CN100336532C - Oral medicinal preparation against drug addiction and its preparing method - Google Patents
Oral medicinal preparation against drug addiction and its preparing method Download PDFInfo
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- CN100336532C CN100336532C CNB2005100123021A CN200510012302A CN100336532C CN 100336532 C CN100336532 C CN 100336532C CN B2005100123021 A CNB2005100123021 A CN B2005100123021A CN 200510012302 A CN200510012302 A CN 200510012302A CN 100336532 C CN100336532 C CN 100336532C
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Abstract
The present invention provides an oral preparation product for drug abstinence. The oral preparation product of the present invention is prepared from raw material medicine of 200 to 400 portions of Chinese milkwort herb, 150 to 255 portions of honeysuckle flower, 60 to 90 portions of scutellaria, 70 to 100 portions of cape jasmine fruit, 100 to 150 portions of red sage root, 80 to 120 portions of angelica, 120 to 180 portions of astragalus root, 35 to 55 portions of ginseng, 35 to 55 portions of deglued antler, 60 to 100 portions of prepared rehmannia root, 100 to 150 portions of white paeony root, 60 to 100 portions of tortoise shell and 40 to 60 portions of hemlock parsley by weight. Clinical observation prove that when a drug abstinence cigarette preparation of the present invention is used for detoxification treatment on opium addicts, all abstinence syndromes are obviously reduced in a second day after the treatment, the abstinence syndromes especially insomnia, addiction, anorexia, etc. have obvious reduction, the urine morphine rehabilitation time is between 2 and 4 days, and the present invention has no obvious toxic side effect, few adverse effect and no abnormal biochemical and laboratory examination result. Through the clinical observation, the drug abstinence cigarette preparation of the present invention has the characteristics of high detoxification speed, conspicuous curative effect, no obvious toxic side effect, etc. The medical composition of the present invention does not comprise any drug ingredient, and has no addiction.
Description
Technical field
The present invention relates to a kind of drug oral preparation and preparation method that is used to quit drug abuse, belong to herbal composite formulation products and processing technique field.
Background technology
As everyone knows, traffic in drugs, drug abuse have become a global serious social problem, have brought very big harm for society, economy, public security.Always all at the effective ways of research drug rehabilitation, at present many Therapeutic Method are applied in medical practice, and have obtained certain effect for many years in various countries.Have as Western medicine drug rehabilitation main method: (1) substitutes diminishing method.Choice drug is a methadone, and it is an opioid receptor agonist.Principle is that promptly successively decreased day by day next day after capacity replaced, " first quick and back slow, only subtract do not add ".In fact it substitute another kind of addictive drug with a kind of addictive drug, but can form body, psychological dependence and toleration after the prolonged application, occurs withdrawal symptom-organic mental state syndrome when inactive, as dysphoria, anxiety insomnia etc.; (2) non-opium dropping drug dependence treatment.Its main medicine is a clonidine, does not have an addiction, can suppress withdrawal symptom preferably.Major side effects is drowsiness, postural hypotension companion pale complexion, dyspnea; (3) opioid antagonist is dispelled malicious and is induced drug rehabilitation.Itself since artificial blocking-up opiate receptor, make the addict in various degree withdrawal symptom inevitably occur, be difficult for being accepted by the addict.
The Western medicine detoxification is better, and rehabilitation is difficult, though main because the therapy of the alternative detoxification of opioid drug is more steady early stage, the drug withdrawal difficulty, and protracted abstinence symptom (psa) is often more obvious after the detoxification.Protracted abstinence symptom (psa) is to cause the one of the main reasons of reverting to take drugs after the detoxification to patient's puzzlement.
The Chinese herbal medicine drug rehabilitation is with a long history, from the overall process of the cause of disease, pathogenesis, treatment, rehabilitation rounded system is arranged to quitting drug abuse, and the Chinese herbal medicine drug rehabilitation has abundant medical practice basis, and himself special advantages is arranged.Detoxification by Chinese medicine medicine source is extensive, rare addiction, and especially the effect of Chinese herbal medicine multisystem, many target spots can be brought into play Accommodation preferably at protracted abstinence symptom (psa) complexity, multisystem and the prevention of reverting to take drugs.
Summary of the invention
It is not remarkable that the present invention is intended to solve existing anti-additive medicament effect aspect control opiates withdrawal symptom, maybe must adopt the opiates decreasing therapy, and be not easy problem that the patient is thoroughly given up.A kind of safe, effective, compositions that self does not have addicted Chinese herbal medicine drug rehabilitation fumicants and preparation technology thereof are provided.
