CN105296346B - A kind of box DNA sequencer of the dual shockproof framework with liner plate - Google Patents
A kind of box DNA sequencer of the dual shockproof framework with liner plate Download PDFInfo
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- CN105296346B CN105296346B CN201510731443.2A CN201510731443A CN105296346B CN 105296346 B CN105296346 B CN 105296346B CN 201510731443 A CN201510731443 A CN 201510731443A CN 105296346 B CN105296346 B CN 105296346B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The present invention relates to a kind of box DNA sequencer of the dual shockproof framework with liner plate, it includes reaction record subsystem, agent delivery system and control system, and the sequenator casing of the above-mentioned each system of carrying, wherein, described sequenator casing includes body supports component, the bottom of described body supports modular support casing, sidepiece, the cutting part of two housing areas in rear portion and left and right；Also include left side storehouse trim panel assembly component, it is arranged in the left side housing area of body supports component, be coated on outside reaction record subsystem.The box DNA sequencer of dual shockproof framework of the present invention with liner plate, is internally provided with lining plate structure in reaction record subsystem periphery, casing, it is ensured that reaction system good heat insulation effect, suitable reaction temperature is provided for reaction chip.
Description
Technical field
The present invention relates to DNA sequencing field, more particularly to a kind of box DNA sequencing of the dual shockproof framework with liner plate
Instrument.
Background technology
In DNA sequencing technology field, pyrosequencing techniques (pyrosequencing), are in 1987 by Nyren et al.
A kind of new enzyme cascade sequencing technologies grown up in year, its repeatability and accurate performance and Sanger method DNA sequencing skills
Art is compared favourably, and speed is greatly improved.
Integrated operation flow is described as follows：DNA sample carries out adjunction head, single-stranded caught by after broken using storehouse reagent is built
Obtain, be bound to microballoon, microemulsion PCR amplifications, demulsification liquid, obtain and set up DNA library on microballoon, using sample-adding plate by library
Enzyme needed with sequencing reaction etc. is laid to the sequence testing chip with micro reaction pool, and sequence testing chip and sequencing reagent are attached to main frame
On, sequencing program is started according to module number and position by control computer, automation carries out sequencing reaction, the data of generation
Transmit to Data Analysis Computer, complete computation analysis software after sequencing and carry out image procossing, sequence reading, quality point
The work such as analysis, sequence assembly, finally give the sequence information of DNA sample.
During actual DNA sequencing, it is desirable to which sequencing reaction and agent delivery device should have stable, closed behaviour
Make environment；Existing DNA sequencing equipment is difficult to meet the demand, and especially for reaction record system part, system should have
There is good thermal environment to ensure being smoothed out for reaction.
In view of drawbacks described above, creator of the present invention obtains this creation finally by prolonged research and practice.
The content of the invention
It is an object of the invention to provide a kind of box DNA sequenators of the dual shockproof framework with liner plate, to gram
Take above-mentioned technological deficiency.
To achieve the above object, the present invention provides a kind of box DNA sequencer of the dual shockproof framework with liner plate, its
Include the sequenator casing of reaction record subsystem, agent delivery system and control system, and the above-mentioned each system of carrying, its
In,
Described sequenator casing includes body supports component, bottom, the side of described body supports modular support casing
Portion, the cutting part of two housing areas in rear portion and left and right；
Body supports component is made up of steel plate splicing, is fixed by way of splicing or screw fastening；It includes base
Component, top plate member, the support frame assembly of casing side frame, buffer system mounting seat are connected and composed with base assembly；
Described reaction record subsystem and agent delivery system are separately positioned on left and right two parts area of sequenator casing
In, described set-up of control system records the rear side of subsystem in the reaction on the left of casing in interval；
Also include left side storehouse trim panel assembly component, it is arranged in the left side housing area of body supports component, cladding
Outside reaction record subsystem, it includes being arranged on the first trim panel of centre and is separately positioned on the first trim panel two
Side and connected second trim panel and the 3rd trim panel, the first interior trim is also associated with the outside of the second trim panel and mends slab
Slab is mended with the second interior trim.
Further, the first described trim panel is arranged on the front end of reaction warehouse component, is provided with rectangular opening in the middle of it, uses
To cause the turnable reaction warehouse in described reaction warehouse component to pass through；
Vertical the second interior trim connecting plate and the 3rd interior trim connecting plate is set respectively in the left and right sides of the first trim panel, point
It is not connected with the second trim panel and the 3rd trim panel.
Further, the second described trim panel and the 3rd trim panel have identical structure, are bending plate, second
Trim panel includes trim panel mainboard, and it includes the rectangular slab of bottom and is arranged on rectangular slab side and the bar shaped upwardly extended
Plate, both are integrally formed, be connected with stripe board for the second bending plate, it is vertically arranged with stripe board and rectangular slab, and outwards
Bending；
Connected vertically with the second bending plate sidepiece is the 3rd bending plate.
Further, described support frame assembly includes left side vertical plate component, separates the middle riser of left and right two tanks
Component, right side riser component and be arranged on right side riser forward portion right side mend slab, side stand rearways board component, be arranged on top
The first cable fixed seat and the second cable fixed seat on board component.
Further, described left side vertical plate component, middle riser component surround the reaction capacity for accommodating reaction warehouse component
Put chamber；First cable fixed seat is set in top plate member, and left side casing is divided into the reaction warehouse accommodating cavity of front side by the steel plate
With the circuit board accommodating cavity of rear side；Middle riser component and right side riser component surround reagent chamber.
Further, described top plate member, it includes front side board, right plate, back side panel, left plate, above-mentioned each plate it
Between be sequentially connected with successively, and each plate is bending plate, including vertical plate and level board, and vertical plate is arranged on the outer of level board
Connection forms support section before and after side, level board；
Intermediate plate is connected between front side board and back side panel, division board is provided between intermediate plate and left plate；
Fluid path accommodating cavity is formed between intermediate plate and right plate, reaction warehouse accommodating cavity is formed between front side board and division board.
