CN104352688A - Traditional Chinese medicine formula for stopping novel drug addiction and carrying out rehabilitation treatment on sequelae and preparation method thereof - Google Patents

Traditional Chinese medicine formula for stopping novel drug addiction and carrying out rehabilitation treatment on sequelae and preparation method thereof Download PDF

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CN104352688A
CN104352688A CN201410649944.1A CN201410649944A CN104352688A CN 104352688 A CN104352688 A CN 104352688A CN 201410649944 A CN201410649944 A CN 201410649944A CN 104352688 A CN104352688 A CN 104352688A
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chinese medicine
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medicine formula
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CN104352688B (en
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陈建字
朱华涛
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WUHAN YANGJITAI MATERIAL MEDICA INSTITUTE
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WUHAN YANGJITAI MATERIAL MEDICA INSTITUTE
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Abstract

The invention relates to the technical field of traditional Chinese medicine formulas and preparation methods thereof, and particularly relates to a traditional Chinese medicine formula for stopping novel drug addiction and carrying out rehabilitation treatment on sequelae and a preparation method thereof. The traditional Chinese medicine formula comprises the following components in parts by weight: 20-45 parts of carambola flowers, 30-35 parts of salvia miltiorrhiza, 20-35 parts of polygala amflra, 30-45 parts of rhizoma acori graminei, 9-18 parts of gardenia jasminoides, 15-30 parts of fructus schizandrae, 25-50 parts of dried tangerine or orange peel, 40-50 parts of herba violae, 30-35 parts of radix semiaquilegiae, 40-50 parts of dandelion roots, 30-35 parts of Chinese milkwort, 20-30 parts of semen ziziphi spinosae, 20-30 parts of feather cockscomb seeds, 25-30 parts of mother-of-pearl, 30-35 parts of snakegourd seeds, 20-30 parts of pinellia ternate, and 10-20 parts of fritillaria cirrhosa. The traditional Chinese medicine formula disclosed by the invention is good in curative effect, and fills up a gap in stopping domestic novel drug addiction and carrying out rehabilitation treatment on sequelae.

Description

A kind of for guarding against the Chinese medicine formula and preparation method of controlling novel drug and sequela rehabilitation
Technical field
The present invention relates to Chinese medicine formula and preparation method thereof technical field, being specifically related to a kind of for guarding against the Chinese medicine formula and preparation method of controlling novel drug and sequela rehabilitation.
Background technology
The present invention is according to one of Qing Dynasty Hubei Province east four large well-known doctors, the smoking cessation secret recipe of the treating narcotic addiction highly skilled doctor Yang Ji Thailand equally celebrated for their achievements with Li Shizhen (1518-1593 A.D.), obtain on successful basis based on the sheet research and development of opiates drug-relief medicine Jinan-Tai'an, accumulating and enriching experience, continue explore and draw traditional Chinese medical science marrow optimization of C/C composites, for being addicted to drug type feature and to harm rule the present age, by the diagnosis and treatment data analysis to present stage, the novel drug addictions such as methamphetamine hydrochloride and sequela thereof, Western medicine diagnose belongs to the category of nervous lesion and schizophrenia or hysteria, substantially antipsychotics symptom management can only be used, cannot effect a radical cure, and likely therefore cause long-term drug dependence, its side effect makes again hepatic and renal function impaired further, add the methamphetamine class drug experience that most domestic narcotic house is also imperfect at present, be all unwilling at present to accept for medical treatment, national also unified accepts platform and method for medical treatment.The present invention successfully solves a stopping narcotic taking difficult problem for novel drug class; The clinical practice of formula of the present invention proves, the addiction of novel drug class and sequela patient, particularly drug taking overdose poisoner, applies this formula and carries out conditioning and treating, can treating narcotic addiction obtain rehabilitation smoothly; Belong to Chinese medicinal drug withdrawal application new results.
