A kind of colpitic Chinese medicine composition of the treatment containing Folium Artemisiae Argyi
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of colpitic Chinese medicine composition of the treatment containing Folium Artemisiae Argyi.
Background technology
Vaginitis is the inflammation of connective tissue under vaginal mucosa and mucosa, is the common disease of Out-patient Clinic of Department of Gynecology.Normal healthy women,
Due to anatomy and biochemical characteristics, vagina has nature defense function to the intrusion of pathogen, when the natural defense function of vagina
Destroyed, then pathogen is prone to invade, and causes colpitis.Vaginitis changes with the character of leucorrhea and outward clinically
Cloudy infections causalgia of itching is Major Clinical feature, and sexual anhedonia is the most common, infects when involving urethra, can have the symptom such as dysurea, urgent micturition.Often
The vaginitis seen has bacterial vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis.
Traditional Chinese medical herbal treatment gynaecopathia is to start with from Overall View, depressed liver-energy dispersing and QI regulating, strengthening the body resistance, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, clearly
Thermal detoxification." Complete Effective Prescriptions for Women " says: Mr. and Mrs people pudendal pruritus person, is that worm-eaten is done.Three worms are between the intestines and stomach, because of deficiency of five ZANG-organs,
Three worm actions, in ulceration at external genitals.Its worm makees heat, micro-, for itching, heavy then be bitterly the most also.Leukorrhagia too much refers to that woman's leukorrhagia amount substantially increases
Many, color, matter, abnormal smells from the patient are abnormal, or with local and General Symptoms person." female section brief points " propose leukorrhagia is too much to be lost by taste
Empty, yang-energy sink caused, advocates spleen invigorating yang invigorating leukorrhagia stopping.The Therapeutic Principle of primary disease is that assistant is with dampness removing heat extraction based on qi-restoratives righting.
It is in close relations that primary disease disease sends out many functional disorders dirty with liver,spleen,kidney three, and treatment should be tied to nurse one's health liver,spleen,kidney function
Close companion and see that symptom carries out the dialectical and side's of sending medication.
Chinese invention patent application 201410208508.0 discloses one and treats colpitic Chinese medicine composition and preparation method thereof,
This Chinese medicine includes following Chinese crude drug: Radix Angelicae Sinensis, Poria, Herba Leonuri, Herba Epimedii, the Rhizoma Pinelliae, Cortex Cinnamomi, Radix Ginseng Rubra, Rhizoma Atractylodis, Radix Saposhnikoviae,
Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Astragali, Semen Persicae.This Chinese medicine composition has certain curative effect to vaginitis, but easily recurs, therapeutic effect
Individual variation is bigger.
Summary of the invention
It is an object of the invention to overcome prior art not enough, it is provided that one can effectively treat colpitic Chinese medicine composition.
For realizing the purpose of the present invention, technical solution of the present invention is as follows:
A kind of colpitic Chinese medicine composition of the treatment containing Folium Artemisiae Argyi, including the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 20-25 part, Radix Angelicae Sinensis 18-22 part, Rhizoma Coptidis 18-22 part, Herba Corydalis Bungeanae 14-20 part, Fructus Perillae Frutescentis 12-18 part, Chinese scholartree
Flower 14-18 part, Herba Moslae 9-16 part, Folium Isatidis 8-13 part, Rhizoma Dioscoreae 8-13 part, Rhizoma Zingiberis 6-16 part and Radix Glycyrrhizae 5-15 part.
Preferably, Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 20 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Coptidis 18 parts, Herba Corydalis Bungeanae 14 parts, Fructus Perillae Frutescentis 12 parts, 14 parts of Flos Sophorae, Herba Moslae 9
Part, Folium Isatidis 8 parts, Rhizoma Dioscoreae 8 parts, Rhizoma Zingiberis 6 parts and 5 parts of Radix Glycyrrhizae.
It is further preferred that Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, Radix Angelicae Sinensis 22 parts, Rhizoma Coptidis 22 parts, Herba Corydalis Bungeanae 20 parts, Fructus Perillae Frutescentis 18 parts, 18 parts of Flos Sophorae, Herba Moslae 16
Part, Folium Isatidis 13 parts, Rhizoma Dioscoreae 13 parts, Rhizoma Zingiberis 16 parts and 15 parts of Radix Glycyrrhizae.
