CN105326692B - A kind of radioresistance moisturizing sun screen and preparation method thereof - Google Patents
A kind of radioresistance moisturizing sun screen and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
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Abstract
The invention belongs to cosmetic technical fields, and in particular to a kind of radioresistance moisturizing sun screen, the sun screen include the component of following weight percent meter:Water, butanediol, trehalose, allantoin, acrylamide dimethyltaurine ammonium/VP copolymers, dimethyl silicone polymer, isononanoic acid isononyl alcohol ester, tridecanol stearate, the hard ester alcohol of spermaceti (and) cetearyl glucoside, stearine (and) 100 stearates of PEG, mica, zinc oxide, barium sulfate, oat beta glucan, extract solution from aloe, Phenoxyethanol and methyl hydroxybenzoate.Radioresistance moisturizing sun screen of the present invention is effectively isolated electromagnetic radiation, skin-moisturizing, skin, and clear patch skin, safe and non-stimulating.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of radioresistance moisturizing sun screen and preparation method thereof.
Background technology
In daily life, computer, mobile phone, microwave, Wi-Fi ... are seen everywhere.Nowadays, each of us places oneself in the midst of electricity
Among the immanent encirclement of magnetic wave, it may be said that we are exactly to live in such a everywhere to have in the environment of radiation.Research
Show:Electromagenetic wave radiation is inhibited to the langerhans' cells in skin and dermal cell, causes corium confluent monolayer cells work(
The change of energy, it is very big to skin lesion, and belong to the injury of accumulation property, dark and gloomy skin, even aging, canceration can be caused.Such as skin
Contact computer, mobile phone, micro-wave oven etc. for a long time, langerhans' cells quantity can greatly reduce, and dermal cell activity reduces, and weaken
The defence immunocompetence of skin.
Electromagnetic radiation is classified as the fourth-largest environomental pollution source after water source, air, noise by the World Health Organization, into
To endanger the stealth " killer " of human health.It is former in 2005 Chinese residents common skin diseases of health ministry publication
Because in sequence, first place is occupied in electromagnetic radiation in city dweller, in the data announced in the World Health Organization, because radiation-induced
Skin cancer accounts for a quarter in global cutaneum carcinoma patient numbers.
Sun screen in the market usually with isolation ultraviolet, color make-up, bright color as the main purpose, and for long-time face
For the crowd of the products such as computer, mobile phone, in terms of isolating electromagnetic radiation the effect of, is insufficient, it is therefore desirable to which research and development are a kind of effectively
Radiation-resistant sun screen.
The leaf epidermis of plant is located at the outside of epidermal cell, is made of the cuticula and wax that deposit.Cuticula is substantially
Reticular structure in forming process, constantly has wax filling therebetween, these wax layers being filled in cuticula reticular structure are claimed
For interior wax coat;It forms the structure for there was only wax component again outside cuticula, is outer wax coat.Outer wax coat can generally be formed certainly
The wax crystal that I assembles.It is observed with scanning electron microscope, wax crystalline mi morphosis is in diversity.Plant Taxonomy
Often this wax layer structure for having specific microcosmic conformation is referred to as wax quilt for family.Leaf Epidermis wax component is complicated, is typically considered to
It is the mixture of a kind of organic substance.By means of gas chromatography-mass spectrum, researcher has found the fat that main ingredient is long-chain
Acid, alcohol, aldehyde, ester and n ~ alkane also have other such as cyclic terpene, phenols, sterol even carotenoids in certain plants epicutile wax
The ingredients such as element.