Summary of the invention
The present invention be directed to the stopping narcotic taking application in TCM formula of novel drug class addiction patient, incorporate the detoxification of traditional treating narcotic addiction step, physiological function conditioning, Mental health such as to form at the crucial problem in the stage, reduce drug dependence, drug craving, preventing suction again and reparation nervous lesion sequela etc.The each medicinal raw material of the present invention is easy to get, and can purchase the commercially available prepared slices of Chinese crude drugs, and economical and practical, is widely used, and not only can use in medical institutions, is also applicable to community's treating narcotic addiction and family's treating narcotic addiction of volunteer addict.
We are in the drug addiction treatment process of novel drug class, can not only directly detoxification, improve significantly and alleviate withdrawal symptom, alleviate nervous lesion progressively repairing, more can improve body's immunity, improve body condition, strengthen resistance against diseases, promote appetite, improvement function, accelerate health give up after rehabilitation.Can also nurse one's health body at convalescence, the mental symptoms such as elimination insomnia forgetfulness, anxiety-depression, suspicious hallucination, agitation are terrified comprehensively.
In order to realize object of the present invention, the technical scheme that the present invention takes is as follows:
For guarding against the Chinese medicine formula controlling novel drug and sequela rehabilitation, it comprises following composition:
Carambola flower 20-45 weight portion, Radix Salviae Miltiorrhizae 30-35 weight portion, Radix Polygalae 20-35 weight portion, Rhizoma Acori Graminei 30-45 weight portion, Yellow Fructus Gardeniae 9-18 weight portion, Fructus Schisandrae Chinensis 15-30 weight portion, Pericarpium Citri Reticulatae 25-50 weight portion, Herba Violae 40-50 weight portion, Radix Semiaquilegiae 30-35 weight portion, Radix Herba Taraxaci 40-50 weight portion, Herba Polygalae Chinensis 30-35 weight portion, Semen Ziziphi Spinosae 20-30 weight portion, Semen Celosiae 20-30 weight portion, Concha Margaritifera 25-30 weight portion, Semen Trichosanthis 30-35 weight portion, Rhizoma Pinelliae 20-30 weight portion, Bulbus Fritillariae Cirrhosae 10-20 weight portion.
Preferably, in described Chinese medicine formula, also comprise Mel 100-150 weight portion, the preferred honey of lychee flowers of described Mel.
Preferred, also comprise the jowar wine of 100-120 parts by volume more than 50 degree in described Chinese medicine formula, described parts by volume is mL:g with the unit ratio of weight portion.
Mel and jowar wine are as making concrete dosage form adjuvant used in described Chinese medicine formula, when adjuvant is Mel, are applicable to making capsule and tablet; Adjuvant be Mel and jowar wine time, be applicable to making oral liquid extractum and Chinese medicine decoct.
The addiction that Chinese medicine formula of the present invention is mainly applicable to rely on because sucking methamphetamine hydrochloride, head-shaking pill, ancient, the happy novel drug such as water, ketamine (KET) of fiber crops and psychotropic substances carries out detoxication and rehabilitation; Reuse carambola flower, Radix Semiaquilegiae, Radix Herba Taraxaci, Herba Violae in we's formula for monarch, heat-clearing and toxic substances removing, Pericarpium Citri Reticulatae, Yellow Fructus Gardeniae unclog and readjust irritability, remove Liver and kidney pressure, while with Herba Polygalae Chinensis, Radix Salviae Miltiorrhizae for minister, merit arrogates to oneself blood-activating and qi-promoting, can strengthen blood circulation promoting and blood stasis dispelling; The Rhizoma Pinelliae, Semen Trichosanthis, Bulbus Fritillariae Cirrhosae eliminate the phlegm and disappear dizzy, and alleviate dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and joins Concha Margaritifera, Semen Ziziphi Spinosae, Semen Celosiae, Radix Polygalae, Rhizoma Acori Graminei can clearing away heart-fire for tranquillization; Sun Simiao cloud: informal dress Fructus Schisandrae Chinensis is with tonifying five ZANG-organs gas.Prescription manufacturing process: add high spirit and Mel and can optimize the removing toxic substances conditioning functions of we and improvement and to take medicine problem under difficulty bitter to the taste; All medicines share, can treating both the principal and secondary aspects of a disease, common play detoxification disappear addiction, suppressing hyperactive liver for descending adverse qi, the detoxicating that uncharms, clearing away heart-fire for tranquillization, blood circulation promoting regulates qi, activating muscle and blood, warming the kidney and strengthening the spleen, improve effect of neurotransmitter conduction vigor.