Further, sequenator casing is also flat including offside door assembly component, offside door assembly component, buffering liquid case handling
Platform component, left side cover plate assembly, rear side cover plate assembly, upper cover plate；
Reaction record subsystem, including reaction warehouse component and CCD camera are provided with the casing of left side；Set in right case
There are agent delivery system, including pump valve pipe integrated unit, liquid case hoistable platform and display, control is provided with rear side of casing
Component processed；
Reagent delivery to reacting in record subsystem, is reacted record point by described control system control agent delivery system
Reaction warehouse component is provided with system, reagent flows through the reaction chip being arranged in reaction warehouse component and reacted, reaction record
CCD camera in subsystem gathers the photo in course of reaction and obtains surveyed DNA sequence dna after analysis.
Beneficial effects of the present invention are compared with prior art：The present invention has the box of the dual shockproof framework of liner plate
DNA sequencer, with the frame structure being made up of steel plate, damping effect is strong；Sequencing reaction and agent delivery device should have steady
Fixed, closed operating environment；Overall structure is stable, and efficiency high is sequenced.Sequenator should have during agent delivery, sequencing reaction
There is continuous, controllable characteristic.
Lining plate structure is internally provided with reaction record subsystem periphery, casing, it is ensured that the insulation of reaction system well
Effect, suitable reaction temperature is provided for reaction chip.
The DNA sequencer of the present invention has easy for installation, compact conformation between the robust structure of many recanalization, each structure,
Stability is high.Reaction warehouse component can be installed, fixed and adjust described reaction chip, it is ensured that reaction chip is in stable environment
It is middle to be reacted, also, reaction chip being capable of conveniently taking-up and locking.
The present invention sets casing in the reaction warehouse component of DNA sequencing and the periphery of reagent component so that reaction warehouse has
Enough precision, stability and spaces of cleaning；Space is reasonable, be easily portable adjustment.
Casing is provided with left and right two parts space, and reaction component and agent delivery, storage assembly, left and right space are accommodated respectively
Interior equipment works respectively, forms streamlined operation, and testing efficiency is high.
The liquid-supplying system of the DNA sequencer of the present invention controls the storage, conveying, selection of reagent by control unit；Liquid case
Hoistable platform component is moved reagent delivery to specified location by guide rail, easy to control, accurate；Liquid case hoistable platform is by pump valve
Transported above and below the gentle fliud flushing case loading/unloading platform component of integrated tube assembly, complete reagent conveying, course of reaction.
Brief description of the drawings
Fig. 1 is the functional block diagram of the DNA sequencer of the present invention；
Fig. 2 a are the overall structure diagram of the DNA sequencer casing of the present invention；
Fig. 2 b are the first structure schematic diagram of the body supports component of the DNA sequencer casing of the present invention；
Fig. 2 c are the second structural representation of the body supports component of the DNA sequencer casing of the present invention；
Fig. 3 records the overall structure diagram of subsystem for the DNA sequencer reaction of the present invention；
Fig. 4 is the first dimensional structure diagram of the reaction warehouse component of the present invention；
Fig. 5 a are the first dimensional structure diagram of the turnable warehouse of the present invention；
Fig. 5 b are the second dimensional structure diagram of the turnable warehouse of the present invention；
Fig. 6 a are the dimensional structure diagram of the locating piece of the present invention；
Fig. 6 b are the structural representation of the electronic lock of the present invention；
Fig. 6 c are the structural representation of the electronics lock of the present invention；
Fig. 6 d are the cross section structure diagram of the electronic lock of the present invention；
Cross section structure diagrams of the Fig. 7 for turnable reaction warehouse component of the invention along first lug；
Fig. 8 is the 3rd dimensional structure diagram of the turnable warehouse of the present invention；
Fig. 9 a are the structural representation of the reaction chip component of the present invention；
Fig. 9 b are the structural representation of the reaction chip mounting seat of the present invention；
Fig. 9 c are the structural representation of the medial surface of the reaction warehouse base of the present invention；
Fig. 9 d are the structural representation of the lateral surface of the reaction warehouse base of the present invention；
Fig. 9 e are the structural representation of the temperature control component cover plate of the present invention；
Figure 10 a are the cross section structure diagram along liquid inlet and outlet of the reaction chip component of the present invention；
Cross section structure diagrams of Figure 10 b for turnable reaction warehouse component of the invention along adaptive adjustment part；
Figure 11 is turnable reaction warehouse component cross section structure diagram of the invention；
Figure 12 a are the cross section structure diagram of the back shroud of the present invention；
Figure 12 b are the dimensional structure diagram of the bonnet board component of the present invention；
Figure 12 c are the dimensional structure diagram of the back shroud of the present invention；
Figure 13 a are the dimensional structure diagram of the top plate member of the DNA sequencer casing of the present invention；
Figure 13 b are the dimensional structure diagram of the left side storehouse trim panel assembly component of the DNA sequencer casing of the present invention；
Figure 14 a are the dimensional structure diagram of the liquid case hoistable platform component of the present invention；
Figure 14 b are the side structure schematic view of the liquid case hoistable platform component of the present invention；
Figure 15 a are the structural representation of the left side storehouse trim panel assembly component of the DNA sequencer casing of the present invention；
Figure 15 b are the dimensional structure diagram of the first trim panel of the present invention；
Figure 15 c are the dimensional structure diagram of the second trim panel of the present invention；
Figure 15 d are the dimensional structure diagram of the 3rd trim panel of the present invention；
Figure 16 a are the dimensional structure diagram of the liquid case hoistable platform component of the present invention；
Figure 16 b are the side structure schematic view of the liquid case hoistable platform component of the present invention.
Embodiment
Below in conjunction with accompanying drawing, the forgoing and additional technical features and advantages are described in more detail.
