CN105288308A - Traditional Chinese medicine preparation for curing diabetic foot and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for curing diabetic foot and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw herbal materials: herb of sibirica walking fern, lamiophlomis rotate, root of Chinese aralia, lesser bougainvillea flower, Korean pine seed, Japanese premna herb, meretrix linnaeus meat, pleioblastus amarus, elk horn, berba aristolochiae mollissimae, carpesium abrotanoides, pink reineckea herb, herb of wilson yarrow, kalanchoe laciniata, herb of irisleaf saussurea and vernonia gratiosa. The traditional Chinese medicine preparation provided by the invention has the beneficial effects that the traditional Chinese medicine preparation for diabetic foot can be matched with a western medicine treatment method, can cure diabetic foot, and has the advantages of being high in effective rate and curative rate, fast in action, safe and free of toxic and side effects, and the preparation process is simple.

Description

A kind of Chinese medicine preparation for the treatment of diabetic foot and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of diabetic foot and preparation method thereof.

Background technology

Diabetic foot is one of common chronic complicating diseases of diabetes.Diabetics is owing to being subject to the impact of hyperglycemia for a long time, and lower limb vascular hardens, vessel wall thickening, flexibility decrease, forms thrombosis then, and is combined into speckle, lower limb vascular is caused to block, local nerve is got involved, and lower limb lesion tissue, finally diabetic foot occurs, show as acrodynia, numbness, paraesthesia, and the even amputation of ulcer, gangrene can be developed into, make patient very painful, and treatment quite difficulty.

Diabetic foot refers to diabetes complicated lower limb peripheral nerve and vascular lesion, also known as diabetic acromelic gangrene, belongs to the category such as " quenching one's thirst ", " arthralgia due to stagnation of blood ", " necrosis " of the traditional Chinese medical science.Quench one's thirst with the passing of time, body fluid deficiency liquid is few, deficiency of both QI and YIN, prolonged illness people network, and blood stasis network hinders, hinder in limbs venation, venation is retarded by silt, stagnation of QI and blood may bring about pain, obstruction of collaterals by blood stasis, and muscle arteries and veins loses supports, can not replenishing vital QI with drugs of warm nature and warm human body, muscle, muscles and bones, then skin and flesh is withered, and necrosis comes off, and acra loses supports and is diabetic foot.Zhao help imperial decree write " Shengji Zonglu quench one's thirst door " say: " person of quenching one's thirst ... do not control for a long time, then meridians are jammed, and stay in muscle, become carbuncle ".

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of therapeutic effect good and Chinese medicine preparation of the treatment diabetic foot that toxic and side effects is little and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of diabetic foot, described Chinese medicine preparation comprises following raw medicinal material: Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae), Conch Meretricis seu Cyclinae meat, Germinatus Pleioblasti, Cornu Elaphuri davidiani, Herba Aristolochiae Mollissimae, Radix Carpesii, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Camptosori Sibirici 15 ~ 25 parts, Radix Lamiophlomidis Rotatae 10 ~ 20 parts, Cortex araliae chinensis spends 20 ~ 30 parts, Flos Bougainvillea Glabrae 15 ~ 30 parts, Semen pini koraiensis 10 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 10 ~ 20 parts, Conch Meretricis seu Cyclinae meat 15 ~ 30 parts, Germinatus Pleioblasti 15 ~ 25 parts, Cornu Elaphuri davidiani 20 ~ 30 parts, Herba Aristolochiae Mollissimae 20 ~ 35 parts, Radix Carpesii 15 ~ 25 parts, Radix Cynanchi Paniculati 10 ~ 25 parts, Herba Achillea Wilsonianae 20 ~ 35 parts, Herba Kalanchoes Laciniatae 20 ~ 30 parts, Herba saussureae romuleifoliae 15 ~ 30 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Camptosori Sibirici 20 ~ 25 parts, Radix Lamiophlomidis Rotatae 15 ~ 20 parts, Cortex araliae chinensis spends 20 ~ 25 parts, Flos Bougainvillea Glabrae 15 ~ 25 parts, Semen pini koraiensis 15 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 ~ 20 parts, Conch Meretricis seu Cyclinae meat 20 ~ 25 parts, Germinatus Pleioblasti 15 ~ 20 parts, Cornu Elaphuri davidiani 20 ~ 25 parts, Herba Aristolochiae Mollissimae 20 ~ 30 parts, Radix Carpesii 20 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Herba Achillea Wilsonianae 25 ~ 30 parts, Herba Kalanchoes Laciniatae 20 ~ 25 parts, Herba saussureae romuleifoliae 15 ~ 25 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Camptosori Sibirici 23 parts, Radix Lamiophlomidis Rotatae 18 Fen, Cortex araliae chinensis spend 21 parts, Flos Bougainvillea Glabrae 20 parts, Semen pini koraiensis 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 parts, Conch Meretricis seu Cyclinae meat 22 parts, Germinatus Pleioblasti 18 parts, Cornu Elaphuri davidiani 25 parts, Herba Aristolochiae Mollissimae 25 parts, Radix Carpesii 22 parts, Radix Cynanchi Paniculati 15 parts, Herba Achillea Wilsonianae 27 parts, Herba Kalanchoes Laciniatae 23 parts, Herba saussureae romuleifoliae 20 parts and Cortex Ampelopsis Aconitifoliae Radicis 13 parts.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis and Germinatus Pleioblasti are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

