CN105250971A - Drug for preventing and treating piglet typhoid and preparation method thereof - Google Patents
Drug for preventing and treating piglet typhoid and preparation method thereof Download PDFInfo
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- CN105250971A CN105250971A CN201510775470.XA CN201510775470A CN105250971A CN 105250971 A CN105250971 A CN 105250971A CN 201510775470 A CN201510775470 A CN 201510775470A CN 105250971 A CN105250971 A CN 105250971A
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Abstract
The invention discloses a drug for preventing and treating piglet typhoid and a preparation method thereof. The drug is prepared from, by mass, 180-215 parts of japanese cinnamon fruits, 280-325 parts of slender acanthopanax, 240-295 parts of dendrobium officinale, 270-320 parts of divaricate saposhnikovia roots, 180-230 parts of common hogfenneI roots, 195-240 parts of rhizoma zingiberis, 280-320 parts of rheum officinale, 355-405 parts of pine needles, 265-310 parts of affine cudweed and 290-325 parts of lucid ganoderma. According to the drug for preventing and treating the piglet typhoid, no incompatibility exists in compatibility of all the raw materials, the occurrence rate of the piglet typhoid can be significantly decreased, and the good preventing and treating effects on the piglet typhoid are achieved; in addition, no toxic or side effect exists, use is safe, and no harmful drug residue exists.
Description
Technical field
The present invention relates to pig drug world, particularly a kind ofly prevent and treat medicine of piglet typhoid fever and preparation method thereof.
Background technology
Piglet typhoid fever is by a kind of infectious disease of salmonellal piglet.Acute person is septicemia, and chronic person is necrotic enteritis, often betides 6 monthly ages below piglet, particularly 2 ~ 4 the monthly age piglet common, all can occur throughout the year, when rainy humidity, cold, season alternation, incidence rate is high.
Their early stage mostly is acute, and sick temperature of pig body is elevated to about 41 DEG C, inappetence or absolutely useless, and lethargy, shivers, and often extrudes mutually, is stacked; Asoscope is dry, and eye conjunctiva flushing, has sticky discharge.First constipation, rear diarrhoea, discharges the loose stool of faint yellow stench.Sick pig walking is unstable, and the back of a bow is bent over, and the burnt the part between the ribs and the hips of hair hangs, dyspnea, and stadium is 2-5 days, if treat not in time, dead in the majority.The medicine for the treatment of piglet typhoid fever is much Antibiotics Western medicine, although have certain therapeutic effect, shortcoming is that Drug resistance is more serious.Chinese herbal medicine have natural, have no side effect, residual without chemicals, not easily the feature such as to develop immunity to drugs.The Chinese medicine preparation being used for the treatment of piglet typhoid fever is at present less, and weak effect, cure rate is low, and the course for the treatment of is long, and cost is high.
Summary of the invention
An object of the present invention be overcome prior art above-mentioned deficiency and a kind of medicine preventing and treating piglet typhoid fever is provided, in medicine of the present invention there is not incompatibility in each material combination, obviously can reduce the incidence rate of piglet typhoid fever, good preventive and therapeutic action is had to piglet typhoid fever, and have no side effect, use safety, remains without hazardous drugs.
Another object of the present invention is to provide a kind of preparation method of said medicine, and its technique is simple, and its crude drug is common, cheap.
Technical scheme of the present invention is: a kind of medicine preventing and treating piglet typhoid fever, and it is made up of the crude drug of following masses part proportioning: Fructus cinnamomi japonici 180-215 part, slender acanthopanax 280-325 part, Herba Dendrobii 240-295 part, Radix Saposhnikoviae 270-320 part, Radix Peucedani 180-230 part, Rhizoma Zingiberis 195-240 part, Radix Et Rhizoma Rhei 280-320 part, Folium Pini 355-405 part, Herba Gnaphalii Affinis 265-310 part, Ganoderma 290-325 part.
