CN216547371U - Detection device of reagent storage assembly - Google Patents

Abstract

The utility model provides a detection device of a reagent storage assembly, which comprises: the frame assembly comprises a bottom shell and a separation cover, the separation cover divides the inner space of the bottom shell into a first accommodating space with an open top and a closed second accommodating space, and the reagent storage assembly to be tested is arranged in the first accommodating space; and the control assembly is arranged in the second accommodating space. The technical scheme of the application can effectively solve the problem of poor test accuracy in the related technology.

Description

Detection device of reagent storage assembly

Technical Field

The utility model relates to the field of biological reagent detection, in particular to a detection device of a reagent storage assembly.

Background

With the continuous maturity of sequencing technology and the gradual release of policy, gene sequencing has a wide application prospect in the fields of early disease screening, microorganism, genetic detection and the like, the whole industry starts to develop at a high speed, and the market has an increasing demand on sequencers. As a core module of the gene sequencer, namely a reagent storage module, the functional integrity and reliability of the gene sequencer directly influence the performance and stability of the sequencer.

In the batch production process, efficient, rapid and accurate performance tests (such as temperature control performance tests, reagent needle motion performance tests, fluid circuit sealing performance tests and the like) of the reagent storage module are crucial to improving the production efficiency and improving the product stability. However, since the reagent storage module contains liquid, the liquid may affect the accuracy of the performance test, so that the accuracy is not good.

Disclosure of Invention

The utility model mainly aims to provide a detection device of a reagent storage assembly, which is used for solving the problem of poor test accuracy in the related technology.

In order to achieve the above object, the present invention provides a detection apparatus of a reagent storage pack, comprising: the frame assembly comprises a bottom shell and a separation cover, the separation cover divides the inner space of the bottom shell into a first accommodating space with an open top and a closed second accommodating space, and the reagent storage assembly to be tested is arranged in the first accommodating space; and the control assembly is arranged in the second accommodating space and is connected with the reagent storage assembly.

Further, the drain pan includes the bottom plate and sets up the curb plate in the border department of bottom plate, separates the cover and includes the roof and set up the bounding wall in roof border department, and partial curb plate sets up in order to form the second accommodation space with roof and bounding wall butt joint.

The side plates comprise a first side plate, a second side plate and a third side plate, wherein the first side plate, the second side plate and the third side plate are oppositely arranged, the third side plate is connected between the first side plate and the second side plate, the height of the first side plate is greater than that of the second side plate, the third side plate comprises a first plate section connected with the first side plate and a second plate section connected with the second side plate, the height of the first plate section is greater than that of the second plate section, and the height of the second plate section is greater than that of the second side plate; the coaming is in butt joint fit with the first side plate and the first plate section.

Further, the frame component also comprises a sealing door which is pivotally connected with the second side plate, and a door lock which is matched with the sealing door is arranged on one side, facing the second side plate, of the enclosing plate.

Furthermore, the detection device also comprises a detection assembly, the detection assembly comprises a pressure gauge, an injection pump, a water tank and a connecting pipe, the water tank is arranged in the heat insulation box of the reagent storage assembly, and the connecting pipe is connected with the reagent needle, the pressure gauge, the injection pump and the water tank of the reagent storage assembly to form a detection loop.

Further, the manometer sets up on the lateral wall of drain pan, and the syringe pump sets up in second accommodation space, separates to cover and is provided with the opening that supplies the syringe pump to stretch out.

Further, detection device still includes the power of setting in the second accommodation space, and the control assembly includes the temperature control integrated circuit board, and the temperature control integrated circuit board is connected with the temperature sensor who sets up in the hot box of reagent storage component, set up the refrigerating plant of the hot box rear side of reagent storage component and set up the radiator fan in the hot box rear side of reagent storage component.

Further, the control assembly also comprises a motion controller and a motor driver, and the motor driver is respectively connected with the motion controller and a driving motor of the reagent storage assembly.

Further, detection device is still including setting up the main control unit in the drain pan outside, and main control unit is connected with temperature control integrated circuit board and motion control ware.

Further, the bottom of the bottom shell is provided with a supporting foot pad.