When the dosage form of described Chinese medicine preparation is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 50%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

Beneficial effect of the present invention: the Chinese medicine preparation that diabetic foot of the present invention uses, can coordinate western medical treatment method, and treatment diabetic foot, has effective percentage and cure rate is high, rapid-action, the advantage of safe without toxic side effect, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of diabetic foot, Chinese medicine preparation comprises following raw medicinal material: Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae), Conch Meretricis seu Cyclinae meat, Germinatus Pleioblasti, Cornu Elaphuri davidiani, Herba Aristolochiae Mollissimae, Radix Carpesii, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis.

The pharmacology of various raw medicinal material is as follows:

Herba Camptosori Sibirici: [another name] gap bridge grass, Radix Rhodiolae Yunnanensis, Pyrrosia assimilis(Bak.) Ching.[source] medical material Ji Yuan: be the herb of Aspleniaceae plant walking fern.[nature and flavor] are light; Flat.[return through] heart channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Hemostasis; Removing toxic substances.Main thromboangiitis obliterans; Hemiplegia; Metrorrhagia; Traumatic hemorrhage; Neurodermatitis; Ulcer of the lower limb.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Lamiophlomidis Rotatae: [source] medical material Ji Yuan: be root and rhizome or the herb of labiate Radix Lamiophlomidis Rotatae.[nature and flavor] sweet in the mouth; Bitter; Property is put down.[function cures mainly] blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main traumatic injury; Bones and muscles pain; Arthralgia; Dysmenorrhea; Metrorrhagia.[each discussion] 1. " Traditional Chinese Medicine in Sichuan will ": blood circulation promoting competent silt, pain relieving, circulation of qi promoting, detumescence, reunion of fractured tendons and bones.Control and get injured by a fall muscles and bones and diseases such as frustrating gas of spraining one's back.2. " Qinghai-Tibet medicine illustrated handbook ": mend marrow, hemostasis.Flow yellow fluid after controlling edema, yellow fluid is amassed in joint, spongy bone inflammation.[extracts] " China's book on Chinese herbal medicine "

Cortex araliae chinensis flower: [source] medical material Ji Yuan: be the flower that thing Cortex araliae chinensis is planted by five sections of adding.[nature and flavor] bitter in the mouth; Puckery; Property is put down.[function cures mainly] stops blooding.Main haematemesis.[each discussion] 1. " Traditional Chinese Medicine in Sichuan will ": removing dampness and detoxicating, and dissipating blood stasis amasss, and subduing inflammation, except cold and heat.2. " Jiangxi medical herbs ": blood circulation promoting competent silt, dispelling wind damp eliminating.3. " Shaanxi Chinese herbal medicine ": reducing swelling and alleviating pain, invigorating spleen for diuresis.Treating rheumatic arthritis, acute, chronic hepatitis, traumatic injury, fracture, edema due to deficiency, innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Flos Bougainvillea Glabrae: [another name] purple triangle, purple sub-orchid.[source] medical material Ji Yuan: be the flower of Nyctaginaceae Plant Light Flos Bougainvillea Glabrae.[nature and flavor] are bitter; Puckery; Warm in nature; [return through] Liver Channel.[function cures mainly] promoting blood flow to regulate menstruation; Change warm leukorrhagia stopping.Main blood stasis amenorrhea; Menoxenia; Leucorrhea with red and white discharge.[each discussion] " Kunming conventional medical herbs among the people ": QI and blood regulating.Control women's leucorrhea with red and white discharge, menoxenia.[extracts] " China's book on Chinese herbal medicine "

