CN105325413A - Bactericidal composition containing mandipropamid and bromothalonil - Google Patents
Bactericidal composition containing mandipropamid and bromothalonil Download PDFInfo
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- CN105325413A CN105325413A CN201510719604.6A CN201510719604A CN105325413A CN 105325413 A CN105325413 A CN 105325413A CN 201510719604 A CN201510719604 A CN 201510719604A CN 105325413 A CN105325413 A CN 105325413A
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- bromothalonil
- mandipropamid
- bactericidal composition
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Abstract
The invention discloses a bactericidal composition containing mandipropamid and bromothalonil. The effective components are the mandipropamid and the bromothalonil, the weight part ratio of the mandipropamid to the bromothalonil is 1:10-10:1, and the total weight percentage of the mandipropamid and the bromothalonil in the bactericidal composition is 1%-90%. According to the demands of practical application, the bactericidal composition can be prepared into one of water emulsion, micro-emulsion, a suspending agent, wettable powder and water dispersible granules and has the obvious synergistic effect on cucumber downy mildew, a cucumber bacterial angular leaf spot disease and other diseases, the using dosage of a pesticide is reduced, the pesticide cost is reduced, the service life of the pesticide is prolonged, and the adverse impact of the pesticide on the ecological environment is reduced.
Description
Technical field
The bactericidal composition that the present invention relates to is with mandipropamid and bromothalonil for active ingredient, for preventing and treating cucumber downy mildew, cucumber bacterial angular leaf spot.
Background technology
The resistance problem of agricultural disease is a global problem, is the emphasis problem that agricultural science and technology worker pays close attention to always.Along with the continuity year in year out of disease chemical control, the increase of Pesticide use amount and not scientifical use agricultural chemicals, germ resistance is day by day serious, and the germ kind producing resistance is on the increase.Meanwhile, the use agricultural chemicals of high strength, causes Practice for Pesticide Residue in Agricultural Products to exceed standard, environmental pollution and the increase of peasant's drug cost etc., is unfavorable for agricultural sustainable development.Therefore, the bactericide agricultural chemicals of efficient, the low toxicity of research and development, environmental protection has positive effect to agricultural sustainable development.
Mandipropamid, English name: mandipropamid, chemical name: 2-(the chloro-phenyl of 4-)-N-[2-(3-methoxyl group-4-(2-propargyl alcoholate)-phenyl)-ethyl group]-2-(2-propargyl alcoholate)-with acid amides; Mandipropamid belongs to CAA series bactericidal agent, good preventive effect is had by the microbial leaf diseases of Oomycete cause of disease to the overwhelming majority, to the spore being in the sprouting stage, there is high activity, the formation of mycelial growth and spore can being suppressed in addition, having stronger therapeutic action to being in preclinical plant disease.Mandipropamid, to the special efficacy such as cucumber downy mildew, potato late blight, also has activity to cucumber bacterial angular leaf spot.Because the wax coat of leaf table has good affinity to this medicine, so mandipropamid has extraordinary lasting effect.
Bromothalonil, English name: bromothalonil, the bromo-2 bromomethyl glutaronitriles of chemical name: 2-; Bromothalonil is a kind of wide spectrum, low toxicity, mildew-resistant, algae-killing bactericidal agent, can suppress and root out the growth of bacterium, fungi and algae, is applicable to that textile, leather etc. are anticorrosion, mildew-resistant, water for industrial use algae removal.Have good control efficiency to corps diseases, have special efficacy especially to anthracnose, to bacterial disease as bacterial angular leaf spot, bacterial wilt, wildfire etc. also have very high activity, the downy mildew caused lower bacteria is also effective.
The gourd vegetable crops such as cucumber usually can be subject to infecting of multiple diseases in planting process.Wherein, downy mildew and bacterial angular leaf spot are two main diseases, and usually mix generation, and the disease symptom of two kinds of diseases is extremely similar, and grower is difficult to resolution and causes pesticide control mistake in.The present invention will prevent and treat the compound of downy mildew and bacterial angular leaf spot, and be made into the composite preparation simultaneously can preventing and treating above-mentioned two kinds of diseases, a drug just can be dealt with problems, high-efficiency environment friendly, saving.
