosis of controlling rabbit.
Claims (3)
1. prevent and treat the compound Chinese medicinal herb extract of rabbit coccidiosis for one kind, it is characterized in that being prepared from by Herba Artemisiae Annuae, Fructus Carpesii, Rhizoma Zingiberis, Semen Torreyae, the Radix Aucklandiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei, Herba anemones vitifoliae and Radix Sanguisorbae, the weight proportion scope of crude drug is: Herba Artemisiae Annuae 22-28 part, Fructus Carpesii 13-17 part, Rhizoma Zingiberis 13-17 part, Semen Torreyae 13-17 part, Radix Aucklandiae 13-17 part, Rhizoma Coptidis 8-12 part, Radix Et Rhizoma Rhei 8-12 part, Herba anemones vitifoliae 3-7 part and Radix Sanguisorbae 3-7 part.
2. the compound Chinese medicinal herb extract of control rabbit coccidiosis according to claim 1, is characterized in that the conventional weight proportion of crude drug is: 5 parts of 25 parts of Herba Artemisiae Annuaes, 15 parts of Fructus Carpesiis, 15 parts of Rhizoma Zingiberiss, 15 parts of Semen Torreyaes, 15 parts of the Radix Aucklandiae, 10 parts of Rhizoma Coptidis, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba anemones vitifoliaes and Radix Sanguisorbaes.
3. according to the preparation method of the compound Chinese medicinal herb extract of the control rabbit coccidiosis described in claim 1 and 2, it is characterized in that: (1) takes crude drug according to the weight proportion of above-mentioned each crude drug and mixes, water extraction first, amount of water is 12 times of crude drug weight, soak water extraction after 120 minutes, extraction time is 2 hours, filters; (2) secondary water extraction, amount of water is crude drug 6 times, extraction time is 1.5 hours, filters; (3) merge twice filtrate, and be concentrated into 0.8 times of weight of crude drug.
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| CN201410343807.5A CN104138591A (en) | 2014-07-19 | 2014-07-19 | Compound Chinese herbal extracting solution for preventing and treating rabbit coccidiosis and preparation method thereof |
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| CN201410343807.5A CN104138591A (en) | 2014-07-19 | 2014-07-19 | Compound Chinese herbal extracting solution for preventing and treating rabbit coccidiosis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143834A (en) * | 2018-02-10 | 2018-06-12 | 东兰县广元养殖专业合作社 | A kind of drug for preventing coccidiosis of rabbit and preparation method thereof |
-
2014
- 2014-07-19 CN CN201410343807.5A patent/CN104138591A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 邓裕贤: "中药防治兔球虫病的应用与前景", 《中国畜禽种业》 * |
| 陶岳荣等编著: "《科学养兔指南》", 31 August 2013 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143834A (en) * | 2018-02-10 | 2018-06-12 | 东兰县广元养殖专业合作社 | A kind of drug for preventing coccidiosis of rabbit and preparation method thereof |
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