Compared with prior art, advantage of the present invention and beneficial effect are:
1, the present invention has cracked novel drug addiction and the irreversible difficult problem of poisoning sequela nervous lesion, and most of addict is exactly abandoning cure because of the irreversible publicity of supertition, has to throw the handle after the blade, and continues depravity; And a part of excessive poisoner, can only accept the long-term antipsychotics symptom management of original costliness, cannot be completely free of drug dependence, have to bear misery and the mental suffering of side effect, even go to extremes road or the selection that have are committed suicide.
2, the present invention can divide the order of importance and emergency according to the drug addiction degree of novel drug and poisoning sequela patient different characteristic and symptom, apply in a flexible way, short-term heavy dose can reach quick toxin expelling, restrain drug addiction, alleviate and cure the frightened hallucination symptom of anxiety-depression, low dose of long-term taking can nourishing the liver and blood, plays QI and blood regulating and run regulating YIN and YANG balance, accumulation healthy energy, preventing suction again effect of building body.
3, Chinese medicine formula raw material of the present invention is easy to get, and is the commercially available prepared slices of Chinese crude drugs, and its price is not high, particularly carambola flower, is that the fruit carambola tree of southern establishing in large scale is hit unnecessary flower collection down and dries rear gained florescence.Compendium of Material Medica records carambola flower principal solution wind heat, promotes the production of body fluid, quenches the thirst.There is resolving heat and reducing pathogenic fire, the loud and clear voice that wets one's whistle, diuresis, removing toxic substances, relieving alcoholic intoxication, hemostasis, removing toxic substances and promoting tissue regeneration, the effect such as aid digestion.
4, suck novel drug as methamphetamine hydrochloride etc., the main manifestations of its sequela is: depressed, lethargy is depressed, anxiety dysphoria, occurs mental disorder or death, and some patients has impulsion hurting people or smashing objects or suicide autolesionism.Add both at home and abroad all without alternative medicine and radical cure method, make them seek medical advice without door, particularly because of the family of economic bust by long-term murder by poisoning, the antipsychotics of long-term taking costliness is not accomplished at all.The invention of we, take into account curative effect and material benefit, add effective, treatment cycle is short, gives the hope that this kind of addict and poisoner realize rehabilitation, while obtaining therapeutic effect, also has corresponding social benefit, the establishment of the nontoxic society of power-assisted.
Detailed description of the invention
Applicant will do Chinese medicine formula of the present invention and preparation method thereof and medical usage in conjunction with specific embodiments and further elaborate below, and object is to make those skilled in the art have more deep understanding and cognition to technical scheme of the present invention and effect.
All embodiments should not be understood to the restriction to claims of the present invention request protection domain in any degree below.
For guarding against the Chinese medicine formula controlling novel drug and sequela rehabilitation, the formula list of each embodiment schematically as follows:
In above embodiment 1-4, except Mel and jowar wine, 17 kinds of Chinese crude drugs are the common commercially available prepared slices of Chinese crude drugs.
Embodiment 5: a kind of listed by embodiment 1 formula raw material be prepared into the method for oral liquid extractum, its step is as follows:
The first step: by Herba Violae 40 grams, Radix Semiaquilegiae 30 grams, Radix Herba Taraxaci 40 grams, Herba Polygalae Chinensis 30 grams, Semen Ziziphi Spinosae 20 grams, Semen Celosiae 25 grams, Radix Salviae Miltiorrhizae 30 grams, Semen Trichosanthis 30 grams, the Rhizoma Pinelliae 20 grams, Radix Polygalae 20 grams, Rhizoma Acori Graminei 30 grams, Fructus Schisandrae Chinensis 15 grams, carambola spends 20 grams to mix, the 8-10 times of cold water at every turn adding medical material gross weight first soaks one hour, and then extraction is decocted twice under 100 degrees Celsius, decoct 80 minutes at every turn, merge extracted twice liquid, add 100 milliliters of 53 degree of jowar wines, 30-60 minutes are decocted again under 100 degrees Celsius, abundant volatilization alcoholic content, decoct and namely pour out filtration after remaining about 1000 milliliters, filtrate is for subsequent use.