By applying the technical scheme of the utility model, the detection device of the reagent storage assembly comprises a frame assembly and a control assembly. Specifically, the frame subassembly includes the drain pan and separates the cover, and control assembly and the reagent storage assembly that awaits measuring all set up inside the drain pan, separate the cover and divide into first accommodation space and second accommodation space with the inner space of drain pan, and the second accommodation space is the enclosure space. Wherein the reagent storage assembly is arranged in the first accommodating space; the control assembly is arranged in the second accommodating space, so that liquids such as condensed water generated by the reagent storage assembly can be effectively prevented from entering the second accommodating space, electronic components of the control assembly are protected, and efficient, rapid and accurate temperature control and motion control are realized. Therefore, the technical scheme of the application can effectively solve the problem of poor test accuracy in the related technology.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the utility model and, together with the description, serve to explain the utility model and not to limit the utility model. In the drawings:

FIG. 1 shows an embodiment of a test device of a reagent storage assembly according to the present invention and a schematic view of a split structure of the reagent storage assembly;

FIG. 2 is a schematic perspective view showing a partial structure of the detecting unit of FIG. 1 and a reagent storage unit;

FIG. 3 shows a schematic diagram of the main controller of the detection apparatus of FIG. 1;

FIG. 4 is a schematic rear view showing a partial structure of the detecting unit of FIG. 1;

FIG. 5 shows a front view of the test device of FIG. 1 and a reagent storage assembly;

FIG. 6 shows a flow diagram of a liquid in a detection circuit of a detection assembly of the detection device of FIG. 1; and

fig. 7 shows a temperature control flow and a motion control flow block diagram of the detection apparatus of fig. 1.

Wherein the figures include the following reference numerals:

1. a separation cover; 101. a top plate; 102. enclosing plates; 2. a bottom case; 201. a base plate; 202. a first side plate; 203. a second side plate; 204. a first plate section; 205. a second plate section; 3. a reagent storage assembly; 301. a heat insulation box; 302. a support; 303. a drive motor; 304. a reagent needle; 4. a power source; 5. a temperature control board card; 6. rotating the valve control plate; 7. rotating the valve adaptor plate; 8. an IO interface board; 9. a terminal block; 10. a filter; 11. a pressure gauge; 12. an injection pump; 13. a sealing door; 14. a motor driver; 15. a door lock; 16. supporting the foot pad; 17. a main controller; 18. a water tank; 19. a connecting pipe; 20. a refrigeration device; 21. a heat dissipation fan.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the utility model, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

As shown in fig. 1 and 4, the detection apparatus of the reagent storage pack of the present embodiment includes: the frame assembly comprises a bottom shell 2 and a separation cover 1, wherein the separation cover 1 separates the inner space of the bottom shell 2 into a first accommodating space with an open top and a closed second accommodating space, and a reagent storage assembly 3 to be tested is arranged in the first accommodating space; and a control assembly disposed in the second accommodating space and connected to the reagent storage assembly 3.

By applying the technical scheme of the embodiment, the detection device of the reagent storage assembly comprises a frame assembly and a control assembly. Specifically, the frame assembly includes a bottom case 2 and a partition cover 1, the control assembly and the reagent storage assembly 3 to be tested are both disposed inside the bottom case 2, and the partition cover 1 divides an inner space of the bottom case 2 into a first accommodation space and a second accommodation space. Wherein the reagent storage assembly 3 is arranged in the first accommodation space; the control assembly is arranged in the second accommodating space, the second accommodating space is a closed space, liquid such as condensed water generated by the reagent storage assembly 3 can be effectively prevented from entering the second accommodating space, electronic components of the control assembly are protected, and efficient, rapid and accurate temperature control and motion control are achieved. Therefore, the technical scheme of the embodiment can effectively solve the problem of poor test accuracy in the related technology.