Semen pini koraiensis: [another name] Semen Pini, Semen pini koraiensis, new Luo Songzi.[source] medical material Ji Yuan: be the seed of pinaceae plant Pinus koraiensis.Gather and store: gathering after the 9-10 month is really ripe, after drying, taking out seed, life is used or is fried use.[nature and flavor] are sweet; Slightly warm in nature.[return through] liver; Lung; Large intestine channel.[function cures mainly] moisturizes, and nourishes blood, and dispels the wind.Main dryness of the lung dry cough, stool constipation due to insufficiency, all dizziness due to wind, joint wind, migratory arthralgia.And have moist skin, apply the function of Rong Maofa.[extracts] " China's book on Chinese herbal medicine "

Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae): [source] medical material Ji Yuan: be stem, the leaf of Verbenaceae Herba Premnae Microphyllae.[nature and flavor] bitter in the mouth; Micro-pungent; Cold in nature.[return through] liver; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing.Main malaria; Have loose bowels; Dysentery; Drunk headache; Carbuncle, furuncle; Erysipelas; Snake bite and insect sting; Wound hemorrhage [each discussion] 1. Collective Notes to the Canon of Materia medica: treat malaria effective.Also wine stain skin, treats cardiac and abdominal pain.2. " Hunan medicine will ": heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control and let out dysentery, diabetes, intermittent fever due to phlegm.3. " Jiangxi traditional herbal medicine proved recipe ": refrigerant antipyretic, relieve internal heat eliminating carbuncle.Treating malaria disease; External application cutter axe wound.[extracts] " China's book on Chinese herbal medicine "

Conch Meretricis seu Cyclinae meat: [another name] sea clam meat, Carnis Mactrae meat.[source] medical material Ji Yuan: be the meat of Veneridae animal Conch Meretricis seu Cyclinae.Gather and store: after catching sea clam, getting meat, using fresh herb or dry.[nature and flavor salty in the mouth; Property is put down.[function cures mainly] is moisturized and is quenched the thirst; Softening hardness and disperse swelling.Master quenches one's thirst; Pulmonary tuberculosis; Night sweat due to yin deficiency goiter; Scrofula.[extracts] " China's book on Chinese herbal medicine "

Germinatus Pleioblasti: [another name] Germinatus Pleioblasti.[source] medical material Ji Yuan: be the tender Seedling of grass bitter bamboo.[nature and flavor] are bitter; Cold.[function cures mainly] clearing heat and relieving fidgetness; Dehumidifying; Diuretic.Main calentura excessive thirst; Jaundice due to damp-heat; Dysuria; Beriberi.[each discussion] 1. supplement to the Herbal: main to sit up, go appearance and on tongue heat yellow, quench one's thirst, improving eyesight, alcoholic intoxication, except steam, strong people.2. " dietitian's heart mirror ": manage vexed vexed, physical strength profiting, quenches the thirst, master quenches one's thirst, dredging water passages, the therapeutic method to keep the adverse QI flowing downwards, and reason wind heat, beriberi, steaming and decocting eats it.[extracts] " China's book on Chinese herbal medicine "

Cornu Elaphuri davidiani: [source] medical material Ji Yuan: be the ossified angle that animal in deer family elk is male.[nature and flavor] sweet in the mouth; Warm in nature.[return through] kidney channel; [function cures mainly] warming the kidney to invigorate YANG; Benefiting essence and marrow; Bone and muscle strengthening; Benefit blood vessels.Main insufficiency of kidney-YANG; Asthenia damage of essence; Soreness of the waist and knees; Bones and muscles pain; Syndrome of deficiency of blood.[each discussion] 1. " detailed outline ": the antler YANG invigorating of deer, and right kidney essense QI-insufficiency person should it, the antler nourishing YIN of gruel, left kidney hematopenia person suitable it.This is eternal micro-secret, though forefathers' method tool, and reason does not send, therefore the confused altar of theorist.2. " not Lu ": main numbness, hemostasis, physical strength profiting.3. milling in the Meng: tonify deficiency labor, fills out marrow.Husband's cold air and wind again, bones and muscles pain, makes the long clothes of powder.4. " Japan hanako materia medica ": add essence and mend marrow, beneficial blood vessels, warm waist knee joint, happy color, tonifying YANG, treats pathogenic wind, partially controls husband, victory Cornu Cervi.Control waist knee joint not only, mend all disorders of blood.5. " detailed outline ": nourishing YIN and benefiting blood, merit and young pilose antler are together.[extracts] " China's book on Chinese herbal medicine "

Herba Aristolochiae Mollissimae: [another name] clear bone phoenix, cat ear, save with wearing, Mao Xiang, Herba Solani Lyrati, Flos Caryophylli, yellowish banks rose, flour wind, rabbit ear, Mao Fengcao, monkey Auricled Hedyotis Herb.[source] medical material Ji Yuan: be the herb of aristolochiaceae plant Herba Aristolochiae Mollissimae.[nature and flavor] are pungent; Bitter; Flat.[return through] liver; Stomach warp.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral; Pain relieving.Main air pain of dampness syndrome; Numb limbs and tense tendons; Muscles and bones contracture; Epigastric pain; Traumatic pain; Traumatic hemorrhage; Acute mastitis and multiple pyogenic infection.[each discussion] " decoction pieces is newly joined ": loose migratory arthralgia, dredging collateral, controls pain all over the joints.[extracts] " China's book on Chinese herbal medicine "