Refer to shown in Fig. 1, it is the functional block diagram of the DNA sequencer casing of the present invention, the DNA surveys of the embodiment of the present invention
Sequence instrument includes the sequenator casing of reaction record subsystem, agent delivery system and control system, and the above-mentioned each system of carrying,
In the present embodiment, described reaction record subsystem and agent delivery system are separately positioned on the left and right sides of sequenator casing
In interval, and connected by the agent delivery pipeline being arranged in casing；Described set-up of control system is interval on the left of casing
The rear side of interior reaction record subsystem, control reaction subsystem and agent delivery system are acted according to predetermined sequential.
Reagent delivery to reacting in record subsystem, is reacted record point by described control system control agent delivery system
Reaction warehouse component is provided with system, reagent flows through the reaction chip being arranged in reaction warehouse component and reacted, reaction record
CCD camera in subsystem gathers the photo in course of reaction and obtains surveyed DNA sequence dna after analysis.
Refer to shown in Fig. 2 a, it is the overall structure diagram of the DNA sequencer casing of the present invention, the embodiment of the present invention
Sequenator casing include body supports component 21, be arranged on the liner board component of the inner side of body supports component 21, offside door is total
Into component 23, offside door assembly component 26, buffering liquid case loading/unloading platform component 25, left side cover plate assembly 30, rear side cover plate assembly,
Upper cover plate 3110.
It is right that described liner board component includes left side storehouse interior finishing panel assembly 24, right side storehouse left side interior finishing panel assembly and right side storehouse
Side interior finishing panel assembly 22.
In embodiments of the present invention, casing, which is divided into left and right two parts, left side casing, is provided with reaction record subsystem, i.e.,
Reaction warehouse component and CCD camera；Agent delivery system, including the lifting of pump valve pipe integrated unit, liquid case are provided with right case
Platform and display, are provided with control assembly on rear side of casing.Operationally, pump valve integrated unit by reagent solution according to suitable
Sequence is delivered in reaction warehouse component, completes chemical reaction, under the control of the control unit, and CCD camera completes to take pictures, and finally passes through
Cross data analysis to take pictures result, point draw a conclusion.
Wherein, the bottom of the supporting box of body supports component 21, sidepiece, the segmentation of two housing areas in rear portion and left and right
Portion；Plaque is provided with the medial support component of the housing area of left and right two, plays heat-insulated and increase structural stability
Effect；In left side, the front portion of casing is provided with offside door assembly component 23, can be to being arranged on when opening offside door assembly component
Reaction warehouse component in left box body is operated；Offside door assembly component 26 is provided with the right side of the casing of right side, can during opening
Pump valve integrated unit is operated, various reagents pipe and control valve road are set in the subregion.
Refer to shown in Fig. 2 b-2c, it is the structural representation of the body supports component of the present invention；The embodiment of the present invention
Body supports component is made up of steel plate splicing, is fixed by way of splicing or screw fastening；It include base assembly 212,
Top plate member 2112, the support frame assembly 211 of casing side frame is connected and composed with base assembly 212, and buffer system is installed
Seat 213.Wherein, centre of the described support frame assembly 211 including left side vertical plate component 2116, separation left and right two tanks is stood
Board component 2115, right side riser component 2117 and be arranged on right side riser forward portion right side mend slab 2119, side stand rearways
Board component 2118, the second cable fixed seat 2113 being arranged in top plate member 2112 and the first cable fixed seat 2114,
And the connecting plate 2133 that each component links together.
Wherein, described left side vertical plate component 2116, middle riser component 2115 surround the reaction for accommodating reaction warehouse component
Storehouse accommodating cavity 200；First cable fixed seat 2114 is set in top plate member, and left side casing is divided into the anti-of front side by the steel plate
Answer the circuit board accommodating cavity 20 of storehouse accommodating cavity 200 and rear side；Middle riser component 2115 and right side riser component 2117 surround examination
Agent chamber 2001.The middle steel plate of top plate member is provided with the first bending plate 2141 and the second bending plate 2142, both one into
The part of type, the respectively bending on the side of steel plate two formation, is formed between the first bending plate 2141 and the second bending plate 2142
Wire casing, passes through for wire.
Described buffer system mounting seat 213 includes being separately positioned on left side vertical plate component 2116 and middle riser component
Platform group is set on platform support panel 2132 and Reagent Tube support base 2131 on 2115, described platform support panel 2132
Part and reaction warehouse component thereon.
Casing of the present invention is connected using plate, not only easy for installation, and the structural strength that each component links together
Height, can support the weight of reaction warehouse component, camera and pump valve integrated unit, and can provide stabilization, reliable environment.
Refer to shown in Fig. 3, it records the overall structure diagram of subsystem for the DNA sequencer reaction of the present invention, this
In inventive embodiments reaction record subsystem include reaction warehouse component 12, motion platform component 14, motion control unit 15,
CCD camera 101 and platform support component 13, wherein,
Described reaction warehouse component 12, setting reaction chip component in it, in the presence of control system, reaction solution enters
Chemically reacted in reaction chip, produce visible ray；Described motion platform component 14, CCD camera is fed into suitably by it
Picture-taking position, collection of taking pictures is carried out to the visible optical information that is produced in reaction chip；Described platform component 13, it is propped up
The described reaction warehouse component 12 of support, motion platform component 14；Described motion control unit, it is to CCD camera and reaction core
The operation of piece is controlled in real time.
In embodiments of the present invention, described reaction warehouse component 12 can be installed, fixed and adjust described reaction chip,
Ensure that reaction chip is reacted in stable environment, also, reaction chip conveniently can take out and lock.
Refer to shown in Fig. 4, described reaction warehouse component 12 includes being arranged on perpendicular on described platform component 13
The door frame 121 directly set, turnable reaction warehouse component 124 is provided with the top in the outside of door frame 121, in turnable reaction warehouse
The lower end of component 124 is connected with turnable basement 122, and turnable basement 122 is fixed on the middle part of door frame 121, and reaction may be reversed
Storehouse component 124 can rotate around described turnable basement 122, to take out or be put into reaction chip.