The mixture of different pesticide species is the common methods of control agricultural pest.Being screened by formulation of pesticide, filter out rational formula, can effectively improve actual control efficiency, reduce dosage, reduce costs, delay the drug-fast generation of damage by disease and insect, is the important means that agricultural synthesis is administered.The recipe determination of the present inventor to mandipropamid and bromothalonil conducts in-depth research, and finds that mandipropamid and bromothalonil carry out mixture and have obvious synergistic effect in certain mixed ratio scope to multiple fungi, after further study, completes the present invention.
Composition and the application of mandipropamid and bromothalonil there is no report at present.
Summary of the invention
The object of the invention is to: overcome that dosage in prior art is large, cost is high, large to ecotope harm, to shortcomings such as crop safety are low, there is provided a kind of efficient, low toxicity, safety, environmental protection, drug cost is low, has the bactericidal composition of notable synergistic effect.
Another object of the present invention is used for preventing and treating cucumber downy mildew, cucumber bacterial angular leaf spot by this bactericidal composition.
For achieving the above object, the technical solution adopted in the present invention is: a kind of bactericidal composition containing mandipropamid and bromothalonil, active ingredient is mandipropamid and bromothalonil, the ratio of weight and number of mandipropamid and bromothalonil is 1:10 ~ 10:1, and mandipropamid and bromothalonil weight summation in the composition percentage by weight are 1% ~ 90%.
Bactericidal composition of the present invention according to well known to a person skilled in the art method, can select suitable usual auxiliaries, is mixed with the application forms of the applicable agricultural uses such as aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules.
The usual auxiliaries of bactericidal composition of the present invention also containing pesticidal preparations, comprise one or more mixing in solvent, emulsifier, wetting agent, stabilizing agent, dispersant, thickener, defoamer, antifreezing agent, disintegrant, binding agent, filler, filler, medium etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
Bactericidal composition of the present invention, for preventing and treating plant disease agriculturally, is particularly useful for preventing and treating cucumber downy mildew, cucumber bacterial angular leaf spot.
, early stage or the use of disease initial stage of origination should be there is in disease when applying in bactericidal composition of the present invention.
Bactericidal composition of the present invention, usually adopts the method for spraying to use, also can adopt other operation techniques agriculturally applied as required.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, obvious synergy or summation action is shown in certain ratio range, the control efficiency of composition to germ is significantly improved than single dose, reduce the using dosage of agricultural chemicals, decrease times for spraying, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope.
2, bactericidal composition provided by the invention, the combination of two kinds of effective ingredients, expands fungicidal spectrum, and a drug can solve various crop disease problem, compensate for defect when single dose uses and limitation.
3, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and it applies huge economic benefit and social benefit.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Embodiment 1:22% mandipropamid bromothalonil suspending agent.
Concrete operation step is: first mixed by other auxiliary agent, and in clipper, shear-mixed is even, then adds mandipropamid and bromothalonil, in ball crusher, grinds 2-3h, make a diameter all at below 5mm, can obtain 22% mandipropamid bromothalonil suspending agent.
Embodiment 2:20% mandipropamid bromothalonil aqueous emulsion.
Concrete operation step is: first mandipropamid and bromothalonil, trimethylbenzene, Sorbitan fatty acid ester are mixed, and dissolves and becomes uniform oil phase.Again part water and other auxiliary agents are mixed, dissolve and become uniform aqueous phase.Then oil phase is added aqueous phase while high-speed stirred in a kettle., slowly add water to and reach phase inversion point, carry out high speed shear afterwards, and add remaining water, shear about 30min, 20% mandipropamid bromothalonil aqueous emulsion can be obtained.
Embodiment 3:18% mandipropamid bromothalonil microemulsion.
Concrete operation step is: first mandipropamid and bromothalonil fatty acid methyl ester are dissolved completely, and then add other auxiliary agent, mix, finally add water, after fully stirring, can obtain 18% mandipropamid bromothalonil microemulsion.
Embodiment 4:30% mandipropamid bromothalonil wetting powder.