It is further preferred that Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 24 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Coptidis 20 parts, Herba Corydalis Bungeanae 18 parts, Fructus Perillae Frutescentis 17 parts, 17 parts of Flos Sophorae, Herba Moslae 14
Part, Folium Isatidis 10 parts, Rhizoma Dioscoreae 10 parts, Rhizoma Zingiberis 8 parts and 6 parts of Radix Glycyrrhizae.
Accordingly, the present invention also provides for a kind of described preparation method treating colpitic Chinese medicine composition containing Folium Artemisiae Argyi, including
Following steps:
Step 1, by Folium Artemisiae Argyi, Rhizoma Coptidis, Herba Corydalis Bungeanae, Rhizoma Zingiberis and Radix Glycyrrhizae decontamination, clean, dry, after pulverizing cross 100-200
Mesh sieve, obtains uniform fine powder;
Step 2, Radix Angelicae Sinensis, Fructus Perillae Frutescentis, Flos Sophorae, Herba Moslae, Folium Isatidis and Rhizoma Dioscoreae powder are broken into coarse powder;
Step 3, coarse powder step 2 prepared, add coarse powder weight 4-8 times amount water soaking 1-3 hour, and intense fire decocts boiling
15-45 minute, then with slow fire boiling 1-3 hour;Filtering, filtering residue adds coarse powder weight 2-4 times amount water, and intense fire decocts boiling 10-30
Minute, then with slow fire boiling 1-2 hour, filter, merge twice filtrate, filtrate is concentrated into relative density under 50-60 DEG C of environment and is
The concentrated solution of 1.10-1.20, drying under reduced pressure, cross 100-200 mesh sieve after pulverizing, obtain uniform fine powder;
Step 4, fine powder step 1 and step 3 made mix, and add suitable adjuvant, conventional with modern Chinese medicine compositions
Technique makes dosage form needed for clinic, such as capsule, tablet, pill, powder or granule etc..
The source of Chinese crude drug, nature and flavor used by Chinese medicine composition of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature;Return liver,spleen,kidney warp;Dispersing cold for relieving pain, temperature
Through hemostasis.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature;Return liver, the heart, spleen channel;Replenishing and activating blood,
Menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Bitter in the mouth, cold in nature;GUIXIN, spleen,
Stomach, liver, gallbladder, large intestine channel;Heat clearing and damp drying, eliminating fire and detoxication.
Herba Corydalis Bungeanae: the herb of Papaveraceae Genus Corydalis Herba Corydalis Bungeanae.Bitter in the mouth, cold in nature;GUIXIN, spleen channel;Heat-clearing and toxic substances removing, invigorates blood circulation
Detumescence.
Fructus Perillae Frutescentis: for the fruit of labiate common perilla.Acrid in the mouth, warm in nature;Return lung, spleen, large intestine channel;The therapeutic method to keep the adverse QI flowing downwards, expectorant, profit
Lung, wide intestinal.
Flos Sophorae: this product is the dry flower and alabastrum of leguminous plant Chinese scholartree.Bitter in the mouth, cold nature;Return liver, large intestine channel;Cooling blood for hemostasis,
Purging liver-fire.
Herba Moslae: this product is the dry aerial parts of labiate Mosla chinensis Maxim..Acrid in the mouth, slightly warm in nature;Attach to the lung and stomach meridians;Diaphoresis solution
Table, and middle dampness removing.
