CN105267820A - Externally-used paste preparation treating bone tuberculosis and preparation method - Google Patents
Externally-used paste preparation treating bone tuberculosis and preparation method Download PDFInfo
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Abstract
The invention discloses an externally-used paste preparation treating bone tuberculosis and a preparation method. The externally-used paste preparation is prepared from the following main bulk drugs in parts by weight: 8-15 parts of herba lycopi, 6-14 parts of rhizome of kirilow rhodiola, 9-15 parts of herba ecliptae, 8-16 parts of twig and leaf of manyflower supplejack, 11-17 parts of chinese hibisci rosae-sinensis flower, 9-14 parts of opuntia dillenii haw, 8-14 parts of flos rosae chinensis, 7-13 parts of all-grass of wildcelery, 9-12 parts of diospyros rhombifolia Hemsl., 8-13 parts of flower of japanese glorybower, 10-16 parts of root of twelve stamen melastoma, 9-13 parts of sharpleaf galangal fruit, and 8-12 parts of root of kirilow rhodiola. The paste preparation directly acts on an affected part and efficiently rapidly gives play to effect, and is capable of adjusting body tissue organ functions and improving body immunity, thereby realizing the purpose of curing bone tuberculosis. Also, the paste preparation simultaneously treats principal and subordinate symptoms, does not cause recurrence, is free of side effect, and does not generate drug resistance.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of externally used paste and preparation method for the treatment of bone tuberculosis.
Background technology
Bone tuberculosis is a kind of very common orthopaedic disease.Tuberculosis of bone and joint is equivalent to Chinese medicine " tuberculosis of bone and joint " or " bone tuberculosis " category.What the traditional Chinese medical science thought primary disease mostly is congenital defect, and skeleton is hollow, or damage causes qi-blood disharmony to some extent, and wind-cold damp pathogen is taken advantage of a weak point and caused the turbid cohesion of expectorant, stays caused by the skeleton.Although the understanding of traditional Chinese medical science scholar to primary disease etiology and pathogenesis is still not quite similar at present, mostly think that primary disease is the card of rate void mark reality, i.e. congenital defect, deficiency of the kidney bone sky is disease basis; The turbid cohesion of expectorant, wind and cold is attacked, or damages to some extent, be then the mark of disease.Its pathological changes is at bone, and its source of disease is at kidney.Bone tuberculosis general manifestation weight differs, and is generally chronic progression process, has low grade fever more, becomes thin, the symptom such as inappetence, the now many speedups of erythrocyte sedimentation rate, has to do puncture chemical examination during hydrarthrosis and can find tulase, local slower development.Mostly be accidental arthralgia in early days, increase the weight of gradually and transfer regular pain to, time movable, pain increases the weight of, there is tenderness, pain can be radiated to other position, has muscular spasm because of pain during activity, cause the active in joint and passive activity limited, persistency muscular spasm can cause arthrogryposis or become row, and suffering limb is amyotrophy because of apraxia.Bone tuberculosis 95% is secondary to pulmonary tuberculosis.When Abwehrkraft des Koepers reduces, can breed formation focus, just occur clinical symptoms, primary disease is multiple at spinal column, accounts for 50%, is secondly hip joint, knee joint, ankle joint etc.Age of onset is the most common with less than 10 years old Children and teenager.The performance of bone tuberculosis is different according to position, and slowly, the course of disease is longer, the not obvious easy mistaken diagnosis of early symptom in morbidity, late period General Symptoms weight, can show and have bad physiques, inappetence, slight fever, arteries and veins slightly speeds.
Bone tuberculosis clinical symptoms shows: 1, dysfunction.The joint function disturbance of usual patient occurs more Zao than affected part pain.In order to alleviate the pain of affected part, each joint is often forced in special position, position as sagging in shoulder joint, elbow joint semi-flexed position.Hip joint flexing position, ankle joint drop foot position.Tuberculosis of spine commonly uses two hand rest lower jaws, thoracic vertebra or tuberculosis of spine person muscle protection spasm, causes bend over difficulty and the distinctive postures such as lost article found of carefully squatting.2, pain.How not obvious initial stage local pain is, treats that pathological development stimulates or oppresses its contiguous nerve root, as the appearance intercostal neuralgia of tuberculosis of spine; Tuberculosis of spine stimulates or compressing lumbar plexus causes lumbago and skelalgia; When simple bone tuberculosis or synovial tuberculosis develop into total joint tuberculosis, pain increases the weight of, and often at this moment just causes the attention of patient.In order to ease the pain, affected muscles is in spasticity always, so as to shielding.When patient posture changes, especially when nighttime sleep loses the protection of muscle spasm, pain is more obvious, and children's often shows night cry etc.3, deformity.Along with pathological development, osteoarthrosis and vertebrae destroy, and above-mentioned distinctive posture continues constant and further develops, and joint motion is limited further and occur deformity, and spinal tuberculosis has more ready-made angle kyphosis deformity.4, swelling.The local swelling of extremities joint tuberculosis is easy to find, skin color is acted normally usually, local slightly hotness.Arthroncus increases gradually, the amyotrophy of limbs, and diseased joints is many in fusiformis.Spinal tuberculosis is because of anatomy relationship, and early stage body surface can without exceptionly find, along with pathological development, the other abscess of vertebra increases and also travels to body surface along muscle gap, and cold abscess can come across the recessed and lower limb root of cervical region, back, lumbar triangle, ilium etc.As abscess travels to body surface, skin involvement, visible epidermis flushing, local temperature also can increase, and the skin of even wearing out had forms sinus tract.Patient has more existing low grade fever simultaneously, and local pain increases the weight of.The diagnosis of tuberculosis of bone and joint is contributed to when cold abscess occurs.
