CN105233232A - Traditional Chinese medicine compound treating elderly constipation and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine compound treating elderly constipation. The traditional Chinese medicine compound comprises an external application preparation and an internal application preparation. The compound is characterized in that the external application preparation is prepared from large field snails, soil mirabilite, gleditsia officinalis, fistular onion stalks, fresh ginger, fermented soya beans, peppers, clover oil and saponin. The internal application preparation is prepared from sagittaria sagittifolia, ova of mantis, cynomorium, polygonatum odoratum, basella alba, water spinach, Chinese torreya, fig, fructus cannabis, semen cassiae, semen plantaginis, angelica sinensis and radix ophiopogonis. The invention further discloses a preparation method of the traditional Chinese medicine compound treating elderly constipation. Compatibility is reasonable, the mode combining external application and internal application is adopted, medicine effects are remarkably improved, and the compound can enrich and benefit essence and blood, warm and invigorate kidney yang, tonify the lung and strengthen the spleen, clear away heat and purge pathogenic fire and relax bowel, truly treats both symptoms and root causes, and achieves a remarkable treatment effect.

Description

A kind of Chinese medicine composition for the treatment of constipation of old people and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, is a kind of Chinese medicine composition for the treatment of constipation of old people and preparation method thereof specifically.

Background technology

Constipation is very common digestive problems, especially more general in elderly population.The factors such as old people Duo Yin intestinal function goes down, cause defecation to be short of power, and cause enteral food debris to run slow, moisture absorption too much causes functional constipation.

Constipation is divided into constipation due to disorder of QI, constipation due to insufficiency, constipation due to accumulation of pathogenic cold and functional constipation clinically; Constipation due to insufficiency is divided into again the deficiency of vital energy and blood deficiency two kinds.

Constipation due to deficiency of QI: though feature is for there to be awareness of defecation, faces and exerts and earn weak, defecate not stiff, Mental fatigue timidness due to deficiency of QI, the tender thin fur of tongue, deficient pulse;

Blood deficiency and constipation: feature is constipation, pale complexion, light red tongue thready pulse;

Constipation due to accumulation of pathogenic cold: feature is that difficulty in defecation is puckery, in abdomen or have cold type of pain, happiness heat is disliked cold, pale tongue with white fur, deep-slow pulse;

Constipation due to disorder of QI: feature is constipation, eructation is done frequently, abdominal distention and pain, breast side of body feeling of fullness, greasy and thin fur, stringy pulse;

Functional constipation: feature is constipation with dry stool, thirst and liking cold drink, dry, rough and yellow fur, rapid pulse.

At present, about the treatment of constipation, a lot of scheme is give also in prior art, as Chinese patent CN102698161B discloses " a kind of Chinese medicine composition for the treatment of senile constipation ", its formula is " Herba Cistanches, Caulis Spatholobi, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Polygoni Multiflori Preparata, Herba Cynomorii, the Radix Stemonae, Herba Houttuyniae, Fructus Perillae, Semen Armeniacae Amarum, Fructus Aurantii Immaturus, Fructus Perillae, Radix Platycodonis ", wherein " Herba Cynomorii " and " Radix Angelicae Sinensis " overlaps with two taste crude drug in formula of the present invention, but account for ratio is different in formula, cause the therapeutic effect that obtains also different, so do not form impact to the present invention, and for example Chinese patent CN102949633B discloses " Chinese medicine composition for the treatment of constipation ", its formula is " Pericarpium Citri Reticulatae Viride, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Lignum Aquilariae Resinatum, Calyx Kaki, Radix Et Rhizoma Nardostachyos, Fructus Toosendan, Semen Litchi, Radix Rehmanniae Preparata, Arillus Longan, Massa Medicata Fermentata, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Semen Ricini, Folium Sennae, Fructus Perillae, Rhizoma Chuanxiong, Flos persicae, Mel ", compared with formula of the present invention, without coincidence crude drug, therefore the present invention is not also impacted.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for the treatment of constipation and preparation method thereof.

For achieving the above object, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis, Mirabilitum, Fructus Gleditsiae Abnormalis, Bulbus Allii Fistulosi, Rhizoma Zingiberis Recens, Semen Sojae Preparatum, Fructus Piperis, Oleum Caryophylli; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae, Ootheca Mantidis, Herba Cynomorii, Rhizoma Polygonati Odorati, Herba basellae rubrae, Caulis et Folium Ipomoeae aquaticae, Semen Torreyae, Fructus Fici, Fructus Cannabis, Semen Cassiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Ophiopogonis.