Radix Carpesii: [source] medical material Ji Yuan: be the herb of feverfew Radix Carpesii.[nature and flavor] bitter in the mouth; Pungent; Cold in nature.[return through] returns tripe; Lung meridian.[function cures mainly] heat clearing away; Reduce phlegm; Removing toxic substances; Parasite killing; Removing blood stasis with potent drugs; Hemostasis.Main tonsillitis, sore throat, anxious chronic infantile convulsion, toothache, furuncle swelling toxin, hemorrhoid complicated by anal fistula, itchy skin eruption; Venom; Malnutrition due to parasitic infestation; Abdominal mass due to blood stasis; Spit blood; Epistaxis; Stranguria with blood; Wound hemorrhage.[each discussion] 1. " Bencao Jingshu ": Radix Carpesii, pungent can eliminating stagnation, cold can heat extraction, therefore main blood stasis, abdominal mass due to blood stasis is for extremely, and hematochezia stops blooding.Dysuria, due to interior-heat, then normal urination is also for heat extraction.Pungently coldly to dispel heat by wet dissipation, then small worm is from except also.Eliminating impediment person, the merit of drying also.Remove stagnation of pathogenic heat in the heart, only excessive thirst, hot eliminating stagnation of dispelling, the merit of tonifying YIN also.The person of relieving oedema or abdominal distension through diuresis or purgation, damp and hot loose, then water is from disappearing.Its main removing blood stasis, granulation promoting, diuresis, kills three worms, and except all poison swell, furuncle flaccidity hemorrhoid, penetrate in incised wound, the more than person of itching over the body urticaria, and that wipes has stood, and the power of removing heat from blood heat extraction eliminating stagnation also.2. " herbal classic ": main blood stasis, abdominal mass due to blood stasis.Hematochezia, hemostasis, diuresis.3. " not Lu ": except small worm, go numbness, except stagnation of pathogenic heat in the heart, only excessive thirst, relieves oedema or abdominal distension through diuresis or purgation, tells down greatly.4. Tang Materia Medica: main removing blood stasis, granulation promoting, quenches the thirst, diuresis, kills three worms.Except all poison swell furuncle, fistula hemorrhoid, penetrate in incised wound.The more than person of itching over the body urticaria, that wipes is vertical own.5. " wild plant figure says ": tender leaf is mashed and controlled tinea pedis.[extracts] " China's book on Chinese herbal medicine "

Radix Cynanchi Paniculati: [another name] subduing the wind syndrome muscle, copper chopsticks, lamp-stand seven, Rhizoma Paridis.[source] medical material Ji Yuan: be the rhizome of liliaceous plant north Rhizoma Paridis.[nature and flavor] are bitter; Cold.[function cures mainly] expelling wind and removing dampness; Heat clearing away is calmed the frightened; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Calentura is twitched; Laryngopharynx swelling and pain; Carbuncle; Scrofula; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Achillea Wilsonianae: [another name] Achillea millefolium, horse Fructus Foeniculi, Caulis et Folium Pothi Repentis, Herba Achilleae, wild Herba Achilleae, Herba pteridis vittatae.[source] medical material Ji Yuan: be the herb of feverfew Yunnan Millefolium.[nature and flavor] acrid in the mouth fiber crops; Bitter; Slightly warm in nature.[function cures mainly] expelling wind and removing dampness; Eliminating stasis to stop pain; Removing toxic substances edema.Main rheumatalgia; Stomachache; Toothache; Traumatic injury stasis of blood pain; Carbuncle sore tumefacting virus; Snake bite and insect sting.[each discussion] 1. " mountain of papers Chinese herbal medicine ": expelling wind and removing dampness, detumescence hemostasis, and control haematemesis, have blood in stool, rheumatalgia, lumbago, traumatic hemorrhage, furuncle swells and ache, toothache.2. " choosing of Simao, Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, dissipating blood stasis analgesia.Control traumatic injury, fracture, rheumatic arthralgia, pulmonary tuberculosis hemoptysis, bronchitis, tonsillitis, spit blood, amenorrhea, dysmenorrhea, mass in abdomen.Traumatic hemorrhage, venom.3. " Yunnan Chinese herbal medicine ": restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain, anti-inflammation hemostasia.[extracts] " China's book on Chinese herbal medicine "