It is studied about the production wax defect mutant of corn such as the research of Leaf Epidermis wax radiation-resisting functional, Long
The radiation resistance of leaves of plants table wax layer, the results showed that:Compared with normal plant, the angles of corn plant leaves of wax is lacked from shape to something lost
It passes substance all to be significantly increased by the injury of ultraviolet light, a large amount of ultraviolet light can be absorbed by also demonstrating the leaf table wax of extraction;Wax
Leaf more than the matter leaf fewer than wax can absorb more ultraviolet lights.The research to various plants such as peas such as Robberecht
The result shows that:Leaf table wax has the radiation of ultraviolet light barrier action, and the only ultraviolet light less than 1% passes through leaf epidermis wax
Matter enters mesophyll.Holmes and Keiller has found that the wax layer of leaf table is higher than the epidermal hair reflection efficiency of leaf epidermis, and can be simultaneously
Reflect ultraviolet light (330nm) and photosynthesis absorb light (680nm), after removal wax leaf epidermis to the reflectivity of both light all
It has dropped, wherein the degree bigger declined to ultraviolet reflection rate.As it can be seen that Leaf Epidermis wax has good radioresistance,
But through retrieval, rarely seen Leaf Epidermis wax, especially application of the folium artemisiae argyi wax in cosmetics.
Invention content
For overcome the deficiencies in the prior art, the purpose of the present invention is to provide a kind of radioresistance moisturizing sun screens, have
Effect isolation electromagnetic radiation, skin-moisturizing, skin, and clear patch skin, it is safe and non-stimulating.
To achieve these goals, technical scheme is as follows:
A kind of radioresistance moisturizing sun screen includes the component of following weight percent meter:Water 45 ~ 80%, butanediol 2 ~ 8%,
Trehalose 1 ~ 4%, allantoin 0.05 ~ 0.5%, acrylamide dimethyltaurine ammonium/VP copolymers 0.2 ~ 2%, polydimethylsiloxanes
Alkane 1 ~ 5%, isononanoic acid isononyl alcohol ester 2 ~ 6%, tridecanol stearate 1 ~ 5%, the hard ester alcohol of spermaceti (and) cetearyl glucoside
0.5 ~ 3%, stearine (and) PEG-100 stearates 1 ~ 5%, mica 0.05 ~ 0.5%, zinc oxide 1 ~ 5%, barium sulfate 0.5
~ 3%, avenabeta glucosan 1 ~ 5%, extract solution from aloe 1 ~ 5%, Phenoxyethanol 0.1 ~ 0.2% and methyl hydroxybenzoate 0.1 ~ 0.3%.
In order to further enhance the radioresistance effect of sun screen of the present invention, the radioresistance moisturizing sun screen further includes folium artemisiae argyi
Wax 2 ~ 5% and Blumea oil 1 ~ 5%.
As the preferred embodiment of the present invention, the radioresistance moisturizing sun screen by following weight percent meter component
Composition:Folium artemisiae argyi wax 4%, Blumea oil 3%, water 66.25%, butanediol 5%, trehalose 1%, allantoin 0.15%, acrylamide diformazan
Base taurine ammonium/VP copolymers 0.2%, dimethyl silicone polymer 4%, isononanoic acid isononyl alcohol ester 3%, tridecanol stearate 2%,
The hard ester alcohol of spermaceti (and) cetearyl glucoside 1.5%, stearine (and) PEG-100 stearates 1%, mica
0.1%th, zinc oxide 3%, barium sulfate 1.5%, avenabeta glucosan 2%, extract solution from aloe 2%, Phenoxyethanol 0.1% and methyl hydroxybenzoate
0.1%。
Folium artemisiae argyi wax of the present invention and Blumea oil are made by following methods:Fresh folium artemisiae argyi is taken first, and column is filled after crushing;It connects
The medicinal material column installed with hexamethylene recycling elution, after having liquid discharge, surveys the flow velocity of lower efflux, after recycling elution 5BV,
Tail connects a silicagel column absorption and uses, and after continuing cycling through elution 3BV, removes medicinal material column, the hexamethylene in the medicinal material column that fanned the air with air pump,
The hexamethylene got, which is loaded in silicagel column, to be adsorbed;The last wax that hexamethylene is separately taken to rinse in silicagel column is to be eluted
After wash water color shoals, the hexamethylene in the column that fanned the air with air pump merges with eluent, after recycling hexamethylene with Rotary Evaporators
Obtain folium artemisiae argyi wax;With 20% Ethyl acetate-cyclohexane eluting silica gel column, after eluting 3BV, ethyl acetate in the column that fanned the air with air pump-
After hexamethylene, after recycling Ethyl acetate-cyclohexane with Rotary Evaporators, folium artemisiae argyi oil extractum is obtained;Folium artemisiae argyi oil extractum is added to point
In sub- distilling apparatus, isolated Blumea oil is distilled.