Second step: by fully grinding after Concha Margaritifera 25 grams, Bulbus Fritillariae Cirrhosae 10 grams, Yellow Fructus Gardeniae 9 grams, Pericarpium Citri Reticulatae 25 grams mixing, after sieving by 100 mesh sieve, obtain medicated powder for subsequent use.
3rd step: by the mixing of the medicated powder of the filtrate of first step gained and second step gained, be blended into 100 grams of honey of lychee flowers after fully rocking fusion, put into drug-decocting pot again boiling sterilization namely into about 1100 milliliters of Chinese medicine oral liquid extractum, be divided into 9 parts, about 120 milliliters every part.This is three days oral doses, one day three times, once a.
Embodiment 6: a kind of listed by embodiment 2 formula raw material be prepared into the method for Chinese medicine decoct, its step is as follows:
By Herba Violae 45 grams, Radix Semiaquilegiae 32 grams, Radix Herba Taraxaci 48 grams, Herba Polygalae Chinensis 34 grams, Semen Ziziphi Spinosae 25 grams, Semen Celosiae 30 grams, Radix Salviae Miltiorrhizae 35 grams, Concha Margaritifera 28 grams, Semen Trichosanthis 33 grams, the Rhizoma Pinelliae 30 grams, Bulbus Fritillariae Cirrhosae 13 grams, Radix Polygalae 25 grams, Rhizoma Acori Graminei 35 grams, Yellow Fructus Gardeniae 15 grams, Fructus Schisandrae Chinensis 30 grams, Pericarpium Citri Reticulatae 35 grams and carambola spend 25 grams to mix, add 1500 milliliters, cold water to soak one hour, and then decoct to 700 milliliters of i.e. pourable medicinal liquids under 100 degrees Celsius, in medical material, again add 1200 milliliters of cold water again decoct to 600 milliliters according to upper method and pour out medicinal liquid, the medicinal liquid of extracted twice is mixed, add 120 milliliters of 53 degree of jowar wines, 30 minutes are decocted again under 90-100 degree Celsius of lower slow fire, abundant volatilization alcoholic content, add honey of lychee flowers 150 grams after decocting remaining about 1350 milliliters to shake up after mixing, be divided into 9 parts.This is three days doses, one day three times, once takes portion.
Embodiment 7: a kind of listed by embodiment 3 formula raw material be prepared into the method for capsule, its step is as follows:
The first step, by Herba Violae 50 grams, Radix Semiaquilegiae 33 grams, Radix Herba Taraxaci 50 grams, Herba Polygalae Chinensis 33 grams, Semen Ziziphi Spinosae 30 grams, Semen Celosiae 22 grams, Radix Salviae Miltiorrhizae 33 grams, Semen Trichosanthis 34 grams, the Rhizoma Pinelliae 27 grams, Radix Polygalae 33 grams, Rhizoma Acori Graminei 40 grams, Pericarpium Citri Reticulatae 30 grams, Fructus Schisandrae Chinensis 20 grams and carambola spend 35 grams to mix, coarse powder is ground into through chopping up, add 1000 milliliters of 70wt% ethanol as solvent, soak percolation after 24 hours, collecting liquid of just filtering is that 60% of this step medical material gross weight is separately deposited, percolation is continued according to upper method, collect continuous liquid of filtering, be incorporated to after being less than 40 degrees Celsius of cryoconcentration and just filter in liquid, add honey of lychee flowers 120g, be condensed into thick paste, for subsequent use.
Second step, by fully grinding after Concha Margaritifera 26 grams, Bulbus Fritillariae Cirrhosae 17 grams, Yellow Fructus Gardeniae 12 grams mixing, for subsequent use with making medicated powder after 200 mesh sieve.
3rd step, by first and second step gains mixing, carry out drying after fully stirring, time dry, temperature controls at 40-60 DEG C, 5 hours drying times.