Its further preferred mass part proportioning is: Fructus cinnamomi japonici 180-210 part, slender acanthopanax 280-320 part, Herba Dendrobii 240-290 part, Radix Saposhnikoviae 280-320 part, Radix Peucedani 190-230 part, Rhizoma Zingiberis 195-235 part, Radix Et Rhizoma Rhei 290-320 part, Folium Pini 360-405 part, Herba Gnaphalii Affinis 270-310 part, Ganoderma 300-325 part.
Its further preferred mass part proportioning is: Fructus cinnamomi japonici 180-205 part, slender acanthopanax 280-315 part, Herba Dendrobii 240-280 part, Radix Saposhnikoviae 290-320 part, Radix Peucedani 200-230 part, Rhizoma Zingiberis 200-235 part, Radix Et Rhizoma Rhei 290-315 part, Folium Pini 370-405 part, Herba Gnaphalii Affinis 270-300 part, Ganoderma 300-320 part.
Its further preferred mass part proportioning is: Fructus cinnamomi japonici 190-205 part, slender acanthopanax 290-315 part, Herba Dendrobii 250-280 part, Radix Saposhnikoviae 290-310 part, Radix Peucedani 200-220 part, Rhizoma Zingiberis 200-230 part, Radix Et Rhizoma Rhei 290-305 part, Folium Pini 380-405 part, Herba Gnaphalii Affinis 280-300 part, Ganoderma 300-315 part.
Its further preferred mass part proportioning is: Fructus cinnamomi japonici 195-205 part, slender acanthopanax 290-310 part, Herba Dendrobii 250-270 part, Radix Saposhnikoviae 290-300 part, Radix Peucedani 200-210 part, Rhizoma Zingiberis 200-210 part, Radix Et Rhizoma Rhei 300-305 part, Folium Pini 390-405 part, Herba Gnaphalii Affinis 290-300 part, Ganoderma 300-310 part.
Its further preferred mass part proportioning is: Fructus cinnamomi japonici 200 parts, slender acanthopanax 300 parts, Herba Dendrobii 260 parts, Radix Saposhnikoviae 300 parts, Radix Peucedani 200 parts, Rhizoma Zingiberis 200 parts, Radix Et Rhizoma Rhei 300 parts, Folium Pini 400 parts, Herba Gnaphalii Affinis 300 parts, Ganoderma 300 parts.
Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of piglet typhoid fever, it mainly comprises the steps:
One, medicine material is taken by proportion by weight;
Two, the raw material pulverizing will claimed, mix homogeneously, obtains the medicine preventing and treating piglet typhoid fever.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 100-300 mesh sieve.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 150-300 mesh sieve.
The primary symbols that the present invention uses and name resolving as follows:
-: numerical range, such as 1-5 represents 1 to 5.
The primary raw material medicine that the present invention uses is described as follows:
Fructus cinnamomi japonici: the one in Flos Osmanthi Fragrantis, aiphyllium.Bark taupe, sprout is slightly in four ribs, and by brown short down, Herb has aroma.Leaf alternate or near to life, keratin, oblong or nearly wide lanceolar, Quan Yuan, three go out arteries and veins in swelling below, and thready pulse is laterally parallel.Panicle is by pubescence; Spend few, both sexes, yellow green; Holder meat.Berry is oval, black purple time ripe.Warming middle-JIAO, warming the stomach, suppressing the hyperactive liver, kidney tonifying, cold expelling, the only sound of vomiting.Be used for the treatment of the cold pain of gastral cavilty.
Slender acanthopanax: have another name called: five Ye Luci, Cortex Acanthopanacis Radicis point, belongs to Umbellales, araliaceous shrubs, high 2-3 rice; Joint dredges the flat thorn of raw contrary flexure usually.Brightly yellowish green; The nearly full edge in calyx edge or have 5 little teeth; Fruit oblate spheroid.Control trusted subordinate's hernia, stomachache, in QI invigorating benefit, it is turbid separately can to treat cellulitis skin ulcer the moon, and invigorating middle warmer benefit essence, strengthening bone and muscle, strengthens will.Curing mainly congestion for many years amasss at musculus cutaneus, not enough in numbness is wet, the improving eyesight therapeutic method to keep the adverse QI flowing downwards.Control apoplexy joint contraction anxious, mend five kinds of strain and seven kinds of impairment.Wine brewing drink, also controls migratory arthralgia, and extremity contraction is anxious.Make powder infusing drugs in wine drink, control ocular disease.
