CN105311212A - Traditional Chinese medicine for treating chronic nasosinusitis and preparation method - Google Patents
Traditional Chinese medicine for treating chronic nasosinusitis and preparation method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating chronic nasosinusitis and a preparation method. The traditional Chinese medicine comprises the following raw medicinal materials: cottonrose hibiscus flower, tomentose anemone root, diplospora dubia, Chinese ixeris herb, tibet lancea herb, Australian cowplant root or leaf, shinyleaf pricklyash root, common tetragonia herb, shortstem ardisia root or herb, pubescent blumea herb, pearlwort, aquatic malachium herb, Chinese umbrellaleaf rhizome and Hongkong pavetta leaf. The traditional Chinese medicine has an exact curative effect on chronic nasosinusitis, and is small in toxic or side effect and low in adverse reaction rate.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of chronic sinusitis.
Background technology
Chronic sinusitis is the common disease of hals,Nasen und Ohrenheilkunde.Due to Long-term Infection, nasal sinuses excess secretion causes Rhino Sinus compound operation to block, and in hole chamber, secretions gathers and gets rid of termination with antibacterial, causes or increases the weight of the mucosal inflammation of local, finally make fibre function impaired.
Chronic sinusitis belongs to Chinese medicine " nasal sinusitis " category.Often because of flu exopathogen recurrent exerbation, delay difficulty more forms." Waike Zhengzong, Orthodox Manual of External Diseases " is thought: " always because wind and cold condensates into Naohu, strongly fragrant heat-transformation of a specified duration, when just suffering from, wind and cold or wind heat attack table, enter nose key, and then evil poison is detained for a long time, ties in nose key, caused by energy stagnation and blood stasis ".
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of chronic sinusitis, Chinese medicine of the present invention has definite curative effect to chronic sinusitis, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of chronic sinusitis, its raw medicinal material comprises: Flos Hibisci Mutabilis, Radix Anemones Tomentosae, Radix Tricalysiae dubiae, Herba Ixeritis chinensis, Herba Lanceae Tibeticae, Radix Gymnematis Sylvestris, Radix Zanthoxyli, Herba tetragoniae, Radix ardisiae brevicaulis, Herba Blumeae Mollis, Herba Saginae Japonicae, Herba malachii aquatici, Rhizoma et Radix Diphylleiae and Caulis et Folium Pavettae Hongkongensis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Flos Hibisci Mutabilis 10 ~ 20 parts, Radix Anemones Tomentosae 5 ~ 15 parts, Radix Tricalysiae dubiae 15 ~ 25 parts, Herba Ixeritis chinensis 40 ~ 50 parts, Herba Lanceae Tibeticae 5 ~ 15 parts, Radix Gymnematis Sylvestris 15 ~ 25 parts, Radix Zanthoxyli 25 ~ 35 parts, Herba tetragoniae 10 ~ 20 parts, Radix ardisiae brevicaulis 15 ~ 25 parts, Herba Blumeae Mollis 40 ~ 50 parts, Herba Saginae Japonicae 25 ~ 35 parts, Herba malachii aquatici 5 ~ 15 parts, Rhizoma et Radix Diphylleiae 5 ~ 15 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Hibisci Mutabilis 10 ~ 15 parts, Radix Anemones Tomentosae 5 ~ 10 parts, Radix Tricalysiae dubiae 15 ~ 20 parts, Herba Ixeritis chinensis 40 ~ 45 parts, Herba Lanceae Tibeticae 5 ~ 10 parts, Radix Gymnematis Sylvestris 15 ~ 20 parts, Radix Zanthoxyli 25 ~ 30 parts, Herba tetragoniae 10 ~ 15 parts, Radix ardisiae brevicaulis 15 ~ 20 parts, Herba Blumeae Mollis 40 ~ 45 parts, Herba Saginae Japonicae 25 ~ 30 parts, Herba malachii aquatici 5 ~ 10 parts, Rhizoma et Radix Diphylleiae 5 ~ 10 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Hibisci Mutabilis 11 parts, Radix Anemones Tomentosae 6 parts, Radix Tricalysiae dubiae 18 parts, Herba Ixeritis chinensis 42 parts, Herba Lanceae Tibeticae 9 parts, Radix Gymnematis Sylvestris 16 parts, Radix Zanthoxyli 29 parts, Herba tetragoniae 13 parts, Radix ardisiae brevicaulis 17 parts, Herba Blumeae Mollis 44 parts, Herba Saginae Japonicae 26 parts, Herba malachii aquatici 7 parts, Rhizoma et Radix Diphylleiae 6 parts and Caulis et Folium Pavettae Hongkongensis 12 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.02 ~ 0.2 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.002 ~ 0.02 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature of spray dryer 170 ~ 180 DEG C, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder,
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to chronic sinusitis, and toxic and side effects is little, has no adverse reaction.
