CN105283169B - 用于高水溶性药物的控释的包衣 - Google Patents
用于高水溶性药物的控释的包衣 Download PDFInfo
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- CN105283169B CN105283169B CN201480028712.2A CN201480028712A CN105283169B CN 105283169 B CN105283169 B CN 105283169B CN 201480028712 A CN201480028712 A CN 201480028712A CN 105283169 B CN105283169 B CN 105283169B
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- encapsulated layer
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Surgery (AREA)
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- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers & Plastics (AREA)
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| US61/815,910 | 2013-04-25 | ||
| PCT/US2014/035527 WO2014176545A1 (en) | 2013-04-25 | 2014-04-25 | Coatings for controlled release of highly water soluble drugs |
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| CN105283169A CN105283169A (zh) | 2016-01-27 |
| CN105283169B true CN105283169B (zh) | 2018-11-30 |
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| US9814805B2 (en) * | 2013-04-25 | 2017-11-14 | Innovative Surface Technologies, Inc. | Coatings for controlled release of highly water soluble drugs |
| US10744233B2 (en) | 2016-02-24 | 2020-08-18 | Innovative Surface Technologies, Inc. | Crystallization inhibitor compositions for implantable urological devices |
| EP3642383B1 (en) | 2017-06-22 | 2022-12-21 | The Procter & Gamble Company | Films including a water-soluble layer and a vapor-deposited inorganic coating |
| US11192139B2 (en) * | 2017-06-22 | 2021-12-07 | The Procter & Gamble Company | Films including a water-soluble layer and a vapor-deposited organic coating |
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| CN1964748A (zh) * | 2004-04-06 | 2007-05-16 | 苏莫迪克斯公司 | 用于生物活性剂的涂料组合物 |
| CN102712825A (zh) * | 2009-12-21 | 2012-10-03 | 创新涂层技术有限公司 | 涂层剂以及涂覆制品 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| US5271945A (en) | 1988-07-05 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Sustained release microcapsule for water soluble drug |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| US5714360A (en) | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
| US7682647B2 (en) * | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| US6278018B1 (en) | 1999-12-14 | 2001-08-21 | Surmodics, Inc. | Surface coating agents |
| DE60331552D1 (de) * | 2002-08-13 | 2010-04-15 | Medtronic Inc | Darreichungssysteme von wirkstoffen mit poly(ethylene-co(meth)akrylate, medizinische vorrichtung und verfahren |
| AU2003287633A1 (en) | 2002-11-08 | 2004-06-03 | Innovational Holdings, Llc | Method and apparatus for reducing tissue damage after ischemic injury |
| AU2004237774B2 (en) | 2003-05-02 | 2009-09-10 | Surmodics, Inc. | Implantable controlled release bioactive agent delivery device |
| US7811274B2 (en) | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
| US20050100577A1 (en) * | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
| US7901451B2 (en) * | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| US20080075753A1 (en) | 2006-09-25 | 2008-03-27 | Chappa Ralph A | Multi-layered coatings and methods for controlling elution of active agents |
| US8163034B2 (en) | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
| WO2013033159A1 (en) * | 2011-08-31 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Reduction of biofilms on medical devices |
| RU2010121860A (ru) | 2007-10-30 | 2011-12-10 | ЮТиАй ЛИМИТЕД ПАРТНЕРШИП (CA) | Способ и устройство для длительного высвобождения склерозирующего агента |
| EP2265293B1 (en) | 2008-04-18 | 2015-11-04 | SurModics, Inc. | Coating systems for the controlled delivery of hydrophilic bioactive agents |
| EP2344212A4 (en) | 2008-09-19 | 2013-06-05 | Innovative Surface Technologies Inc | DRUG RELEASE SUPERHYDROPHOBIC COATINGS |
| US20110159072A1 (en) | 2009-12-30 | 2011-06-30 | Surmodics, Inc. | Controlled release matrix |
| US20120100187A1 (en) | 2010-10-26 | 2012-04-26 | Surmodics, Inc. | Coatings and methods for controlled elution of hydrophilic active agents |
| US20120302950A1 (en) | 2011-05-26 | 2012-11-29 | Carefusion 2200, Inc. | Active pleurodesis catheter |
| US8697112B2 (en) * | 2011-07-08 | 2014-04-15 | Covalon Technologies | Method for treating a surface with a coating comprising a microencapsulated therapeutic agent and device with treated surface |
| US9814805B2 (en) * | 2013-04-25 | 2017-11-14 | Innovative Surface Technologies, Inc. | Coatings for controlled release of highly water soluble drugs |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1964748A (zh) * | 2004-04-06 | 2007-05-16 | 苏莫迪克斯公司 | 用于生物活性剂的涂料组合物 |
| CN102712825A (zh) * | 2009-12-21 | 2012-10-03 | 创新涂层技术有限公司 | 涂层剂以及涂覆制品 |
Also Published As
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| JP6255483B2 (ja) | 2017-12-27 |
| AU2014256955A1 (en) | 2015-12-03 |
| US20180043063A1 (en) | 2018-02-15 |
| EP2988730A1 (en) | 2016-03-02 |
| JP2016517870A (ja) | 2016-06-20 |
| US10098989B2 (en) | 2018-10-16 |
| AU2014256955B2 (en) | 2018-02-22 |
| CA2909069A1 (en) | 2014-10-30 |
| CA2909069C (en) | 2018-10-16 |
| WO2014176545A1 (en) | 2014-10-30 |
| US20160067385A1 (en) | 2016-03-10 |
| US9814805B2 (en) | 2017-11-14 |
| CN105283169A (zh) | 2016-01-27 |
| EP2988730A4 (en) | 2017-03-29 |
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