4th step, is crushed to the microgranule of more than 800 orders by super micron mill by above-mentioned dried Chinese medicine, about 139 grams.
5th step, sends microgranules more than above-mentioned 800 orders into capsule workshop, loads a Capsules, by every containing 0.5g medicated powder, makes capsule.Oral three times of every day of adult, each six.This dosage form is conditioning and treating medication, and the present embodiment formula dosage is 15 days consumptions.
Embodiment 8: a kind of listed by embodiment 4 formula raw material be prepared into the method for tablet, its step is as follows:
The first step, by Herba Violae 43 grams, Radix Semiaquilegiae 35 grams, Radix Herba Taraxaci 44 grams, Herba Polygalae Chinensis 35 grams, Semen Ziziphi Spinosae 28 grams, Semen Celosiae 28 grams, Radix Salviae Miltiorrhizae 31 grams, Semen Trichosanthis 35 grams, the Rhizoma Pinelliae 23 grams, Radix Polygalae 35 grams, Rhizoma Acori Graminei 45 grams and carambola spend 45 grams to mix, coarse powder is ground into through chopping up, add 1000 milliliters of 70wt% ethanol as solvent, soak percolation after 24 hours, collecting liquid of just filtering is that 70% of this step medical material gross weight is separately deposited, percolation is continued according to upper method, collect continuous liquid of filtering, be incorporated to after being less than 40 degrees Celsius of cryoconcentration and just filter in liquid, add honey of lychee flowers 110 grams, be condensed into thick paste, for subsequent use.
Second step, by fully grinding after the mixing of Concha Margaritifera 30 grams, Bulbus Fritillariae Cirrhosae 20 grams, Yellow Fructus Gardeniae 18 grams, Pericarpium Citri Reticulatae 50 grams and Fructus Schisandrae Chinensis 25 grams, makes medicated powder after sieving for subsequent use by 100 mesh sieve.
3rd step, by first and second step gains mixing, carry out drying after fully stirring, time dry, temperature controls at 50-70 DEG C, 6 hours drying times.
4th step, is crushed to the microgranule of more than 800 orders by super micron mill by above-mentioned dried Chinese medicine.
5th step, sends microgranules more than above-mentioned 800 orders into tabletting workshop, is pressed into the tablet of every sheet 0.5g.Oral three times of every day of adult, each six.This dosage form is also the medicine for treatment of conditioning phase, and the present embodiment formula dosage is 15 days consumptions.
Clinical practice example
Control due to the domestic ring to novel drug and lack experience and platform disappearance, major part methamphetamine class novel drug patient, Grade A hospital spirit, nerve, psychological internal medicine or professional spirit's hospital for treatment can only be arrived, diagnosis and symptomatic therapy are often with reference to treatment of schizophrenia pattern, give Who Long Take Psychoactive Drug, temporarily suppress and relief of symptoms, can not thoroughly solve sequela problem, therefore what have even relies on medicine for a long time, forms new hepatic and renal function injure; Since 2008, our Chinese medicine against drug dependence research and development group is at the invitation of prohibition of drug group of Nanan of Quanzhou City of Fujian Province, Chinese medicinal drug withdrawal diagnosis and treatment and rehabilitation guide work is carried out to Coastal Area of Fujian Surveyed, application the present invention is successfully that the addiction that numerous patient solves novel drug is given up and a sequela rehabilitation difficult problem, last the clinical practice of 6 years, present Chinese medicine and control the new function in field at novel drug ring, Be very effective, success case is numerous, below respectively using Application Example and model case as application note of the present invention.