Herba Kalanchoes Laciniatae: [source] medical material Ji Yuan: be the herb of crassulaceae plants Herba Kalanchoes Laciniatae.[nature and flavor] are sweet; Bitter; Cold.[return through] heart; Liver; Lung meridian.[function cures mainly] dissipating blood stasis stops blooding; Heat-clearing and toxic substances removing.Main traumatic injury; Sprain; Traumatic hemorrhage; Pharyngolaryngitis; Scald; Eczema; Carbuncle pyogenic infections from tumour or sore; Venom.[each discussion] be Guangzhou army " conventional Chinese herbal medicine handbook " 1.: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control venom, skin infection abscess, traumatic injury.2. " Guangxi Chinese herbal medicine ": cooling blood for hemostasis.Control traumatic hemorrhage, burn, eczema.[extracts] " China's book on Chinese herbal medicine "

Herba saussureae romuleifoliae: [another name] The sky clears after the rain, Fructus Cannabis grass, Radix Glycyrrhizae.[source] medical material Ji Yuan: for Compositae plants herb or the root of line leaf hieracioides.[nature and flavor] acrid in the mouth; Bitter; Property is put down.[function cures mainly] dispels the wind removing toxic substances; Eliminating stasis to stop pain.Main rheumatic numbness; Arthritis ache; Sciatica; Traumatic injury; Venom.[each discussion] be " choosing of Yunnan Chinese herbal medicine " 1.: removing toxic substances, dissipating blood stasis, pain relieving.Dispelling the wind and dampness pathogens is numb, arthralgia, traumatic injury, high heat.2. " Yunnan Chinese herbal medicine ": removing toxic substances removing food stagnancy.Control venom, infantile malnutrition.[extracts] " China's book on Chinese herbal medicine "

Cortex Ampelopsis Aconitifoliae Radicis: [another name] sheep vine shoot, careless Fructus Vitis viniferae.[source] medical material Ji Yuan: for vitaceae ampelopsis aconitifolia roughly the same.[nature and flavor] are pungent; Heat.[return through] heart; Kidney channel.[function cures mainly] expelling wind and removing dampness; Dissipating blood stasis for subsidence of swelling.Main anemofrigid-damp arthralgia; Traumatic injury congestive edema; Ulcer sore pain.[each discussion] " Shaanxi Chinese herbal medicine ": promoting blood circulation to remove blood stasis, eliminating inflammation and expelling toxin, granulation promoting long bone, except wind damp eliminating.Control traumatic injury, fracture, furuncle swells and ache, rheumatic arthritis.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Camptosori Sibirici 15 ~ 25 parts, Radix Lamiophlomidis Rotatae 10 ~ 20 parts, Cortex araliae chinensis spends 20 ~ 30 parts, Flos Bougainvillea Glabrae 15 ~ 30 parts, Semen pini koraiensis 10 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 10 ~ 20 parts, Conch Meretricis seu Cyclinae meat 15 ~ 30 parts, Germinatus Pleioblasti 15 ~ 25 parts, Cornu Elaphuri davidiani 20 ~ 30 parts, Herba Aristolochiae Mollissimae 20 ~ 35 parts, Radix Carpesii 15 ~ 25 parts, Radix Cynanchi Paniculati 10 ~ 25 parts, Herba Achillea Wilsonianae 20 ~ 35 parts, Herba Kalanchoes Laciniatae 20 ~ 30 parts, Herba saussureae romuleifoliae 15 ~ 30 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Camptosori Sibirici 20 ~ 25 parts, Radix Lamiophlomidis Rotatae 15 ~ 20 parts, Cortex araliae chinensis spends 20 ~ 25 parts, Flos Bougainvillea Glabrae 15 ~ 25 parts, Semen pini koraiensis 15 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 ~ 20 parts, Conch Meretricis seu Cyclinae meat 20 ~ 25 parts, Germinatus Pleioblasti 15 ~ 20 parts, Cornu Elaphuri davidiani 20 ~ 25 parts, Herba Aristolochiae Mollissimae 20 ~ 30 parts, Radix Carpesii 20 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Herba Achillea Wilsonianae 25 ~ 30 parts, Herba Kalanchoes Laciniatae 20 ~ 25 parts, Herba saussureae romuleifoliae 15 ~ 25 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Camptosori Sibirici 23 parts, Radix Lamiophlomidis Rotatae 18 Fen, Cortex araliae chinensis spend 21 parts, Flos Bougainvillea Glabrae 20 parts, Semen pini koraiensis 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 parts, Conch Meretricis seu Cyclinae meat 22 parts, Germinatus Pleioblasti 18 parts, Cornu Elaphuri davidiani 25 parts, Herba Aristolochiae Mollissimae 25 parts, Radix Carpesii 22 parts, Radix Cynanchi Paniculati 15 parts, Herba Achillea Wilsonianae 27 parts, Herba Kalanchoes Laciniatae 23 parts, Herba saussureae romuleifoliae 20 parts and Cortex Ampelopsis Aconitifoliae Radicis 13 parts.

