CN1931122A - Nanometer skin-activating emulsion cosmetics and its prepn process - Google Patents
Nanometer skin-activating emulsion cosmetics and its prepn process Download PDFInfo
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Abstract
The present invention discloses one kind of nanometer skin-activating emulsion cosmetics, which is transparent oil-in-water micro emulsion cosmetics prepared with active components including ginsenoside, 3-amino propanol phosphate and vitamin C ethyl ether in 0.50-6.50 wt%, nanometer emulsion matrix in 77.00-95.00 wt% and supplementary material in 1.60-16.80 wt% and through mixing. The nanometer skin-activating emulsion cosmetics has high stability, high transdermal permeability and effects of protecting skin, nursing face, decreasing wrinkles, smoothening skin and delaying skin senility.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of cosmetics that contain natural plant extracts, particularly a kind of can skin care, strengthen skin activity, make it whippy nanometer skin-activating emulsion cosmetics.
Background technology
With advancing age, blood circulation of skin is bad, and adaptive capacity descends, the skin histology hypofunction, and the surface texture and the deep structure of skin change, the thinning of skin hardening, cuticle thickening and pigment increase; The composition of nature moisturizing factor has very big change, and moisture-keeping functions descends, and skin is dry because of hydropenia, because of oil starvation tarnishes; The connective tissue of corium changes, and becomes its softish outward appearance of skin disappearance by high resiliency and strong absorptive, and soluble collagen is rotten, and content descends, and lacks elasticity, loses tension force and sagging and wrinkle occurs.
Present commercially available cosmetics of a great variety, function is different, people are by adding some Chinese medicine, natural plant extracts or biological preparation in cosmetics, as Semen Vitis viniferae extract, Radix Polygoni Multiflori extract and superoxide dismutase etc., utilize the metabolism and the physiological structure of their biological activity adjustment skin, play effects such as resisting age of skin, anti-pigmentation to a certain extent.These cosmetics are cream frost, emulsion or certain liquid composite mostly, instability, and easily layering, the storage life is short.The viscosity of cream kind and emulsion class cosmetics is bigger, being applied in has kind of a greasy feeling on the skin, even can form a kind of air-locked film, is unfavorable for the release of metabolite of skin and the Transdermal absorption of active component, help growing of assorted bacterium, cause the generation of dermatosis.The viscosity of astringent is lower, can not well be attached on the skin, and moisture easily evaporates, and causes well skin permeation of its effective ingredient, its loss of activity, and bioavailability is lower.Skin surface has one deck horny layer, and it is that active component enters the intravital natural cover for defense, and some micromolecule can enter deep skin by hair follicle or corneocyte gap, can not enter deep skin but some macromole just are blocked in the outside.But nanometer emulsion particle diameter has good permeability for a short time, can help the absorption of active component, fine addressing the above problem.
Summary of the invention
At the defective and the deficiency of above-mentioned prior art, the purpose of this invention is to provide the nanometer skin-activating emulsion cosmetics that a kind of system is stable, viscosity is lower, solubilization is arranged.
A kind of nanometer skin-activating emulsion cosmetics of the present invention, it is to add some cosmetic active ingredients and adjuvant and the cosmetic composition that forms in nano-emulsion system substrate.Matrix system is to be emulsifying agent with the polyethenoxy ether class non-ionic surface active agent; With in caprylic/capric triglyceride, olive oil, vitamin E, Jojoba oil, isopropyl myristate, iso-octyl palmitate, the isopropyl palmitate one or more is oil phase; With the distilled water is water.With vitamin C ethylether, 3-aminopropanol phosphate ester and ginsenoside is active component.Adjuvant has CD-38 marine polysaccharide emollient, amino acid humectant, fruit acid skin care agent, essence, antiseptic and α-bisabolol.The vitamin C ethylether is by the Cu of restraint of tyrosinase
2+Activity is blocked melanic formation, effective freckle removing and whitening, and anti-inflammation, the repair cell activity promotes collagen protein to produce, and gives skin activity; The ginsenoside promotes horny layer degraded to make the cuticular layer attenuation, promotes the propagation metabolism of genetic horizon cell and collagen fiber, strengthens the resistance of skin, uvioresistant, the anti-coarse and effect of chapping; 3-aminopropanol phosphate ester improves the ossein synthesizing activity, is a kind of safe, wrinkle resistant raw material efficiently.