Further, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 9 ~ 15g, Mirabilitum 6 ~ 8g, Fructus Gleditsiae Abnormalis 4 ~ 6g, Bulbus Allii Fistulosi 16 ~ 18g, Rhizoma Zingiberis Recens 12 ~ 16g, Semen Sojae Preparatum 10 ~ 14g, Fructus Piperis 3 ~ 5g, Oleum Caryophylli 5 ~ 7g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 2 ~ 6g, Ootheca Mantidis 4 ~ 10g, Herba Cynomorii 6 ~ 12g, Rhizoma Polygonati Odorati 8 ~ 14g, Herba basellae rubrae 10 ~ 16g, Caulis et Folium Ipomoeae aquaticae 7 ~ 15g, Semen Torreyae 5 ~ 9g, Fructus Fici 9 ~ 13g, Fructus Cannabis 1 ~ 9g, Semen Cassiae 11 ~ 17g, Semen Plantaginis 15 ~ 19g, Radix Angelicae Sinensis 11 ~ 17g, Radix Ophiopogonis 13 ~ 15g.

As preferably, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 12g, Mirabilitum 7g, Fructus Gleditsiae Abnormalis 5g, Bulbus Allii Fistulosi 17g, Rhizoma Zingiberis Recens 14g, Semen Sojae Preparatum 12g, Fructus Piperis 4g, Oleum Caryophylli 6g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 4g, Ootheca Mantidis 7g, Herba Cynomorii 9g, Rhizoma Polygonati Odorati 11g, Herba basellae rubrae 13g, Caulis et Folium Ipomoeae aquaticae 11g, Semen Torreyae 7g, Fructus Fici 11g, Fructus Cannabis 5g, Semen Cassiae 14g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 14g.

As preferably, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 9g, Mirabilitum 6g, Fructus Gleditsiae Abnormalis 4g, Bulbus Allii Fistulosi 16g, Rhizoma Zingiberis Recens 12g, Semen Sojae Preparatum 10g, Fructus Piperis 3g, Oleum Caryophylli 5g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 2g, Ootheca Mantidis 4g, Herba Cynomorii 6g, Rhizoma Polygonati Odorati 8g, Herba basellae rubrae 10g, Caulis et Folium Ipomoeae aquaticae 7g, Semen Torreyae 5g, Fructus Fici 9g, Fructus Cannabis 1g, Semen Cassiae 11g, Semen Plantaginis 15g, Radix Angelicae Sinensis 11g, Radix Ophiopogonis 13g.

As preferably, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 15g, Mirabilitum 8g, Fructus Gleditsiae Abnormalis 6g, Bulbus Allii Fistulosi 18g, Rhizoma Zingiberis Recens 16g, Semen Sojae Preparatum 14g, Fructus Piperis 5g, Oleum Caryophylli 7g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 6g, Ootheca Mantidis 10g, Herba Cynomorii 12g, Rhizoma Polygonati Odorati 14g, Herba basellae rubrae 16g, Caulis et Folium Ipomoeae aquaticae 15g, Semen Torreyae 9g, Fructus Fici 13g, Fructus Cannabis 9g, Semen Cassiae 17g, Semen Plantaginis 19g, Radix Angelicae Sinensis 17g, Radix Ophiopogonis 15g.

The invention still further relates to a kind of preparation method for the treatment of the Chinese medicine composition of constipation of old people, comprise the following steps:

The preparation of step one, externally applied formulation:

1, take the Cipangopaludina chinensis of corresponding weight portion, Mirabilitum, Fructus Gleditsiae Abnormalis, Semen Sojae Preparatum and Fructus Piperis removing impurity post-drying by formula, pulverize, cross 60 mesh sieve, obtain mixed powder for subsequent use;

2, take Bulbus Allii Fistulosi, the Rhizoma Zingiberis Recens of corresponding weight portion by formula, after juice extractor squeezing, obtain mixed juice for subsequent use;

3, take the Oleum Caryophylli of corresponding weight portion by formula, mix with gained mixed powder and mixed juice, after stirring, at 50 ~ 60 DEG C, simmer down to relative density is the thick extractum of 1.25 ~ 1.32, finally makes plaster and uses;

The preparation of step 2, oral preparations: the crude drug taking corresponding weight by formula adds suitable quantity of water decoction 3 ~ 5 times, each 1 ~ 2h, after having decocted at every turn, elimination residue, merge fried liquid, obtain admixing medical solutions, gained admixing medical solutions is made tablets after concentrated, drying.