The present invention also provides the preparation methods of above-mentioned radioresistance moisturizing sun screen, include the following steps:
S1, Jiang Shui, butanediol, trehalose, allantoin and acrylamide dimethyltaurine ammonium/VP copolymers add in emulsification
In pot, 75 ~ 80 DEG C of stirrings are heated to being completely dissolved, obtain material A;
S2, by dimethyl silicone polymer, isononanoic acid isononyl alcohol ester, tridecanol stearate, the hard ester alcohol of spermaceti (and) whale
Wax stearyl glucoside, stearine (and) PEG-100 stearates, mica, zinc oxide and barium sulfate added in oil cauldron,
75 ~ 80 DEG C of stirrings are heated to being completely dissolved, obtain material B;
S3, the material B is pumped into the material A, stirred evenly, open homogeneous, constant temperature stirring, cooling;
S4,40 DEG C are cooled to, add in avenabeta glucosan, extract solution from aloe, Phenoxyethanol and methyl hydroxybenzoate, be sufficiently stirred
Uniformly, it cools down up to radioresistance moisturizing sun screen.
Further, the addition of folium artemisiae argyi wax and Blumea oil is further included in the step S2.
Folium artemisiae argyi wax of the present invention as a Leaf Epidermis wax can effective radioresistance, while also have profit
The effect of skin, antibacterial, skin of releiving;The barium sulfate is used as barium meal in medicine, can effectively stop that radiation passes through;The oxygen
It is a kind of wide spectrum screener to change zinc, has electrostatic screen and antistatic property;The avenabeta glucosan not only has sun-proof work
With and can reduce pain inflammation, moreover it is possible to langerhans' cells is promoted to be proliferated, the immunocompetence of skin can be enhanced.The folium artemisiae argyi wax
Matter, barium sulfate, zinc oxide combine collaboration with avenabeta glucosan, the electricity such as effective anti-radio wave, microwave, visible ray, ultraviolet light
Magnetic radiation, in conjunction with natural extracts such as Blumea oil, extract solution from aloe, potent skin-moisturizing, skin;Coordinate butanediol, seaweed again simultaneously
The matrix of the compositions such as sugar, allantoin and acrylamide dimethyltaurine ammonium/VP copolymers, obtain radioresistance moisturizing of the present invention every
Electromagnetic radiation, skin-moisturizing, skin, and clear patch skin be both effectively isolated from frost, it is safe and non-stimulating.
Therefore, compared with prior art, advantage of the invention is that:
(1)Radioresistance moisturizing sun screen of the present invention has good radiation resistance, can isolation ultraviolet, visible ray, nothing
The electromagnetic radiation such as line electric wave, microwave so as to reduce the radiation injury suffered by skin, reduce the radiation injury degree of skin, and system
Stablize, it is safe.
(2)Radioresistance moisturizing sun screen of the present invention is safe, nonirritant, and stay in grade contains folium artemisiae argyi wax, folium artemisiae argyi
The natural materials such as oil, avenabeta glucosan, extract solution from aloe clearly paste skin, effective radioresistance, while potent moisturizing, moisturizing.
(3)The raw material of radioresistance moisturizing sun screen of the present invention is easy to get, low manufacture cost, while preparation method is simple, technique
Stablize, there is good application prospect.
Specific embodiment
The present invention is further described, but the present invention is not limited only to following embodiment below by way of specific embodiment.
In the scope of the present invention or do not departing from present disclosure, in spirit and scope, to radioresistance moisturizing of the present invention every
It is suitably modified from frost, replaces the identical component of effect, it will become apparent to those skilled in the art that they are all
It is deemed to be included within the scope of the present invention.