Herba Dendrobii: have another name called: Herba hedyotis costatae, Yunnan iron sheet.Belong to micro-specific item, the perennial herbaceous plant that grows nonparasitically upon another plant of the orchid family.Flavor efficacy: sweet in the mouth, cold nature.To promote the production of body fluid nourishing the stomach; Nourishing YIN and clearing away heat; Lung moistening kidney tonifying; The strong waist of improving eyesight.
Radix Saposhnikoviae: another name copper rues, Hui Yun, time careless, Rhizoma Cibotii.Gui Jing: urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.Nature and flavor: acrid in the mouth; Sweet; Slightly warm in nature.Medical material Ji Yuan: be the root of umbelliferae Saposhnikovia divaricata.Effect is classified: diaphoretic medicine, dispel-wind drug.
Radix Peucedani: perennial herb, collar is sturdy, stem upper leaf stockless, and petal is avette, brown, the florescence 8-9 month, the fruit phase 10-11 month.Be grown on the hillside border of height above sea level 250-2000 rice, in the hillside thick grass of roadside or half feminine gender.Cough can be treated; Treatment headache; Eliminate the phlegm.
Rhizoma Zingiberis: be the dry rhizome of zingiber.Winter excavates, and removing fibrous root and silt, dry or cold drying.Take advantage of fresh slices to dry or cold drying person is called " dried ginger slice ".Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, cold fluid-retention is breathed with cough.
Radix Et Rhizoma Rhei: States Pharmacopoeia specifications medicine Radix Et Rhizoma Rhei should from the dry root welding technology of sorrel, Rheum officinale, Rheum tanguticum.Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, and removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.[nature and flavor with return through] are bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.[function with cure mainly] heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.To stagnate constipation for excess-heat, heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Folium Pini: be the needle of Pinaceae Pinus, there is effect of dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, blood-promoting and mind-easing.
Herba Gnaphalii Affinis: another name: spinach spinach grass, Herba Gnaphalii Affinis, soft passeris montani saturati grass, tarragon, face Artemisia, affine cudweed, water bush clover etc., Tian Ai, Latin literary fame: GnaphaliumaffineD.Don are Compositae, cottonweed, annual herb.The branch bottom oblique ascension that the upright or base portion of stem sends, high 10-40 centimetre or higher, about 3 millimeters, base portion footpath, top is branch not, has rill, and by the thick cotton wool of white, the long 8-20 millimeter of internode, top internode is rare reaches 5 centimetres.Leaf stockless, spoon-shaped falls lanceolar or the shape of falling ovum cochlear, and stem and leaf is used as medicine, and for antitussive, the ordinary medication of eliminate the phlegm, control asthma and bronchitis and non-infectious ulcer, wound, for oral administration also have blood pressure lowering curative effect.
Ganoderma: also known as Lin Zhongling, best with the Ganoderma grown in woods.Profile is umbrella, cap kidney shape, semicircle or subcircular, is the sporophore of On Polyporaceae Ganoderma.There is effect of invigorating QI and tranquilization, relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
When drug use method of the present invention is fed at every turn, every 500 kg diet, take the medicine of 2500-3000 gram of control piglet typhoid fever, then by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, and every pig 0.5-0.8 kilogram is added with the feedstuff of medicine at every turn, within 10 days, be a course for the treatment of, a course for the treatment of of this medicine can be fed every 10 days.
In medicine of the present invention there is not incompatibility in each material combination, facts have proved that this medicine obviously can reduce the incidence rate of piglet typhoid fever, have good preventive and therapeutic action, and have no side effect, use safety to piglet typhoid fever, remains without hazardous drugs.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to scope of invention.