Application Example:
A, in drug addiction treatment, for the methamphetamine hydrochloride of methamphetamine class and the ancient addiction treating narcotic addiction of head-shaking pill fiber crops, the methamphetamine hydrochloride of age more than 18 one full year of life and head-shaking pill, ancient addiction patient diagnosed 310 people of fiber crops, mostly be prohibition of drug office at different levels of Quanzhou, Fujian city and medical and health services agency recommends medical staff, symptom is obvious mainly with novel drug addiction dependence characteristics, insomnia forgetfulness, anxiety-depression, lethargy, build is become thin, suspicious hallucination, dysphoria is main, disease time is for stopping the rear 3-7 days that takes drugs, the longest history of drug abuse more than 9 years, through the oral liquid extractum prepared by the embodiment of the present invention 5, every day three times, each portion, taking medicine before meal, namely patients acuity withdrawal symptom symptom is alleviated for about 3 days, follow-up rehabilitation adopts embodiment 7 or embodiment 8 to give medication after meal, one day three times, one time 6 or six, take one month continuously, namely preliminary treating narcotic addiction and rehabilitation efficacy is reached, medicine drug craving reduces, healthy physical signs obviously promotes, various dysphoria, insomnia forgetfulness, Anxiety And Depression Symptoms disappears or alleviates, period in a medicine, has no side effect to the heart, liver, kidney, hemopoietic system etc., does not also produce new drug dependence.
B, for the clinical treatment of the excessive acute poisoning sequela of novel drug, case sample is from various parts of the country, see a doctor out of admiration for a famous person, there is obvious novel drug acute poisoning nervous lesion feature more, Symptoms is arrhythmia, breast is vexed, hypopnea, headache is dizzy, vainly hope manic, frightened suspicious, words and deeds are out of control, self inflicted injury suicidal tendency or violent tenet is had to be main, disease time is 1-3 days after acute poisoning, morbidity is at the latest tested for last excessive Xi Du Frequency dead volume and is produced fear, recover normal in a few days voluntarily, more than interval half a year because again falling ill by certain direct stimulation, these cases all adopt the Chinese medicine decoct of the embodiment of the present invention 6, every day three times, each portion, taking medicine before meal, namely alleviates for about 5-6 days, and the capsule that follow-up rehabilitation adopts embodiment 7 or 8 to prepare or tablet give medication after meal, one day three times, one time 6 or six, take one month continuously, namely reach preliminary rehabilitation efficacy, this type clinical trial statistics sufferer 156 people, recovering normal person through treatment is 130 people, accounts for total 156 people's 83.3%, the various symptom person of being improved in varying degrees 22 people, accounts for total 156 people's 14.1%, without positive effect person 4 people, account for 2.6%, total effective rate is 97.4%.Period in a medicine, has no side effect to the heart, liver, kidney, hemopoietic system etc., does not also produce new drug dependence.
Model case
1, Huang Zhiyong (assumed name), man, in 27 years old this year, Fujian people from Nan'an, often indulged in the bar before 8 years together with friend, drank federal syrup for a cough before this and added cola and refresh oneself, and then arrived dozen K (ketamine) addiction, until suck methamphetamine hydrochloride.Because of with crossing the multiple drugs such as syrup for a cough, KET and methamphetamine hydrochloride, forming multi-medicament and relying on and multiple nervous lesion.Find the obfuscation of its face when coming medical, skin slightly makes, perspiration of becoming thin, two muddiness is dull, personality is cold and detached; Private prosecution and family members reflect disease opinion: insomnia forgetfulness, inappetence, constipation; When not taking drugs, sluggish, physical weakness, drowsy, be reluctant also repeatedly to occur communication anxiety-depression and suspicious hallucination, manic uneasiness, feel bad go mad.Treat three days through the embodiment of the present invention 5 oral liquid extractum, symptom takes a turn for the better, and adopt embodiment 7 capsule after treatment one month subsequently, further consultation inspection meets rehabilitation index.
2, Yang's (name conceals), female is 27 years old, married.Spring in 2009 starts to suck head-shaking pill and 3 years (methamphetamine class drugs) addiction time of methamphetamine hydrochloride.Readme: brains is uncomfortable, suspicious hallucination, short-tempered, anxiety-depression, cervical region is ached, and brains is tightened, and temple are beated, numbness of hands and feet, arrhythmia, sometimes can grit one's teeth, and is difficult to adapt to orthobiosis.Disease is seen: the cured Huang of complexion, emaciated physique, and body of the tongue is yellow, thick fur is sliding, and tongue limit point has blood stasis purpura.Treat and take three days with the oral liquid extractum of embodiment 5 preparation, sensory symptoms alleviation next day of taking medicine, can stand substantially; After second day is taken, depressed, the suspicious hallucination of having started to experience anxiety has and obviously alleviates; After 3rd day, self-induction sleep quality promotes, and appetite increases, and the tight sense of headache disappears, and trick is no longer numb; Advise it to continue and use oral liquid extractum, dosage reduces by half, and continues to take one month; So far, readme brothers are warm, and whole body is micro-sweating, for QI and blood is unobstructed, now have rosy cheeks, and spirit is good, happiness activity, and body weight increases 2kg, and disappeared addiction.