Detailed description of the invention
The invention provides a kind of Chinese medicine and preparation method for the treatment of chronic sinusitis, its raw medicinal material comprises: Flos Hibisci Mutabilis, Radix Anemones Tomentosae, Radix Tricalysiae dubiae, Herba Ixeritis chinensis, Herba Lanceae Tibeticae, Radix Gymnematis Sylvestris, Radix Zanthoxyli, Herba tetragoniae, Radix ardisiae brevicaulis, Herba Blumeae Mollis, Herba Saginae Japonicae, Herba malachii aquatici, Rhizoma et Radix Diphylleiae and Caulis et Folium Pavettae Hongkongensis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Flos Hibisci Mutabilis: [source] is the flower of Malvaceae plant Hibisci Mutabilis.[nature and flavor] are pungent, flat.[return through] returns liver, lung meridian.[function cures mainly] heat clearing away, removing heat from blood, detumescence, removing toxic substances.Control carbuncle, furuncle, scald, cough due to lung-heat, spit blood, metrorrhagia, leucorrhea.
Radix Anemones Tomentosae: [source] is the root of the large fire weed of ranunculaceae plant.[nature and flavor] are bitter, temperature.[return through] returns lung, large intestine channel.[function cures mainly] resolving phlegm and dissipating blood stasis, promoting digestion and removing stagnation, preventing the attack (or recurrence) of malaria, removing toxic substances, parasite killing.Main impairment caused by overstrain cough with asthma, traumatic injury, infantile malnutrition, malaria, furuncle carbuncle, stubborn dermatitis.
Radix Tricalysiae dubiae: [source] is the root of Maguireothamnus speciosus Radix Tricalysiae dubiae.[nature and flavor] are bitter, cool.[return through] returns Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Main scrofula, carbuncle on the back, head scab, treating swelling and pain by traumatic injury.
Herba Ixeritis chinensis: the herb that [source] is feverfew Herba Ixeritis chinensis or root.[nature and flavor] bitter in the mouth, cold in nature.[function cures mainly] heat-clearing and toxic substances removing, detumescence and apocenosis, cooling blood for hemostasis.Main acute appendicitis, lung abscess, cough due to lung-heat, enteritis, dysentery, cholecystitis, pelvic inflammatory disease, furuncle toxic swelling, eczema scrotum, spits blood, epistaxis, metrorrhagia, traumatic injury.
Herba Lanceae Tibeticae: [source] is the herb of goatweed Fructus Lanceae tibeticae.[nature and flavor] sweet in the mouth is bitter, cold in nature.[function cures mainly] lung heat clearing evacuation of pus, removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat, lung abscess, influenza, dysentery, laryngopharynx swelling and pain.
Radix Gymnematis Sylvestris: the root that [source] is medicine asclepiadaceae plant Largeleaf Gymnema or browse.[nature and flavor] put down, bitter.[return through] GUIXIN, liver, spleen channel.[function cures mainly] clearing away heat and cooling blood, evacuation of pus is subsided a swelling, pain relieving granulation promoting.Main air pain of dampness syndrome, laryngopharynx swelling and pain, scrofula, acute mastitis, furuncle, eczema, innominate toxic swelling, venom.
Radix Zanthoxyli: [source] is the herb of Maguireothamnus speciosus Geophila herbacea (L) O Kumtze.[nature and flavor] are bitter, pungent, are slightly cold.[function cures mainly] detumescence and apocenosis, eliminating stasis to stop pain.Main swollen ulcer drug, traumatic pain, venom.