Folium Isatidis: this product is the dried leaves of cruciferae isatis.Bitter in the mouth, cold in nature;GUIXIN, stomach warp;Heat-clearing and toxic substances removing is cool
Blood speckle removing.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth, property is put down;Return lung, spleen, kidney channel;Spleen invigorating, tonifying the lung,
Reinforce the kidney, benefit essence.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber.Acrid in the mouth, property heat;Return spleen, stomach, kidney, the heart, lung meridian;Warming middle-JIAO dissipates
Cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down;GUIXIN, lung,
Spleen, stomach warp;Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese medicine composition of the present invention:
The Chinese medicine composition of the present invention foundation traditional Chinese medical science is to colpitic dialectical cognition, it then follows the compatibility theory of Chinese medicine, scientific compatibility, with
Time in order to make the preparation facilitating easy-to-use and stable curative effect, enhance the usage amount of medical material.Chinese medicine composition prescription of the present invention be with
Folium Artemisiae Argyi, Radix Angelicae Sinensis, Rhizoma Coptidis are monarch drug, antalgic, eliminating fire and detoxication;With Herba Corydalis Bungeanae, Fructus Perillae Frutescentis, Flos Sophorae as ministerial drug, removing heat from blood is only
Blood, purging liver-fire;With Herba Moslae, Folium Isatidis, Rhizoma Dioscoreae, Rhizoma Zingiberis as adjuvant drug, liver heat removing tonifying the lung, tonification warming middle-JIAO;With Radix Glycyrrhizae for making medicine,
The coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, complement each other, and synergism plays expelling wind and cold, heat clearing and damp drying altogether, the merit of eliminating fire and detoxication,
Vaginitis is had the most significant curative effect.
Compared with prior art, beneficial effect of the present invention is summarized as follows:
Chinese medicine composition the most of the present invention select natural herb, safety and stability, have no side effect, compatibility is suitable, have expelling wind and cold,
Heat clearing and damp drying, the effect such as eliminating fire and detoxication;
2. zoopery shows that Chinese medicine composition of the present invention, compared to the colpitic medicine of existing treatment, has and more preferably alleviates pain
Itching, resist the effect of inflammation, embodiment two and embodiment three all reach the effective percentage of 100%, show Chinese drug-treated group of the present invention
Compound effect on treatment vaginitis is notable;
Chinese medicine composition the most of the present invention medical treatment combines, evident in efficacy, has preferable potential applicability in clinical practice, in addition its preparation technology
Simple and easy to do, efficacy stability, it is easy to popularization and application.
Detailed description of the invention
Below will by specific embodiment, the present invention is described further, it will be understood by those skilled in the art that the present invention divided by
It may also be made that outside lower embodiment that other similar changing obtain similar result without deviating from present disclosure and scope.
Embodiment one
The embodiment of the present invention 1 Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 19 parts, the Radix Astragali 17 parts, Herba Lysimachiae 15 parts, Radix Aconiti Lateralis Preparata 14 parts, Ramulus Cinnamomi 12 parts, Radix Angelicae Sinensis 14 parts, Radix Paeoniae 9 parts,
Radix Angelicae Pubescentis 6 parts, Caulis Spatholobi 6 parts, Herba Taxilli 8 parts and 3 parts of Radix Glycyrrhizae;
Preparation method is as follows:
Step 1, by Folium Artemisiae Argyi, Rhizoma Coptidis, Herba Corydalis Bungeanae, Rhizoma Zingiberis and Radix Glycyrrhizae decontamination, clean, dry, after pulverizing cross 200 mesh sieves,
Obtain uniform fine powder;
Step 2, Radix Angelicae Sinensis, Fructus Perillae Frutescentis, Flos Sophorae, Herba Moslae, Folium Isatidis and Rhizoma Dioscoreae powder are broken into coarse powder;
Step 3, coarse powder step 2 prepared, add coarse powder weight 4 times amount water soaking 1 hour, and intense fire decocts boiling 15 points
Clock, then decoct 1 hour with slow fire;Filtering, filtering residue adds coarse powder weight 2 times amount water, and intense fire decocts boiling 10 minutes, then with civilian
Fire decocts 1 hour, filters, merges twice filtrate, and it is the concentrated solution of 1.10 that filtrate is concentrated into relative density under 50 DEG C of environment, subtracts
Pressure crosses 100 mesh sieves after dry, pulverize, and obtains uniform fine powder;
Step 4, fine powder step 1 and step 3 made mix, and add suitable adjuvant, conventional with modern Chinese medicine compositions
Technique makes powder.