As shown in fig. 1, 2 and 5, specifically, the reagent storage assembly 3 includes an insulated box 301, a movement mechanism, and a cooling device 20 and a cooling fan 21 provided at the rear side of the insulated box 301, the test reagent is placed in the insulated box 301, and the cooling device 20 and the cooling fan 21 can maintain the inside of the insulated box 301 within a predetermined temperature. Meanwhile, the reagent storage assembly 3 further comprises a temperature sensor disposed inside the insulated cabinet 301, which is capable of detecting the temperature inside the insulated cabinet 301 in real time so that the control system controls the refrigeration device 20 and the heat dissipation fan 21 to adjust the temperature inside the insulated cabinet 301 so that the inside of the insulated cabinet 301 is maintained within a predetermined temperature. The movement mechanism comprises a support 302, a driving motor 303 arranged above the support 302 and a reagent needle 304 driven by the driving motor 303, wherein the support 302 is arranged above the heat insulation box 301, and the heat insulation box 301 is provided with a reagent needle hole for the reagent needle 304 to pass through. The inner wall of the heat insulating box 301 is provided with a heat insulating material, and the reagent needle 304 can suck the reagent in the heat insulating box 301 through the reagent needle hole. The above-described movement mechanism provided outside the heat insulating box 301 and above the heat insulating box 301 means that the main structure of the movement mechanism is located above the heat insulating box 301, and a partial structure of the movement mechanism may be inserted into the heat insulating box 301.

It should be noted that, the second accommodating space is a closed space, which means that protective walls are provided on all surfaces of the second accommodating space to prevent liquids such as condensed water generated by the reagent storage assembly 3 from entering the second accommodating space, and since the control assembly needs to be connected to the reagent storage assembly 3 by a line, an opening is provided on the protective wall of the second accommodating space to connect the reagent storage assembly by a line.

As shown in fig. 1, the bottom case 2 includes a bottom plate 201 and side plates disposed at edges of the bottom plate 201, the partition cover 1 includes a top plate 101 and a surrounding plate 102 disposed at edges of the top plate 101, and a part of the side plates are disposed in abutment with the top plate 101 and the surrounding plate 102 to form a second accommodating space. The second accommodation space which is sealed and arranged can effectively prevent liquids such as condensed water generated by the reagent storage assembly 3 from entering the second accommodation space, protect electronic components of the control assembly, and realize efficient, rapid and accurate temperature control and motion control.

As shown in fig. 1, the side panels include a first side panel 202, a second side panel 203 and a third side panel connected between the first side panel 202 and the second side panel 203, the first side panel 202 has a height greater than that of the second side panel 203, the third side panel includes a first panel segment 204 connected with the first side panel 202 and a second panel segment 205 connected with the second side panel 203, the first panel segment 204 has a height greater than that of the second panel segment 205, and the second panel segment 205 has a height greater than that of the second side panel 203; enclosure 102 is in abutting engagement with first side panel 202 and first panel segment 204. The side plate and the separation cover 1 are simple in structure and easy to protect the control assembly.

As shown in fig. 1, 5 and 6, the detection device further comprises a detection assembly, the detection assembly comprises a pressure gauge 11, a syringe pump 12, a water tank 18 and a connecting pipe 19, the water tank 18 is arranged in the heat insulation box 301 of the reagent storage assembly 3, and the connecting pipe 19 connects the reagent needle 304, the pressure gauge 11, the syringe pump 12 and the water tank 18 to form a detection loop. The detection assembly can perform functional detection on a core module, namely the reagent storage assembly 3, in the production preparation stage of the gene sequencer, eliminate abnormal faults and improve the reliability of the whole machine. Specifically, whether the fluid pipeline of the detection device is abnormal or not and whether the pressure of the reagent needle pipeline is normal or not (namely, the sealing performance of the reagent needle pipeline is detected) can be detected, the normal operation of the reagent storage assembly 3 is ensured, and the test efficiency and the reliability are high.

Specifically, the steps of connecting the fluid circuits of the detection assembly are as follows: the reagent storage pack 3 to be tested is placed in the inspection station (i.e., the first accommodation space), the water tank 18 is placed in the reagent storage pack 3, and the reagent needle 304 is moved to the bottom by the driving motor 303 into the water tank 18. The reagent needle 304 is connected with the pressure gauge 11 through the reagent needle tube joint in the connecting tube 19, the pressure gauge 11 and the injection pump 12 are connected through the testing tube in the connecting tube 19, and finally the injection pump 12 is connected with the water tank 18 through the testing tube in the connecting tube 19, so that the connection of a fluid loop is realized.