Technical scheme of the present invention is achieved in that this drug oral preparation that is used to quit drug abuse, and it is characterized in that it is made by following raw medicaments in portion by weight: Herba Polygalae Telephioidis 200-400, Flos Lonicerae 150～255, Radix Scutellariae 60～90, Fructus Gardeniae 70-100, Radix Salviae Miltiorrhizae 100-150, Radix Angelicae Sinensis 80-120, Radix Astragali 120-180, Radix Ginseng 35-55, Cornu Cervi Degelatinatum 35-55, Radix Rehmanniae Preparata 60-100, Radix Paeoniae Alba 100-150, Carapax Et Plastrum Testudinis 60-100, Rhizoma Chuanxiong 40-60.
The described drug oral preparation that is used to quit drug abuse is made by following raw medicaments in portion by weight: Herba Polygalae Telephioidis 333.3, Flos Lonicerae 208.3, Radix Scutellariae 75, Fructus Gardeniae 83.3, Radix Salviae Miltiorrhizae 125, Radix Angelicae Sinensis 100, the Radix Astragali 150, Radix Ginseng 41.7, Cornu Cervi Degelatinatum 41.7, Radix Rehmanniae Preparata 83.3, the Radix Paeoniae Alba 125, Carapax Et Plastrum Testudinis 83.3, Rhizoma Chuanxiong 50.
Herba Polygalae Telephioidis described in the described drug oral preparation that is used to quit drug abuse comprises Herba Polygalae Chinensis, little Herba Polygalae Telephioidis or ZIBEIJINNIU.
The preparation method of the described drug oral preparation that is used to quit drug abuse may further comprise the steps:
(1) get Radix Angelicae Sinensis and Rhizoma Chuanxiong, cataclasm, add 10 times of amounts of water, soaked 1 hour, water vapour distillation volatile oil is collected volatile oil, device collection in addition behind the extracting liquid filtering, medicinal residues are standby;
(2) get Radix Salviae Miltiorrhizae, Fructus Gardeniae and Radix Scutellariae, add the alcohol reflux twice of 10 times of amounts 70%, each 1.5 hours, extracting liquid filtering, medicinal residues are standby; Filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into clear paste, and is standby;
(3) depletion timothy, the Radix Paeoniae Alba, the Radix Astragali, Carapax Et Plastrum Testudinis and Radix Rehmanniae Preparata are cataclasm, merge with step (2) medicinal residues, add 10 times of amounts of water, decoct 2 times, each 1.5 hours, when decocting for the second time, add Flos Lonicerae, extracting liquid filtering, the aqueous solution behind the oil is carried in adding (1), is condensed into clear paste;
(4) get step (3) clear paste, spray drying obtains dried cream powder, adds Cornu Cervi Degelatinatum, Radix Ginseng fine powder, and mix homogeneously sprays into step (1) volatile oil, adds the pharmaceutical preparation adjuvant and makes oral formulations.
Oral formulations described in the preparation method of the described drug oral preparation that is used to quit drug abuse comprises capsule, tablet, soft capsule, drop pill, oral liquid.
Pharmaceutical preparation adjuvant described in the preparation method of the described drug oral preparation that is used to quit drug abuse comprises magnesium stearate, sodium carboxymethyl cellulose, starch, Icing Sugar.
Technological progress effect of the present invention is that its prescription mechanism and opium decrease Tianjin consumption liquid because of hot fragrant sour and astringent causing, and the pathogenesis of cutting down the impairment of QI-blood matches, and with strengthening vital QI to eliminate pathogenic factors, setting upright is benefiting QI and nourishing blood, Yin-nourishing and Yang-supporting, tonification internal organs in the hope of performance Chinese medicine advantage; The eliminating evil tobacco poisoning of promptly dispeling is transferred smooth QI and blood, has received better curative effect in clinical use, for opiates drug addiction person provides determined curative effect, takes safe new product of Chinese medicine.Show that by clinical observation the present invention fumicants treatment opiate addiction patient that quits drug abuse all obviously descends in withdrawal symptom scoring in second day of detoxification treatment, especially descends obviously with have a sleepless night, crave for, anorexia etc., urinating the morphine clearance time is 2～4 days.Do not see obvious toxic and side effects, untoward reaction is slight, and biochemistry and lab testing be no abnormality seen as a result.Clinical observation the present invention fumicants of quitting drug abuse has characteristics such as detoxification is fast, curative effect is high, no obvious toxic-side effects.And this pharmaceutical composition does not contain any drug ingredient, no addiction.
