CN105287982A - Traditional Chinese medicine oral liquid for treating epilepsy and preparation method for traditional Chinese medicine oral liquid - Google Patents

Abstract

The invention relates to a traditional Chinese medicine oral liquid for treating epilepsy, and further relates to a preparation method for the traditional Chinese medicine oral liquid for treating epilepsy. According to the traditional Chinese medicine oral liquid for treating epilepsy, active pharmaceutical ingredients of the prepared oral liquid comprise the following effective constituents in parts by weight: 25-35 parts of uncaria rhynchophylla, 10-22 parts of benzoin, 11-25 parts of rhizoma acori graminei, 10-19 parts of calculus bovis, 13-23 parts of cicada ecdysis, 8-16 parts of paper mulberry fruit, 15-25 parts of jasmine flower, 16-29 parts of valeriana officinalis, 15-27 parts of codonopsis pilosula, 14-22 parts of camphor, 10-19 parts of antelope horn, 10-21 parts of spina date seed, 9-18 parts of milkwort, 12-21 parts of purple perilla, 11-19 parts of concha margaritiferallsta, 9-20 parts of white muscardin silkworm, 10-21 parts of deerhorn glue, 10-21 parts of liquid storax, 9-20 parts of pseudostellaria heterophylla and 10-21 parts of radix glycyrrhizae. The traditional Chinese medicine has an excellent curative effect.

Description

A kind of Chinese medicine oral liquid for the treatment of epilepsy and preparation method thereof

Technical field

The present invention relates to treatment epilepsy technical field, specifically a kind of Chinese medicine oral liquid for the treatment of epilepsy and preparation method thereof.

Background technology

" epilepsy " or " epilepsy " that epilepsy (epilepsy) is namely commonly called as, it is the electric discharge of cerebral neuron paroxysmal abnormality, cause a kind of chronic disease of of short duration cerebral disorder, paroxysmal movement, sensation, autonomic nerve, consciousness and mental disorder can be shown as, cause the cause of disease of epilepsy varied, according to causing, the cause of disease of epilepsy is different, can be divided into idiopathy syndrome, symptomatic epilepsy syndrome and possible symptomatic epilepsy syndrome.

The traditional Chinese medical science thinks that epileptics is at brain key, relates to the heart, liver,spleen,kidney four is dirty.Pathologic feature is that the domination of pathogen is weakened body resistance, domination of pathogen person, and pertinacious phlegm resistance key is main, and liver-wind, blood stasis, stagnated fire help cruel for it; Weakened body resistance person, because of recurrent exerbation, or ferritic is weak, causes in the heart, liver,spleen,kidney and loses, and QI and blood consumption wound, the turbid interior life of expectorant is lain concealed.Because expectorant has poly-loose, wind has sound, and gas has along inverse, thus time when sending out only.Stage of attack wind-phlegm gushes, and evil resistance thinking, inside disturbs gods, outer amenorrhea network; Resting stage internal organs deficiency of qi and yin, the turbid interior life of expectorant.Send out for a long time and do not heal, internal organs are more empty, and expectorant knot is darker, and recurrent exerbation, is into obstinate disease.

On current doctor trained in Western medicine Major Clinical, the conventional carbamazepine that uses is commonly used to treat epilepsy, this medicine of life-time service often causes dizzy drowsiness, weak, nauseating, erythra, vomiting, accidental granulocytopenia, reversibility thrombocytopenia, aplastic anemia and toxic hepatitis etc. is even caused to make regular check on hemogram, thus treatment difficulty is further increased, there is certain drawback in use, bring certain limitation to the treatment of epilepsy.

Summary of the invention

The object of the invention is to overcome the above problems, and provide to responding well to treatment to epilepsy soon, a kind of Chinese medicine oral liquid for the treatment of epilepsy that relapse rate is low and preparation method thereof.