Electronics lock set 125 is additionally provided with the left of the upper end of described door frame 121, only in electronics lock set 125
During opening, turnable reaction warehouse component 124 can be rotated, reaction chip is operated.In embodiments of the present invention, if
Door frame 121, support reaction chip and dependency structure are equipped with, the stability of system is substantially increased.
Reaction warehouse component 124, which may be reversed, to be included warehouse may be reversed, and is provided with the center section of described turnable warehouse
Back shroud 1242, to encapsulate Reagent Tube；The first rotating part is provided with bottom, it includes the first accommodating chamber 1243, to hold
Receive turnable basement 122, the first accommodating chamber 1243 is arranged on the centre position of bottom；It is to be symmetrical arranged in the first accommodating chamber both sides
First lug 1244, the centre of first lug 1244 is provided with through hole 1246；To connect with described turnable basement 122
Connect.Turnable basement is rotated relative to turnable warehouse in the first accommodating chamber 1243, with higher stability, is ensured simultaneously
The transmission of reagent and data is unimpeded.Door frame 121 is the structure that one side has sidepiece baffle plate 1211, and it is integrally formed.
Refer to shown in Fig. 4, the turnable basement 122 in the embodiment of the present invention has the company of two the second lugs 1221
Base is connect, the second lug 1221 is symmetricly set on a side 1223 of base, through hole 1224 is provided with the middle of it, with institute
The through hole 1246 set in the middle of the first lug 1244 on turnable warehouse stated is co-axially mounted, also, the second lug 1221
Installed in the inner side of first lug 1244.
Incorporated by reference to shown in Fig. 2, in embodiments of the present invention, the both sides of described turnable basement 122 are arranged on sidepiece gear
In plate 1211 and contact positioning with sidepiece baffle plate 1211；Described first lug 1224 is co-axially mounted with the second lug 1221
Afterwards, end and the upper-end contact of turnable basement 122, also, the sidepiece of warehouse and the sidepiece baffle plate of door frame 121 may be reversed
1211 medial surfaces are contacted, it is ensured that warehouse may be reversed and is located just at turnable basement 122 in sidepiece baffle plate 1211.
Refer to shown in Fig. 5 a and 5b, reaction chip component be installed on the inside of the centre of described turnable warehouse,
Accordingly, the first cavity 1785 for accommodating reagent pipeline is provided with the centre that warehouse may be reversed, at the bottom of the first cavity 1785
Portion is provided with first boss 1784, and support member of the first boss 1784 to carry described reaction chip component is convex first
Platform 1784 is provided with four guide rod mounting holes 1786, and guide rod mounting hole 1786 passes through the two ends that warehouse may be reversed, reaction core
Piece component and support member, reaction chip component is connected with turnable warehouse；Set in the upper end of described first boss 1784
Second boss 1783 is equipped with, second boss 1784 is to position described support member；Set in the described upper end of second boss 1784
Locating surface 1782 is equipped with, locking screw nail 1787 is provided with locating surface 1782.Described in above-mentioned first cavity body structure positioning
Reaction chip component, also, reaction chip component is in normal work, it is impossible to and rotate, be merely able to move along guide rod.
The He of Reagent Tube mounting hole 1788 is provided with the upper surface of the first accommodating chamber 1243 of described turnable warehouse
Electric wire mounting hole, being provided with to pass through in pipe clamp 03, pipe clamp 03 in Reagent Tube mounting hole 1788 has Reagent Tube 02 and electric wire 01.
The dead bolt for being additionally provided with the dead bolt 1252 in electronics lock set 125 in the sidepiece of described turnable warehouse is installed
Hole；In the presence of locking member, warehouse may be reversed and is fixed together with door frame 121.
The upper end in the outside of described turnable warehouse is provided with pressing piece 1241, only pressed by pressing piece 1241
Pressure, which is set, can rotate described turnable warehouse.In embodiments of the present invention, incorporated by reference to shown in Fig. 8, described pressing
1241 one end of part are provided with the structure that opening 1730, one end are provided with hook, and described hook and the upper end-stopping plate of door frame connect
Connect, when pressing piece 1241 is by downward active force, hook departs from door frame baffle plate, and reaction warehouse body may be reversed can be with respect to door
Frame rotates.
In embodiments of the present invention, described pressing piece 1241 is arranged in a positioning block 1762, under locating piece 1762
End is provided with spring 1761, and spring is arranged in spring base 1763, and spring base 1763, which is threadably mounted at, may be reversed reaction warehouse
In the spring base hole 1781 of the upper surface of intermediate throughholes 1785.
Incorporated by reference to shown in Fig. 5 b and 6a, locating piece 1762 is arranged on the locating piece installation cavity that reaction warehouse upper end may be reversed
In 1791, positioning step 1790 is provided with cavity.Locating piece 1762 in the embodiment of the present invention includes the upper He of through hole 1794
Lower through-hole 1797, one of both passes through described pressing piece 1241；Set in the side of locating piece locating and machining hole 1796 and
Mounting hole 1795.The lower end for the through hole for installing pressing piece 1241 is provided with spring eye, spring passes through the hole and pressing piece 1241
Bottom contact.
The embodiment of the present invention sets electronics lock set and pressing piece, and two are carried out to reaction warehouse component and door frame may be reversed
Secondary locking, is respectively adopted automatically controlled and mechanical structure mode, it is ensured that reaction chip is run in security context, it is to avoid maloperation.
Incorporated by reference to shown in Fig. 6 b and 6c, electronics lock set 125 of the invention includes electronics lock and inductive switch 1251, institute
The inductive switch stated is arranged on electronics lock, and electronics lock is arranged on the sidepiece of turnable warehouse, in embodiments of the present invention,
Electronics lock includes sidepiece installing plate 1843, and mounting hole 1844 is offered on sidepiece installing plate 1843；Electronic lock is made by peace
Dress hole 1844 and mounting screw are fixed on turnable warehouse.It is provided with symmetrically in the described side of sidepiece installing plate 1843
The first framework 1841 and second framework 1842, left in the centre of the first framework and second framework and inductive switch 1251 be installed
Space.