Application publication number CN102293974A(application number 201110250840.X) Chinese patent literature disclose a kind of Chinese medicine composition and preparation method for the treatment of bone tuberculosis, the Chinese medicine composition of this treatment bone tuberculosis comprises: Carapax Trionycis, Rhizoma Atractylodis Macrocephalae, Radix Platycodonis, stir-fry Squama Manis, Scorpio, the Radix Stemonae, Bulbus Fritillariae Cirrhosae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Rhizoma Pinelliae, Rhizoma Picrorhizae, Radix Stellariae, Scolopendra, large Gecko, Radix Glycyrrhizae, Mel.Application publication number CN104606352A(application number 201510073022.5) Chinese patent literature disclose a kind of compound bone tuberculous bolus for the treatment of bone tuberculosis, it is made up of 14 taste crude drug such as Herba Hedyotidis Diffusae, Spica Prunellae, Radix Scrophulariae, the Radix Pulsatillae, Zaocys, Cornu Cervi Pantotrichum, Radix Angelicae Sinensis, Scolopendra, Radix Ginseng, the Radix Astragali, Radix Glycyrrhizae, Gekko Swinhonis, Scorpio, Flos Carthamis.Application publication number CN104887805A(application number 201510389728.2) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of bone tuberculosis, the raw material of this Chinese medicine preparation is Scorpio, Radix Achyranthis Bidentatae, Scolopendra, Carapax Trionycis, Cornu Cervi Pantotrichum, Radix Clematidis, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Asteris, Cortex Phellodendri, Olibanum, Radix Dipsaci, Rhizoma Drynariae, Radix Ginseng Rubra, Radix Angelicae Sinensis, Radix Rubiae, the Cortex Eucommiae, Poria, Auricularia, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae.The drug prices such as the Squama Manis used in above-mentioned patent documentation, Radix Ginseng, Cornu Cervi Pantotrichum are more expensive, add the financial burden of patient.
The Therapeutic Method of bone tuberculosis routine adopts antituberculotics and operative treatment, and antituberculotics effectively can control, kill tubercule bacillus, but long-term edible meeting have side effects to Liver and kidney vitals, even causes producing fastbacteria in body; Operation can mitigate the disease at short notice, but cures the symptoms, not the disease, and just remove the pathogenic bacterium of patient part, once resistance declines, pathogenic bacteria is easy to again cause a disease.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of externally used paste and preparation method for the treatment of bone tuberculosis.The present invention directly acts on affected part, can play a role efficiently and effectively, can the function of reconditioner soma organ, and improve immunity of organisms, thus reach the object of curing bone tuberculosis, treating both the principal and secondary aspects of a disease, does not recur, and has no side effect, and can not produce drug resistance.
Technical scheme of the present invention is:
The externally used paste for the treatment of bone tuberculosis, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Lycopi 8-15, Rhizoma Rhodiolae kirilowii 6-14; Herba Ecliptae 9-15, Ramulus et folium berchemiae floribundae 8-16, Flos Hibisci Rosae-Sinensis 11-17; Coagulum Opuntiae sucus 9-14; Flos Rosae Chinensis 8-14, Herba Apii graveolentis 7-13, Radix seu Ramulus Diospyroris rhombifoliae 9-12; Flos clerodendri japonici 8-13; Herba Melastomatis dodecandri 10-16, Fructus Alpiniae Oxyphyllae 9-13, Radix Rhodiolae 8-12.