The producer of part material and article No. are as follows in the embodiment of the present invention:
The formula of 1 ~ 4 radioresistance moisturizing sun screen of the embodiment of the present invention is as follows:
Wherein, the folium artemisiae argyi wax and Blumea oil are made by following methods:Fresh folium artemisiae argyi is taken first, by the folium artemisiae argyi after crushing
It is fitted into a 30L steel column;Then the medicinal material column installed with hexamethylene recycling elution after having liquid discharge, surveys lower efflux
Flow velocity, after recycling elution 5BV, the silicagel column absorption that tail meets a 20L is used, and after continuing cycling through elution 3BV, removes medicinal material column,
The hexamethylene to be fanned the air with air pump in medicinal material column, the hexamethylene got, which is loaded in silicagel column, to be adsorbed;Finally separately hexamethylene is taken to rinse
Wax in silicagel column, after the wash water color eluted shoals, the hexamethylene in the column that fanned the air with air pump is closed with eluent
And with Rotary Evaporators recycle hexamethylene after folium artemisiae argyi wax;With 20% Ethyl acetate-cyclohexane eluting silica gel column, 3BV is eluted
Afterwards, after the Ethyl acetate-cyclohexane to be fanned the air with air pump in column, after recycling Ethyl acetate-cyclohexane with Rotary Evaporators, folium artemisiae argyi is obtained
Oil extractum;Folium artemisiae argyi oil extractum is added in molecular distillation apparatus, distills isolated Blumea oil.
The preparation method of 1 ~ 4 radioresistance moisturizing sun screen of the embodiment of the present invention is as follows:
S1, Jiang Shui, butanediol, trehalose, allantoin and acrylamide dimethyltaurine ammonium/VP copolymers add in emulsification
In pot, 75 DEG C of stirrings are heated to being completely dissolved, obtain material A;
S2, by dimethyl silicone polymer, isononanoic acid isononyl alcohol ester, tridecanol stearate, the hard ester alcohol of spermaceti (and) whale
Wax stearyl glucoside, stearine (and) PEG-100 stearates, mica, zinc oxide and barium sulfate added in oil cauldron,
75 DEG C of stirrings are heated to being completely dissolved, obtain material B;
S3, the material B is pumped into the material A, stirred evenly, open homogeneous, constant temperature stirring, cooling;
S4,40 DEG C are cooled to, add in avenabeta glucosan, extract solution from aloe, Phenoxyethanol and methyl hydroxybenzoate, be sufficiently stirred
Uniformly, it cools down up to radioresistance moisturizing sun screen.
The addition of folium artemisiae argyi wax and Blumea oil is further included in the step S2.
Through 1 ~ 4 product of the embodiment of the present invention is examined to meet the pertinent regulations requirement of QB/T 1857-2013, sense index
(Color and luster, fragrance, structure)Meet industry regulation, physical and chemical index(PH, heat-resisting, cold-resistant, active matter)Meet industry with sanitary index
Regulation.
Comparative example one, the formula of two sun screens are as follows:
The folium artemisiae argyi wax of comparative example one, two and the preparation method of sun screen with reference to the moisturizing of radioresistance of the embodiment of the present invention every
Preparation method from frost.
Comparative example three
Formula of this comparative example sun screen and preparation method thereof is the same as embodiment 3.As different from Example 3:It ends preparing
When leaf wax and Blumea oil, hexamethylene is replaced using ethyl alcohol, 20% Ethyl acetate-cyclohexane is replaced by 20% ethyl acetate-second
Alcohol.
Test example one, radioresistance moisturizing sun screen ultraviolet injury resistant zoopery of the present invention
The mechanism of radiation injury is:Effects of ionizing radiation causes a series of freedom in organism biomembrane, enzyme, nucleic acid etc.
The injury response of base, lipid peroxide are body main radiativity poisonous substances after irradiation, and body not yet finds to appoint after irradiation
What damage when, it has just been generated, therefore, it be both radiation after product and aggravate radiation injury.Body defenses free radical
The protection system of lipid peroxidation injury is mainly enzyme scavenger:It is anti-in body including SOD, catalase (CAT) etc.