Each amounts of components of nanometer skin-activating emulsion cosmetics of the present invention is also groped experimental summary in a large number through the inventor and is drawn, and each amounts of components is for all to have curative effect preferably in following weight percentage ranges:
A kind of nanometer skin-activating emulsion cosmetics, it is to be made by following raw materials by weight percent:
The ginsenoside 0.50%～1.00%
3-aminopropanol phosphoesterase 30 .01%～2.50%
Vitamin C ethylether 0.01%～3.00%
Surfactant 10.00%～33.56%
Oil 2.00%～5.50%
Adjuvant 1.60%～16.80%
Water 50.00%～75.00%
The gross weight of above-mentioned raw materials is 100%.
Described glass or plastic containers.
Described non-ionic surface active agent is the polyoxyethylene ether castor oil hydrogenated.
Described oil is one or more in isopropyl myristate, Jojoba oil, caprylic/capric triglyceride, vitamin E, olive oil, isopropyl palmitate, the iso-octyl palmitate.
Described adjuvant is one or more in CD-38 marine polysaccharide emollient, amino acid humectant, fruit acid skin care agent, essence, antiseptic, the α-bisabolol.
Described water is distilled water.
Another object of the present invention provides the preparation method of nanometer skin-activating emulsion cosmetics, may further comprise the steps:
1) take by weighing each raw material active component, surfactant, a kind of oil or miscella, distilled water and adjuvant in proportion, standby;
2) with the ginsenoside in surfactant, a kind of oil or miscella and the active component at room temperature mixing as oil phase;
3) with water-soluble active ingredient 3-aminopropanol phosphate ester, vitamin C ethylether, adjuvant and the distilled water mixing of recipe quantity, as water;
4) stir oil phase rapidly in 20 ℃～30 ℃ water-baths, slowly drip water in the time of stirring, the continuous stirring is transparent liquid until system;
5) at room temperature the essence and the antiseptic of recipe quantity joined in the system, promptly obtain particle diameter less than the nano-emulsion of the 100nm product of making up;
With the made centrifugal 20min of nano-emulsion cosmetic product 75000r/min, reserved sample observing under 3.5 ℃ of refrigerators, 25 ℃, 37 ℃ and 60 ℃ conditions of room temperature is not all found breakdown of emulsion, flocculation and layering, and outward appearance does not have significant change.
Nanometer skin-activating emulsion cosmetics of the present invention, particle diameter are between 10～100nm, and its viscosity can be adjusted as required, help the absorption of active component, can make skin tender smooth, be rich in gloss and elasticity, can improve the stability and the quality of cosmetics again, tempting outward appearance is arranged.
Nanometer skin-activating emulsion cosmetics of the present invention, compared following advantage with existing cosmetics:
(1) preparation method is simple, and energy consumption is low, can not destroy the activity of active component in the course of processing;
(2) system is stable, and is not stratified, can preserve for a long time;
(3) have beautiful outward appearance, viscosity is lower, can adjust according to the personal considerations;
(4) solubilization is arranged, some active component can be solubilized in oil or the aqueous solution, long-time nothing precipitation;
(5) granule is less, and good permeability is arranged, and improves the utilization rate of active component;
(6) surface tension is low, and good adsorptivity is arranged.Water solublity and fat-soluble composition are arranged among the ginsenoside, after being made into microemulsion system, effective ingredient wherein enters different phases according to its partition coefficient, container in the granule can be adsorbed infiltration skin fast, nourish deep skin, material among the foreign minister is attached to skin surface, plays the effect of skin protection.
The specific embodiment
Below further set forth nanometer skin-activating emulsion cosmetics stability of the present invention and biological effect by testing example.