As shown in fig. 1 and 5, a pressure gauge 11 is disposed on an outer sidewall of the bottom case 2, a syringe pump 12 is disposed in the second receiving space, and an opening through which the syringe pump 12 extends is disposed on the partition cover 1. The manometer 11 sets up in the outside of drain pan 2, conveniently observes the numerical value of manometer 11, separates to be provided with the opening that supplies syringe pump 12 to stretch out on the cover 1 and is convenient for realize the tube coupling between manometer 11 and the syringe pump 12.

In this embodiment, the detection device further includes a power source 4 disposed in the second accommodating space, the control component includes a temperature control board 5, and the temperature control board 5 is connected to a temperature sensor disposed in the heat insulation box 301 of the reagent storage component 3, a refrigeration device 20 disposed behind the heat insulation box 301 of the reagent storage component 3, and a heat dissipation fan 21 disposed behind the heat insulation box 301 of the reagent storage component 3. Specifically, one power line branched from the terminal block 9 is connected to the temperature control board 5 to supply power thereto. The temperature control board card 5 is connected with a cooling fan 21, a refrigerating device 20 and a temperature sensor on the reagent storage component 3. The control and temperature feedback reading functions of the reagent storage component 3 refrigerating system are realized.

In this embodiment, the control assembly further includes a motion controller and a motor driver 14, and the motor driver 14 is connected to the motion controller and the driving motor 303 respectively. One power line branched from the terminal block 9 is connected to the motion controller to supply power thereto. The motion controller is connected with the motor driver 14 and then connected with the motor of the driving motor 303, so as to realize the up-and-down motion control of the reagent needle 304 on the reagent storage component 3. Meanwhile, the motion controller receives an upper and lower limit feedback signal of the motion mechanism, controls the upper and lower motion strokes of the reagent needle 304, realizes the automatic control of the motion of the reagent needle and detects whether the motion performance of the reagent storage component 3 meets the requirement.

As shown in fig. 7, in the present embodiment, it is possible to realize the control of the refrigeration system of the reagent storage module 3, the temperature feedback reading function, and the automatic control of the movement of the reagent needle 304, and determine whether or not the reagent storage module 3 satisfies the temperature keeping requirement based on the refrigeration effect of the refrigeration apparatus 20, the temperature adjustment capability in the heat shield box 301, and the like, and determine whether or not the movement performance of the reagent needle 304 satisfies the requirement based on the movement of the reagent needle 304.

As shown in fig. 3, the detection device further includes a main controller 17 disposed outside the bottom case 2, and the main controller 17 is connected to the temperature control board 5 and the motion controller. Specifically, the power supply 4 may be connected to the filter 10 and the fuse by power lines, and multiple 24V power lines may be branched off through the terminal block 9 to supply power to the motion controller and the temperature control board 5. The main controller 17 is connected with the motion controller and the temperature control board 5 through the IO interface board 8, so as to control the control system by the main controller 17, further control the motion system and the temperature adjustment system of the reagent storage assembly 3 (mainly realize temperature adjustment by controlling the refrigeration device 20), and detect whether the heat insulation performance of the reagent storage assembly 3 and the motion performance of the reagent needle 304 meet the requirements.

As shown in fig. 1, the bottom of the bottom case 2 is provided with a support pad 16. The supporting foot pad 16 can support the bottom case 2, and the stability of the whole detection device is ensured.

As shown in fig. 4, in the present embodiment, the front side of the heat insulation box 301 of the detection apparatus is provided with an opening through which the water supply tank 18 passes, the frame assembly further includes a sealing door 13 for closing the opening, the sealing door 13 is pivotally connected to the second side plate 203, and the side of the partition cover 1 facing the reagent storage assembly 3 (i.e., the side of the apron 102 facing the second side plate 203) is provided with a pressing type door lock 15 (the door lock 15 may be a bead-hitting door lock) which is engaged with the sealing door 13. Specifically, the reagent component to be tested is placed into the station to be tested, the sealing door 13 is closed, and the sealing door 13 is locked by the door lock 15 and tightly attached to the reagent storage component 3 to realize the sealing and heat preservation of the cavity of the reagent heat insulation box 301.