The externally used paste for the treatment of bone tuberculosis, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Lycopi 10-12; Rhizoma Rhodiolae kirilowii 8-12, Herba Ecliptae 11-14, Ramulus et folium berchemiae floribundae 10-14; Flos Hibisci Rosae-Sinensis 12-15, Coagulum Opuntiae sucus 11-13, Flos Rosae Chinensis 9-12; Herba Apii graveolentis 8-11; Radix seu Ramulus Diospyroris rhombifoliae 10-11, Flos clerodendri japonici 9-12, Herba Melastomatis dodecandri 12-14; Fructus Alpiniae Oxyphyllae 10-12, Radix Rhodiolae 9-11.
The externally used paste for the treatment of bone tuberculosis, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Lycopi 11; Rhizoma Rhodiolae kirilowii 10, Herba Ecliptae 13, Ramulus et folium berchemiae floribundae 12; Flos Hibisci Rosae-Sinensis 13, Coagulum Opuntiae sucus 12, Flos Rosae Chinensis 11; Herba Apii graveolentis 10; Radix seu Ramulus Diospyroris rhombifoliae 10.5, Flos clerodendri japonici 11, Herba Melastomatis dodecandri 13; Fructus Alpiniae Oxyphyllae 11, Radix Rhodiolae 10.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dry 6-9 hour, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is the 1/3-2/3 of Fructus Alpiniae Oxyphyllae weight, and moistening 2-4 hour puts to steam in container and steams 3-5.5 hour, takes out, spreads out in porcelain dish, dry in the shade, smash to pieces, crosses 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dry 8-12 hour, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 1.8-3 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is the 1/6-1/2 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
Preferably be in step (1), 55 DEG C of dry 6.5-8 hour.
Preferably be that, in step (3), amount of water is the 2/5-3/5 of Fructus Alpiniae Oxyphyllae weight.
Preferably be in step (3), moistening 2.5-3.5 hour.
Preferably be, in step (3), to put to steam in container and steam 4-5 hour.
Preferably be in step (4), 60 DEG C of dry 9-11 hour.
Preferably be in step (5), the amount of vaseline is 2-2.8 times of step (1), step (2), step (3) and step (4) gained gross weight.
Preferably be in step (5), the amount of Oleum sesami is the 1/5-1/3 of step (1), step (2), step (3) and step (4) gained gross weight.
Be more preferably, 55 DEG C of dryings 7 hours in step (1).
Be more preferably, in step (3), amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight.
Be more preferably, moistening 3 hours in step (3).
Be more preferably, mid-the steaming in container of step (3) is steamed 4.5 hours.
Be more preferably, 60 DEG C of dryings 10 hours in step (4).
Be more preferably, in step (5), the amount of vaseline is 2.5 times of step (1), step (2), step (3) and step (4) gained gross weight.
Be more preferably, in step (5), the amount of Oleum sesami is 1/4 of step (1), step (2), step (3) and step (4) gained gross weight.
The externally used paste scientific formula for the treatment of bone tuberculosis provided by the invention, preparation method is simple, easy to use.In addition, excellent results of the present invention also shows:
1, directly act on affected part, can play a role efficiently and effectively;
2, there is blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, expelling wind and removing dampness, reducing swelling and alleviating pain, QI invigorating nourish heart, effect of heat-clearing and toxic substances removing,
Can the function of reconditioner soma organ, improve immunity of organisms, thus reach the object of curing bone tuberculosis;
3, treating both the principal and secondary aspects of a disease, does not recur;
4, have no side effect, can not drug resistance be produced;
5, medicine source extensively and price is comparatively cheap.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the externally used paste for the treatment of bone tuberculosis, the primary raw material medicine getting following weight parts is prepared from (every part is 420g): Herba Lycopi 8 parts, Rhizoma Rhodiolae kirilowii 6 parts; Herba Ecliptae 9 parts, Ramulus et folium berchemiae floribundae 8 parts, Flos Hibisci Rosae-Sinensis 11 parts; Coagulum Opuntiae sucus 9 parts; Flos Rosae Chinensis 8 parts, Herba Apii graveolentis 7 parts, Radix seu Ramulus Diospyroris rhombifoliae 9 parts; Flos clerodendri japonici 8 parts; Herba Melastomatis dodecandri 10 parts, Fructus Alpiniae Oxyphyllae 9 parts, Radix Rhodiolae 8 parts.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dryings 6 hours, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/3 of Fructus Alpiniae Oxyphyllae weight, moistening 2 hours, puts to steam in container and steams 3 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dryings 8 hours, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 1.8 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is 1/6 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
The using method of the externally used paste of gained treatment bone tuberculosis of the present invention is: be spread out on cloth by products obtained therefrom of the present invention, be attached to affected part, if affected part ulceration, must be cut into an aperture, make ulceration show outside plaster by the middle of plaster, be convenient to pus and flow out.