Herba tetragoniae: [another name] shore Caulis et Folium Lactucae sativae, white Herba tetragoniae, white Herba Gynurae bicoloris, white kind look for.[source] medical material Ji Yuan: be the herb of Aizoaceae plant Herba tetragoniae.Gather and store: gathering when blooming between summer, autumn, cleaning, dry or using fresh herb.[nature and flavor] are sweet; Micro-pungent; Property is put down.[return through] lung; Liver; Large intestine channel.[function cures mainly] wind and heat dispersing; Removing toxic substances and promoting subsidence of swelling.The hot conjunctival congestion of main air; Treatment skin ulcer swells and ache; Intestinal is scorching; Septicemia; Tumor.
Radix ardisiae brevicaulis: the root that [source] is Myrsinacea plant Radix ardisiae brevicaulis or herb.[nature and flavor] are pungent, micro-hardship, puckery, flat.[function cures mainly] expelling wind and clearing away heat, dissipating blood stasis for subsidence of swelling.Control laryngopharynx swelling and pain, acute toothache, rheumatism bones and muscles pain, lumbago, traumatic injury, innominate toxic swelling.
Herba Blumeae Mollis: [source] is the herb of feverfew pubescence Herba Blumeae Balsamiferae.[nature and flavor] mildly bitter flavor, property is put down.[function cures mainly] clearing away lung-heat to relieve cough, removing toxic substances pain relieving.Main cough due to lung-heat, infantile malnutrition, headache, nasal sinusitis, pleuritis, stomatitis, mastitis.
Herba Saginae Japonicae: [source] is the herb of pinkwort Herba Saginae Japonicae.[nature and flavor] are bitter, pungent, cool in nature.[return through] returns liver, stomach warp.[function cures mainly] removing pathogenic heat from blood and toxic substance from the body, killing parasites for relieving itching.Main dermatitis rhus, tinea alba, eczema, erysipelas, scrofula, innominate toxic swelling, venom, nasal sinusitis, caries pain, internal traumatic injury.
Herba malachii aquatici: [source] is the herb of pinkwort cattle Herba stellariae mediae.[nature and flavor] are sweet, acid, and property is put down.[return through] returns liver, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Main dyspnea and cough due to lung-heat, dysentery, carbuncle, hemorrhoid, toothache, menoxenia, infantile malnutrition.
Rhizoma et Radix Diphylleiae: [source] is Berberidaceae plant China unmrellaleaf and the root and rhizome of northeast unmrellaleaf.[nature and flavor] are bitter, pungent, and property is put down.[return through] returns liver, kidney channel.[function cures mainly] heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness.Main air pain of dampness syndrome, traumatic injury, menoxenia, lower abdomen pain, venom, carbuncle furuncle.
Caulis et Folium Pavettae Hongkongensis: [source] is the stem and leaf of Maguireothamnus speciosus Caulis et Folium Pavettae Hongkongensis.[nature and flavor] are bitter, pungent, cold.[return through] GUIXIN, spleen channel.[function cures mainly] heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Main cold, fever, heatstroke, hepatitis, traumatic injury, pathogenic wind toxic mange.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Flos Hibisci Mutabilis 10 ~ 20 parts, Radix Anemones Tomentosae 5 ~ 15 parts, Radix Tricalysiae dubiae 15 ~ 25 parts, Herba Ixeritis chinensis 40 ~ 50 parts, Herba Lanceae Tibeticae 5 ~ 15 parts, Radix Gymnematis Sylvestris 15 ~ 25 parts, Radix Zanthoxyli 25 ~ 35 parts, Herba tetragoniae 10 ~ 20 parts, Radix ardisiae brevicaulis 15 ~ 25 parts, Herba Blumeae Mollis 40 ~ 50 parts, Herba Saginae Japonicae 25 ~ 35 parts, Herba malachii aquatici 5 ~ 15 parts, Rhizoma et Radix Diphylleiae 5 ~ 15 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 20 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Hibisci Mutabilis 10 ~ 15 parts, Radix Anemones Tomentosae 5 ~ 10 parts, Radix Tricalysiae dubiae 15 ~ 20 parts, Herba Ixeritis chinensis 40 ~ 45 parts, Herba Lanceae Tibeticae 5 ~ 10 parts, Radix Gymnematis Sylvestris 15 ~ 20 parts, Radix Zanthoxyli 25 ~ 30 parts, Herba tetragoniae 10 ~ 15 parts, Radix ardisiae brevicaulis 15 ~ 20 parts, Herba Blumeae Mollis 40 ~ 45 parts, Herba Saginae Japonicae 25 ~ 30 parts, Herba malachii aquatici 5 ~ 10 parts, Rhizoma et Radix Diphylleiae 5 ~ 10 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Flos