CN1052885C

CN1052885C - Chinese medicine herbs for giving off drug of opium

Info

Publication number: CN1052885C
Application number: CN94100966A
Authority: CN
Inventors: 焦晓; 李生林; 李英奇; 李维华
Original assignee: 焦晓
Priority date: 1993-10-12
Filing date: 1994-02-03
Publication date: 2000-05-31
Anticipated expiration: 2014-02-03
Also published as: CN1092319A

Abstract

The present invention provides a formula of a traditional Chinese medicine called medicine for giving up drugs and a preparation method of water decoction thereof. The medicine for giving up drugs is mainly prepared from 39 Chinese herbal medicines of glauberite, talc, gypsum, magnetite, dragon bone, astragali, licorice, radix scutellariae, etc. The medicine for giving up drugs can effectively make symptoms of lacrimation, hydrostomia, stomachache, headache, etc. appearing when drug addiction paroxysm controlled within a shorter time without suffering and dependence after withdrawal.

Description

A kind of Chinese herbal medicine of giving up opium poison

The present invention relates to a kind of preparing process of quit drug abuse prescription and water decoction thereof, this side does not contain any spirituality anesthetis and analeptic, is pure Chinese medicine decoction.

At present, drug abuse is the ubiquitous a kind of vile practices in countries in the world, so drugs mainly are heroin, cocaine, morphine, Fructus Cannabis, morphine class and non-morphinoid derivatives (II) things such as opium, its toxicity is to destroy the enzyme of human acth element, and neural sensitivity is reduced, have function of detoxification and have liver in the tissue only, but it also can only destroy the drugs of minimum lethal dose, remainder then is dissolved in the blood and by bone marrow and absorbs, and another part is discharged from kidney with original shape.These drugs system spirit and nerve anesthetis can be anaesthetized cerebral cortex, make the people glad and hallucination is arranged, thereby very easily produce hobby and habit-forming, cause chronic poisoning, and forfeiture is lived and work capacity.Bring factor leading to social instability to society.

China is after the eighties, and cloudlike, your place and northwest, ground such as inland revive the drug abuse phenomenon, and are on the rise in outlying district, China southwest, and in some place, take drugs open or semi-overization become serious social concern.The decision about the prohibition of drug has been passed through in the 17 meeting of nineteen ninety December the 7th Standing Committee of the National People's Congress on the 28th, scientific research/medical matters and public security department have carried out the research anti-additive medicament, and obtain certain achievement, the 1-4 drug-breaking medicine that provides as China's Ministry of Public Health, but wherein No. 1, just the successively decrease medicine of spirituality anesthetis content of No. 2 and No. 3 drug-breaking medicine, No. 4 drug-breaking medicine are that these medicines of comfort sex pill can not thoroughly be given up drug addiction, in addition, Chinese patent CN-1053187A.CN-1072852A, C patent 1074127A also discloses some drug-breaking medicine slice prescriptions or water decoction prescription, and these are filled a prescription mainly by the Chinese herbal medicine compatibility, and can make patient's narcotics abstinence in a short time.

The purpose of this invention is to provide a kind of narcotic Chinese herbal medicine drug rehabilitation of spirituality prescription that do not use, make junkie give up drug addiction in a short time safely, and minimizing produces the phenomenon of reverting to take drugs.

Each component and content in the Chinese medicine preparation of the present invention are stated as follows: its content is weight percentage:

Mirabilitum crystallina 1.5-10, Talcum 2.5-15, Gypsum Fibrosum 2.5-15, Magnetitum 1.5-6.5; Os Draconis 1.2-6.5, Concha Ostreae 1.2-6.8, Radix Aconiti Lateralis Preparata 0.5-5, Radix Glycyrrhizae 1-12; Radix Astragali 2.5-15, Radix Sophorae Tonkinensis 1.5-7, Massa Medicata Fermentata 0.5-3, Fructus Hordei Germinatus 0.6-2.55; Fructus Crataegi 0.6-3, Radix Scutellariae 1.2-4.5, Cortex Phellodendri 1.2-5; Radix Isatidis 1.2-4.5, Herba Taraxaci 1.2-4.5, Scorpio 1.2-5; Bombyx Batryticatus 1-3, Rhizoma Corydalis 1.5-5, Flos Caryophylli 0.5-2.5; Lignum Aquilariae Resinatum 0.5-2.5, Radix Aucklandiae 0.5-2.5, Ramulus Uncariae Cum Uncis 1.5-4.5; Rhizoma Chuanxiong 1.5-4.5, Radix Angelicae Dahuricae 0.8-3.6, Rhizoma Cimicifugae 1.5-5; Rhizoma Et Radix Notopterygii 1.2-4.5, Radix Arnebiae (Radix Lithospermi) 1.2-4.6, Radix Angelicae Pubescentis 1.2-4.2; Rhizoma Acori Graminei 1.2-4.6, Margarita 0.4-1.6, Borneolum Syntheticum 0.05-0.3; succinum 0.1-1.2, Cinnabaris 0.05-0.35, Calculus Bovis 0.05-0.4; Fel Ursi 0.045-0.5, Cornu rhinocerotis 0.1-0.5, Saigae Tataricae 0.05-0.3.