Detailed description of the invention
embodiment 1
Take Fructus cinnamomi japonici 200g slender acanthopanax 300g Herba Dendrobii 260g Radix Saposhnikoviae 300g Radix Peucedani 200g Rhizoma Zingiberis 200g Radix Et Rhizoma Rhei 300g Folium Pini 400g Herba Gnaphalii Affinis 300g Ganoderma 300g, these material compositions are the quality after drying, 150-300 order is ground into super micron mill, mix homogeneously, then pack with plastic bag sealing, the medicine of obtained control piglet typhoid fever.
using method:during each nursing, every 500 kilograms of feedstuffs mixed up, take the medicine of 2760 grams of the present embodiment control piglet typhoid fever, then by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, and every pig 0.5-0.8 kilogram is added with the feedstuff of medicine at every turn, within 10 days, be a course for the treatment of, a course for the treatment of of this medicine can be fed every 10 days.
embodiment 2-14, comparative example 1-2
Embodiment 2-12 is except raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process and using method identical with embodiment 1, comparative example 1 eliminates Fructus cinnamomi japonici on the basis of embodiment 1, comparative example 2 eliminates Folium Pini on the basis of embodiment 2, the raw material that embodiment 1-12, comparative example 1-2 use and quality as shown in Table 1 below, table 1 below illustrates embodiment 1-12, raw material that comparative example 1-2 uses and quality.
Table 1
Clinical trial one:
10-11 month in 2014, carry out the clinical trial of control piglet typhoid fever medicine in cultivation base, Hunan.The medicine of the control piglet typhoid fever adopting embodiment 1 to obtain, suffers from typhoid fever piglet by clinical treatment 150, is equally divided into 2 groups, the every 500 kilograms of feedstuffs mixed up of test group, take 1930 grams of control piglet typhoid fever medicines, every day is sooner or later each feeds once, allows piglet free choice feeding.Matched group is injection enrofloxacin, and every kg body weight 2.5 milligrams, intramuscular injection, every day 2 times, is used in conjunction 10 days.After 10 days, result of the test show, test group compared with matched group, therapeutic effect significant difference (P<0.05).Cure rate and total effective rate are 97.3% and 98.7%, exceed 21.3% and 20.0% respectively than matched group.Test group piglet is after curing, and development condition is good, without rebound phenomenon; And after the healing of matched group piglet, indivedual piglet still occurs repeatedly.
Clinical trial two:
On the pig farm that epidemic situation occurs, the piglet that 300 health do not fallen ill is divided into 15 groups at random, often organize 20, wherein 12 groups is chemoprophylaxis group, 2 groups is comparative example group, feed respectively the feedstuff that described in embodiment 1-12, comparative example 1-2, medicine is made into, another group is matched group, feeds and does not add the identical feedstuff of medicine.15 groups of other measures of piglet all normally to be sterilized immune programme for children by pig farm.Within 10 days, be a course for the treatment of, fed again a course for the treatment of of this medicine every 10 days.The results are shown in Table 2.
Table 2
Result shows: the sickness rate of chemoprophylaxis group piglet typhoid fever is than comparative example and low many of matched group, and the spirit of medicine group morbidity pig, appetite are all better than comparative example and matched group, illness symptom also comparatively comparative example and matched group light.
The present invention is not limited to the medicine as control piglet typhoid fever, as long as the composition of raw materials medicine identical or equivalent with the present invention just drops within protection scope of the present invention.Also drop on making any one Chinese medicine preparation with the raw material preventing and treating the medicine same recipe of piglet typhoid fever of the present invention within protection scope of the present invention, as long as the medicine that namely composition of raw materials is identical with the present invention just drops within protection scope of the present invention.
Claims (9)
1. prevent and treat medicine of piglet typhoid fever and preparation method thereof for one kind, it is characterized in that being made up of the crude drug of following masses part proportioning: Fructus cinnamomi japonici 180-215 part, slender acanthopanax 280-325 part, Herba Dendrobii 240-295 part, Radix Saposhnikoviae 270-320 part, Radix Peucedani 180-230 part, Rhizoma Zingiberis 195-240 part, Radix Et Rhizoma Rhei 280-320 part, Folium Pini 355-405 part, Herba Gnaphalii Affinis 265-310 part, Ganoderma 290-325 part.