In embodiments of the present invention, described inductive switch 1251 includes being arranged on the framework 1255 of outside, framework 1255
One side on be provided with connection screw thread hole 1256, it is fixed with described electronics lock by attachment screw 1254；Described
Attachment screw 1254 is by the framework 1841 of lug 1258 and first, the second framework 1842 on side, to increase electronics lock
Bonding strength.Control circuit 1252 is also associated with described inductive switch 1251, to be carried out to inductive switch 1251
Control.
Refer to shown in Fig. 6 d, described electronics lock set 125 is arranged on the sidepiece that warehouse and door frame 121 may be reversed, lock
Tongue 1253 enters after stretching out to be arranged in the dead bolt hole 1247 of turnable warehouse sidepiece, realizes locking；When dead bolt 1253 is pierced in electricity
In the presence of swashing, when being retracted from dead bolt hole 1247 is interior, described turnable warehouse can be rotated.
The use of door frame, be not only able to cause reaction chip component Stability Analysis of Structures, moreover, also cause may be reversed warehouse with
Turnable basement compact conformation, is easy to operation；The positioning of CCD camera and reaction chip is more accurate.
The first mounting hole 1210 is provided with the bottom of door frame 121, to be connected with motion platform component 14；In door
The second mounting hole being connected with turnable basement sidepiece is additionally provided with the middle part of frame.
Incorporated by reference to shown in Fig. 7, in embodiments of the present invention, in order to save structure space and ensure the steady of reagent delivery
It is fixed, it is provided with examination in the through hole of the lug 1221 of through hole 1246 and second set in the middle of described first lug 1244
The fixation kit of agent pipe first, it includes the pipe joint 1265, the first packing ring 1264, the first rotary shaft being arranged in the lug of left side
1261, and be arranged on right side lug in reagent pipe joint 1266, second packing ring 1267, the second rotary shaft 1269, wherein, institute
The first packing ring 1264 and second packing ring 1267 stated are arranged between turnable warehouse and turnable basement, in the present embodiment,
The diameter of the through hole 1246 set in the middle of described first lug 1244 is less than the diameter of the through hole of the second lug 1221,
The positioning rib positioned to packing ring is formed in both medial ends, after two packing rings are installed, inside diameter of gasket is just with the
The diameter of the through hole of two lugs 1221 is identical.Positioning rib and packing ring are set in embodiments of the present invention, it is ensured that may be reversed
Gapless between warehouse and turnable basement, both stability after combining are good, will not be rocked because there is gap, and
And, packing ring adds both contacts area so that stress reduction between the two, extension device service life.
The first rotation is installed on the inside of the inner side of the through hole 1246 set in the middle of first lug 1244 and packing ring
The rotary shaft 1269 of axle 1261 and second, the structure of two rotary shafts is identical, is the quill shaft with positioning convex ring；In rotary shaft
One end set positioning convex ring, connection screw thread hole is provided with, to the lug connection portion with described turnable warehouse
1263 are connected, accordingly, and the positioning recess for positioning the positioning convex ring is provided with the end of described through hole 1246.
It is recess in the centre at the both ends of rotary shaft 1269, inner side recess is used to and described pipe joint 1265, reagent pipe joint
1266 install positioning.Live wire and Reagent Tube 02 are respectively mounted in pipe joint 1265, reagent pipe joint 1266, it is distinguished
Lead in reaction chip component.Due to setting the component that can mutually overturn in the embodiment of the present invention, in upset, to avoid to pipe
Part is impacted, and Reagent Tube is installed in through-holes, substantially increases the security performance of Reagent Tube.
Refer to shown in Fig. 8, in embodiments of the present invention, described reaction chip component is arranged on described turnable storehouse
The inner side of body.The observation portion 1724 contacted with CCD camera is provided with the inside of reaction chip component, is provided with transparent
Baffle plate, to be taken pictures to course of reaction.
Refer to shown in Fig. 9 a, reaction chip component of the invention includes reaction chip mounting seat 127, reaction warehouse base
Component 126 and the shading positioning component 128 that reaction warehouse base assembly 126 and reaction chip mounting seat 127 are locked, opened；
In order to easily take out and close to reaction chip, reaction chip mounting seat 127 can be with the phase of reaction warehouse base assembly 126
To rotation.
Refer to shown in Fig. 9 b, it is the structural representation of the reaction chip mounting seat of the present invention, is installed in reaction chip
The center section of seat 127 is provided with reaction chip, and cover plate 1277 is provided with reaction chip；Installed in the both sides of reaction chip
There is chute pressing plate 1279, reaction chip to be fixed.A side portion of reaction chip mounting seat 127 is provided with installation
Seat supports component, it is used in taking-up or chip placement, the described reaction chip mounting seat of support；It includes torsional-spring supported portion
1273, it is arranged in mounting seat, the described torsion spring to support, described torsional-spring supported portion 1273 carries protruding end 1274 for one
Recess, in the reaction chip mounting seat 127 described in rotation, protruding end 1274 is contacted with 1261 at first, in the present embodiment,
Described protruding end 1274 is arranged on the middle part of recess and the edge of chip installation position；Using the structure of mounting seat in itself
Reaction chip mounting seat is supported, better reliability, it is ensured that chip can be safely removed and placed.
The drawing that described mounting seat support component also includes torsion spring 1272, is connected with torsion spring 1272 and is arranged on torsion spring two ends
Mandrel 1271, described tension axle 1271 is arranged on lug boss 1275, when starting reaction chip mounting seat, described torsion
Spring 1272 supports mounting seat, and finally relies on the positioning of protruding end 1274, realizes support.
The first rotary shaft hole 1276 is additionally provided with the end of described lug boss 1275, to reaction warehouse base 1261
Connection.Locating slot 1278 is additionally provided with the sidepiece of reaction chip mounting seat.