The technical solution used in the present invention is: a kind of Chinese medicine oral liquid for the treatment of epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 25 ~ 35 parts, Benzoinum 10 ~ 22 parts, Rhizoma Acori Graminei 11 ~ 25 parts, Calculus Bovis 10 ~ 19 parts, Periostracum Cicadae 13 ~ 23 parts, Fructus Broussonetiae 8 ~ 16 parts, Flos Jasmini Sambac 15 ~ 25 parts, Rhizoma et radix valerianae 16 ~ 29 parts, Radix Codonopsis 15 ~ 27 parts, Camphora 14 ~ 22 parts, Cornu Saigae Tataricae 10 ~ 19 parts, Semen Ziziphi Spinosae 10 ~ 21 parts, Radix Polygalae 9 ~ 18 parts, Folium Perillae 12 ~ 21 parts, Concha Margaritifera 11 ~ 19 parts, Bombyx Batryticatus 9 ~ 20 parts, Colla cornus cervi 10 ~ 21 parts, Styrax 10 ~ 21 parts, Radix Pseudostellariae 9 ~ 20 parts, 10 ~ 21 parts, Radix Glycyrrhizae.

Further, a kind of Chinese medicine oral liquid for the treatment of epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 28 ~ 32 parts, Benzoinum 14 ~ 18 parts, Rhizoma Acori Graminei 15 ~ 20 parts, Calculus Bovis 13 ~ 16 parts, Periostracum Cicadae 17 ~ 20 parts, Fructus Broussonetiae 11 ~ 13 parts, Flos Jasmini Sambac 18 ~ 22 parts, Rhizoma et radix valerianae 19 ~ 24 parts, Radix Codonopsis 18 ~ 24 parts, Camphora 17 ~ 20 parts, Cornu Saigae Tataricae 13 ~ 16 parts, Semen Ziziphi Spinosae 13 ~ 16 parts, Radix Polygalae 11 ~ 15 parts, Folium Perillae 14 ~ 17 parts, Concha Margaritifera 13 ~ 16 parts, Bombyx Batryticatus 13 ~ 17 parts, Colla cornus cervi 12 ~ 15 parts, Styrax 12 ~ 18 parts, Radix Pseudostellariae 13 ~ 16 parts, 13 ~ 17 parts, Radix Glycyrrhizae.

Further; treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 30 parts, Benzoinum 15 parts, Rhizoma Acori Graminei 17 parts, Calculus Bovis 15 parts, Periostracum Cicadae 18 parts, Fructus Broussonetiae 12 parts, Flos Jasmini Sambac 20 parts, Rhizoma et radix valerianae 21 parts, Radix Codonopsis 19 parts, Camphora 18 parts, Cornu Saigae Tataricae 14 parts, Semen Ziziphi Spinosae 15 parts, Radix Polygalae 12 parts, Folium Perillae 16 parts, Concha Margaritifera 14 parts, Bombyx Batryticatus 15 parts, Colla cornus cervi 14 parts, Styrax 13 parts, Radix Pseudostellariae 15 parts, 16 parts, Radix Glycyrrhizae.

Further, a kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy, preparation method is as follows:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

Instructions of taking: adult every day 2 times, each 100ml, 10 days is a course for the treatment of sooner or later.

Medical material effect of the present invention is resolved as follows:

Ramulus Uncariae Cum Uncis sweet in the mouth, cool in nature, have dispelling wind and relieving convulsion, effect of heat clearing away suppressing the hyperactive liver, for liver-wind stirring up internally, infantile convulsion is twitched, and hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, has a headache dizzy.Benzoinum, taste is fragrant, property is put down, and has out and steals clear god, promoting flow of QI and blood, effect of pain relieving, and for apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, trusted subordinate's pain, puerperal blood faints, infantile convulsion.Rhizoma Acori Graminei has removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, and effect of refreshment Fructus Alpiniae Oxyphyllae is not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Calculus Bovis gas delicate fragrance, mildly bitter flavor is then sweet, cool in nature, can be used for antipyretic, removing toxic substances, arresting convulsion.The disease such as Zhi Gaore coma for oral administration, demented, infantile convulsion, tic, laryngopharynx swelling and pain, aphtha carbuncle, uremia are controlled in external.Periostracum Cicadae sweet in the mouth, salty, cool in nature, there is dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving acuity of vision and removing nebula, effect of endogenous wind stopping relieving convulsion, for anemopyretic cold, epidemic febrile disease from the beginning of, pharyngalgia hoarseness, measles without adequate eruption, rubella pruritus, cataract, anxious chronic infantile convulsion, tetanus is demonstrate,proved, and the nocturnal fretfulness in infants is uneasy.Flos Jasmini Sambac acrid in the mouth, sweet, warm in nature, have and regulate the flow of vital energy, dissipating depression of QI, ward off dirty, and in effect, for dysentery stomachache, conjunctival congestion is red and swollen, sore.Rhizoma et radix valerianae acrid in the mouth, sweet, warm in nature, calm the nerves, regulate the flow of vital energy, pain relieving, for neurasthenia, insomnia, hysteria, epilepsy, stomach abdominal distention and pain, lumbago and skelalgia, traumatic injury.Radix Codonopsis sweet in the mouth, property is put down, and has invigorating the spleen and replenishing QI, quenches the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid, and for deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.Camphora has orifice opening, qi stagnation removing, wards off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect, cures mainly the symptoms such as scabies pruritus, traumatic pain, toothache.Cornu Saigae Tataricae has suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, and effect of loose blood removing toxic substances, is usually used in liver-wind stirring up internally, and infantile convulsion is twitched, and pre-eclampsia, high hot convulsion is fainted, and epilepsy is gone mad, and has a headache dizzy, cataract, maculae caused by violent heat pathogen, carbuncle sore tumefacting virus.Semen Ziziphi Spinosae sweet in the mouth, acid, property is put down, and can nourish conscience, calm the nerves, arresting sweating, control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Radix Polygalae bitter in the mouth, pungent, warm in nature, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Folium Perillae can fall apart exterior cold, and diaphoresis power is comparatively strong, for wind and cold table disease, sees aversion to cold, heating, the disease such as lossless.Concha Margaritifera salty in the mouth, cold in nature, there is suppressing the hyperactive liver and subsiding YANG, effect of calm the nerves arresting convulsion, liver heat removing and eyesight improving, suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.Bombyx Batryticatus salty in the mouth, flat, have expelling wind to relieve convulsion, effect of dissipating phlegm and resolving masses, controls apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis.Colla cornus cervi temperature compensation Liver and kidney, beneficial intensive culture blood, dizzy for blood deficiency, the acid of waist knee joint is cold, and asthenia is become thin.The pungent fragrance of Styrax is strong, has the effect of refreshment of having one's ideas straightened out, and it is logical to be longer than temperature, wards off dirty, therefore should control that bluish complexion, cool skin, tongue are white, the constipation due to cold pathogen coma of slow pulse, treatment apoplexy syncope due to accumulation of phlegm, infantile convulsion etc.Radix Pseudostellariae has benefit strengthening spleen and lung, and effect of supplementing QI for promoting the production of body fluid, controls cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, and edema, quenches one's thirst, metal fatigue.Radix Glycyrrhizae sweet in the mouth, property are flat, and it contains number of chemical composition, and effect is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough.

The present invention has following beneficial effect:

(1) Ramulus Uncariae Cum Uncis dispelling wind and relieving convulsion, effect of heat clearing away suppressing the hyperactive liver, for liver-wind stirring up internally, infantile convulsion is twitched, and hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, has a headache dizzy, and Ramulus Uncariae Cum Uncis is monarch drug.Benzoinum is opened and is stolen clear god, promoting flow of QI and blood, Rhizoma Acori Graminei removing dampness is whetted the appetite, to have one's ideas straightened out eliminating phlegm, refreshment Fructus Alpiniae Oxyphyllae, Calculus Bovis is used for antipyretic, removing toxic substances, arresting convulsion, Periostracum Cicadae dispelling wind and heat pathogens, endogenous wind stopping relieving convulsion, Flos Jasmini Sambac regulating the flow of QI to alleviate depression, ward off dirty and in, Rhizoma et radix valerianae is calmed the nerves, regulate the flow of vital energy, pain relieving, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Flos Jasmini Sambac, Rhizoma et radix valerianae is ministerial drug, can to calm regulating the flow of QI to alleviate depression by auxiliary monarch drug, Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid, Camphora has orifice opening, qi stagnation removing, Cornu Saigae Tataricae suppressing the hyperactive liver to relieve the wind syndrome, loose blood removing toxic substances, Semen Ziziphi Spinosae nourishes conscience, calm the nerves, arresting sweating, Radix Polygalae is calmed the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence, Folium Perillae can fall apart exterior cold, Radix Codonopsis, Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae is adjuvant drug, can to have one's ideas straightened out eliminating phlegm by collaborative monarch drug, refreshment Fructus Alpiniae Oxyphyllae, Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, to calm the nerves arresting convulsion, Bombyx Batryticatus expelling wind to relieve convulsion, dissipating phlegm and resolving masses, Colla cornus cervi temperature compensation Liver and kidney, benefit intensive culture blood, Styrax is had one's ideas straightened out refreshment, and Radix Pseudostellariae mends strengthening spleen and lung, supplementing QI for promoting the production of body fluid, Radix Glycyrrhizae replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae, can mutually to calm the nerves arresting convulsion by synergism.