When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:

The first step, Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis and Germinatus Pleioblasti are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

When the dosage form of described Chinese medicine preparation is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 50%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: capsule prepared by the present invention

Get Herba Camptosori Sibirici 230g, Radix Lamiophlomidis Rotatae 180g, Cortex araliae chinensis flower 210g, Flos Bougainvillea Glabrae 200g, Semen pini koraiensis 250g, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 150g, Conch Meretricis seu Cyclinae meat 220g, Germinatus Pleioblasti 180g, Cornu Elaphuri davidiani 250g, Herba Aristolochiae Mollissimae 250g, Radix Carpesii 220g, Radix Cynanchi Paniculati 150g, Herba Achillea Wilsonianae 270g, Herba Kalanchoes Laciniatae 230g, Herba saussureae romuleifoliae 200g and Cortex Ampelopsis Aconitifoliae Radicis 130g.

Its preparation method comprises the following steps:

The first step, Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis and Germinatus Pleioblasti are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 85 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.

Embodiment 2: liniment prepared by the present invention

Get Herba Camptosori Sibirici 210g, Radix Lamiophlomidis Rotatae 170g, Cortex araliae chinensis flower 240g, Flos Bougainvillea Glabrae 230g, Semen pini koraiensis 180g, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 170g, Conch Meretricis seu Cyclinae meat 230g, Germinatus Pleioblasti 160g, Cornu Elaphuri davidiani 220g, Herba Aristolochiae Mollissimae 290g, Radix Carpesii 210g, Radix Cynanchi Paniculati 170g, Herba Achillea Wilsonianae 280g, Herba Kalanchoes Laciniatae 210g, Herba saussureae romuleifoliae 160g and Cortex Ampelopsis Aconitifoliae Radicis 180g.

Its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 50%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8 times amount soak by water 3 hours, and second time adds weight portion 9 times amount soak by water 3 hours, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 24-38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.75g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.75 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>43.75 crude drug/kg of the present invention, every day, maximum dosage-feeding was 87.5 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 10.25g crude drug/day/people, adult body weight in 60KG, average dosage is 0.171g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 31g) oral administration gavage Chinese medicine of the present invention is 512 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to three groups of mices (often organize 20) by 13.25,25.36 and 42.29g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all 128 routine cases all derive from this Out-patient Department and inpatient, is divided into treatment group (65 example) and matched group (63 example) at random.In treatment group 65 example, man 33 example, female 32 example; 44 ~ 72 years old age; Diabetes medical history 2 ~ 18 years; Type 2 diabetes mellitus 59 example, type 1 diabetes 6 example; Diseased region: left lower extremity 34 example, right lower extremity 31 example; Gangrene degree: I grade of 14 example, II grade of 21 example, III grade of 17 example, IV grade of 13 example.In matched group 63 example, man 33 example, female 30 example; 45 ~ 72 years old age; Diabetes medical history 2 ~ 18 years; Type 2 diabetes mellitus 58 example, type 1 diabetes 5 example; Diseased region: left lower extremity 33 example, right lower extremity 30 example; Gangrene degree: I grade of 13 example, II grade of 20 example, III grade of 16 example, IV grade of 14 example.All patients all meet the diagnostic criteria of diabetic foot.Experimental group and matched group no significant difference on age, sex, diseased region and severity extent, two groups of data comparing difference not statistically significants (P > 0.05), have comparability.

Diagnostic criteria: the standard that the national diabetic foot academic conference of first, diabetes association of Chinese Medical Association is drafted: limb artery blood supply insufficiency, neural malnutrition appear in (1) diabetics, as acra send out cool, power leakage in running, lame, pain, numbness, insensitive or lose performance.Skin is lossless, and acra is cool, and edema or withered, colour-darkening, fine hair comes off.Clawfoot, chicken feet toe, Charcot's joint etc.(2) acra arteriopalmus weakens or disappears, and angiostenosis place can hear vascular murmur, and body front-reflection is blunt or disappear.(3) acra chapped skin or vesicle, blood blister, erosion, ulcer, gangrene or downright bad.(4) color ultrasound shows arteriosclerosis, narrow, and inaccessible, blood flow slows down.(5) ankle/upper arm index < 0.97.(6) electromyogram: nerve conduction velocity slows down, h reflex weakens or disappears.(7) angiography or CTA display: stricture of artery, obturation.(8) x-ray: osteoporosis, destruction, Charcot's joint.(1) in ~ (3), there are 2, in conjunction with in (4) ~ (8) 1.