Refer to shown in Fig. 9 c, it is the structural representation of the medial surface of the reaction warehouse base of the present invention, in reaction warehouse
Reaction pond body 1266 is provided with medial surface, reaction tank 1267 is set in reaction pond body 1266 center section, in reaction tank 1267
Surrounding 1706 be provided with sealing ring, prevent reaction reagent from leaking.One end of reaction warehouse base 1261 is provided with raised line 1705,
To be positioned with the cover plate after installation.The torsional-spring supported structure corresponding with reaction chip mounting seat is provided with the other end, its
Including symmetrically arranged two protruding ends 1268, the second rotary shaft hole 1269 is being provided with, itself and the first rotary shaft hole
1276 is coaxial, and rotary shaft sequentially passes through holes；The region 1260 and localization region for torsion spring activity are additionally provided with the end
1707, it is provided with the region the screwed hole 1712 for reacting Hatch Board will be installed.
Refer to shown in Fig. 9 d, it is the structural representation of the lateral surface of the reaction warehouse base of the present invention, at reaction warehouse bottom
The center section of the lateral surface of seat is provided with temperature control component, and temperature sensor installation is provided with the center section of reaction warehouse base
Groove 1262, heating wire mounting groove 1704 is provided with the bottom of mounting groove 1262, and heating wire and temperature sensor are placed respectively.
A positioning boss 1703 is additionally provided with mounting groove, it when being installed with temperature control component cover plate 1263 to position.In temperature control group
Positioning recess 1702 corresponding with positioning boss 1703 is provided with part cover plate 1263.
The surrounding of temperature sensor mounting groove 1262 is provided with four guide rod mounting holes 1742, set in upper and lower sides
There is adaptive spring mounting hole 1741；It is also equipped with being oriented to rod aperture 1701 on cover plate 1263.
Shading positioning component mounting groove 1265 is additionally provided with reaction warehouse base, to install described shading positioning group
Part 128, is provided with installation base 1744 in it.
Incorporated by reference to shown in Figure 10 a-10b, the middle part of reaction warehouse base is provided with electrical heating wire 1754, it is arranged on
In the heating wire mounting groove 1704 of base；TEMP is provided with the temperature sensor mounting groove 1262 on electrical heating wire top
Device 1720 and control assembly, to detect the temperature of reaction tank and be adjusted according to the threshold value of setting；In temperature sensor
1720 and control assembly 1753 also pour and be inoculated with seal 1263, its be encapsulating resin.Examination is respectively arranged with the two ends of reaction tank
Agent pipe installs screwed hole 1721, to be connected with Reagent Tube；The end for installing screwed hole 1721 in Reagent Tube is provided with inlet
1723 and liquid outlet 1713, liquid inlet and outlet is communicated with the two ends of reaction tank, to cycle detection reagent.
The avris of the interior grooves of reaction tank is provided with sealing ring 1713.It is provided with the centre of reaction chip mounting seat
Reaction chip 04, reagent flows through reaction chip and reacted.
In embodiments of the present invention, Reagent Tube 02 is by the Reagent Tube mounting hole 1788 of turnable warehouse, and being arranged on to turn over
The centre of roll-over body is provided with the first cavity 1785 for accommodating reagent pipeline, and final coupled reaction pond body, reagent cartridge passes through each
The sealing of cavity is planted, stability is high, is hardly damaged.
Back shroud 1242 is fixed with rear side of reaction warehouse, the centre of back shroud 1242 is provided with adaptive adjustment part
1751, refer to shown in Figure 12 a-12c, two rows are provided with the middle of the inner side of back shroud 1242 raised line 1809 is installed, installing
The centre of raised line 1809 is provided with the first installation base 1812 and the second installation base 1811, and screw thread is offered on installation base
Hole 1802, adaptive adjustment part 1751 is arranged in the screwed hole 1802.
In embodiments of the present invention, the connection end of described adaptive adjustment part 1751 and back shroud is the end of thread, and anti-
The connection end for answering storehouse component is the polished rod 1805 for being provided with spring 1806, and nut 1804 is provided between the ends and is positioned,
After installation is complete, nut 1804 is close to installation base.
It is passage 1803 between two described raised lines 1809, enables to Reagent Tube to pass through；Also set on back shroud
It is equipped with the stiffener plate 1812 vertical with raised line 1809；In raised line 1809 and the bit plane of upper surface 1810 of boss；In plate below
Peripheral framework 1807 centre and corner be provided with trip bolt hole 1801, to described turnable reaction warehouse company
Connect fixation.
Above-mentioned bonnet board component, is not only able to carry out face sealing to reaction warehouse component, additionally it is possible to install fixed adaptive tune
One integral piece, it is simple in construction.
In embodiments of the present invention, it may be reversed between reaction warehouse and reaction warehouse base 126 and be provided with adaptive adjustment part
1751, the end spring of adaptive adjustment part 1751 and the end contact of reaction warehouse base；When being fed using CCD camera, phase
When machine is with reaction chip component touch, when adjusting camera position, it can be adjusted by the way of movable, it is now, adaptive
Adjustment part is answered to change the position of reaction chip component according to the change in location of camera, it is ensured that with higher accuracy of detection,
Simultaneously, it is to avoid system is caused to damage.
Refer to shown in Figure 13 a-13b, top plate member 2112 in embodiments of the present invention, it include front side board 2124,
It is sequentially connected with successively between right plate 2125, back side panel 2143, left plate 2153, above-mentioned each plate, and each plate is bending
Plate, including vertical plate and level board, connection forms support section before and after vertical plate is arranged on the outside of level board, level board.
Intermediate plate 2123 is connected between the 2143 of front side board 2124 and back side panel, in intermediate plate 2123 and left plate 2153
Between be provided with division board 2128；Fluid path accommodating cavity is formed between intermediate plate 2123 and right plate 2143, in front side board 2124
Reaction warehouse accommodating cavity is formed between division board 2128.