2. medicine preventing and treating piglet typhoid fever according to claim 1 and preparation method thereof, is characterized in that Fructus cinnamomi japonici 180-210 part, slender acanthopanax 280-320 part, Herba Dendrobii 240-290 part, Radix Saposhnikoviae 280-320 part, Radix Peucedani 190-230 part, Rhizoma Zingiberis 195-235 part, Radix Et Rhizoma Rhei 290-320 part, Folium Pini 360-405 part, Herba Gnaphalii Affinis 270-310 part, Ganoderma 300-325 part.
3. medicine preventing and treating piglet typhoid fever according to claim 1 and preparation method thereof, is characterized in that Fructus cinnamomi japonici 180-205 part, slender acanthopanax 280-315 part, Herba Dendrobii 240-280 part, Radix Saposhnikoviae 290-320 part, Radix Peucedani 200-230 part, Rhizoma Zingiberis 200-235 part, Radix Et Rhizoma Rhei 290-315 part, Folium Pini 370-405 part, Herba Gnaphalii Affinis 270-300 part, Ganoderma 300-320 part.
4. medicine preventing and treating piglet typhoid fever according to claim 1 and preparation method thereof, is characterized in that Fructus cinnamomi japonici 190-205 part, slender acanthopanax 290-315 part, Herba Dendrobii 250-280 part, Radix Saposhnikoviae 290-310 part, Radix Peucedani 200-220 part, Rhizoma Zingiberis 200-230 part, Radix Et Rhizoma Rhei 290-305 part, Folium Pini 380-405 part, Herba Gnaphalii Affinis 280-300 part, Ganoderma 300-315 part.
5. medicine preventing and treating piglet typhoid fever according to claim 1 and preparation method thereof, is characterized in that Fructus cinnamomi japonici 195-205 part, slender acanthopanax 290-310 part, Herba Dendrobii 250-270 part, Radix Saposhnikoviae 290-300 part, Radix Peucedani 200-210 part, Rhizoma Zingiberis 200-210 part, Radix Et Rhizoma Rhei 300-305 part, Folium Pini 390-405 part, Herba Gnaphalii Affinis 290-300 part, Ganoderma 300-310 part.
6. medicine preventing and treating piglet typhoid fever according to claim 1 and preparation method thereof, is characterized in that Fructus cinnamomi japonici 200 parts, slender acanthopanax 300 parts, Herba Dendrobii 260 parts, Radix Saposhnikoviae 300 parts, Radix Peucedani 200 parts, Rhizoma Zingiberis 200 parts, Radix Et Rhizoma Rhei 300 parts, Folium Pini 400 parts, Herba Gnaphalii Affinis 300 parts, Ganoderma 300 parts.
7. prevent and treat the preparation method of the medicine of piglet typhoid fever according to claim 1, it is characterized in that comprising the steps:
One, by proportion by weight weighting raw materials;
Two, the crude drug claimed is pulverized, mix homogeneously, obtain the medicine preventing and treating piglet typhoid fever.
8. the preparation method of the medicine of described control piglet typhoid fever according to claim 7, after it is characterized in that step 2 raw material pulverizing, crosses 100-300 mesh sieve.
9. the preparation method of the medicine of described control piglet typhoid fever according to claim 7, after it is characterized in that step 2 raw material pulverizing, crosses 150-300 mesh sieve.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664487A (en) * | 2009-09-17 | 2010-03-10 | 喻安然 | Medicament used for treating swine fever caused by cold fire and preparation method thereof |
| JP2012092081A (en) * | 2010-10-25 | 2012-05-17 | Makoto Yafuji | Process for producing melia azedarach extract |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664487A (en) * | 2009-09-17 | 2010-03-10 | 喻安然 | Medicament used for treating swine fever caused by cold fire and preparation method thereof |
| JP2012092081A (en) * | 2010-10-25 | 2012-05-17 | Makoto Yafuji | Process for producing melia azedarach extract |
Non-Patent Citations (1)
| Title |
|---|
| 施泽荣等: "《农家快速养猪法》", 30 April 2003 * |
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