Hibisci Mutabilis 11 parts, Radix Anemones Tomentosae 6 parts, Radix Tricalysiae dubiae 18 parts, Herba Ixeritis chinensis 42 parts, Herba Lanceae Tibeticae 9 parts, Radix Gymnematis Sylvestris 16 parts, Radix Zanthoxyli 29 parts, Herba tetragoniae 13 parts, Radix ardisiae brevicaulis 17 parts, Herba Blumeae Mollis 44 parts, Herba Saginae Japonicae 26 parts, Herba malachii aquatici 7 parts, Rhizoma et Radix Diphylleiae 6 parts and Caulis et Folium Pavettae Hongkongensis 12 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.02 ~ 0.2 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.002 ~ 0.02 times, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature of spray dryer 170 ~ 180 DEG C, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder,
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Flos Hibisci Mutabilis 110g, Radix Anemones Tomentosae 60g, Radix Tricalysiae dubiae 180g, Herba Ixeritis chinensis 420g, Herba Lanceae Tibeticae 90g, Radix Gymnematis Sylvestris 160g, Radix Zanthoxyli 290g, Herba tetragoniae 130g, Radix ardisiae brevicaulis 170g, Herba Blumeae Mollis 440g, Herba Saginae Japonicae 260g, Herba malachii aquatici 70g, Rhizoma et Radix Diphylleiae 60g and Caulis et Folium Pavettae Hongkongensis 120g;
Prepare according to the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.01 times, granulate, tabletting, makes.
Embodiment 2: granule
Get Flos Hibisci Mutabilis 140g, Radix Anemones Tomentosae 80g, Radix Tricalysiae dubiae 160g, Herba Ixeritis chinensis 430g, Herba Lanceae Tibeticae 50g, Radix Gymnematis Sylvestris 190g, Radix Zanthoxyli 260g, Herba tetragoniae 120g, Radix ardisiae brevicaulis 150g, Herba Blumeae Mollis 420g, Herba Saginae Japonicae 280g, Herba malachii aquatici 90g, Rhizoma et Radix Diphylleiae 80g and Caulis et Folium Pavettae Hongkongensis 140g;
Prepare according to the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 times, mixture is the ethanol of 95%, be heated to boiling reflux 2 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 70 DEG C subsequently under vacuum 0.05Mpa, relative density is the mastic of 1.00, spraying dry, the inlet temperature 180 DEG C of spray dryer, leaving air temp 90 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.3 times in the dried cream powder obtained, makes granule, in 60 DEG C of dryings, obtains granule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.34g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>41.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 83.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 28g) oral administration gavage Chinese medicine of the present invention is 583 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.55,22.85 and 42.23g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 130 routine cases are my Out-patient Department patient.All be diagnosed as chronic sinusitis, get rid of and have nasal polyp and serious deviation of nasal septum person.Patient is divided into treatment group and matched group at random, wherein treatment group 65 people, male 45 people, women 20 people, 18 ~ 60 years old age, average (30.8 ± 1.6) year; The course of disease 5 months ~ 6 years, average 3.3 years.Matched group 65 people, male 42 people, women 23 people, 18 ~ 62 years old age, average (31.5 ± 1.3) year; The course of disease 6 months ~ 6 years, average 3.5 years.Two groups in age, sex, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: the standard formulated with reference to department of otorhinolaryngology otorhinolaryngology branch of Chinese Medical Association, editorial board of Chinese hals,Nasen und Ohrenheilkunde periodical publisher.(1) have that nasal obstruction, rhinorrhea, headache are vexed, degradation medical history under olfactory sensation, and reach more than 3 months persons.(2) toposcopy finds there is purulent secretion in middle nasal meatus, olfactory cleft or nasal cavity.(3) nasal sinuses nasal cavity x-ray or CT examination display nasal conchae hypertrophy, sinus highmori, sieve hole, sphenoid sinus increase in density or have hydrops disease.(4) after nasal meatus or olfactory cleft punish secretion smear or maxillary puncture, antibacterial culturing and effect experiment are the positive.3 persons met in above-mentioned 4 can be diagnosed as chronic sinusitis.