Test example 1 stability test
1, centrifugal acceleration test is to the influence of nanoemulsions stability
Get the present invention of making in right amount in centrifuge tube, sealing orifice is put in the high speed centrifuge, carries out centrifugally with the rotating speed of 7500r/min, still keeps clear through the centrifugal nanoemulsions of 20min, does not see the profit lamination, keeps original outward appearance.
2, light stability experiment
Nanometer skin-activating emulsion of the present invention is packed in the vial, and sealing places under the sight, and light at room temperature is according to 10d, in 1d, 3d, 5d, 10d sampling.The result shows that the present invention keeps the clear outward appearance, and color does not change, phenomenons such as no layering and breakdown of emulsion.
3, temperature stability experiment
Nanometer skin-activating emulsion of the present invention is sub-packed in several vials, and being placed at after the sealing keeps sample under 3.5 ℃ in refrigerator, 25 ℃, 37 ℃ and 60 ℃ conditions of room temperature investigates 3 months, and every 10d sampling is observed.The result shows that the present invention all keeps the outward appearance of clear, not breakdown of emulsion and layering under these four kinds of temperature conditions.
The 2 nanometer skin-activating emulsion cosmetics biological effect experiments of the present invention of test example
1, test material
Be subjected to the reagent thing: prepare nanometer skin-activating emulsion, commercially available ginsenoside's skin care item and moist skin-active breast according to the prescription of embodiment and method.
Experimental animal: 54 of the healthy 10 month female white mice of Kunming kind, body weight 38.8 ± 2.4g.
2, test method
In cleaning, ventilation, drying, under the room temperature condition, feed identical feedstuff.Be divided into experimental group and matched group at random, every group each 18, epilation is at the mouse back 16cm that loses hair or feathers before the experiment
2The nanometer skin-activating emulsion that contains the ginsenoside is smeared at the experimental mice back, every day 2 times; Matched group is smeared the commercially available ginsenoside's skin care item and the moist skin-active breast of equivalent, during respectively at medication the 10th, 20,30d, two groups each get 6 at random, gets its drug effect position skin after the cervical vertebra dislocation is put to death, and measures the content that is equal to area skin weight and hydroxyproline thereof.
The mensuration of skin weight: mice is tried the position skin edge and is cut off, and skin is peeled off naturally, removes the fat and the connective tissue of adhesion, lie on the rubber slab, the skin degree of tightness is the card punch sampling of 1.2cm with diameter in the raw, takes by weighing skin weight with the electronic balance precision.
The skin hydroxyproline content is measured: get the skin after weighing, and rinsing in cold saline, filter paper is wiped away dried, get in the beaker that 50mg places 10ml, skin is shredded, add cold saline to 5ml with the little shears of ophthalmology, carry out homogenate with Potter-Elvehjem Tissue Grinders, in frozen water, carry out.The homogenate for preparing skin hydroxyproline determination kit measurement.
3, result of the test
3.1 the comparison of equal area skin weight sees Table 1.
Table 1 ginsenoside nano-emulsion is to equal area skin weight influence (n=6)
| Administration time (d) | Ginsenoside's skin care item matched group (mg) | Moisten skin-active breast matched group (mg) | Nanometer skin-activating emulsion experimental group (mg) |
| 10 20 30 | 59.50±0.55 59.50±0.55 58.33±0.51 Δ | 62.50±0.55 65.33±0.52 Δ 67.50±0.54 Δ | 69.67±0.52 * 71.66±0.51 *Δ 72.50±0.54 *Δ |
Annotate: compare * P＜0.05 with negative and positive controls in the same time; Same group of different time compares Δ P＜0.05.
3.2 the comparison of light proline content sees Table 2 in the skin.
Table 2 ginsenoside nano-emulsion is to skin hydroxyl hydroxyproline content influence (n=6)
| Administration time (d) | Ginsenoside's skin care item matched group (μ g/mg) | Moisten skin-active breast matched group (μ g/mg) | Nanometer skin-activating emulsion experimental group (μ g/mg) |
| 10 20 30 | 6.33±0.52 6.83±0.40 Δ 6.00±0.32 | 7.16±0.41 7.33±0.51 7.66±0.52 | 8.00±0.50* 8.50±0.54* Δ 8.84±0.46* Δ |
Annotate: compare * P＜0.05 with negative and positive controls in the same time; Same group of different time compares Δ P＜0.05.