3, Mr. Zhou, man, 28 years old, people from Shishi City, acute methamphetamine hydrochloride sequela; Overseas-funded enterprise operating officer, because curious and business reception, drug taking overdose, before this sudden cardiac arrest, then uncomfortable in chest, feel vital organs of the human body function uneven, cause intelligence, emotion and personality to occur the symptom of serious distortion; Belong to methamphetamine hydrochloride acute poisoning sequela through diagnosis, the Chinese medicine decoct giving embodiment 6 takes five days, and sensory symptoms is alleviated; The capsule continuing to give embodiment 7 preparation takes one month, through the basic rehabilitation of further consultation, follows up a case by regular visits to and do not recur after 1 year.
4, Mr. Chen, 20 years old, people from Foochow, the end of the year 2013, because young ignorant and curiosity, new girl friend is accompanied to suck methamphetamine hydrochloride, once excessive poisoning, often feel various uncomfortable from head to foot, suspecting oneself at any time can be dead, once the spirit internal medicine diagnosis and treatment of total institute of Fujian Concord Hospital and the military region, Foochow were arrived at the beginning of 2014, all give symptomatic treatment with hysteria or schizophrenia, take antipsychotics and have no improvement in three months, seek help on August 20th, 2014 to present inventor place, the traditional Chinese medical science checks: body of the tongue is lighter, red tip of the tongue, thick fur, two cun, arteries and veins moistens puckery, right pass is slightly grand, chi floating and large pulse, heavily by unable, be diagnosed as heart kidney two empty, mental derangement, the Chinese medicine decoct giving embodiment 6 preparation takes three days, and after medicine, spirit is gradually shaken, and terrified troubled thoughts subtract greatly, and appetite and sleep quality increase, the capsule of enjoining it to continue to take the embodiment of the present invention 7 immediately one month, all diseases all disappear, and expression is normal.
5, Mr. Huang, 23 years old, Quanzhou people from Nan'an, started to suck methamphetamine hydrochloride from 17 years old, after being found by its father and mother, detention of repeatedly reporting to the police, the isolation drug addiction treatment of Yi Song treating narcotic addiction hospital, all fail to break away from drug addiction puzzlement, and all schizophrenic symptoms is more serious, propensity to violence, developing into words and deeds cannot automatic control, set fire oneself house, then seeks medical advice; Be methamphetamine hydrochloride nervous lesion sequela after diagnosing, oral liquid extractum prepared by the application embodiment of the present invention 5 is treated three days symptoms and is alleviated, the capsule then adopting embodiment 7 to prepare continues to strengthen curative effect, auxiliary in psychological instruction, further consultation after one month, various all schizophrenic symptoms disappears, and physiology physical health index is good, and the test of psychiatric evaluation meets health standards.
Above numerical example patient over the course for the treatment of, carries out physical examination to patient after taking medicine continuously three days, finds the system such as breathing, circulation, nerve, blood and Liver and kidney function without obvious harmful effect; After taking medicine continuously one month after basic rehabilitation, all recover normal through the every health indicator of further consultation health check-up, the low dose that few patients need continue discontinuity is taken medicine, and belongs to useful psychological hint and warning function, pays a return visit no abnormality seen fluctuation after rehabilitation.