In embodiments of the present invention, the upper end connection upper cover plate 3110 of top plate member 2112, in the vertical of right plate 2125
Portion is provided with integrally formed connection sheet 2151；The vertical portion of back side panel 2143 is provided with connecting plate 2133.
The wire casing being made up of its bending part, including rear side wire casing 2127 be set on intermediate plate 2123, and wire is from rear side line
Groove 2127 is passed through in reaction warehouse component by the first cable fixed seat 2114.It is front side connecting portion 2122 in front side, left side is
Left side connecting portion 2121, is threaded hole thereon, to be connected with upper cover plate；Left side is the first rear side connecting portion 2130, rear side
For the second rear side connecting portion 2129；Lock 2150 is set on second rear side connecting portion 2129.
The edge of top plate is provided with connecting portion 2152.
The left side storehouse trim panel assembly component of the present invention, it is arranged in the left side housing area of body supports component, bag
Overlay on outside reaction record subsystem, it includes being arranged on the first trim panel 241 of centre and is separately positioned on the first interior trim
The both sides of plate 241 and the trim panel 243 of connected second trim panel 242 and the 3rd, are also connected with the outside of the second trim panel 242
There is the first interior trim to mend the interior trim of slab 244 and second and mend slab 245.
The agent delivery system of the embodiment of the present invention includes control unit, buffering liquid case loading/unloading platform component, liquid case lifting
The integrated tube assembly of platform assembly, pump valve, wherein, described buffering liquid case loading/unloading platform can load and unload various reagents, and pass through liquid
The position specified is transported to above and below case hoistable platform component, for described pump valve integrated pipe Component driver, the pump valve is integrated
The Reagent Tube that tube assembly selection needs, the open and close controlling of driving and hydraulic valve through hydraulic pump, by specified reagent delivery extremely
Reacted in reaction warehouse component；The action of each above-mentioned element is uniformly controlled by control unit.
The liquid case hoistable platform component of the embodiment of the present invention is the mechanism that pumps that motor leading screw drives, and it is installed
In the right side casing of sequenator.Its support base for including motor 401, being connected with motor and supporting motor
402nd, lead screw assembly, the reaction liquid case lifting seat 408 installed in sidepiece being connected with motor, wherein, described reaction
With buffer solution case loading/unloading platform component is equiped with liquid case lifting seat 408, reaction is arranged on and reaction with liquid case lifting seat 408
On installing plate 404 with the connection of liquid case lifting seat, under the driving of screw mechanism, reaction liquid case lifting seat Reagent Tube group is carried
Move up and down.
The intermediate plate 4081 that reaction includes being connected with installing plate with liquid case lifting seat 408, is arranged on the support of intermediate plate both sides
Horizontal ends are provided with plate 4082, supporting plate 4082, to place buffering liquid case loading/unloading platform component.
The output shaft of described motor 401 is connected with leading screw 403, and leading screw is arranged in base 405, base 405 with
The end of motor 401 is connected by support base 402；The sidepiece of base 405 is provided with stroke detection switch 406.It is described
The output shaft of motor be connected by shaft coupling 4035 with the connection end 4034 of leading screw；Nut 4031 is connected with leading screw,
Nut is fixed on nut seat 4032；Leading screw lower end is by bearings, and bearing end is provided with bearing (ball) cover 4011.
The liquid case hoistable platform component of the embodiment of the present invention is moved reagent delivery to specified location, controlling party by guide rail
Just, precisely；Liquid case hoistable platform will be transported above and below the gentle fliud flushing case loading/unloading platform component of the integrated tube assembly of pump valve, complete reagent defeated
Give, course of reaction.
The left side storehouse trim panel assembly component of the present invention is arranged on left side vertical plate component 2116 and middle riser component 2115
Between, upper end coating reaction storehouse component, lower end cladding is arranged on the exhausted bath box on the downside of reaction warehouse component.
To prevent dust granule from entering in reaction warehouse component, meanwhile, with good radiating effect.
It include being arranged on the first trim panel 241 of centre and be separately positioned on the both sides of the first trim panel 241 and and its
The second trim panel 242 and the 3rd trim panel 243 of connection, the first interior trim is also associated with the outside of the second trim panel 242 and mends thickness
The interior trim of plate 244 and second mends slab 245.
First trim panel 241 is arranged on the front end of reaction warehouse component, is provided with rectangular opening in the middle of it, described to cause
Turnable reaction warehouse in reaction warehouse component passes through, it is necessary to which when changing reaction chip, reaction may be reversed after trim panel is installed
Warehouse can pass through the rectangular opening.
It is the first horizontal interior trim connecting plate 2412, itself and the plate in top plate member in the upper end of the first trim panel 241
Lower surface contact, in the present embodiment, with the horizontal part of the front side connecting portion 2122 of the front side board 2124 in top plate member
Lower end in contact.Vertical the second interior trim connecting plate 2414 and the 3rd interior trim is set respectively in the left and right sides of the first trim panel 241
Connecting plate 2413, is connected with the second trim panel 242 and the 3rd trim panel 243 respectively.
Second trim panel 242 and the 3rd trim panel 243 have identical structure, are bending plate, the second trim panel 242
Including trim panel mainboard 2432, it includes the rectangular slab of bottom and is arranged on rectangular slab side and the stripe board upwardly extended,
Both are integrally formed, be connected with stripe board for the second bending plate, it is vertically arranged with stripe board and rectangular slab, and to rolled over
It is curved；Connected vertically with the second bending plate sidepiece is the 3rd bending plate 2433.Latticed hole 2423 is provided with rectangular slab, is used
To radiate.Same structure, the 4th bending plate 2422 is provided with the 3rd trim panel 243, its structure and the second bending plate phase
Together.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, and the embodiment is simultaneously not used to
The scope of the claims of the present invention is limited, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the technology of the present invention
In the range of scheme.