Experimental result shows that during medication 10d, skin weight and hydroxyproline content have increase trend, but not statistically significant.When medication 20d and 30d, compare with matched group, the skin weight and the hydroxyproline content of experimental group obviously increases (P＜0.05).
Observe the zest of the present invention in the experimentation, give a mark 0～0.4 according to skin irritation reaction standards of grading to skin.The result shows that the present invention is non-stimulated to animal and since animal to pungent than people sensitivity, can determine that it is to the effect of application on human skin nonirritant.
Nanometer skin-activating emulsion of the present invention can be with active component rapid permeability cortical tissue, cell stimulating activity, obviously increase hydroxyproline content in the skin, make the synthetic increase of collagen protein in the skin, and then the collagen fiber increase, the skin thickening, and by increasing the skin metabolism function, delaying decrepitude of skin makes skin high resilience gloss.
Further specify product of the present invention and preparation method below in conjunction with specific embodiment.
Embodiment 1
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 22.46g, isopropyl myristate 1.00g, olive oil 2.00g, vitamin E 1.00g, ginsenoside 0.70g, vitamin C ethylether 3.00g, CD-38 marine polysaccharide emollient 5.00g, amino acid humectant 4.05g, α-bisabolol 1.00g, distilled water 58.99g, rose essence 0.50g, outstanding agate 0.30g, standby.
2) with polyoxyethylene ether (40) castor oil hydrogenated, isopropyl myristate, olive oil, vitamin E and the ginsenoside of described weight at room temperature mixing as being oil phase.
3) with vitamin C ethylether, CD-38 marine polysaccharide emollient, amino acid humectant, α-bisabolol and the distilled water mixing of described weight as water.
4) stir oil phase rapidly in 30 ℃ of water-baths, slowly drip water in the time of stirring, the continuous stirring is transparent liquid until system.
5) at room temperature the rose essence and the Jie Ma of described weight joined in the system, promptly obtain particle diameter less than the nano-emulsion of the 100nm product of making up.
Embodiment 2
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 33.56g, myristic acid isopropyl ester 1.30g, olive oil 2.60g, vitamin E 1.30g, ginsenoside 1.00g, vitamin C ethylether 1.50g, CD-38 marine polysaccharide emollient 3.00g, amino acid humectant 2.00g, α-bisabolol 0.60g, distilled water 52.64g, rose essence 0.30g, outstanding agate 0.20g, standby.
2) other step is with embodiment 1.
Embodiment 3
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 20.13g, myristic acid isopropyl ester 2.14g, caprylic/capric triglyceride 2.14g, Jojoba oil 0.75g, ginsenoside 0.75g, 3-aminopropanol phosphate ester 2.50g, CD-38 marine polysaccharide emollient 3.00g, amino acid humectant 2.50g, α-bisabolol 0.30g, fruit acid skin care agent 1.89g, distilled water 63.40g, rose essence 0.25g, outstanding agate 0.25g, standby.
2) other step is with embodiment 1.
Embodiment 4
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 33.56g, myristic acid isopropyl ester 2.70g, caprylic/capric triglyceride 2.70g, Jojoba oil 0.90g, ginsenoside 1.00g, 3-aminopropanol phosphate ester 1.25g, CD-38 marine polysaccharide emollient 1.00g, amino acid humectant 0.10g, α-bisabolol 0.60g, fruit acid skin care agent 0.10g, distilled water 55.89g, rose essence 0.10g, outstanding agate 0.10g, standby.
2) other step is with embodiment 1.
Embodiment 5
1) take by weighing polyoxyethylene ether (40) Oleum Ricini 32.56g, myristic acid isopropyl ester 1.00g, Jojoba oil 0.90g, vitamin E 0.20g, ginsenoside 0.62g, CD-38 marine polysaccharide emollient 1.24g, amino acid humectant 2.01g, α-bisabolol 0.30g, distilled water 60.68g, rose essence 0.25g, outstanding agate 0.25g, standby.