Toxicity test
One, short term toxicity test: for the oral liquid extractum of embodiment 5, with 60g medicament/kg, be equivalent to 50 times of adult's (60kg meter) consumption per day, a gavage (ig) is in Mice Body, observe 4d all animals have no overt toxicity reaction or occur dead, therefore the dosis tolerata of a mice ig is not less than 60g medicament/kg.Again for the tablet of embodiment 8, with 50 medicament/kg, be equivalent to 100 times of adult's (60kg meter) consumption per day, a gavage (ig) is in Mice Body, observe 5d all animals have no overt toxicity reaction or occur dead, therefore the dosis tolerata of a mice ig is not less than 50/kg.
Two, long term toxicity test: the oral liquid extractum prepared according to embodiment 5 respectively with high (60g medicament/kg), in (40g medicament/kg), low (20g medicament/kg) Three doses (be equivalent to 30,20,10 times of the clinical people's consumption of oral liquid extractum, every day three times, continuous gavage gives surrounding and makes convalescent period (drug withdrawal 1-4 days) Reversible observe, by observing rat general signs, the detection toxicity test data display of the objective indicator such as biochemical, the histopathologic examination of major blood, meet non-toxic and safe standard.Therefore, the long-term successive administration of this invention prescription can be thought to rat without overt toxicity reaction and retardance toxicity.
List of references: Ministry of Health of the People's Republic of China was in revised " amphetamines relies on diagnoses and treatment guideline " in 2009

Claims (10)

1. for guarding against the Chinese medicine formula controlling novel drug and sequela rehabilitation, it is characterized in that, described Chinese medicine formula comprises following composition:
Carambola flower 20-45 weight portion, Radix Salviae Miltiorrhizae 30-35 weight portion, Radix Polygalae 20-35 weight portion, Rhizoma Acori Graminei 30-45 weight portion, Yellow Fructus Gardeniae 9-18 weight portion, Fructus Schisandrae Chinensis 15-30 weight portion, Pericarpium Citri Reticulatae 25-50 weight portion, Herba Violae 40-50 weight portion, Radix Semiaquilegiae 30-35 weight portion, Radix Herba Taraxaci 40-50 weight portion, Herba Polygalae Chinensis 30-35 weight portion, Semen Ziziphi Spinosae 20-30 weight portion, Semen Celosiae 20-30 weight portion, Concha Margaritifera 25-30 weight portion, Semen Trichosanthis 30-35 weight portion, Rhizoma Pinelliae 20-30 weight portion, Bulbus Fritillariae Cirrhosae 10-20 weight portion.
2. Chinese medicine formula according to claim 1, is characterized in that: described Chinese medicine formula also comprises Mel 100-150 weight portion.
3. Chinese medicine formula according to claim 2, is characterized in that: described Mel is honey of lychee flowers.
4. the Chinese medicine formula according to Claims 2 or 3, is characterized in that: described Chinese medicine formula also comprises jowar wine 100-120 parts by volume, and described parts by volume is mL:g with the unit ratio of weight portion.
5. Chinese medicine formula according to claim 4, is characterized in that: described jowar wine is the jowar wine of more than 50 degree.
6. Chinese medicine formula according to claim 5, is characterized in that: described jowar wine is the jowar wine of 53 degree.
7. according to the capsule that described Chinese medicine formula arbitrary in claim 1-3 is made.
8. according to the tablet that described Chinese medicine formula arbitrary in claim 1-3 is made.
9. the oral liquid extractum that the Chinese medicine formula according to claim 4 or 5 or 6 is made.
10. the Chinese herbs decoction that the Chinese medicine formula according to claim 4 or 5 or 6 is made.
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* Cited by examiner, † Cited by third party
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CN107224542A (en) * 2016-03-25 2017-10-03 邱定武 A kind of traditional herbal medicine and its preparation for being used to quit drug abuse
WO2017205666A1 (en) * 2016-05-25 2017-11-30 National Health Research Institutes Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine

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CN101156941A (en) * 2007-09-21 2008-04-09 林绍文 A drug rehabilitation medicine for preventing suction again
CN102038706A (en) * 2009-10-19 2011-05-04 深圳市源柏菲中医药开发有限公司 Drug treatment and rehabilitation Chinese herbal composition

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CN107224542A (en) * 2016-03-25 2017-10-03 邱定武 A kind of traditional herbal medicine and its preparation for being used to quit drug abuse
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