The specific embodiment
Embodiment 1
Prescription ratio: Herba Polygalae Telephioidis 333.3, Flos Lonicerae 208.3, Radix Scutellariae 75, Fructus Gardeniae 83.3, Radix Salviae Miltiorrhizae 125, Radix Angelicae Sinensis 100, the Radix Astragali 150, Radix Ginseng 41.7, Cornu Cervi Degelatinatum 41.7, Radix Rehmanniae Preparata 83.3, the Radix Paeoniae Alba 125, Carapax Et Plastrum Testudinis 83.3, Rhizoma Chuanxiong 50
Its preparation method is as follows:
(1) get Radix Angelicae Sinensis and Rhizoma Chuanxiong, suitably cataclasm, add 10 times of amounts of water, soaked 1 hour, vapor distillation extracts volatile oil, collects volatile oil, device collection in addition behind the extracting liquid filtering, medicinal residues are standby;
(2) get Radix Salviae Miltiorrhizae, Fructus Gardeniae and Radix Scutellariae, add the ethanol of 10 times of amounts 70%, extract twice, each 1.5 hours, extracting liquid filtering, medicinal residues are standby, and filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into clear paste, and is standby;
(3) depletion timothy, the Radix Paeoniae Alba, the Radix Astragali, Carapax Et Plastrum Testudinis and Radix Rehmanniae Preparata, suitably cataclasm, together with above-mentioned medicinal residues, add 10 times of amounts of water, decoct 2 times, each 1.5 hours, add Flos Lonicerae when decocting for the second time, extracting liquid filtering, the aqueous solution behind the oil is carried in adding, is condensed into clear paste;
(4) qinghuo reagent, spray drying obtains dried cream powder, adds Cornu Cervi Degelatinatum, Radix Ginseng fine powder, and mix homogeneously sprays into (1) volatile oil, adds the magnesium stearate of medicine total amount 1%, mixing, encapsulated 1000, the test of pesticide effectiveness sees Appendix 1.
Embodiment 2
Prescription ratio: Herba Polygalae Telephioidis 200, Flos Lonicerae 255, Radix Scutellariae 60, Fructus Gardeniae 100, Radix Salviae Miltiorrhizae 100, Radix Angelicae Sinensis 120, the Radix Astragali 120, Radix Ginseng 35, Cornu Cervi Degelatinatum 35, Radix Rehmanniae Preparata 100, the Radix Paeoniae Alba 100, Carapax Et Plastrum Testudinis 60, Rhizoma Chuanxiong 40.
Its preparation method is with step (1), (2), (3) of embodiment 1, and the medicine that step (4) is obtained adds magnesium stearate, sodium carboxymethyl cellulose, and starch, Icing Sugar is pressed into tablet.
Embodiment 3
Prescription ratio: Herba Polygalae Telephioidis 400, Flos Lonicerae 150, Radix Scutellariae 90, Fructus Gardeniae 70, Radix Salviae Miltiorrhizae 150, Radix Angelicae Sinensis 80, the Radix Astragali 180, Radix Ginseng 55, Cornu Cervi Degelatinatum 40, Radix Rehmanniae Preparata 100, the Radix Paeoniae Alba 150, Carapax Et Plastrum Testudinis 100, Rhizoma Chuanxiong 60.
Its preparation method is the volatile oil with the step of embodiment 1 (1), and the concentrated extracting solution of step (2), (3) directly mixes with Cornu Cervi Degelatinatum, Radix Ginseng fine powder, adds Mel and makes oral liquid.
Listed examples of the present invention is intended to further illustrate process, and scope of the present invention is not constituted any restriction.The product that obtains with the embodiment of the invention and all can obtain the oral formulations product that is used to quit drug abuse via claims 1,2,3,4,5,6 described methods of the present invention.
Claims (5)
1, a kind of drug oral preparation that is used to quit drug abuse, it is characterized in that: the crude drug of making its active ingredient is to be made of following components by part by weight: Herba Polygalae Telephioidis 200-400, Flos Lonicerae 150～255, Radix Scutellariae 60～90, Fructus Gardeniae 70-100, Radix Salviae Miltiorrhizae 100-150, Radix Angelicae Sinensis 80-120, Radix Astragali 120-180, Radix Ginseng 35-55, Cornu Cervi Degelatinatum 35-55, Radix Rehmanniae Preparata 60-100, Radix Paeoniae Alba 100-150, Carapax Et Plastrum Testudinis 60-100, Rhizoma Chuanxiong 40-60.