Therapeutic Method:
Matched group: each 0.5g of oral amoxicillin capsule, each 0.2g of metronidazole, is every day 3 times, and nasal cavity drips 1% ephedrine nasal drop every day 3 times, every day 2, and two nasal cavity hockets collunarium.7 days courses for the treatment of, treat 4 courses for the treatment of.
Treatment group: oral Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times.Nasal cavity drips 1% ephedrine nasal drop every day 3 times, every day 2, and two nasal cavity hockets collunarium.7 days courses for the treatment of, treat 4 courses for the treatment of.
Curative effect judging standard: cure: subjective symptoms disappears, nasal airflow, nasal cavity checks that the inspection of nasal sinuses x-ray is normal without glutinous pus tears.Effective: subjective symptoms disappears substantially, nasal cavity entire body is good, and there are a little pus tears in nostril, front and back, and nasal sinuses x-ray checks that hole chamber density shade alleviates.Effective: subjective symptoms alleviates, nasal cavity sticks pus tears to be reduced, and sometimes has a stuffy nose, substantially unchanged before the inspection comparatively of nasal sinuses x-ray.Invalid: subjective symptoms is without improvement, and toposcopy sign is without improvement.
Therapeutic outcome: see the following form.
| Group | n | Cure | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 65 | 40 | 13 | 8 | 4 | 61(93.85％) |
| Matched group | 65 | 23 | 12 | 14 | 16 | 49(75.38％) |
Treatment group compares with matched group, and treatment group curative effect is better than matched group, and two groups of Different therapeutical effects have statistical significance (P<0.05).
Untoward reaction: untoward reaction does not appear in treatment group, untoward reaction rate is 0%; Feeling sick appears in matched group 5 example, and 3 examples occur dizzy, and disappear after drug withdrawal, untoward reaction rate is 12.31%, and treatment group untoward reaction rate is starkly lower than matched group.
Concrete case: grandson, man, 35 years old.Have the medical history such as nasal obstruction, rhinorrhea to reach 1 year half, toposcopy find middle nasal meatus, in have purulent secretion.Nasal sinuses nasal cavity x-ray inspection display nasal conchae hypertrophy, sinus highmori, the increase in density of sieve hole.Nasal meatus punishment secretion smear antibacterial culturing and effect experiment are the positive.Be diagnosed as chronic sinusitis.Give Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times, nasal cavity drips 1% ephedrine nasal drop, every day 3 times, every day 2, and two nasal cavity hockets collunarium.Treat 3 courses for the treatment of to cure.Follow up a case by regular visits to and do not recur for 3 months.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat a Chinese medicine for chronic sinusitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Flos Hibisci Mutabilis, Radix Anemones Tomentosae, Radix Tricalysiae dubiae, Herba Ixeritis chinensis, Herba Lanceae Tibeticae, Radix Gymnematis Sylvestris, Radix Zanthoxyli, Herba tetragoniae, Radix ardisiae brevicaulis, Herba Blumeae Mollis, Herba Saginae Japonicae, Herba malachii aquatici, Rhizoma et Radix Diphylleiae and Caulis et Folium Pavettae Hongkongensis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Flos Hibisci Mutabilis 10 ~ 20 parts, Radix Anemones Tomentosae 5 ~ 15 parts, Radix Tricalysiae dubiae 15 ~ 25 parts, Herba Ixeritis chinensis 40 ~ 50 parts, Herba Lanceae Tibeticae 5 ~ 15 parts, Radix Gymnematis Sylvestris 15 ~ 25 parts, Radix Zanthoxyli 25 ~ 35 parts, Herba tetragoniae 10 ~ 20 parts, Radix ardisiae brevicaulis 15 ~ 25 parts, Herba Blumeae Mollis 40 ~ 50 parts, Herba Saginae Japonicae 25 ~ 35 parts, Herba malachii aquatici 5 ~ 15 parts, Rhizoma et Radix Diphylleiae 5 ~ 15 