(2) Pulvis concha Mactrae carries out parch, medicine is made to be convenient to preparation and adjustment, reduce the property that the taste of medicine is greasy, correct bad smell, the refreshment nootropic effect of medicine can be strengthened, add saline and carry out salt stir-fry, brine strength is 20%, saline is fried afterwards and medicine plays synergism, can strengthen the effect of enriching blood and invigorating blood circulation, and effectively treats symptom of waiting so long stagnation of QI day; Grinding makes the starch in medical material, protein is separated out more fully at subsequent step; Decoction can change the irritation effect of medicine, relatively mildly acts on human body, promotes the absorption of medicine; Supercritical extraction, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent, thus make the object that oral liquid reaches refining.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further elaborated.

Embodiment 1:

Treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 25 parts, Benzoinum 10 parts, Rhizoma Acori Graminei 11 parts, Calculus Bovis 10 parts, Periostracum Cicadae 13 parts, Fructus Broussonetiae 8 parts, Flos Jasmini Sambac 15 parts, Rhizoma et radix valerianae 16 parts, Radix Codonopsis 15 parts, Camphora 14 parts, Cornu Saigae Tataricae 10 parts, Semen Ziziphi Spinosae 10 parts, Radix Polygalae 9 parts, Folium Perillae 12 parts, Concha Margaritifera 11 parts, Bombyx Batryticatus 9 parts, Colla cornus cervi 10 parts, Styrax 10 parts, Radix Pseudostellariae 9 parts, 10 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

Embodiment 2:

Treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 35 parts, Benzoinum 22 parts, Rhizoma Acori Graminei 25 parts, Calculus Bovis 19 parts, Periostracum Cicadae 23 parts, Fructus Broussonetiae 16 parts, Flos Jasmini Sambac 25 parts, Rhizoma et radix valerianae 29 parts, Radix Codonopsis 27 parts, Camphora 22 parts, Cornu Saigae Tataricae 19 parts, Semen Ziziphi Spinosae 21 parts, Radix Polygalae 18 parts, Folium Perillae 21 parts, Concha Margaritifera 19 parts, Bombyx Batryticatus 20 parts, Colla cornus cervi 21 parts, Styrax 21 parts, Radix Pseudostellariae 20 parts, 21 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

Embodiment 3:

Treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 28 parts, Benzoinum 14 parts, Rhizoma Acori Graminei 15 parts, Calculus Bovis 13 parts, Periostracum Cicadae 17 parts, Fructus Broussonetiae 11 parts, Flos Jasmini Sambac 18 parts, Rhizoma et radix valerianae 19 parts, Radix Codonopsis 18 parts, Camphora 17 parts, Cornu Saigae Tataricae 13 parts, Semen Ziziphi Spinosae 13 parts, Radix Polygalae 11 parts, Folium Perillae 14 parts, Concha Margaritifera 13 parts, Bombyx Batryticatus 13 parts, Colla cornus cervi 12 parts, Styrax 12 parts, Radix Pseudostellariae 13 parts, 13 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

Embodiment 4:

Treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 32 parts, Benzoinum 18 parts, Rhizoma Acori Graminei 20 parts, Calculus Bovis 16 parts, Periostracum Cicadae 20 parts, Fructus Broussonetiae 13 parts, Flos Jasmini Sambac 22 parts, Rhizoma et radix valerianae 24 parts, Radix Codonopsis 24 parts, Camphora 20 parts, Cornu Saigae Tataricae 16 parts, Semen Ziziphi Spinosae 16 parts, Radix Polygalae 15 parts, Folium Perillae 17 parts, Concha Margaritifera 16 parts, Bombyx Batryticatus 17 parts, Colla cornus cervi 15 parts, Styrax 18 parts, Radix Pseudostellariae 16 parts, 17 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

Embodiment 5:

Treat a Chinese medicine oral liquid for epilepsy, the crude drug effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 30 parts, Benzoinum 15 parts, Rhizoma Acori Graminei 17 parts, Calculus Bovis 15 parts, Periostracum Cicadae 18 parts, Fructus Broussonetiae 12 parts, Flos Jasmini Sambac 20 parts, Rhizoma et radix valerianae 21 parts, Radix Codonopsis 19 parts, Camphora 18 parts, Cornu Saigae Tataricae 14 parts, Semen Ziziphi Spinosae 15 parts, Radix Polygalae 12 parts, Folium Perillae 16 parts, Concha Margaritifera 14 parts, Bombyx Batryticatus 15 parts, Colla cornus cervi 14 parts, Styrax 13 parts, Radix Pseudostellariae 15 parts, 16 parts, Radix Glycyrrhizae.

A kind of preparation method for the treatment of the Chinese medicine oral liquid of epilepsy:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.

1, zoopery

Animal acute toxicity experiment: the Chinese medicine oral liquid of above-mentioned preparation is carried out LD50 test to mice, using dosage is: be 17045mg/M by body surface area consumption, is equivalent to 100 times of people's consumption; Be 5000mg/kg by the consumption of weighing machine, be equivalent to 1000 times of people's consumption.Experimental result is: mice nothing in 72 hours is dead.

Subacute toxicity test is verified: the dosage Chinese medicine oral liquid of above-mentioned preparation being equivalent to continuously people to rat and dog, 100 days, carry out hematological examination, hepatic and renal function, electrocardiogram memory have no significant change.

2, clinical data and case:

In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine epileptics, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.

Clinical therapeutic efficacy criterion is:

Take a turn for the better: common sympton is fainted, the outbreak of hysteria, transient ischemic attack, migraine, psychotic disease, nightmare and somnambulism, narcolepsy, multiple pumping symptoms paroxysmal kinesigenic Dyskinesia:, wait basic disappearance.

Invalid: symptom is not improved.

Therapeutic effect: the present invention is through treating 100 routine epileptics, and 98 examples take a turn for the better, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.

Model case:

Case 1: patient Jiang, man, 48 years old, patient fainted, the outbreak of hysteria, transient ischemic attack, migraine, psychotic disease, and after using 4 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom obviously alleviates, and continued 1 course for the treatment of of use, symptom improvement.

Case 2: patient Lee, man, 4 years old, patient sleeps's myoclonus, fright at night, nightmare and somnambulism, narcolepsy, multiple pumping symptoms paroxysmal kinesigenic Dyskinesia:, after using 2 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom is obviously improved, continue 2 courses for the treatment of of use, symptom takes a turn for the better.

Case 3: patient Jiang, female, 36 years old, patient's hysteria, transient ischemic attack, migraine, psychotic disease show effect, and after using 3 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom is clearly better, after continuing to use 2 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom takes a turn for the better.