2) other step is with embodiment 1.
Embodiment 6
1) take by weighing polyoxyethylene ether (40) Oleum Ricini 22.46g, myristic acid isopropyl ester 1.00g, Jojoba oil 0.90g, vitamin E 0.20g, ginsenoside 1.00g, CD-38 marine polysaccharide emollient 4.00g, amino acid humectant 4.00g, α-bisabolol 1.00g, distilled water 64.94g, rose essence 0.25g, outstanding agate 0.25g, standby.
2) other step is with embodiment 1.
Embodiment 7
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 22.40g, isopropyl palmitate 6.00g, ginsenoside 0.75g, vitamin C ethylether 1.50g, 3-aminopropanol phosphate ester 1.25g, CD-38 marine polysaccharide emollient 3.08g, amino acid humectant 4.05g, α-bisabolol 0.30g, distilled water 60.07g, rose essence 0.30g, outstanding agate 0.30g, standby.
2) other step is with embodiment 1.
Embodiment 8
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 14.00g, isopropyl palmitate 2.00g, ginsenoside 0.50g, CD-38 marine polysaccharide emollient 5.00g, amino acid humectant 8.00g, α-bisabolol 1.20g, distilled water 68.50g, rose essence 0.50g, outstanding agate 0.30g, standby.
2) other step is with embodiment 1.
Embodiment 9
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 33.56g, isopropyl palmitate 4.00g, ginsenoside 1.00g, vitamin C ethylether 3.00g, 3-aminopropanol phosphate ester 2.50g, CD-38 marine polysaccharide emollient 1.00g, amino acid humectant 0.10g, α-bisabolol 0.20g, distilled water 54.44g, rose essence 0.10g, outstanding agate 0.10g, standby.
2) other step is with embodiment 1.
Embodiment 10
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 22.40g, iso-octyl palmitate 3.75g, ginsenoside 0.75g, CD-38 marine polysaccharide emollient 3.00g, amino acid humectant 4.05g, α-bisabolol 0.60g, distilled water 67.70g, rose essence 0.30g, outstanding agate 0.20g, standby.
2) other step is with embodiment 1.
Embodiment 11
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 14.00g, iso-octyl palmitate 5.50g, ginsenoside 1.00g, CD-38 marine polysaccharide emollient 5.00g, amino acid humectant 8.00g, α-bisabolol 1.00g, distilled water 64.70g, rose essence 0.50g, outstanding agate 0.30g, standby.
2) other step is with embodiment 1.
Embodiment 12
1) take by weighing polyoxyethylene ether (40) castor oil hydrogenated 33.56g, iso-octyl palmitate 2.00g, ginsenoside 0.50g, CD-38 marine polysaccharide emollient 1.00g, amino acid humectant 0.10g, α-bisabolol 0.20g, distilled water 62.44g, rose essence 0.10g, outstanding agate 0.10g, standby.
2) other step is with embodiment 1.
Claims (7)
1. nanometer skin-activating emulsion cosmetics is characterized in that it is to be made by following weight percentages:
The ginsenoside 0.50%～1.00%
3-aminopropanol phosphoesterase 30 .01%～2.50%
Vitamin C ethylether 0.01%～3.00%
Surfactant 10.00%～33.56%
Oil 2.00%～5.50%
Adjuvant 1.60%～16.80%
Water 50.00%～75.00%
The gross weight of above-mentioned raw materials is 100%.
2. cosmetics according to claim 1 is characterized in that, described glass or plastic containers.
3. cosmetics according to claim 2 is characterized in that, described non-ionic surface active agent is the polyoxyethylene ether castor oil hydrogenated.
4. cosmetics according to claim 1 is characterized in that, described oil is more than any one or two kinds of in isopropyl myristate, Jojoba oil, caprylic/capric triglyceride, vitamin E, olive oil, isopropyl palmitate, the iso-octyl palmitate.
5. cosmetics according to claim 1 is characterized in that, described adjuvant is more than any one or two kinds of in CD-38 marine polysaccharide emollient, amino acid humectant, fruit acid skin care agent, essence, antiseptic, the α-bisabolol.