In formula of the present invention, the pharmacology of each crude drug is as follows:

1, Cipangopaludina chinensis sweet-salty, cold in nature, enters liver, spleen, urinary bladder channel, has effect of clearing away heat and promoting diuresis, removing dampness and detoxicating, for accumulation of heat urinary obstruction, jaundice, beriberi, edema, quench one's thirst, hemorrhoid, have blood in stool, the disease such as conjunctival congestion and swelling pain, furuncle swelling toxin;

2, Mirabilitum salty in the mouth is bitter, cold in nature, returns stomach, large intestine channel, has effect of relieving constipation by purgation, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat, stagnant for excess-heat, abdominal distention distending pain, constipation due to dry stool, and acute appendicitis such as to swell and ache the disease;

3, Fructus Gleditsiae Abnormalis acrid in the mouth is salty, warm in nature, enters lung, stomach, large intestine channel, and having eliminates the phlegm has one's ideas straightened out, effect of mass dissipating and swelling eliminating, for apoplexy locked mouth, remain unconscious, epilepsy abundant expectoration, close key obstructed, sore throat stagnation of phlegm, pertinacious phlegm are breathed with cough, the diseases such as not well and constipation due to dry stool of coughing up phlegm;

4, Bulbus Allii Fistulosi acrid in the mouth, warm in nature, attaches to the lung and stomach meridians, and has delivering, activates yang, detoxifies, effect of parasite killing, cures mainly the diseases such as cold, YIN-cold stomachache, constipation and anuresis, dysentery, sore, carbuncle and painful swelling, abdominal pain due to worm stagnation;

5, Rhizoma Zingiberis Recens acrid in the mouth, slightly warm in nature, returns lung, spleen, stomach warp, has effect of relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, solution poison of drug, is applicable to affection of exogenous wind-cold, headache, phlegm retention, cough, gastrofrigid vomiting; After suffering wet, the cold invasion and attack of ice and snow, water, suddenly drink it with ginger decoction, can blood be promoted, disperse cold-evil;

6, Semen Sojae Preparatum are put down, and salty in the mouth, attaches to the lung and stomach meridians, and have stomach function regulating, relieving restlessness, solution raw meat poison, effect that cold removing is warm, cure mainly anemofrigid cold, heating of being afraid of cold, cold and heat headache, nasal obstruction sneeze, stomachache are vomited and diarrhoea, full vexed, the agitation in the heart of chest and diaphragm;

7, Fructus Piperis acrid in the mouth, hot in nature, enters stomach, spleen, large intestine channel, can stomach invigorating feed, warming spleen and stomach for dispelling cold, pain relieving, Deficiency and coldness of spleen and stomach, vomiting, diarrhoea;

8, Oleum Caryophylli sweet in the mouth, pungent, extremely hot in nature, enters stomach, kidney channel, has effect of warming the stomach, the kidney warming, cures mainly the diseases such as cold syndrome of the stomach pain with distension, singultus, vomiting and diarrhoea, arthralgia pain, colic, halitosis, toothache;

9, Rhizoma sagittariae sagittifoliae cold nature, bitter in the mouth, has removing toxic substances diuresis, effect that cancer-resisting, heat radiation disappear knot, heart tonifying lung moistening; The diseases such as lump furuncle, cardiopalmus are nervous, edema, cough due to lung-heat, dyspnea with rapid and short breath suffocated breathing, urination disorder can be treated; And Rhizoma sagittariae sagittifoliae is containing vitamin B1, and vitamin B2 is more, can maintain the normal function of health, strengthen the wriggling of the intestines and stomach, appetite stimulator, keeps good digestion, best for prevention and therapy constipation;

10, Ootheca Mantidis sweet in the mouth, salty, property is put down, and returns liver, kidney channel, has controlling nocturnal emission with astringent drugs reducing urination, effect of reinforcing the kidney and supporting YANG, for diseases such as emission and spermatorrhea, enuresis frequent micturition, urine nebulousurines;