embodiment 2the externally used paste for the treatment of bone tuberculosis, the primary raw material medicine getting following weight parts is prepared from (every part is 420g): Herba Lycopi 15 parts, Rhizoma Rhodiolae kirilowii 14 parts; Herba Ecliptae 15 parts, Ramulus et folium berchemiae floribundae 16 parts, Flos Hibisci Rosae-Sinensis 17 parts; Coagulum Opuntiae sucus 14 parts; Flos Rosae Chinensis 14 parts, Herba Apii graveolentis 13 parts, Radix seu Ramulus Diospyroris rhombifoliae 12 parts; Flos clerodendri japonici 13 parts; Herba Melastomatis dodecandri 16 parts, Fructus Alpiniae Oxyphyllae 13 parts, Radix Rhodiolae 12 parts.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dryings 9 hours, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 2/3 of Fructus Alpiniae Oxyphyllae weight, moistening 4 hours, puts to steam in container and steams 5.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dryings 12 hours, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 3 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is 1/2 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
model case one:wu XX, female, 27 years old.Before more than 1 year, after the right ancon of patient is injured, there is right ancon pain, the symptoms such as swelling.Right elbow joint bone tuberculosis is diagnosed as to the capable MRI of local hospital.After carrying out anti-scarring agent treatment, without being clearly better.Then to our hospital.The right ancon swelling of patient is obvious, and more so, local tenderness is obvious in outside, and local skin temperature is slightly high, and color of the leather is constant, and outside is touched subcutaneous slightly hard, obscure boundary.Elbow joint flexing 100 degree, hyperextension radian disappears, and radial artery pulse is obvious, and acra blood follows and dermal sensation situation can.MRI shows: right ancon inequality signal is even, the visible rope sample height signal shadow in front side, sharpness of border.CT shows: right tuberculosis of elbow joint is fuzzy, articular cartilage damage, articular surface out-of-flatness, surrounding soft tissue's swelling.Be diagnosed as right elbow joint bone tuberculosis.Use the externally used paste of the present embodiment gained treatment bone tuberculosis, the present embodiment products obtained therefrom is spread out on cloth, is attached to affected part.Treat after 1 month, symptom is clearly better.Treat after 3 months, recovery from illness.Follow up a case by regular visits to without recurrence.
embodiment 3the externally used paste for the treatment of bone tuberculosis, the primary raw material medicine getting following weight parts is prepared from (every part is 420g): Herba Lycopi 10 parts, Rhizoma Rhodiolae kirilowii 8 parts; Herba Ecliptae 11 parts, Ramulus et folium berchemiae floribundae 10 parts, Flos Hibisci Rosae-Sinensis 12 parts; Coagulum Opuntiae sucus 11 parts; Flos Rosae Chinensis 9 parts, Herba Apii graveolentis 8 parts, Radix seu Ramulus Diospyroris rhombifoliae 10 parts; Flos clerodendri japonici 9 parts; Herba Melastomatis dodecandri 12 parts, Fructus Alpiniae Oxyphyllae 10 parts, Radix Rhodiolae 9 parts.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dryings 6.5 hours, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 2/5 of Fructus Alpiniae Oxyphyllae weight, moistening 2.5 hours, puts to steam in container and steams 4 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dryings 9 hours, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 2 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is 1/5 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
model case two:song XX, man, 46 years old.Before more than 2 years, there is right upper extremity shoulder joint place swelling pain without obvious inducement in patient, and local skin generates heat, and goes to a doctor, be diagnosed as bone tuberculosis, do not give treatment at local hospital.Rear aggravation, carries out operative treatment.But surgical wound fails to heal, and repeatedly suppurates always, and tunnel, delay is so far.Then my institute's diagnosis and treatment.The two upper limb of patient is isometric, the swelling of right upper arm epimere, and all footpaths are about 24cm, strong side 25cm, respectively there is an operative scar front and back, heal not good enough, local is slightly rubescent, and before right shoulder joint, nearly axillary fossa place has a diameter to be about 4cm enclosed mass, soft, surrounding tissue is comparatively hard, and tenderness is obvious, and a sinus tract is arranged at enclosed mass top, dark about 2cm, inside has a small amount of yellow-white purulence to flow out, the thick odorless of matter, local organization elasticity is slightly poor, Pi Wenlvegao, and shoulder joint is bent and stretched limited.X-ray film shows: right humerus epimere osteoporosis, and part bone trabecula ruptures, a little bone destruction defect.Upper arm epimere soft-tissue density increases.Examine as right shoulder joint bone tuberculosis.Use the externally used paste of the present embodiment gained treatment bone tuberculosis, the present embodiment products obtained therefrom is spread out on cloth, is attached to affected part, be cut into an aperture by the middle of plaster, make ulceration show outside plaster, be convenient to pus and flow out.Treat after 2 months, symptom is clearly better.Treat after 3 months, wound healing, right shoulder joint function recovers.Follow up a case by regular visits to without recurrence.