Concrete operation step is: mandipropamid and bromothalonil, other auxiliary agent are fully stirred in stirred tank, mixes, can obtain 30% mandipropamid bromothalonil wetting powder after airslide disintegrating mill is pulverized.
Embodiment 5:60% mandipropamid bromothalonil water dispersible granule.
Concrete operation step is: mandipropamid and bromothalonil, other auxiliary agent are mixed, pulverize with micro jet, add after mediating after carrying out granulation, drying, screening in fluidized-bed granulation dryer, 60% mandipropamid bromothalonil water dispersible granule can be obtained.
Embodiment 6: bioassay test one.
Cucumber bacterial angular leaf spot test is with reference to " pesticide bioactivity evaluates SOP ", raw survey standard method NY/T1156.16-2008 and NY/T1156.6-2006.Adopt turbidity method: being diluted by the cucumber bacterial angular leaf spot bacterial classification sterile water of the growth of cultivating in advance in NA medium slant is 1 × 10
7the suspension of individual spore/mL concentration, inoculates 100 μ L bacterium liquid respectively in the NB medium treatment of each pastille, and vibrate at being placed in 28 DEG C (120r/min) cultivates, and often 4 repetitions are established in process.Measure the turbidity of each process respectively before starting to cultivate, when control treatment reaches exponential phase, measure and record the turbidity of each process.
According to survey data, calculate the growth inhibition ratio of bacterium, represent with percentage (%) by formula (1), result of calculation retains 2 significant digits.
In formula:
P--growth inhibition ratio;
A
0--blank turbidity value added;
A
1--chemicals treatment turbidity value added.
Synegism evaluation method surveys standard method NY/T1156.6-2006 with reference to raw, the synergistic effect of pharmacy mix is evaluated according to the co-toxicity coefficient method (CTC) of Sun & Johnson (1960), namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC >=120 are synergistic effect.
The percentage composition of the toxicity index × 100 mixture Chinese medicine of the percentage composition+medicament B of A medicament in toxicity index × 100 mixture of theoretical toxicity index (the TTI)=medicament A of mixture
All test datas all adopt DPS statistical software to analyze.The growth inhibition ratio (%) of bacterium is calculated according to test data, and be independent variable x with the logarithm value of drug concentration (mg/L), with the growth inhibition ratio of bacterium for dependent variable y, obtain virulence regression equation formula, correlation coefficient (r), EC
50and EC
90and 95% confidence limit.
Table 1, indoor joint toxicity measuring result to cucumber bacterial angular leaf spot germ.
As can be seen from Table 1, it is 134.84,140.94,141.68,124.00,129.84,131.30,129.30 that mandipropamid and bromothalonil combine cucumber bacterial angular leaf spot germ CTC value with 10:1,5:1,3:1,1:1,1:3,1:5,1:10 respectively, illustrates that mandipropamid and bromothalonil combination have synergistic effect to cucumber bacterial angular leaf spot germ.
Embodiment 7: bioassay test two.
Cucumber downy mildew test adopts field Cucumis sativus stem leaf spray-on process dispenser (having water membrane to be advisable with blade surface), spraying process is carried out on February 25th, 2015, chemical sprayer tool adopts manual sprayer (liquid capacity is about 2.0L), every 10 days spray medicines once, continuous spraying 2 times.Often process selects climing 20 blades of uniform melon of falling ill as efficacy of medicine observing object, and each process repeats for 3 times.
Investigation method
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
According to survey data, calculate disease index and the control efficiency of each process.
Disease index presses formulae discovery, and result of calculation retains 2 significant digits:
When carrying out drug combination toxicity test, this test adopts Wadley method to calculate the coefficient of synergism (SR) of mixture, evaluates the synergy type of mixture.
Wadley method: the synergistic effect evaluating pharmacy mix according to coefficient of synergism (SR), namely SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR>1.5 is synergistic function.Coefficient of synergism (SR) calculates by formula (1), (2):
In formula:
X1--mixture EC
50theoretical value, unit is milligrams per liter (mg/L);
P
a--the percentage composition of A in mixture, unit is percentage (%);
P
b--the percentage composition of B in mixture, unit is percentage (%);
The EC of A in A--mixture
50value, unit is milligrams per liter (mg/L);
The EC of B in B--mixture
50value, unit is milligrams per liter (mg/L).