Embodiment two
The embodiment of the present invention 2 Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 26 parts, the Radix Astragali 23 parts, Herba Lysimachiae 20 parts, Radix Aconiti Lateralis Preparata 20 parts, Ramulus Cinnamomi 18 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae 16 parts,
Radix Angelicae Pubescentis 13 parts, Caulis Spatholobi 13 parts, Herba Taxilli 16 parts and 12 parts of Radix Glycyrrhizae;
Preparation method is as follows:
Step 1, by Folium Artemisiae Argyi, Rhizoma Coptidis, Herba Corydalis Bungeanae, Rhizoma Zingiberis and Radix Glycyrrhizae decontamination, clean, dry, after pulverizing cross 200 mesh sieves,
Obtain uniform fine powder;
Step 2, Radix Angelicae Sinensis, Fructus Perillae Frutescentis, Flos Sophorae, Herba Moslae, Folium Isatidis and Rhizoma Dioscoreae powder are broken into coarse powder;
Step 3, coarse powder step 2 prepared, add coarse powder weight 8 times amount water soaking 3 hours, and intense fire decocts boiling 45 points
Clock, then with slow fire boiling 3 hours;Filtering, filtering residue adds coarse powder weight 4 times amount water, and intense fire decocts boiling 30 minutes, then uses
Slow fire boiling 2 hours, filters, merges twice filtrate, and it is the concentrated solution of 1.20 that filtrate is concentrated into relative density under 60 DEG C of environment,
Drying under reduced pressure, crosses 200 mesh sieves, obtains uniform fine powder after pulverizing;
Step 4, fine powder step 1 and step 3 made mix, and add suitable adjuvant, conventional with modern Chinese medicine compositions
Technique makes tablet.
Embodiment three
The embodiment of the present invention 3 Chinese medicine composition includes the Chinese crude drug of following weight portion:
Folium Artemisiae Argyi 25 parts, the Radix Astragali 22 parts, Herba Lysimachiae 18 parts, Radix Aconiti Lateralis Preparata 16 parts, Ramulus Cinnamomi 16 parts, Radix Angelicae Sinensis 15 parts, Radix Paeoniae 12 parts,
Radix Angelicae Pubescentis 12 parts, Caulis Spatholobi 10 parts, Herba Taxilli 10 parts and 5 parts of Radix Glycyrrhizae;
Preparation method is as follows:
Step 1, by Folium Artemisiae Argyi, Rhizoma Coptidis, Herba Corydalis Bungeanae, Rhizoma Zingiberis and Radix Glycyrrhizae decontamination, clean, dry, after pulverizing cross 200 mesh sieves,
Obtain uniform fine powder;
Step 2, Radix Angelicae Sinensis, Fructus Perillae Frutescentis, Flos Sophorae, Herba Moslae, Folium Isatidis and Rhizoma Dioscoreae powder are broken into coarse powder;
Step 3, coarse powder step 2 prepared, add coarse powder weight 6 times amount water soaking 2 hours, and intense fire decocts boiling 30 points
Clock, then with slow fire boiling 2 hours;Filtering, filtering residue adds coarse powder weight 2 times amount water, and intense fire decocts boiling 15 minutes, then uses
Slow fire boiling 1 hour, filters, merges twice filtrate, and it is the concentrated solution of 1.15 that filtrate is concentrated into relative density under 60 DEG C of environment,
Drying under reduced pressure, crosses 150 mesh sieves, obtains uniform fine powder after pulverizing;
Step 4, fine powder step 1 and step 3 made mix, and add suitable adjuvant, conventional with modern Chinese medicine compositions
Technique makes capsule.
Chinese medicine composition pharmacodynamic study of the present invention:
Test example: the Chinese medicine composition of the present invention impact on rabbit vagina inflammation
1, experiment purpose and method
According to the requirement of " new Chinese medicine pharmaceutical research guide ", study Chinese medicine composition of the present invention hypersensitive mainly in treatment
Pharmacodynamics.Take the embodiment of the present invention one to three gained Chinese medicine composition, observe its impact on vaginitis Rabbit Model.