embodiment 4the externally used paste for the treatment of bone tuberculosis, the primary raw material medicine getting following weight parts is prepared from (every part is 420g): Herba Lycopi 12 parts, Rhizoma Rhodiolae kirilowii 12 parts; Herba Ecliptae 14 parts, Ramulus et folium berchemiae floribundae 14 parts, Flos Hibisci Rosae-Sinensis 15 parts; Coagulum Opuntiae sucus 13 parts; Flos Rosae Chinensis 12 parts, Herba Apii graveolentis 11 parts, Radix seu Ramulus Diospyroris rhombifoliae 11 parts; Flos clerodendri japonici 12 parts; Herba Melastomatis dodecandri 14 parts, Fructus Alpiniae Oxyphyllae 12 parts, Radix Rhodiolae 11 parts.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dryings 8 hours, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 3/5 of Fructus Alpiniae Oxyphyllae weight, moistening 3.5 hours, puts to steam in container and steams 5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dryings 11 hours, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 2.8 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is 1/3 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
model case three:yuan XX, female, 56 years old.Before 3 years, there is an enclosed mass in the right hip of patient, and companion's low grade fever night sweat symptom, goes to a doctor at local hospital, be diagnosed as right hip joint bone tuberculosis, after underwent operative debridement drain and oral anti-scarring agent, symptom is alleviated to some extent, but do not fully recover, right hip is swelling repeatedly still, and ulceration is suppurated.After diagnosis and treatment in many ways, curative effect is not good enough.Then go to a doctor in here.Patient's low grade fever night sweat, body of the tongue is light red, thin fur, deep-thready pulse.Right hip swelling is obvious, and outside right hip, a visible stringer operative scar is about 20cm, has 2cm × 2cm size wound surface in cicatrix, inside have yellow exudate to flow out, without obvious stink, around color of the leather is dun, local organization elasticity is poor, Pi Wenlvegao, right hip joint function limitation of activity.X-ray checks: see that right hip soft tissue swelling is obvious, right hipbone sclerotin has exception.Be diagnosed as right hip joint bone tuberculosis.The present embodiment products obtained therefrom is spread out on cloth, is attached to affected part, be cut into an aperture by the middle of plaster, make ulceration show outside plaster, be convenient to pus and flow out.Treat after 1 month, symptom is clearly better.Treat after 3 months, recovery from illness, right hip joint function recovers.Follow up a case by regular visits to without recurrence.
embodiment 5the externally used paste for the treatment of bone tuberculosis, the primary raw material medicine getting following weight parts is prepared from (every part is 420g): Herba Lycopi 11 parts, Rhizoma Rhodiolae kirilowii 10 parts; Herba Ecliptae 13 parts, Ramulus et folium berchemiae floribundae 12 parts, Flos Hibisci Rosae-Sinensis 13 parts; Coagulum Opuntiae sucus 12 parts; Flos Rosae Chinensis 11 parts, Herba Apii graveolentis 10 parts, Radix seu Ramulus Diospyroris rhombifoliae 10.5 parts; Flos clerodendri japonici 11 parts; Herba Melastomatis dodecandri 13 parts, Fructus Alpiniae Oxyphyllae 11 parts, Radix Rhodiolae 10 parts.
The preparation method of the externally used paste of above-mentioned treatment bone tuberculosis is:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dryings 7 hours, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight, moistening 3 hours, puts to steam in container and steams 4.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dryings 10 hours, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 2.5 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is 1/4 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Lycopi: base is former: be the dry aerial parts of labiate hair leaf lycopus lucidus.The property of medicine: bitter, pungent, tepor.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Rhizoma Rhodiolae kirilowii: base is former: be the root and rhizome of Crassulaceae Rhodida plant Rhodiola kirilowii (Regel) Maxim..Composition: herb is containing butyl alcohol, and daucosterol, rhodioside, hundred arteries and veins are with glycosides.The property of medicine: bitter, puckery, temperature.Return lung, the heart, liver, large intestine channel.Function cures mainly: tranquilizing by nourishing the heart, blood stasis dispelling, hemostasis.Cure mainly deficiency of vital energy and physically weak, weak palpitation and insomnia of losing heart, dizzy dizzy, pain uncomfortable in chest, traumatic injury, menoxenia, metrorrhagia, spits blood, dysentery, diarrhoea.