Claims (5)
1. a kind of box DNA sequencer of the dual shockproof framework with liner plate, it is characterised in that it, which includes reacting recording to divide, is
System, agent delivery system and control system, and the sequenator casing of above-mentioned each system is carried, wherein,
Described sequenator casing includes body supports component, the bottom of described body supports modular support casing, sidepiece, after
The cutting part of two housing areas in portion and left and right；
Reaction record subsystem is provided with the left side casing, the control system controls agent delivery system by reagent delivery
Into reaction record subsystem, reaction warehouse component is provided with the reaction record subsystem, reagent, which flows through, is arranged on reaction warehouse
Reaction chip in component reacts；
Body supports component is made up of steel plate splicing, is fixed by way of splicing or screw fastening；It include base assembly,
Top plate member, the support frame assembly of casing side frame, buffer system mounting seat are connected and composed with base assembly；
Left and right two parts that described reaction record subsystem and agent delivery system are separately positioned on sequenator casing are interval interior,
Rear side of the described set-up of control system in the reaction record subsystem on the left of casing in interval；
Also include left side storehouse trim panel assembly component, it is arranged in the left side housing area of body supports component, be coated on anti-
It should record outside subsystem, it includes being arranged on the first trim panel of centre and is separately positioned on the first trim panel both sides simultaneously
Connected second trim panel and the 3rd trim panel, the first interior trim is also associated with the outside of the second trim panel and mends slab and the
Two interior trims mend slab；
The first described trim panel is arranged on the front end of reaction warehouse component, is provided with rectangular opening in the middle of it, described to cause
Turnable reaction warehouse in reaction warehouse component passes through；
Vertical the second interior trim connecting plate and the 3rd interior trim connecting plate is set respectively in the left and right sides of the first trim panel, respectively with
Second trim panel and the connection of the 3rd trim panel；
Described the second trim panel and the 3rd trim panel has identical structure, is bending plate, and the second trim panel includes interior
Plaque mainboard, the trim panel mainboard includes the rectangular slab of bottom and is arranged on rectangular slab side and the bar shaped upwardly extended
Plate, both are integrally formed, be connected with stripe board for the second bending plate, it is vertically arranged with stripe board and rectangular slab, and outwards
Bending；
Connected vertically with the second bending plate sidepiece is the 3rd bending plate.
2. the box DNA sequencer of the dual shockproof framework according to claim 1 with liner plate, it is characterised in that institute
The support frame assembly stated include left side vertical plate component, separate the middle riser components of left and right two tanks, right side riser component with
And it is arranged on right side benefit slab, side stand rearways board component, the first cable being arranged in top plate member of right side riser forward portion
Line fixed seat and the second cable fixed seat.
3. the box DNA sequencer of the dual shockproof framework according to claim 2 with liner plate, it is characterised in that institute
Left side vertical plate component, the middle riser component stated surround the reaction warehouse accommodating cavity for accommodating reaction warehouse component；Set in top plate member
The first cable fixed seat is put, the circuit board of reaction warehouse accommodating cavity and rear side that left side casing is divided into front side by the steel plate is housed
Chamber；Middle riser component and right side riser component surround reagent chamber.
4. the box DNA sequencer of the dual shockproof framework according to claim 2 with liner plate, it is characterised in that institute
The top plate member stated, it includes being sequentially connected with successively between front side board, right plate, back side panel, left plate, above-mentioned each plate, and
Each plate is bending plate, including vertical plate and level board, and vertical plate is arranged on connection shape before and after the outside of level board, level board
Into support section；
Intermediate plate is connected between front side board and back side panel, division board is provided between intermediate plate and left plate；In centre
Fluid path accommodating cavity is formed between plate and right plate, reaction warehouse accommodating cavity is formed between front side board and division board.
5. the box DNA sequencer of the dual shockproof framework according to claim 2 with liner plate, it is characterised in that survey
Sequence instrument casing also includes offside door assembly component, offside door assembly component, buffering liquid case loading/unloading platform component, left side cover plate group
Part, rear side cover plate assembly, upper cover plate；
Agent delivery system, including pump valve pipe integrated unit, liquid case hoistable platform and display are provided with right case,
Control assembly is provided with rear side of casing；
The reaction record subsystem also includes the photo in CCD camera, CCD camera collection course of reaction and by analysis
Surveyed DNA sequence dna is obtained afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510731443.2A CN105296346B (en) | 2015-11-02 | 2015-11-02 | A kind of box DNA sequencer of the dual shockproof framework with liner plate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510731443.2A CN105296346B (en) | 2015-11-02 | 2015-11-02 | A kind of box DNA sequencer of the dual shockproof framework with liner plate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105296346A CN105296346A (en) | 2016-02-03 |
| CN105296346B true CN105296346B (en) | 2017-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510731443.2A Expired - Fee Related CN105296346B (en) | 2015-11-02 | 2015-11-02 | A kind of box DNA sequencer of the dual shockproof framework with liner plate |
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| Country | Link |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102703312A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102703302A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Installing seat for automatically clamping sequencing chip |
| CN102703311A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Reaction bin for adaptive regulation of DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102766574A (en) * | 2012-05-24 | 2012-11-07 | 中国科学院北京基因组研究所 | Reaction chamber for DNA sequenator |
| CN105273998A (en) * | 2015-10-30 | 2016-01-27 | 北京中科紫鑫科技有限责任公司 | Double-shielding box-type DNA sequencer with portal |
-
2015
- 2015-11-02 CN CN201510731443.2A patent/CN105296346B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102703312A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102703302A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Installing seat for automatically clamping sequencing chip |
| CN102703311A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Reaction bin for adaptive regulation of DNA (Deoxyribose Nucleic Acid) sequencer |
| CN102766574A (en) * | 2012-05-24 | 2012-11-07 | 中国科学院北京基因组研究所 | Reaction chamber for DNA sequenator |
| CN105273998A (en) * | 2015-10-30 | 2016-01-27 | 北京中科紫鑫科技有限责任公司 | Double-shielding box-type DNA sequencer with portal |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105296346A (en) | 2016-02-03 |
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