Oxidizing ferment is the anti-aging substance of " endogenous ".Antioxidant defense enzyme(Such as SOD)Activity, which reduces, can make Skin Cell presentation decline
Old state, senile cell is poor to the repair function of damage since metabolism slows down, and more easily causes light injury, accelerates skin aging.Third
Dialdehyde (MDA) is hurt due to organ senescence or under adverse environmental factor, and peroxidization occurs for tissue or organ membrane lipid
And generate, its content has substantial connection with aging and adverse circumstance injury.UV radiation generates a large amount of ROS, is having exceeded body just
Normal defence capability while antioxidase SOD and CAT in skin is consumed, attacks more insatiable hungers in phosphide on biomembrane film
And aliphatic acid, cause membrane lipid peroxidatio chain reaction, eventually lead to the increase of MDA contents.Ultraviolet light irradiation can induce membrane lipid
Peroxidization causes biomembrane and the damage of DNA.Therefore, the height of SOD contents and MDA contents in skin, determines skin
The size of degree of injury.
First, material and method
1st, animal:SD healthy rats 18,150 ± 30g of weight, half male and half female;Rat adapts to environment one week before experiment,
22-25 DEG C of raising temperature.
2nd, drug:According to the embodiment of the present invention 1,3, sun screen made of the raw material and method of comparative example one, three.
3rd, animal packet:6 groups are randomly divided into after rat back depilation, every group 3:
Blank control group:Back is without any processing, normal to feed;
Radiation patterns group:Back is without any processing, is radiated;
1 group of sun screen:Smear the sun screen 2.0gkg of embodiment 1 in back-1, radiated;
2 groups of sun screen:Smear the sun screen 2.0gkg of embodiment 3 in back-1, radiated;
3 groups of sun screen:Smear the sun screen 2.0gkg of comparative example one in back-1, radiated;
4 groups of sun screen:Smear the sun screen 2.0gkg of comparative example three in back-1, radiated.
2nd, experimental procedure:
1st, rat ultraviolet (UV) B is radiated:Rat is fixed on special plank, is shielded with lead, after exposing processing
Back, be irradiated with UVB therapeutic equipments, dosage 48mJ/cm2.After irradiation 2 days, rat is put to death, observes indices.
2nd, the SOD contents of each group rat skin sample:The quality of each group rat skin sample is weighed, adds in the physiology of precooling
Brine with glass homogenizer grinding and refrigerated centrifuge, is prepared into 10%(V/V)Tissue homogenate.With purchased from Shanghai Suo Laibao biologies
The superoxide dismutase of Science and Technology Ltd.(SOD)Assay kit simultaneously measures rat skin according to the requirement of kit specification
SOD contents in skin sample.With the malonaldehyde purchased from abundant Bioisystech Co., Ltd of upper Hisense(MDA)Assay kit and according to
The requirement of kit specification measures the MDA contents in rat skin sample.
3rd, rat skin Observation On The Morphology:The skin samples of each group rat are placed in formalin and fix 48 hours,
Ethyl alcohol is dehydrated step by step, and ultra-thin section and HE dyeing are carried out after paraffin embedding.
3rd, experimental result:
1st, SOD and MDA contents in each group rat skin, as a result see the table below 1.
SOD and MDA contents in 1 each group rat skin of table
Compared with blank control group, ##P < 0.01;Compared with radiation patterns group, * P < 0.05, * * P < 0.01.
From upper table 1:
(1)After partial radiation, the SOD contents in skin reduce certain model group rats compared with normal group
Level has significant difference(P < 0.01);And sun screen group rat is after partial radiation, the same model group of SOD contents in skin
It compares, there is significant difference(P < 0.05 or P < 0.01), can inhibit the suppression of the reduction of SOD contents, wherein 2 groups of sun screen
Effect processed is the most apparent;
(2)After partial radiation, the MDA contents in skin increase certain model group rats compared with normal group
Level has significant difference(P < 0.01);And sun screen group rat is after partial radiation, the same model group of MDA contents in skin
It compares, there is significant difference(P < 0.05 or P < 0.01), can inhibit the suppression of the raising of MDA contents, wherein 2 groups of sun screen
Effect processed is the most apparent.