In formula:
The coefficient of synergism of SR--mixture;
The EC of X1--mixture
50theoretical value, unit is milligrams per liter (mg/L);
The EC of X2--mixture
50measured value, unit is milligrams per liter (mg/L).
Table 2, joint toxicity measuring result to cucumber downy mildew germ.
As can be seen from Table 2, it is 1.11,1.08,1.20,1.25,1.05,1.09 and 1.14 that mandipropamid and bromothalonil combine cucumber downy mildew germ SR value with 10:1,5:1,3:1,1:1,1:3,1:5,1:10 respectively, illustrates that mandipropamid and bromothalonil combination have synergistic effect to cucumber downy mildew germ.
Embodiment 8: control cucumber downy mildew, bacterial angular leaf spot field trial.
Test site is positioned at Ma An town, Huizhou, adopts spray-on process.Adopt 23.4% mandipropamid suspending agent, 25% bromothalonil missible oil medicament in contrast, 9 chemicals treatment are established in test altogether, each process repeats for 4 times, the sick number of sheets of cucumber is investigated before dispenser, within after dispenser 3 days, 7 days, respectively investigate a control efficiency, record the disease number of sheets, calculate control efficiency, result of the test is as shown in table 3.
Table 3, control cucumber downy mildew, bacterial angular leaf spot result of the test (after medicine 7 days)
As can be seen from Table 3, mandipropamid and bromothalonil mixing rear defence control cucumber downy mildew, the average aggregate preventive effect of bacterial angular leaf spot is better than the process of each contrast single dose, illustrate that mandipropamid and bromothalonil compounded can improve control efficiency, a drug just can solve the two kinds of different diseases simultaneously endangering cucumber, decrease the impact of agricultural chemicals on environment, reduce drug cost.
In sum, the present composition just can solve two kinds of different diseases of cucumber by a drug, and the operability for preventing and treating downy mildew and bacterial angular leaf spot in gourd vegetables actual production is high.
Claims (3)
1. one kind contains the bactericidal composition of mandipropamid and bromothalonil, comprise usual auxiliaries, mandipropamid and bromothalonil, it is characterized in that: the ratio of weight and number of mandipropamid and bromothalonil is 1:10 ~ 10:1, mandipropamid and bromothalonil weight summation in the composition percentage by weight are 1% ~ 90%.
2. a kind of bactericidal composition containing mandipropamid and bromothalonil according to claim 1, is characterized in that: the formulation of described bactericidal composition is the one in aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules.
3. a kind of bactericidal composition containing mandipropamid and bromothalonil is preventing and treating the application on cucumber downy mildew, cucumber bacterial angular leaf spot as claimed in claim 1 or 2.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755754A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
| CN102037968A (en) * | 2011-01-17 | 2011-05-04 | 河北省农林科学院植物保护研究所 | Compound bactericide for mainly treating grey mould of fruits and vegetables |
| CN104604868A (en) * | 2015-01-04 | 2015-05-13 | 山东省蚕业研究所 | Disinfectant for silkworm rearing rooms, silkworm rearing instruments and silkworm rearing beds and application of disinfectant |
| CN105325417A (en) * | 2015-10-28 | 2016-02-17 | 广东中迅农科股份有限公司 | Bactericidal composition containing mandipropamid and kasugamycin |
-
2015
- 2015-10-28 CN CN201510719604.6A patent/CN105325413A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755754A (en) * | 2009-11-03 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Bactericidal composite taking fluazinam as main ingredient |
| CN102037968A (en) * | 2011-01-17 | 2011-05-04 | 河北省农林科学院植物保护研究所 | Compound bactericide for mainly treating grey mould of fruits and vegetables |
| CN104604868A (en) * | 2015-01-04 | 2015-05-13 | 山东省蚕业研究所 | Disinfectant for silkworm rearing rooms, silkworm rearing instruments and silkworm rearing beds and application of disinfectant |
| CN105325417A (en) * | 2015-10-28 | 2016-02-17 | 广东中迅农科股份有限公司 | Bactericidal composition containing mandipropamid and kasugamycin |
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