CN105267776A - 含有13种甘油酯的薏苡仁油、制剂及其应用 - Google Patents
含有13种甘油酯的薏苡仁油、制剂及其应用 Download PDFInfo
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- CN105267776A CN105267776A CN201410342342.1A CN201410342342A CN105267776A CN 105267776 A CN105267776 A CN 105267776A CN 201410342342 A CN201410342342 A CN 201410342342A CN 105267776 A CN105267776 A CN 105267776A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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Abstract
Description
Position | 1HNMR | 13C NMR | Position | 1HNMR | 13C NMR |
C-1′ | 173.9 | C-1″ | 173.5 | ||
C-2′ | 2.32(4H,t,J=5.0Hz) | 34.2 | C-2″ | 2.35(2H,t,J=5.0Hz) | 34.4 |
C-3′ | 25.0 | C-3″ | 25.1 | ||
C-4′ | 29.3 | C-4″ | 29.3 | ||
C-5′ | 29.5 | C-5″ | 29.5 | ||
C-6′ | 29.3 | C-6″ | 29.3 | ||
C-7′ | 29.9 | C-7″ | 29.9 | ||
C-8′ | 27.4 | C-8″ | 27.4 | ||
C-9′ | 5.37(1H,m) | 130.2 | C-9″ | 5.37(1H,m) | 130.2 |
C-10′ | 5.37(1H,m) | 128.2 | C-10″ | 5.37(1H,m) | 128.2 |
C-11′ | 2.77(4H,t,J=6.5Hz) | 25.8 | C-11″ | 2.77(2H,t,J=6.5Hz) | 25.8 |
C-12′ | 5.37(1H,m) | 128.0 | C-12″ | 5.37(1H,m) | 128.0 |
C-13′ | 5.37(1H,m) | 130.4 | C-13″ | 5.37(1H,m) | 130.4 |
C-14′ | 27.4 | C-14′ | ′ | 27.4 | |
C-15′ | 29.8 | C-15″ | 29.8 | ||
C-16′ | 31.7 | C-16″ | 31.7 | ||
C-17′ | 22.7 | C-17″ | 22.7 | ||
C-18′ | 0.89(3H,t,J=6.8Hz) | 14.2 | C-18″ | 0.89(3H,t,J=6.8Hz) | 14.2 |
C-1 | 4.32(1H,dd,J=11.9,4.6Hz) | 62.1 |
4.24(1H,dd,J=12.0,5.6Hz) | |||||
C-2 | 5.08(1H,m) | 72.3 | |||
C-3 | 3.73(2H,d,J=3.2Hz) | 61.8 |
Claims (10)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410342342.1A CN105267776B (zh) | 2014-07-18 | 含有13种甘油酯的薏苡仁油、制剂及其应用 | |
US14/733,079 US9585929B2 (en) | 2014-07-18 | 2015-06-08 | Coix seed oil containing 13 glycerides, and pharmaceutical preparation and use thereof |
SG11201700120XA SG11201700120XA (en) | 2014-07-18 | 2015-07-17 | Coix seed oil comprising 13 glycerides, formulation and application thereof |
KR1020177001301A KR101893812B1 (ko) | 2014-07-18 | 2015-07-17 | 13가지 글리세리드를 포함한 의이인오일, 제제 및 그 응용 |
AP2017009705A AP2017009705A0 (en) | 2014-07-18 | 2015-07-17 | Coix seed oil comprising 13 glycerides, formulation and application thereof |
AU2015291529A AU2015291529B2 (en) | 2014-07-18 | 2015-07-17 | Coix seed oil containing 13 glycerides, and pharmaceutical preparation and use thereof |
EA201790116A EA033751B1 (ru) | 2014-07-18 | 2015-07-17 | Композиция масла семян коикса, способ ее получения и применение |
PCT/CN2015/084294 WO2016008440A1 (zh) | 2014-07-18 | 2015-07-17 | 含有13种甘油酯的薏苡仁油、制剂及其应用 |
JP2017503165A JP6473802B2 (ja) | 2014-07-18 | 2015-07-17 | 13種のグリセリド含むヨクイニン油、製剤及びその応用 |
NZ726577A NZ726577A (en) | 2014-07-18 | 2015-07-17 | Coix seed oil containing 13 glycerides, and pharmaceutical preparation and use thereof |
DK15822401.4T DK3153164T3 (da) | 2014-07-18 | 2015-07-17 | Coixfrøolie der omfatter 13 glycerider, formulering og anvendelse deraf |
PL15822401T PL3153164T3 (pl) | 2014-07-18 | 2015-07-17 | Olej z nasion łzawnicy zawierający 13 glicerydów, jego formułowanie i zastosowanie |
EP15822401.4A EP3153164B1 (en) | 2014-07-18 | 2015-07-17 | Coix seed oil comprising 13 glycerides, formulation and application thereof |
CA2954688A CA2954688C (en) | 2014-07-18 | 2015-07-17 | Coix seed oil comprising 13 glycerides, formulation and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410342342.1A CN105267776B (zh) | 2014-07-18 | 含有13种甘油酯的薏苡仁油、制剂及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105267776A true CN105267776A (zh) | 2016-01-27 |
CN105267776B CN105267776B (zh) | 2016-11-30 |
Family
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116355691A (zh) * | 2023-06-02 | 2023-06-30 | 江西康莱特新森医药原料有限公司 | 一种薏苡仁粗油的提炼方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101940738A (zh) * | 2010-07-27 | 2011-01-12 | 辽宁中医药大学 | 薏苡仁抗癌中药及其制备方法 |
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101940738A (zh) * | 2010-07-27 | 2011-01-12 | 辽宁中医药大学 | 薏苡仁抗癌中药及其制备方法 |
Non-Patent Citations (1)
Title |
---|
杨爽,等: "薏苡化学成分及其活性综述", 《中药材》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116355691A (zh) * | 2023-06-02 | 2023-06-30 | 江西康莱特新森医药原料有限公司 | 一种薏苡仁粗油的提炼方法 |
Also Published As
Publication number | Publication date |
---|---|
JP6473802B2 (ja) | 2019-02-20 |
AU2015291529B2 (en) | 2018-04-19 |
EP3153164A4 (en) | 2017-05-03 |
EP3153164B1 (en) | 2019-05-22 |
AU2015291529A1 (en) | 2016-12-08 |
EA033751B1 (ru) | 2019-11-21 |
KR101893812B1 (ko) | 2018-09-04 |
PL3153164T3 (pl) | 2019-11-29 |
WO2016008440A1 (zh) | 2016-01-21 |
JP2017524047A (ja) | 2017-08-24 |
US20160015769A1 (en) | 2016-01-21 |
CA2954688A1 (en) | 2016-01-21 |
NZ726577A (en) | 2018-06-29 |
US9585929B2 (en) | 2017-03-07 |
CA2954688C (en) | 2019-10-29 |
KR20170014005A (ko) | 2017-02-07 |
EA201790116A1 (ru) | 2017-07-31 |
DK3153164T3 (da) | 2019-08-26 |
AP2017009705A0 (en) | 2017-01-31 |
EP3153164A1 (en) | 2017-04-12 |
SG11201700120XA (en) | 2017-02-27 |
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