2nd, rat skin Observation On The Morphology result:
(1)Blank control group rat skin structural integrity, epidermis and corium boundary line are clear, and epidermis is relatively regular, skin corium compared with
Thickness, dyeing is more uniform, and the cell number of plies is more;
(2)Radiation patterns group rat skin structure disturbance, is hard to tell epidermis and corium boundary line, dyeing is uneven and dyeing compared with
It is shallow;
(3)Sun screen 1,3,4 groups of rat skin structures are more complete than model group rats skin texture, and epidermis and corium boundary line are still
It can be seen that though epidermis unrest, skin corium is relatively regular, dyeing is more uniform;
(4)3 groups of rat skin structures of sun screen are significantly more complete than model group rats skin texture, and epidermis can with corium boundary line
It sees, epidermis is compared with sun screen 1,3,4 groups of rule, and skin corium is relatively regular, and dyeing is more uniform.
Above-mentioned testing result illustrates that radioresistance moisturizing sun screen of the present invention can reduce the radiation injury degree of rat skin, so as to
Prove that radioresistance moisturizing sun screen of the present invention can reduce the radiation injury suffered by rat skin, and safe, wherein containing
The radioresistance of the sun screen of the folium artemisiae argyi wax afforded by hexamethylene and Blumea oil is better, has to skin powerful
Radiation resistance.
The using effect of test example two, radioresistance moisturizing sun screen of the present invention
First, trial target:The sun screen that embodiment 2 ~ 4, comparative example two are prepared
2nd, tested crowd
Gender number:Female, 120 people
Age:Between 25 ~ 50 years old
Health status:Subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
Grouping:It is divided into 4 groups, every group of 30 people, every group of average age 29 ± 2 years old.
3rd, test method:The said goods on probation, are used continuously two weeks, observe and experience using effect.
4th, test assessment result is as follows:
The feedback conclusive table on probation of 2 embodiment of table, 2 radioresistance moisturizing sun screen
The feedback conclusive table on probation of 3 embodiment of table, 3 radioresistance moisturizing sun screen
The feedback conclusive table on probation of 4 embodiment of table, 4 radioresistance moisturizing sun screen
The feedback conclusive table on probation of 5 comparative example of table, two sun screen
From above-mentioned test result:
(1)The clear patch skin of radioresistance moisturizing sun screen of the present invention is shown according to the feedback on probation of subject, is not sticked after use
Greasy, moisture retention is good, and skin is moistened, and isolation effect is good;There is phenomena of cutaneous irritation in non-someone in the questionnaire of subject simultaneously.Implement
With the overall merit highest of 3 radioresistance moisturizing sun screen of embodiment in 2 ~ 4 radioresistance moisturizing sun screen of example, therefore, embodiment 3 is
The most preferred embodiment of radioresistance moisturizing sun screen of the present invention.
(2)The sun screen of comparative example two is free of extract solution from aloe and Blumea oil, and pro-skin and moistening effect are not as good as embodiment 2
~ 4, illustrate each component collaboration of the present invention.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (3)
1. a kind of radioresistance moisturizing sun screen, which is characterized in that be made of the component of following weight percent meter:Water 45 ~ 80%,
Butanediol 2 ~ 8%, trehalose 1 ~ 4%, allantoin 0.05 ~ 0.5%, acrylamide dimethyltaurine ammonium/VP copolymers 0.2 ~ 2%,
Dimethyl silicone polymer 1 ~ 5%, isononanoic acid isononyl alcohol ester 2 ~ 6%, tridecanol stearate 1 ~ 5%, cetostearyl alcohol and spermaceti are hard
Aliphatic radical glucoside 0.5 ~ 3%, stearine and PEG-100 stearates 1 ~ 5%, mica 0.05 ~ 0.5%, zinc oxide 1 ~ 5%,