2, according to the described drug oral preparation that is used to quit drug abuse of claim 1, it is characterized in that: the crude drug of making its active ingredient is to be made of following components by part by weight: Herba Polygalae Telephioidis 333.3, Flos Lonicerae 208.3, Radix Scutellariae 75, Fructus Gardeniae 83.3, Radix Salviae Miltiorrhizae 125, Radix Angelicae Sinensis 100, the Radix Astragali 150, Radix Ginseng 41.7, Cornu Cervi Degelatinatum 41.7, Radix Rehmanniae Preparata 83.3, the Radix Paeoniae Alba 125, Carapax Et Plastrum Testudinis 83.3, Rhizoma Chuanxiong 50.
3,, it is characterized in that preparation method may further comprise the steps according to the preparation method of the described drug oral preparation that is used to quit drug abuse of each claim of claim 1-2:
(1) get Radix Angelicae Sinensis and Rhizoma Chuanxiong, cataclasm, add 10 times of amounts of water, soaked 1 hour, water vapour distillation volatile oil is collected volatile oil, device collection in addition behind the extracting liquid filtering, medicinal residues are standby;
(2) get Radix Salviae Miltiorrhizae, Fructus Gardeniae and Radix Scutellariae, add the alcohol reflux twice of 10 times of amounts 70%, each 1.5 hours, extracting liquid filtering, medicinal residues are standby; Filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into clear paste, and is standby;
(3) depletion timothy, the Radix Paeoniae Alba, the Radix Astragali, Carapax Et Plastrum Testudinis and Radix Rehmanniae Preparata are cataclasm, merge with step (2) medicinal residues, add 10 times of amounts of water, decoct 2 times, each 1.5 hours, when decocting for the second time, add Flos Lonicerae, extracting liquid filtering, the aqueous solution behind the oil is carried in adding (1), is condensed into clear paste;
(4) get step (3) clear paste, spray drying obtains dried cream powder, adds Cornu Cervi Degelatinatum, Radix Ginseng fine powder, and mix homogeneously sprays into step (1) volatile oil, adds the pharmaceutical preparation adjuvant and makes oral formulations.
4, the preparation method of the drug oral preparation that is used to quit drug abuse according to claim 3 is characterized in that described oral formulations comprises capsule, tablet, drop pill, oral liquid.
5, the preparation method of the drug oral preparation that is used to quit drug abuse according to claim 3 is characterized in that described pharmaceutical preparation adjuvant comprises magnesium stearate, sodium carboxymethyl cellulose, starch, Icing Sugar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100123021A CN100336532C (en) | 2005-01-07 | 2005-01-07 | Oral medicinal preparation against drug addiction and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100123021A CN100336532C (en) | 2005-01-07 | 2005-01-07 | Oral medicinal preparation against drug addiction and its preparing method |
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| CN1679739A CN1679739A (en) | 2005-10-12 |
| CN100336532C true CN100336532C (en) | 2007-09-12 |
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| CNB2005100123021A Expired - Fee Related CN100336532C (en) | 2005-01-07 | 2005-01-07 | Oral medicinal preparation against drug addiction and its preparing method |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102000186A (en) * | 2010-11-10 | 2011-04-06 | 罗文礼 | Quick-acting drug abstinence de-addiction pure Chinese medicinal preparation and preparation method thereof |
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2005
- 2005-01-07 CN CNB2005100123021A patent/CN100336532C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 关于阿片类物质成瘾稽延性戒断症状的中医认识与治疗 宋树立、白晓菊，中国医学报，第18卷第5期 2003 * |
| 浅析中医药戒毒的科学性 高学敏，中国药物滥用防治杂志，第30期 2001 * |
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Owner name: JIANGSU JINJIN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHIJIAZHUANG CITY JINYANG PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20091127 |
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Effective date of registration: 20091127 Address after: Renhe Town of Jiangsu County in Rudong Province Ma Tang Road No. 86 zip code: 226401 Patentee after: Jiangsu Jin Jin Pharmaceutical Co., Ltd. Address before: 10, East Second Ring Road, Shijiazhuang, Hebei, zip code: 050031 Co-patentee before: Nanhuanghai Industry Co., Ltd., Jiangsu Patentee before: Shijiazhuang Jinyang pharmaceutical science and Technology Development Co., Ltd. |
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Granted publication date: 20070912 Termination date: 20140107 |