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Flos Hibisci Mutabilis 10 ~ 15 parts, Radix Anemones Tomentosae 5 ~ 10 parts, Radix Tricalysiae dubiae 15 ~ 20 parts, Herba Ixeritis chinensis 40 ~ 45 parts, Herba Lanceae Tibeticae 5 ~ 10 parts, Radix Gymnematis Sylvestris 15 ~ 20 parts, Radix Zanthoxyli 25 ~ 30 parts, Herba tetragoniae 10 ~ 15 parts, Radix ardisiae brevicaulis 15 ~ 20 parts, Herba Blumeae Mollis 40 ~ 45 parts, Herba Saginae Japonicae 25 ~ 30 parts, Herba malachii aquatici 5 ~ 10 parts, Rhizoma et Radix Diphylleiae 5 ~ 10 parts and Caulis et Folium Pavettae Hongkongensis 10 ~ 15 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Flos Hibisci Mutabilis 11 parts, Radix Anemones Tomentosae 6 parts, Radix Tricalysiae dubiae 18 parts, Herba Ixeritis chinensis 42 parts, Herba Lanceae Tibeticae 9 parts, Radix Gymnematis Sylvestris 16 parts, Radix Zanthoxyli 29 parts, Herba tetragoniae 13 parts, Radix ardisiae brevicaulis 17 parts, Herba Blumeae Mollis 44 parts, Herba Saginae Japonicae 26 parts, Herba malachii aquatici 7 parts, Rhizoma et Radix Diphylleiae 6 parts and Caulis et Folium Pavettae Hongkongensis 12 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.02 ~ 0.2 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.002 ~ 0.02 times, granulate, tabletting, makes.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature of spray dryer 170 ~ 180 DEG C, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder,
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine preparation component is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85 ~ 95%, reflux 2 ~ 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;
3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.02 ~ 0.2 times, the starch of 0.2 ~ 0.4 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.002 ~ 0.02 times, granulate, tabletting, makes.
8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 2 ~ 4 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 1 ~ 2 hour, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 70 DEG C subsequently under vacuum 0.03 ~ 0.05Mpa, relative density is the mastic of 1.00 ~ 1.05, spraying dry, the inlet temperature of spray dryer 170 ~ 180 DEG C, leaving air temp 80 ~ 90 DEG C, be ground into powder subsequently, make dried cream powder,
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 50 ~ 60 DEG C of dryings, obtains granule.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106466354A (en) * | 2016-10-26 | 2017-03-01 | 泉州市惠安闽投商贸有限公司 | A kind of treat Chinese medicine of allergic rhinitises and preparation method and application |
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| CN1736435A (en) * | 2005-09-12 | 2006-02-22 | 陈沙 | Chinese medicinal preparation for treating rhinitis and preparation process thereof |
| CN1739667A (en) * | 2005-08-29 | 2006-03-01 | 陈沙 | Capsule for treating rhinitis and its prepn |
| CN104225427A (en) * | 2014-10-11 | 2014-12-24 | 许梅华 | Traditional Chinese medicine for treating blood stasis and Qi stagnation caused scapulohumeral periarthritis and preparation method thereof |
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| CN1739667A (en) * | 2005-08-29 | 2006-03-01 | 陈沙 | Capsule for treating rhinitis and its prepn |
| CN1736435A (en) * | 2005-09-12 | 2006-02-22 | 陈沙 | Chinese medicinal preparation for treating rhinitis and preparation process thereof |
| CN104225427A (en) * | 2014-10-11 | 2014-12-24 | 许梅华 | Traditional Chinese medicine for treating blood stasis and Qi stagnation caused scapulohumeral periarthritis and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106466354A (en) * | 2016-10-26 | 2017-03-01 | 泉州市惠安闽投商贸有限公司 | A kind of treat Chinese medicine of allergic rhinitises and preparation method and application |
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Application publication date: 20160210 |