Barium sulfate 0.5 ~ 3%, avenabeta glucosan 1 ~ 5%, extract solution from aloe 1 ~ 5%, Phenoxyethanol 0.1 ~ 0.2%, methyl hydroxybenzoate 0.1 ~
0.3%th, folium artemisiae argyi wax 2 ~ 5% and Blumea oil 1 ~ 5%;
The folium artemisiae argyi wax and Blumea oil are made by following methods:Fresh folium artemisiae argyi is taken first, and column is filled after crushing;Then hexamethylene is used
The medicinal material column that recycling elution installs after having liquid discharge, surveys the flow velocity of lower efflux, and after recycling elution 5BV, tail connects a silicon
Rubber column gel column absorption is used, and after continuing cycling through elution 3BV, removes medicinal material column, the hexamethylene in the medicinal material column that fanned the air with air pump, the hexamethylene got
Alkane is loaded in silicagel column and adsorbs;The last wax that hexamethylene is separately taken to rinse in silicagel column, wash water color to be eluted
After shoaling, the hexamethylene in the column that fanned the air with air pump merges with eluent, and folium artemisiae argyi wax is obtained after recycling hexamethylene with Rotary Evaporators
Matter;With 20% Ethyl acetate-cyclohexane eluting silica gel column, after eluting 3BV, the Ethyl acetate-cyclohexane in the column that fanned the air with air pump
Afterwards, after recycling Ethyl acetate-cyclohexane with Rotary Evaporators, folium artemisiae argyi oil extractum is obtained;Folium artemisiae argyi oil extractum is added to molecular distillation
In device, isolated Blumea oil is distilled.
2. radioresistance moisturizing sun screen as described in claim 1, which is characterized in that the radioresistance moisturizing sun screen is by following
The component composition of weight percent meter:Folium artemisiae argyi wax 4%, Blumea oil 3%, water 66.35%, butanediol 5%, trehalose 1%, allantoin
0.15%th, acrylamide dimethyltaurine ammonium/VP copolymers 0.2%, dimethyl silicone polymer 4%, isononanoic acid isononyl alcohol ester 3%,
Tridecanol stearate 2%, cetostearyl alcohol and cetearyl glucoside 1.5%, stearine and PEG-100 are stearic
Acid esters 1%, mica 0.1%, zinc oxide 3%, barium sulfate 1.5%, avenabeta glucosan 2%, extract solution from aloe 2%, Phenoxyethanol 0.1%
With methyl hydroxybenzoate 0.1%.
A kind of 3. method for preparing radioresistance moisturizing sun screen as described in claim 1, which is characterized in that including following step
Suddenly:
S1, Jiang Shui, butanediol, trehalose, allantoin and acrylamide dimethyltaurine ammonium/VP copolymers add in emulsification pot
In, 75 ~ 80 DEG C of stirrings are heated to being completely dissolved, and obtain material A;
S2, by folium artemisiae argyi wax, Blumea oil, dimethyl silicone polymer, isononanoic acid isononyl alcohol ester, tridecanol stearate, spermaceti
Stearyl alcohol and cetearyl glucoside, stearine and PEG-100 stearates, mica, zinc oxide and barium sulfate add
Enter in oil cauldron, be heated to 75 ~ 80 DEG C of stirrings to being completely dissolved, obtain material B;
S3, the material B is pumped into the material A, stirred evenly, open homogeneous, constant temperature stirring, cooling;
S4,40 DEG C are cooled to, add in avenabeta glucosan, extract solution from aloe, Phenoxyethanol and methyl hydroxybenzoate, be sufficiently stirred
It is even, it cools down up to radioresistance moisturizing sun screen.
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CN102488627A (en) * | 2011-12-31 | 2012-06-13 | 上海宝姿化妆品有限公司 | Radiation-resistant and moisture-retention make-up base, lotion and water |
CN104688662A (en) * | 2013-12-09 | 2015-06-10 | 吴胜 | Special anti-radiation make-up base cream for pregnant women |
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CN102488627A (en) * | 2011-12-31 | 2012-06-13 | 上海宝姿化妆品有限公司 | Radiation-resistant and moisture-retention make-up base, lotion and water |
CN104688662A (en) * | 2013-12-09 | 2015-06-10 | 吴胜 | Special anti-radiation make-up base cream for pregnant women |
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