Grade scale: Wagner staging: diabetic foot is divided into 6 grades according to nerve, vascular lesion, the ulcer degree of depth and infection.0 grade: have the foot that ulcer of foot danger occurs, but acra is without ulcer.Show as limbs blood supply insufficiency, skin is cold, and color is purple brown, numb, insensitive or sensory deprivation.I grade: superficial ulcer, clinically without infection.Have vesicle, blood blister, cold injury, scald and the skin superficial ulcer caused by other skin injurys, pathological changes does not involve deep tissue.II grade: darker ulcer, often merges cellulitis, sinus tract can be formed, without the infection of abscess or bone.III grade: the degree of depth infects with osseous tissue pathological changes or abscess.Tendon ligament tissue destroys, and cellulitis is fused into large vomica, and purulent secretion and slough increase, but bone destruction is still not obvious.IV grade: circumscribed gangrene (toe, heel or front instep), sclerotin and osteoarthrosis destroy.V grade: full foot gangrene.

Inclusive criteria: meet diabetic foot diagnostic criteria, Wagner clinical scale is I ~ IV grade; Patient is incomplete and other systemic infection situations without the serious heart, Liver and kidney function; Patient without heritability, infectious disease, without malignant tumor, without severe malnutrition; Wound surface is without dead space and inadequate drainage situation; Non-pregnancy or women breast-feeding their children.

Therapeutic Method:

Matched group: adopt insulin injection and/or oral hypoglycemic drug therapy, make blood glucose, glycolated hemoglobin controls in desirable level.Trophic nerve: intramuscular injection methycobal (vitamin B12) 500 μ g, every day 1 time.Improve microcirculation, intramuscular injection 654-2 injection, 1mg/ (kgd), every day 1 time.Infection control: the person that has traumatic infection, selects sensitive antibiotic infection according to wound secretion bacteria cultivation results.Wound surface Local treatment: adopt local " nibbling method " debridement to change dressings.Dry gangrene: chelated iodine and 75% ethanol routine disinfection, slough is removed with the method distribution of " nibbling ", after withered slough and normal structure boundary are known, disposable removing slough can be adopted, then continue to change dressings with the debridement of dealing with problems arising from an accident of " nibbling " method, add anti-infective (selecting antibiotic according to slough bacteria cultivation results) etc. with 654-2 to make medicine sliver local and to change dressings process, every day 1 time.Wet gangrene: routine disinfection, uses the debridement of " nibbling " method, adds anti-infective (selecting 2 clock sensitive antibiotic according to local necrosis secretions bacteria cultivation results) etc. make medicine sliver with 654-2, the drug of topical application drain of row local, every day 1 time.Mixed gangrene: according to the primary and secondary weight of dry gangrene and wet gangrene, jointly implements local " nibbling " method debridement by above two kinds of methods and changes dressings, every day 1 time.30 days courses for the treatment of.

Treatment group: on the basis of matched group, simultaneously oral Chinese medicine embodiment 1 capsule of the present invention, each 2, every day 3 times.30 days courses for the treatment of.

Curative effect judging standard: cure: clinical symptom disappearance, heal in ulcer skin ulcer face, acra peripheral circulation disorders obviously improves.Effective: clinical symptoms is clearly better, skin ulcer face area reduces more than 2/3, and granulation is fresh, and epithelial growth is good, and without slough and pus tongue, skin ulcer week infiltrates band and substantially disappears, and acra peripheral circulation disorders makes moderate progress.Effective: clinical symptoms takes a turn for the better, and skin ulcer face area reduces more than 1/3, and granulation can have Mild edema, and epithelium has growth, can have a small amount of slough or pus tongue, skin ulcer week infiltrates band can lavender, and acra peripheral circulation disorders makes moderate progress.(4) invalid: clinical symptoms, ulcer, infection, gangrenous skin ulcer face etc. are all without improving or increasing the weight of.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.

Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively

Group	Number of cases	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	65	45	8	9	3	62(95.38％)
Matched group	63	29	10	13	11	52(82.54％)

As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, in conjunction with western medicine treatment diabetic foot, relative to matched group on therapeutic effect, has significant improvement.

After a table 2 liang group treats 1 course for the treatment of respectively, healing number and time compare (unit: example)

Group	Number of cases	Medication 15 days	Medication 20 days	Medication 30 days
					Treatment group	45	13(20％)	28(43.07％)	45(69.23％)
Matched group	29	7(11.11％)	15(23.81％)	29(46.03％)

As can be seen from Table 2, relative to matched group, treatment group is better efficacy not only, takes effect also faster.