Herba Ecliptae: base is former: the herb of feverfew Eclipta prostrata.The property of medicine: sweet in the mouth; Acid; Cool in nature.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying; Cooling blood for hemostasis.Main deficiency of the liver and kindey; Have a dizzy spell; Early whitening of beard and hair; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Dysentery; Collapse; Leak; Traumatic hemorrhage.
Ramulus et folium berchemiae floribundae: base is former: for Rhamnaceae plant spends more the stem of Radix Berchemiae Giraldianae, leaf or root.The property of medicine: sweet; Puckery; Tepor.Return liver, gallbladder meridian.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Stomachache; Dysmenorrhea; Puerperal abdonimal pain; Traumatic injury; Tuberculosis of bone and joint; Osteomyelitis; Infantile malnutrition; Hepatitis; Liver cirrhosis.
Flos Hibisci Rosae-Sinensis: base is former: be the flower of Malvaceae plant Hibiscus rosasinensis.The property of medicine: sweet; Light; Flat.GUIXIN, lung, liver, spleen channel.Function cures mainly: lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances.Main cough due to lung-heat; Spitting of blood; Epistaxis; Metrorrhagia; Leucorrhea; Dysentery; Reddish and whitish turbid urine; Carbuncle skin infection.
Coagulum Opuntiae sucus: base is former: be the juice concretion flowed out in the fleshy stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.The property of medicine: sweet; Cold in nature.Function cures mainly: clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Main hemorrhoidal bleeding; Have blood in stool; Furuncle swells; Scald; Palpitation with a distress feeling; Acute infantile convulsion wind.
Flos Rosae Chinensis: base is former: be the flower of rosaceous plant Flos Rosae Chinensis.The property of medicine: sweet; Temperature; Nontoxic.Return liver, kidney channel.Function cures mainly: promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Main menoxenia, dysmenorrhea, amenorrhea, traumatic injury, swelling and pain due to blood stasis, scrofula, carbuncle, scalds.
Herba Apii graveolentis: base is former: be the whole herb with root of samphire Herba Apii graveolentis.The property of medicine: sweet in the mouth; Pungent; Micro-hardship; Cool in nature.Return liver, stomach, lung meridian.Function cures mainly: suppressing the hyperactive liver; Heat clearing away; Dispel the wind; Diuretic; Hemostasis; Removing toxic substances.Main dizziness due to hyperactivity of liver-YANG; Headache due to pathogenic wind-heat; Cough; Jaundice; Urine leaching pain; Hematuria; Metrorrhagia; Leukorrhagia; Skin infection toxic swelling.
Radix seu Ramulus Diospyroris rhombifoliae: base is former: be root or the branch of Ebenaceae plant Radix seu Ramulus Diospyroris rhombifoliae.The property of medicine: bitter; Property is put down.Return Liver Channel.Function cures mainly: clearing away damp-heat; Profit liver and gall; Blood circulation promoting and blood stasis dispelling.Main acute icterohepatitis; Liver cirrhosis; Traumatic injury.
Flos clerodendri japonici: base is former: be the flower of Verenaceae Zhi Wu Cheng paulownia.The property of medicine: sweet; Flat.Return spleen channel.Function cures mainly: calm the nerves; Hemostasis.Main palpitation and insomnia; Bleeding hemorrhoids.
Herba Melastomatis dodecandri: base is former: the root of Melastomateae plants Herba Melastomatis Dodecandri.The property of medicine: bitter in the mouth; Micro-sweet; Property is put down.Return liver, spleen, lung meridian.Function cures mainly: invigorate blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Main dysmenorrhea; Difficult labour; Puerperal abdonimal pain; Retention of placenta; Metrorrhagia; Leucorrhea; Cough; Spit blood; Dysentery; Jaundice; Drench pain; Chronic malaria; Rheumatalgia; Toothache; Scrofula; Hernia; Traumatic injury impairment caused by overstrain; Venom.
Fructus Alpiniae Oxyphyllae: base is former: be the fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.The property of medicine: pungent, temperature.Return spleen, kidney channel.Function cures mainly: warming spleen and stopping diarrhaly take the photograph saliva, warming the kidney reducing urination controlling nocturnal emission with astringent drugs.Main Deficiency and coldness of spleen and stomach, vomit, have loose bowels, coldly in abdomen to educate, the many salivas of mouth, enuresis due to deficiency of the kidney, frequent micturition, seminal emission, nebulousurine.