11, warm in nature, the sweet in the mouth of Herba Cynomorii, has the kidney warming, intestine moistening, defecating feces excretion; Record in " Amplification on Materia Medica addendum ": " nourishing YIN gas controls void and constipation due to dry stool person ", once introduce in " book on Chinese herbal medicine highly necessary ": " control positive azoospermia empty, the moon declines Sanguis Draxonis, and large dryness of the intestine dries up, and constipation is not transported ";

12, Rhizoma Polygonati Odorati tool yin nourishing, moisturize, heat clearing away, promote the production of body fluid, the effect such as cough-relieving, as tonic, cure mainly the diseases such as consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis;

13, Herba basellae rubrae is commonly called as Herba basellae rubrae, sliding abdomen dish, cold in nature, sweet in the mouth is sour, constipation person food especially suitable; Compendium of Material Medica cloud: Herba basellae rubrae " sharp intestine and small intestine ", " Fujian traditional herbal medicine " also says its " purges heat laxation ", " Quanzhou book on Chinese herbal medicine " also cloud: " controlling constipation ", because its property is cool greatly, quite suitable to hot constipation person's food;

14, cold in nature, the sweet in the mouth of Caulis et Folium Ipomoeae aquaticae, " Luchuan book on Chinese herbal medicine " is recorded: " controlling the intestines and stomach heat, large constipation ", " Chinese medicine voluminous dictionary " says that it " treats constipation ", and because its cellulose can strengthen enterokinesia, chronic constipation person should normal food;

15, flat, the sweet in the mouth of Semen Torreyae, has the effect that removing food stagnancy is moisturized; Also say in amplification on Canon of Materia Medica: eat it and " cross laxation at most ", therefore, constipation person, polyphagia has the effect of loosening bowel to relieve constipation;

16, flat, the sweet in the mouth of Fructus Fici, has the effect of invigorating the stomach and promoting bowel movement; Its energy " heat clearing away, intestine moistening " is also said in " occupying diet spectrum with breath ", the suitable normal food of chronic habitual constipation person;

17, Fructus Cannabis sweet in the mouth, property are put down, and return spleen, stomach, large intestine channel, have loosening bowel to relieve constipation, moisturize effect of parasite killing, for blood deficiency and depleted fluid, and dryness of the intestine constipation;

18, Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel, has effect of liver heat removing and eyesight improving, relieving stranguria by diuresis, loosening bowel to relieve constipation, blood fat-reducing blood pressure-decreasing, treatment constipation and hyperlipidemia, hypertension;

19, Semen Plantaginis sweet in the mouth, light, cold nature, returns lung, liver, kidney, urinary bladder channel, has clearing away heat and promoting diuresis, effect that eliminating dampness by diuresis antidiarrheal, improving eyesight are eliminated the phlegm, the disease such as cure mainly dysuria, stranguria with turbid discharge leukorrhagia, edema distension, heat-damp in summer dysentery, conjunctival congestion is hidden from view, expectorant heat syndrome cough is breathed heavily;

20, Radix Angelicae Sinensis sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel, have and enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation, cure mainly all cards of blood deficiency: menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery;

21, Radix Ophiopogonis sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, cure mainly dryness of the lung dry cough, deficiency of YIN consumptive disease coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, the disease such as dryness of the intestine constipation.

Owing to have employed technique scheme, the present invention has following beneficial effect:

Compatibility of the present invention is reasonable, and adopt external application and the mode combined for oral administration, significantly improve the performance of drug effect, energy enrich and benefit essence and blood, warming and recuperating the kidney-YANG, lung benefiting spleen invigorating, clearing away heat-fire, loosening bowel to relieve constipation, really achieve treating both the principal and secondary aspects of a disease, achieve significant therapeutic effect.

Detailed description of the invention

Now in conjunction with specific embodiments, the present invention will be further described.

Embodiment one: a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis, Mirabilitum, Fructus Gleditsiae Abnormalis, Bulbus Allii Fistulosi, Rhizoma Zingiberis Recens, Semen Sojae Preparatum, Fructus Piperis, Oleum Caryophylli; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae, Ootheca Mantidis, Herba Cynomorii, Rhizoma Polygonati Odorati, Herba basellae rubrae, Caulis et Folium Ipomoeae aquaticae, Semen Torreyae, Fructus Fici, Fructus Cannabis, Semen Cassiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Ophiopogonis.