According to the clinical statistics in toxicity test and above table, Chinese medicine provided by the invention, can coordinate western medicine to treat diabetic foot, has rapid-action, effective percentage and cure rate is high, the advantage of safe without toxic side effect.

Concrete case: patient, man, 53 years old, patient had type 2 diabetes mellitus history 6 years, and because of the red and swollen diabrosis of right lower extremity distal exterior, sepage is more than, is admitted to hospital and sees a doctor, on inspection with Wagner classification, be diagnosed as the wet gangrene type of diabetic foot III grade.Control blood glucose, trophic nerve through above-mentioned doctor trained in Western medicine, improve on the basis of microcirculation, infection and wet gangrene wound surface Local treatment, simultaneously oral Chinese medicine embodiment 1 capsule of the present invention, each 2, every day 3 times, medication is cured for 18 days, follows up a case by regular visits to 1 year, is engaged in physical work always and does not recur.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat the Chinese medicine preparation of diabetic foot for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae), Conch Meretricis seu Cyclinae meat, Germinatus Pleioblasti, Cornu Elaphuri davidiani, Herba Aristolochiae Mollissimae, Radix Carpesii, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Camptosori Sibirici 15 ~ 25 parts, Radix Lamiophlomidis Rotatae 10 ~ 20 Fen, Cortex araliae chinensis spend 20 ~ 30 parts, Flos Bougainvillea Glabrae 15 ~ 30 parts, Semen pini koraiensis 10 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 10 ~ 20 parts, Conch Meretricis seu Cyclinae meat 15 ~ 30 parts, Germinatus Pleioblasti 15 ~ 25 parts, Cornu Elaphuri davidiani 20 ~ 30 parts, Herba Aristolochiae Mollissimae 20 ~ 35 parts, Radix Carpesii 15 ~ 25 parts, Radix Cynanchi Paniculati 10 ~ 25 parts, Herba Achillea Wilsonianae 20 ~ 35 parts, Herba Kalanchoes Laciniatae 20 ~ 30 parts, Herba saussureae romuleifoliae 15 ~ 30 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 25 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Camptosori Sibirici 20 ~ 25 parts, Radix Lamiophlomidis Rotatae 15 ~ 20 Fen, Cortex araliae chinensis spend 20 ~ 25 parts, Flos Bougainvillea Glabrae 15 ~ 25 parts, Semen pini koraiensis 15 ~ 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 ~ 20 parts, Conch Meretricis seu Cyclinae meat 20 ~ 25 parts, Germinatus Pleioblasti 15 ~ 20 parts, Cornu Elaphuri davidiani 20 ~ 25 parts, Herba Aristolochiae Mollissimae 20 ~ 30 parts, Radix Carpesii 20 ~ 25 parts, Radix Cynanchi Paniculati 15 ~ 20 parts, Herba Achillea Wilsonianae 25 ~ 30 parts, Herba Kalanchoes Laciniatae 20 ~ 25 parts, Herba saussureae romuleifoliae 15 ~ 25 parts and Cortex Ampelopsis Aconitifoliae Radicis 10 ~ 20 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Camptosori Sibirici 23 parts, Radix Lamiophlomidis Rotatae 18 Fen, Cortex araliae chinensis spend 21 parts, Flos Bougainvillea Glabrae 20 parts, Semen pini koraiensis 25 parts, Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae) 15 parts, Conch Meretricis seu Cyclinae meat 22 parts, Germinatus Pleioblasti 18 parts, Cornu Elaphuri davidiani 25 parts, Herba Aristolochiae Mollissimae 25 parts, Radix Carpesii 22 parts, Radix Cynanchi Paniculati 15 parts, Herba Achillea Wilsonianae 27 parts, Herba Kalanchoes Laciniatae 23 parts, Herba saussureae romuleifoliae 20 parts and Cortex Ampelopsis Aconitifoliae Radicis 13 parts.

5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis and Germinatus Pleioblasti are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is liniment, and its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 50%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and it comprises the following steps:

The first step, Herba Camptosori Sibirici, Radix Lamiophlomidis Rotatae, Cortex araliae chinensis flower, Flos Bougainvillea Glabrae, Semen pini koraiensis and Germinatus Pleioblasti are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix Cynanchi Paniculati, Herba Achillea Wilsonianae, Herba Kalanchoes Laciniatae, Herba saussureae romuleifoliae and Cortex Ampelopsis Aconitifoliae Radicis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is liniment, and its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 50%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.