The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. treat the Chinese medicine oral liquid of epilepsy for one kind, it is characterized in that, the effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 25 ~ 35 parts, Benzoinum 10 ~ 22 parts, Rhizoma Acori Graminei 11 ~ 25 parts, Calculus Bovis 10 ~ 19 parts, Periostracum Cicadae 13 ~ 23 parts, Fructus Broussonetiae 8 ~ 16 parts, Flos Jasmini Sambac 15 ~ 25 parts, Rhizoma et radix valerianae 16 ~ 29 parts, Radix Codonopsis 15 ~ 27 parts, Camphora 14 ~ 22 parts, Cornu Saigae Tataricae 10 ~ 19 parts, Semen Ziziphi Spinosae 10 ~ 21 parts, Radix Polygalae 9 ~ 18 parts, Folium Perillae 12 ~ 21 parts, Concha Margaritifera 11 ~ 19 parts, Bombyx Batryticatus 9 ~ 20 parts, Colla cornus cervi 10 ~ 21 parts, Styrax 10 ~ 21 parts, Radix Pseudostellariae 9 ~ 20 parts, 10 ~ 21 parts, Radix Glycyrrhizae.

2. a kind of Chinese medicine oral liquid for the treatment of epilepsy according to claim 1, it is characterized in that, the effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 28 ~ 32 parts, Benzoinum 14 ~ 18 parts, Rhizoma Acori Graminei 15 ~ 20 parts, Calculus Bovis 13 ~ 16 parts, Periostracum Cicadae 17 ~ 20 parts, Fructus Broussonetiae 11 ~ 13 parts, Flos Jasmini Sambac 18 ~ 22 parts, Rhizoma et radix valerianae 19 ~ 24 parts, Radix Codonopsis 18 ~ 24 parts, Camphora 17 ~ 20 parts, Cornu Saigae Tataricae 13 ~ 16 parts, Semen Ziziphi Spinosae 13 ~ 16 parts, Radix Polygalae 11 ~ 15 parts, Folium Perillae 14 ~ 17 parts, Concha Margaritifera 13 ~ 16 parts, Bombyx Batryticatus 13 ~ 17 parts, Colla cornus cervi 12 ~ 15 parts, Styrax 12 ~ 18 parts, Radix Pseudostellariae 13 ~ 16 parts, 13 ~ 17 parts, Radix Glycyrrhizae.

3. a kind of Chinese medicine oral liquid for the treatment of epilepsy according to claim 1; it is characterized in that, the effective ingredient mass fraction making oral liquid comprises: Ramulus Uncariae Cum Uncis 30 parts, Benzoinum 15 parts, Rhizoma Acori Graminei 17 parts, Calculus Bovis 15 parts, Periostracum Cicadae 18 parts, Fructus Broussonetiae 12 parts, Flos Jasmini Sambac 20 parts, Rhizoma et radix valerianae 21 parts, Radix Codonopsis 19 parts, Camphora 18 parts, Cornu Saigae Tataricae 14 parts, Semen Ziziphi Spinosae 15 parts, Radix Polygalae 12 parts, Folium Perillae 16 parts, Concha Margaritifera 14 parts, Bombyx Batryticatus 15 parts, Colla cornus cervi 14 parts, Styrax 13 parts, Radix Pseudostellariae 15 parts, 16 parts, Radix Glycyrrhizae.

4. treat a preparation method for the Chinese medicine oral liquid of epilepsy, it is characterized in that, described preparation method concrete steps are as follows:

(1) Ramulus Uncariae Cum Uncis, Benzoinum, Rhizoma Acori Graminei, Calculus Bovis, Periostracum Cicadae, Fructus Broussonetiae, Flos Jasmini Sambac, Rhizoma et radix valerianae, Radix Codonopsis are that 2:1 adds Pulvis concha Mactrae and carries out 120 ~ 160 DEG C of parches of advancing according to crude drug and Pulvis concha Mactrae weight ratio, after parch completes, remove Pulvis concha Mactrae;

(2) crude drug Camphora, Cornu Saigae Tataricae, Semen Ziziphi Spinosae, Radix Polygalae, Folium Perillae, Concha Margaritifera, Bombyx Batryticatus, Colla cornus cervi, Styrax, Radix Pseudostellariae, Radix Glycyrrhizae carry out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, and temperature is 100 ~ 120 DEG C;

(3) will obtain loading ball mill grinding 2h through step (1) (2), and cross 80 mesh sieves, obtain grounds travel;

(4) boil 2h after the grounds travel that step (3) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(5) extracting solution that step (4) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid; Extract concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;

(6) add 1000ml purified water in extractum step (5) obtained, after high temperature sterilization, subpackage both obtained.