Chinese herbal medicine formula of the present invention is suitable for decoction, thereby the present invention also provides the fried technology of the water decoction of above-mentioned prescription, and this technology comprises:

(1) with Magnetitum, Mirabilitum crystallina, Gypsum Fibrosum, Talcum, Os Draconis, Concha Ostreae decocting, first intense fire, after changed slow fire 30 minutes, filter cleaner is stand-by;

(2) with Radix Glycyrrhizae, Rhizoma Cimicifugae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, the Radix Angelicae Dahuricae, Radix Arnebiae (Radix Lithospermi), Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Flos Caryophylli, the Radix Astragali, Radix Sophorae Tonkinensis, Radix Scutellariae, Cortex Phellodendri, Herba Taraxaci, Radix Isatidis, Scorpio, Bombyx Batryticatus, Radix Aconiti Lateralis Preparata, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi, Rhizoma Corydalis 1-2 use water logging 1 hour, and it is very little dark that the water yield is crossed medicine 1-2.

(3) above-mentioned (1) gained medicinal liquid is poured in the medicinal liquid of (2), decocted with high heat together and open, change slow fire 10-20 minute, filter cleaner is stand-by;

By above-mentioned (1), (2), the step of (3), with (1), the filtering residue of (3) decocts once again, medicinal liquid be the first time medicinal liquid half, twice medicinal liquid mixing is concentrated into proper volume with slow fire;

(4) with Cornu rhinocerotis, the broken end of Saigae Tataricae is put into big water gaging and is fried in shallow oil surplus proper volume, and filter cleaner is stand-by;

(5) slow fire in medicinal liquids such as Cornu rhinocerotis adding step (3) the gained medicinal liquid is concentrated into proper volume;

(6) with Cinnabaris, Margarita, Calculus Bovis, Borneolum Syntheticum, Fel Ursi, succinum is pulverized and the subpackage bag, and drops into by described order in the mixed liquor of step (5), behind a quarter parcel medicines such as Cinnabaris is taken out, and will be left the medicinal liquid packing and get final product.Water consumption wherein and the proper volume professional after concentrating grasp easily.

Drug rehabilitation Chinese herbal medicine of the present invention has determined curative effect, and effect is fast, and is easy to use, and advantage such as have no side effect is shed tears sialorrhea in the time of making the outbreak of Opium drug addiction, dysphoria, headache, symptoms such as stomachache are controlled, give up no pain, and no dependence, heat-clearing and toxic substances removing also had simultaneously, causing resuscitation with aromatic drugs, the effects such as calmness, anti-inflammatory analgetic, heart tonifying diuresis of calming the nerves.Therapeutic effect is better than some known drug replacement therapy such as cobratoxins, and is stable, oryzanol, and vitamin B6, and some known drug-relief medicines, and reach and surpassed the national anti-additive medicament curative effect standard of perfection that formulate at Chinese dependence drug research center.

The water decoction of the present invention prescription, its occupation mode is oral or intravenous injection, once a day, about every day 50ml, according to degree of intoxication, daily dose can increase and decrease as one sees fit.

Further specify the present invention below by formulation Example.

The prescription of embodiment is (percentage by weight):