6. cosmetics according to claim 1 is characterized in that described water is distilled water.
7. the preparation method of the described nanometer skin-activating emulsion cosmetics of claim 1 may further comprise the steps:
1) take by weighing each raw material active component, surfactant, a kind of oil or miscella, distilled water and adjuvant in proportion, standby;
2) with the ginsenoside in surfactant, a kind of or miscella and the active component at room temperature mixing as oil phase;
3) with water-soluble active ingredient 3-aminopropanol phosphate ester, vitamin C ethylether, adjuvant and the distilled water mixing of recipe quantity, as water;
4) stir oil phase rapidly in 20 ℃～30 ℃ water-baths, slowly drip water in the time of stirring, the continuous stirring is transparent liquid until system;
5) at room temperature the essence and the antiseptic of recipe quantity joined in the system, promptly obtain the nanometer skin-activating emulsion cosmetics of particle diameter less than 100nm.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006101045931A CN100528127C (en) | 2006-09-18 | 2006-09-18 | Nanometer skin-activating emulsion cosmetics and its preparation process |
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| CNB2006101045931A CN100528127C (en) | 2006-09-18 | 2006-09-18 | Nanometer skin-activating emulsion cosmetics and its preparation process |
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| CN1931122A true CN1931122A (en) | 2007-03-21 |
| CN100528127C CN100528127C (en) | 2009-08-19 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664369B (en) * | 2009-05-27 | 2011-04-20 | 董萍 | Trimethylglyine compound nanoemulsion used for nourishing and moisturizing skin and preparation method thereof |
| CN103445998A (en) * | 2012-05-29 | 2013-12-18 | 山东轻工业学院 | Skin whitening composition |
| CN103462846A (en) * | 2013-09-17 | 2013-12-25 | 吉林大学 | Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof |
| CN103598994A (en) * | 2013-11-06 | 2014-02-26 | 苏州冉新生物技术有限公司 | Whitening freckle-removing paste |
| CN103598996A (en) * | 2013-11-04 | 2014-02-26 | 苏州冉新生物技术有限公司 | Spot-fading essence |
| CN108524347A (en) * | 2017-12-28 | 2018-09-14 | 花安堂生物科技集团有限公司 | A kind of moisture saver mask and preparation method thereof |
| CN109223582A (en) * | 2018-10-31 | 2019-01-18 | 延边大学 | Diol type ginsenoside nano-emulsion with anti aging effect function and preparation method thereof |
| CN111603431A (en) * | 2020-06-28 | 2020-09-01 | 西安文理学院 | A skin aging resisting emulsion containing cornu Cervi Pantotrichum and its preparation method |
-
2006
- 2006-09-18 CN CNB2006101045931A patent/CN100528127C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664369B (en) * | 2009-05-27 | 2011-04-20 | 董萍 | Trimethylglyine compound nanoemulsion used for nourishing and moisturizing skin and preparation method thereof |
| CN103445998A (en) * | 2012-05-29 | 2013-12-18 | 山东轻工业学院 | Skin whitening composition |
| CN103462846A (en) * | 2013-09-17 | 2013-12-25 | 吉林大学 | Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof |
| CN103598996A (en) * | 2013-11-04 | 2014-02-26 | 苏州冉新生物技术有限公司 | Spot-fading essence |
| CN103598994A (en) * | 2013-11-06 | 2014-02-26 | 苏州冉新生物技术有限公司 | Whitening freckle-removing paste |
| CN108524347A (en) * | 2017-12-28 | 2018-09-14 | 花安堂生物科技集团有限公司 | A kind of moisture saver mask and preparation method thereof |
| CN109223582A (en) * | 2018-10-31 | 2019-01-18 | 延边大学 | Diol type ginsenoside nano-emulsion with anti aging effect function and preparation method thereof |
| CN111603431A (en) * | 2020-06-28 | 2020-09-01 | 西安文理学院 | A skin aging resisting emulsion containing cornu Cervi Pantotrichum and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN100528127C (en) | 2009-08-19 |
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