CN105249477A - 一种难溶性钙与磷脂复合的钙增强剂的制备方法 - Google Patents
一种难溶性钙与磷脂复合的钙增强剂的制备方法 Download PDFInfo
- Publication number
- CN105249477A CN105249477A CN201510572057.3A CN201510572057A CN105249477A CN 105249477 A CN105249477 A CN 105249477A CN 201510572057 A CN201510572057 A CN 201510572057A CN 105249477 A CN105249477 A CN 105249477A
- Authority
- CN
- China
- Prior art keywords
- calcium
- phosphatide
- slightly solubility
- reinforcing agent
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 239000011575 calcium Substances 0.000 title claims abstract description 48
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 48
- 239000012744 reinforcing agent Substances 0.000 title claims abstract description 15
- 239000000203 mixture Substances 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000000725 suspension Substances 0.000 claims description 34
- 238000001556 precipitation Methods 0.000 claims description 28
- 239000001506 calcium phosphate Substances 0.000 claims description 21
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 21
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 19
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 19
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 19
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 19
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 19
- 229940083466 soybean lecithin Drugs 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 229940067606 lecithin Drugs 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 239000012046 mixed solvent Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 21
- 239000000843 powder Substances 0.000 abstract description 16
- 235000013365 dairy product Nutrition 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 21
- 239000006185 dispersion Substances 0.000 description 18
- 238000010586 diagram Methods 0.000 description 12
- 238000010226 confocal imaging Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 239000011259 mixed solution Substances 0.000 description 6
- 239000010453 quartz Substances 0.000 description 6
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 6
- 229940043267 rhodamine b Drugs 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 150000003904 phospholipids Chemical class 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000020189 fortified milk Nutrition 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510572057.3A CN105249477B (zh) | 2015-09-09 | 2015-09-09 | 一种难溶性钙与磷脂复合的钙增强剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510572057.3A CN105249477B (zh) | 2015-09-09 | 2015-09-09 | 一种难溶性钙与磷脂复合的钙增强剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105249477A true CN105249477A (zh) | 2016-01-20 |
CN105249477B CN105249477B (zh) | 2018-01-30 |
Family
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CN201510572057.3A Active CN105249477B (zh) | 2015-09-09 | 2015-09-09 | 一种难溶性钙与磷脂复合的钙增强剂的制备方法 |
Country Status (1)
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CN (1) | CN105249477B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1374132A (zh) * | 2002-03-22 | 2002-10-16 | 上海交通大学 | 羟基磷灰石与脂质体的核-壳式纳米复合粒子的制备方法 |
CN1413576A (zh) * | 2001-10-24 | 2003-04-30 | 清华大学 | 含钙质的固体化脂质体及其制备方法 |
CN102204867A (zh) * | 2011-05-20 | 2011-10-05 | 尚诚德 | 一种具有降脂补钙功能的脂质体制备方法 |
PL404820A1 (pl) * | 2013-07-23 | 2015-02-02 | Politechnika Warszawska | Sposób otrzymywania nanocząstek hydroksyapatytowych |
-
2015
- 2015-09-09 CN CN201510572057.3A patent/CN105249477B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1413576A (zh) * | 2001-10-24 | 2003-04-30 | 清华大学 | 含钙质的固体化脂质体及其制备方法 |
CN1374132A (zh) * | 2002-03-22 | 2002-10-16 | 上海交通大学 | 羟基磷灰石与脂质体的核-壳式纳米复合粒子的制备方法 |
CN102204867A (zh) * | 2011-05-20 | 2011-10-05 | 尚诚德 | 一种具有降脂补钙功能的脂质体制备方法 |
PL404820A1 (pl) * | 2013-07-23 | 2015-02-02 | Politechnika Warszawska | Sposób otrzymywania nanocząstek hydroksyapatytowych |
Non-Patent Citations (3)
Title |
---|
姚松年 等: "卵磷脂一水有序结构对CaCO3晶型的影响", 《物理化学学报》 * |
罗明生 等: "《药剂辅料大全》", 31 January 2006, 成都:四川科学技术出版社 * |
罗菁菁 等: "载Ca2+温度敏感性脂质体的合成", 《安徽医科大学学报》 * |
Also Published As
Publication number | Publication date |
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CN105249477B (zh) | 2018-01-30 |
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PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhou Peng Inventor after: Lu Naiyan Inventor after: Zhang Xuan Inventor after: Song Jiaoyang Inventor after: Yu Xuejian Inventor after: Ni Ni Inventor before: Zhou Peng Inventor before: Lu Naiyan Inventor before: Zhang Xuan Inventor before: Song Jiaoyang Inventor before: Yu Xuejian Inventor before: Ni Ni |