Mirabilitum crystallina 3.5, Talcum 5, Gypsum Fibrosum 5, Magnetitum 3.5; Os Draconis 3.3, Concha Ostreae 3.2, Radix Aconiti Lateralis Preparata 2.65, Radix Glycyrrhizae 3.5; the Radix Astragali 5.5, Radix Sophorae Tonkinensis 3.4, Massa Medicata Fermentata 1.7, Fructus Hordei Germinatus 1.7; Fructus Crataegi 1.7, Radix Scutellariae 3.4, Cortex Phellodendri 3.4, Radix Isatidis 3.3; Herba Taraxaci 3.3, Scorpio 3.4, Bombyx Batryticatus 2.2, Rhizoma Corydalis 3.5; Flos Caryophylli 1.5, Lignum Aquilariae Resinatum 1.5, the Radix Aucklandiae 1.5, Ramulus Uncariae Cum Uncis 3.4; Rhizoma Chuanxiong 3.5, the Radix Angelicae Dahuricae 2.4, Rhizoma Cimicifugae 3.5, Rhizoma Et Radix Notopterygii 3.4; Radix Arnebiae (Radix Lithospermi) 3.4, Radix Angelicae Pubescentis 3.4, Rhizoma Acori Graminei 3.4, Margarita 1.2; Borneolum Syntheticum 0.1, succinum 0.6, Cinnabaris 0.25, Calculus Bovis 0.2; Fel Ursi 0.2, Cornu rhinocerotis 0.3, Saigae Tataricae 0.1.

The fried technology of its water decoction is ditto described.The toxicity pharmacological testing

This prescription carries out acute toxicity test by Beijing Pharmaceutical Ind. Inst., and test report shows: experiment group behind 200 times the administration volume and concentration oral administration, does not have the young thing phenomena of mortality, half lethal dose LD by 100 times of people's consumptions ₅₀20g/kg.

Generally 1 hour mice voluntary activity occurs and reduces after administration, and the saliva of the having a liking for phenomenon that reposes is arranged, and begins after 24 hours to recover, and recovers normal in 48 hours.

To the rabbit of 20 Different Month by to after people's dose (50ml) administration, none death of mice, the back rabbit activeness of taking medicine is poor, closes the order phenomenon that reposes, and recovers normally after 24 hours.

Show that by above-mentioned acute margin of safety test this prescription is harmless substantially.

This prescription was tested in Dali, Yunnan Province narcotic house in February, 1993, No. 1, the investigational agent of Shi Yonging by name " thick and Si Taning " drug rehabilitation at that time, 21 routine preliminary clinical observations have been carried out, its medication is: provided and administration by development person, per 8 hours once oral, and each 50ml takes medicine altogether and found in three days according to drug addiction outbreak symptom difference, in 1 to 24 hour, come into effect just basic withdrawal about 3 days after taking medicine respectively.Result of the test shows that this prescription helps elimination and alleviate the heroin addiction patient demonstrate,proving the caused misery of shape because of giving up in guarding against the addiction process, and this medicine does not have obvious toxic-side effects, short treating period, and patient is acceptant.Patient does not produce this drug-breaking medicine and craves for after the drug withdrawal, and can not produce the demand of reverting to take drugs to drugs.

Claims

1, a kind of Chinese herbal medicine of giving up opium poison is characterized in that what this medicine was made by following raw materials by weight percent:

2, the compound method of the described drug rehabilitation Chinese herbal medicine of claim 1 water decoction is characterized in that preparing according to the following steps:

(1) Magnetitum, Mirabilitum crystallina, Gypsum Fibrosum, Talcum, Os Draconis, Concha Ostreae are decocted in water, first intense fire, after changed slow fire 30 minutes, filter cleaner is stand-by;

(2) with Radix Glycyrrhizae, Rhizoma Cimicifugae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, the Radix Angelicae Dahuricae, Radix Arnebiae (Radix Lithospermi), Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, the Radix Astragali, Radix Sophorae Tonkinensis, Radix Scutellariae, Cortex Phellodendri, Herba Taraxaci, Radix Isatidis, Scorpio, Bombyx Batryticatus, Radix Aconiti Lateralis Preparata, Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi, Rhizoma Corydalis 1-2 use water logging 1 hour, and it is very little dark that the water yield is crossed medicine 1-2.

(3) above-mentioned (1) gained medicinal liquid is poured in the medicinal liquid of (2), decocted with high heat and open, change slow fire 10-20 minute, filter cleaner is stand-by;

By above-mentioned (1), (2), the step of (3), with (1), (3) step gained filtering residue decocts once again, and last amount of liquid medicine is concentrated into proper volume with twice medicinal liquid mixing with slow fire than reducing by half for the first time;

(5) slow fire in the last gained medicinal liquid of above-mentioned (4) step gained medicinal liquid adding steps (3) is concentrated into proper volume;

(6) with Cinnabaris, Margarita, Calculus Bovis, Borneolum Syntheticum, Fel Ursi, the bag of succinum drops in the mixed liquor of step (5) by listed order then, after 15 minutes, with Cinnabaris, Margarita, Calculus Bovis, Borneolum Syntheticum, Fel Ursi, the packaging bag of succinum is taken out, and remaining medicinal liquid packing is got final product; Wherein each amounts of components percentage ratio is with described in the claim 1.