Method: choose 70 vaginitis rabbit and 10 normal new zealand rabbits (are purchased from Changsha Nan Ke Bioisystech Co., Ltd;
6 ± 0.5 months ages of rabbit;Body weight is 2.5 ± 0.5Kg).Randomly select 50 Rabbits Models and be divided into five groups, respectively model group,
Positive controls, embodiment one group, embodiment two groups and embodiment three groups, often group 10;10 normal new zealand rabbits are
Normal group.The Chinese medicine composition embodiment of the present invention one to three prepared, makes drug solution, respectively gastric infusion
In embodiment one to three group, dosage is 120mg/Kg, every day 2 times, continuous 10 days;Positive controls institute drug is
Nystatin sheet (Lukang Medical Co., Ltd., Shandong produces, traditional Chinese medicines quasi-word H37022917), makes drug solution, fills
Stomach is administered, and dosage is 120mg/Kg, every day 2 times, continuous 10 days;Normal group, model group give same volume
Normal saline, administering mode is the same.
Remaining 20 Rabbits Models and divide equally two groups, respectively the height of embodiment three and low dose group, dosage is respectively
240mg/Kg, 60mg/Kg, foregoing embodiment three groups is middle dosage group, and administering mode is the same.
Successive administration 10 days, observes White Rabbit growth, active situation and pudendum cleaning situation the most afterwards, secondary after drug withdrawal
My god, aseptic cotton carrier takes vaginal secretions smear, carries out Ji's nurse Sa dyeing microscopic examination, by looking in several high power lens visual field under oil mirror
Number of white blood cells carry out vagina cleanness degree classification;Aseptic cotton carrier take vaginal secretions be seeded on selective medium cultivation run business into particular one
Detection in terms of mycology.Collection of specimens, during testing, is weighed in weekly once.
2, criterion
(1) vagina cleanness degree grade scale
Table 1 vagina cleanness degree grade scale
(2) vaginitis healing, improvement standard
Cure: vagina outward appearance is normal, and cleannes I level, without varied bacteria growing, pathologic finding is without inflammatory cell infiltration.
Taking a turn for the better: vagina outward appearance is normal, cleannes II level or I level, nothing or every plate 1~2 pathogenic bacterium colonies, pathologic finding is big
Cause normal.
Invalid: vagina outward appearance is red and swollen, cleannes III level or IV level, more than 2 pathogenic bacterium colonies of every plate, pathologic finding is abnormal.
(3) cure rate and efficient calculating
The number of animals of cure rate (%)=recovery from illness/total number of animals × 100% of each group
Effective percentage (%)=(recovery from illness+improvement number of animals)/total number of animals × 100% of each group
3, experimental result:
Table 2 Chinese medicine composition of the present invention rabbit is treated before and after the change of vagina cleanness degree and curative effect
Table 3 embodiment three Chinese medicine composition rabbit is treated before and after the change of vagina cleanness degree and curative effect
4, conclusion
The impact of vaginitis rabbit vagina cleannes is come by this experiment by the research embodiment of the present invention one to three gained Chinese medicine composition
Judge the Chinese medicine composition of the present invention effect in terms for the treatment of vaginitis.Administration group is administered for continuous 10 days, and none is dead for rabbit, place
Dead domestic rabbit dissection is observed except remaining each internal organs of pulmonary do not find toxic reaction, and rabbit body weight is also without significant change.
As shown in table 2 result, before treatment, the vagina cleanness degree of rabbit is III level or IV level, and after treatment, vagina cleanness degree transfers I to
Level and II level, effective percentage reaches 90%, wherein embodiment two groups and three groups of effective percentage of embodiment reach 100%, wherein best results
For embodiment three Chinese medicine composition.
Table 3 result shows, also can obtain significant curative effect with embodiment three Chinese medicine composition of low dosage, and middle and high dosage
Embodiment three Chinese medicine composition cure rate the highest (80%);Model group is without the animal of recovery from illness.Efficacy result illustrates, in the present invention
The curative effect that rabbit vagina is scorching is more affirmed by drug composition, and has certain safety.