The detection device of the present embodiment further comprises a rotary valve (not shown), a rotary valve control board 6 and a rotary valve adapter board 7, wherein the rotary valve can control different reagents to enter the pipeline. The rotary valve control plate 6 can be connected to the main controller 17 via the rotary valve adaptor plate 7 and control the operation of the rotary valve.

In the description of the present invention, it is to be understood that the orientation or positional relationship indicated by the orientation words such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal" and "top, bottom", etc. are usually based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and in the case of not making a reverse description, these orientation words do not indicate and imply that the device or element being referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore, should not be considered as limiting the scope of the present invention; the terms "inner and outer" refer to the inner and outer relative to the profile of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "above … … surface," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of the present invention should not be construed as being limited.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A test device for a reagent storage assembly, comprising:

a frame assembly including a bottom case (2) and a partition cover (1), the partition cover (1) partitioning an inner space of the bottom case (2) into a first accommodation space having an open top and a closed second accommodation space, a reagent storage assembly (3) to be tested being disposed in the first accommodation space;

and the control assembly is arranged in the second accommodating space and is connected with the reagent storage assembly (3).

2. The detecting device according to claim 1, wherein the bottom case (2) comprises a bottom plate (201) and a side plate disposed at an edge of the bottom plate (201), and the separating cover (1) comprises a top plate (101) and a surrounding plate (102) disposed at an edge of the top plate (101), and a part of the side plate is disposed in butt joint with the top plate (101) and the surrounding plate (102) to form the second accommodating space.

3. The detection device according to claim 2, wherein the side plates comprise a first side plate (202), a second side plate (203) and a third side plate connected between the first side plate (202) and the second side plate (203), the first side plate (202) has a height greater than that of the second side plate (203), the third side plate comprises a first plate segment (204) connected with the first side plate (202) and a second plate segment (205) connected with the second side plate (203), the first plate segment (204) has a height greater than that of the second plate segment (205), and the second plate segment (205) has a height greater than that of the second side plate (203); the shroud (102) is in abutting engagement with the first side panel (202) and the first panel segment (204).

4. A testing device according to claim 3, wherein the frame assembly further comprises a sealing door (13) pivotally connected to the second side plate (203), and wherein the side of the enclosure (102) facing the second side plate (203) is provided with a door lock (15) cooperating with the sealing door (13).

5. The detection apparatus according to claim 4, further comprising a detection component, wherein the detection component comprises a pressure gauge (11), a syringe pump (12), a water tank (18) and a connecting pipe (19), the water tank (18) is arranged in a heat insulation box (301) of the reagent storage component (3), and the connecting pipe (19) is connected with a reagent needle (304) of the reagent storage component (3), the pressure gauge (11), the syringe pump (12) and the water tank (18) to form a detection loop.

6. The detection device according to claim 5, wherein the pressure gauge (11) is arranged on an outer side wall of the bottom case (2), the syringe pump (12) is arranged in the second accommodation space, and the separation cover (1) is provided with an opening through which the syringe pump (12) extends.

7. The detection device according to claim 4, further comprising a power supply (4) disposed in the second accommodation space, wherein the control assembly comprises a temperature control board (5), and wherein the temperature control board (5) is connected to a temperature sensor disposed in the heat insulation box (301) of the reagent storage assembly (3), a refrigeration device (20) disposed behind the heat insulation box (301) of the reagent storage assembly (3), and a heat radiation fan (21) disposed behind the heat insulation box (301) of the reagent storage assembly (3).

8. The detection device according to claim 7, wherein the control assembly further comprises a motion controller and a motor driver (14), the motor driver (14) being connected with the motion controller and a drive motor (303) of the reagent storage assembly (3), respectively.

9. The detection device according to claim 8, characterized in that it further comprises a main controller (17) arranged outside the bottom shell (2), said main controller (17) being connected to the temperature control board (5) and to the motion controller.

10. Detection device according to any one of claims 1 to 9, characterised in that the bottom of the bottom shell (2) is provided with a support foot (16).

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