Radix Rhodiolae: base is former: be the herb of crassulaceae plants Rhodiola sachalinensis, Radix Rhodiolae, Rhodiola Crassulaceae etc.The property of medicine: cold; Sweet; Puckery.Return lung meridian.Function cures mainly: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
test example 1the clinical practice of the externally used paste (embodiment 5) of gained of the present invention treatment bone tuberculosis: in December, 2009 in July ,-2011, screens 240 routine bone tuberculosis patients in 3 hospitals.Wherein, male 130 example, women 110 example, at 13 ~ 52 years old age, average 30.5 years old, the course of disease was the longest 6.5 years, the shortest 3 months.All make a definite diagnosis through x-ray or CT examination and laboratory inspection.Be divided into two groups at random, experimental group and matched group (often organizing 120 people).Two groups of patients compare in the physical data such as sex, age, the course of disease, the state of an illness, and there was no significant difference, has comparability.Experimental group uses gained of the present invention to treat the externally used paste of bone tuberculosis, using method: be spread out on cloth by products obtained therefrom of the present invention, be attached to affected part, if affected part is ulceration, an aperture must be cut into by the middle of plaster, make ulceration show outside plaster, be convenient to pus and flow out.Matched group uses the Drug therapys such as isoniazid, rifampicin, pyrazinamide, ethambutol.After two groups of patients all treat three months, carry out Comparison of therapeutic.
Curative effect situation criterion: cure: systemic conditions is good, local symptom, sign disappear, wound healing, functional rehabilitation or substantially recover, and x-ray inspection display knitting is good, and joint space is clear or merge at functional position; Take a turn for the better: systemic conditions and local symptom, sign take a turn for the better, x-ray checks that pathological changes heals not yet completely, and joint deformity is not corrected completely; Invalid: whole body and local symptom are only slightly improved, x-ray inspection is without being clearly better.Total effectively comprising cures and takes a turn for the better.Result is as shown in table 1.
Table 1: the externally used paste compliance test result [example (%)] of gained treatment bone tuberculosis of the present invention
Therapeutic effect: cure 93 examples in 120 routine patients of experimental group, account for 77.5%; Take a turn for the better 26 examples, accounts for 21.67%; Invalid 1 example, accounts for 0.83%; Total effective rate reaches 99.17%.In 120 routine patients of matched group, cure 32 examples, account for 26.67%; Take a turn for the better 60 examples, accounts for 50%; Invalid 28 examples, account for 23.33%; Total effective rate is 76.67%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with Herba Lycopi, lion, Herba Ecliptae and Ramulus et folium berchemiae floribundae etc., makes the externally used paste for the treatment of bone tuberculosis.Herba Lycopi's blood circulation promoting and blood stasis dispelling in side, line water detumescence.Rhizoma Rhodiolae kirilowii tranquilizing by nourishing the heart, blood stasis dispelling, hemostasis.Herba Ecliptae liver and kidney tonifying; Cooling blood for hemostasis.Ramulus et folium berchemiae floribundae expelling wind and removing dampness; Promoting blood circulation and stopping pain.Flos Hibisci Rosae-Sinensis lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances.Coagulum Opuntiae sucus clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Flos Rosae Chinensis promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Herba Apii graveolentis suppressing the hyperactive liver; Heat clearing away; Dispel the wind; Diuretic; Hemostasis; Removing toxic substances.Radix seu Ramulus Diospyroris rhombifoliae clearing away damp-heat; Profit liver and gall; Blood circulation promoting and blood stasis dispelling.Flos clerodendri japonici is calmed the nerves; Hemostasis.Herba Melastomatis dodecandri is invigorated blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Fructus Alpiniae Oxyphyllae is warming spleen and stopping diarrha takes the photograph saliva, warming the kidney reducing urination controlling nocturnal emission with astringent drugs.The lung heat clearing of Radix Rhodiolae QI invigorating; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.All medicines share, and play blood circulation promoting and blood stasis dispelling altogether, liver and kidney tonifying, expelling wind and removing dampness, reducing swelling and alleviating pain, QI invigorating nourish heart, the effect of heat-clearing and toxic substances removing, can the function of reconditioner soma organ, improve immunity of organisms, thus reach the object of curing bone tuberculosis.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the externally used paste of bone tuberculosis, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Lycopi 8-15; Rhizoma Rhodiolae kirilowii 6-14, Herba Ecliptae 9-15, Ramulus et folium berchemiae floribundae 8-16; Flos Hibisci Rosae-Sinensis 11-17, Coagulum Opuntiae sucus 9-14, Flos Rosae Chinensis 8-14; Herba Apii graveolentis 7-13; Radix seu Ramulus Diospyroris rhombifoliae 9-12, Flos clerodendri japonici 8-13, Herba Melastomatis dodecandri 10-16; Fructus Alpiniae Oxyphyllae 9-13, Radix Rhodiolae 8-12.
2. the externally used paste for the treatment of bone tuberculosis as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Lycopi 10-12; Rhizoma Rhodiolae kirilowii 8-12, Herba Ecliptae 11-14, Ramulus et folium berchemiae floribundae 10-14; Flos Hibisci Rosae-Sinensis 12-15, Coagulum Opuntiae sucus 11-13, Flos Rosae Chinensis 9-12; Herba Apii graveolentis 8-11; Radix seu Ramulus Diospyroris rhombifoliae 10-11, Flos clerodendri japonici 9-12, Herba Melastomatis dodecandri 12-14; Fructus Alpiniae Oxyphyllae 10-12, Radix Rhodiolae 9-11.
3. the externally used paste for the treatment of bone tuberculosis as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Lycopi 11; Rhizoma Rhodiolae kirilowii 10, Herba Ecliptae 13, Ramulus et folium berchemiae floribundae 12; Flos Hibisci Rosae-Sinensis 13, Coagulum Opuntiae sucus 12, Flos Rosae Chinensis 11; Herba Apii graveolentis 10; Radix seu Ramulus Diospyroris rhombifoliae 10.5, Flos clerodendri japonici 11, Herba Melastomatis dodecandri 13; Fructus Alpiniae Oxyphyllae 11, Radix Rhodiolae 10.
4. the preparation method of the externally used paste of the treatment bone tuberculosis as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) Flos Hibisci Rosae-Sinensis, Flos Rosae Chinensis and Flos clerodendri japonici are ground coarse powder altogether, 55 DEG C of dry 6-9 hour, take out, cool, be ground into fine powder, cross 160 mesh sieves;
(2) Coagulum Opuntiae sucus is smashed to pieces, levigate, cross 160 mesh sieves;
(3) get Fructus Alpiniae Oxyphyllae, poach, amount of water is the 1/3-2/3 of Fructus Alpiniae Oxyphyllae weight, moistening 2-4 hour (preferred, moistening 2.5-3.5 hour; Be more preferably, moistening 3 hours), put to steam in container and steam 3-5.5 hour, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(4) by all the other the 8 taste crude drug mixing except Flos Hibisci Rosae-Sinensis, Coagulum Opuntiae sucus, Flos Rosae Chinensis, Flos clerodendri japonici and Fructus Alpiniae Oxyphyllae, 60 DEG C of dry 8-12 hour, take out, are ground into fine powder, cross 160 mesh sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, join in vaseline, the amount of vaseline is 1.8-3 times of step (1), step (2), step (3) and step (4) gained gross weight, furnishing pasty state, add Oleum sesami again, the amount of Oleum sesami is the 1/6-1/2 of step (1), step (2), step (3) and step (4) gained gross weight, fully stirs, to obtain final product.
5. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, is characterized in that, 55 DEG C of dry 6.5-8 hour (preferably 55 DEG C drying 7 hours) in step (1).
6. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, is characterized in that, in step (3), amount of water is the preferred amount of water of 2/5-3/5(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight).
7. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, is characterized in that, mid-the steaming in container of step (3) is steamed 4-5 hour (preferably put to steam in container and steam 4.5 hours).
8. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, is characterized in that, 60 DEG C of dry 9-11 hour (preferably 60 DEG C drying 10 hours) in step (4).
9. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, it is characterized in that, in step (5) amount of vaseline be step (1), the 2-2.8 of step (2), step (3) and step (4) gained gross weight times (amount of preferred vaseline is 2.5 times of step (1), step (2), step (3) and step (4) gained gross weight).
10. the preparation method of the externally used paste for the treatment of bone tuberculosis as claimed in claim 4, it is characterized in that, the amount of Oleum sesami is step (1) in step (5), the amount of the preferred Oleum sesami of 1/5-1/3(of step (2), step (3) and step (4) gained gross weight is 1/4 of step (1), step (2), step (3) and step (4) gained gross weight).
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|---|---|---|---|---|
| CN1114888A (en) * | 1994-07-12 | 1996-01-17 | 周长祥 | Preparation method of traditional Chinese medicine ointment "Suiguning" |
| CN104606352A (en) * | 2015-02-12 | 2015-05-13 | 黄永刚 | Bone tuberculosis treating compound pill |
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2015
- 2015-10-15 CN CN201510661431.7A patent/CN105267820A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114888A (en) * | 1994-07-12 | 1996-01-17 | 周长祥 | Preparation method of traditional Chinese medicine ointment "Suiguning" |
| CN104606352A (en) * | 2015-02-12 | 2015-05-13 | 黄永刚 | Bone tuberculosis treating compound pill |
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| 王殿荣 等: "中药内外兼治治疗骨结核32例临床观察", 《四川中医》 * |
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