Further, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 9g, Mirabilitum 6g, Fructus Gleditsiae Abnormalis 4g, Bulbus Allii Fistulosi 16g, Rhizoma Zingiberis Recens 12g, Semen Sojae Preparatum 10g, Fructus Piperis 3g, Oleum Caryophylli 5g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 2g, Ootheca Mantidis 4g, Herba Cynomorii 6g, Rhizoma Polygonati Odorati 8g, Herba basellae rubrae 10g, Caulis et Folium Ipomoeae aquaticae 7g, Semen Torreyae 5g, Fructus Fici 9g, Fructus Cannabis 1g, Semen Cassiae 11g, Semen Plantaginis 15g, Radix Angelicae Sinensis 11g, Radix Ophiopogonis 13g.

A preparation method for the Chinese medicine composition of above-mentioned treatment constipation of old people, comprises the following steps:

The preparation of step one, externally applied formulation:

1, take the Cipangopaludina chinensis of corresponding weight portion, Mirabilitum, Fructus Gleditsiae Abnormalis, Semen Sojae Preparatum and Fructus Piperis removing impurity post-drying by formula, pulverize, cross 60 mesh sieve, obtain mixed powder for subsequent use;

2, take Bulbus Allii Fistulosi, the Rhizoma Zingiberis Recens of corresponding weight portion by formula, after juice extractor squeezing, obtain mixed juice for subsequent use;

3, take the Oleum Caryophylli of corresponding weight portion by formula, mix with gained mixed powder and mixed juice, after stirring, at 50 ~ 60 DEG C, simmer down to relative density is the thick extractum of 1.25 ~ 1.32, finally makes plaster and uses;

The preparation of step 2, oral preparations: the crude drug taking corresponding weight by formula adds suitable quantity of water decoction 3 ~ 5 times, each 1 ~ 2h, after having decocted at every turn, elimination residue, merge fried liquid, obtain admixing medical solutions, gained admixing medical solutions is made tablets after concentrated, drying.

Embodiment two: a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis, Mirabilitum, Fructus Gleditsiae Abnormalis, Bulbus Allii Fistulosi, Rhizoma Zingiberis Recens, Semen Sojae Preparatum, Fructus Piperis, Oleum Caryophylli; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae, Ootheca Mantidis, Herba Cynomorii, Rhizoma Polygonati Odorati, Herba basellae rubrae, Caulis et Folium Ipomoeae aquaticae, Semen Torreyae, Fructus Fici, Fructus Cannabis, Semen Cassiae, Semen Plantaginis, the Radix Linderae, Radix Betae, Semen Sesami Nigrum, Semen pini koraiensis, Fructus Citri Sarcodactylis, Rhopilema esculenta, semen juglandis, Amaranthus mangostanus L., Radix Zanthoxyli Spinifolii, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Fructus Citri, Semen Platycladi, Radix Angelicae Sinensis, Radix Ophiopogonis, Fructus Rhamni parvifoliae, Endothelium Corneum Anas domestica, Fructus Aurantii Immaturus.

Further, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 12g, Mirabilitum 7g, Fructus Gleditsiae Abnormalis 5g, Bulbus Allii Fistulosi 17g, Rhizoma Zingiberis Recens 14g, Semen Sojae Preparatum 12g, Fructus Piperis 4g, Oleum Caryophylli 6g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 4g, Ootheca Mantidis 7g, Herba Cynomorii 9g, Rhizoma Polygonati Odorati 11g, Herba basellae rubrae 13g, Caulis et Folium Ipomoeae aquaticae 11g, Semen Torreyae 7g, Fructus Fici 11g, Fructus Cannabis 5g, Semen Cassiae 14g, Semen Plantaginis 17g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 14g.

A preparation method for the Chinese medicine composition of above-mentioned treatment constipation of old people, comprises the following steps:

The preparation of step one, externally applied formulation:

1, take the Cipangopaludina chinensis of corresponding weight portion, Mirabilitum, Fructus Gleditsiae Abnormalis, Semen Sojae Preparatum and Fructus Piperis removing impurity post-drying by formula, pulverize, cross 60 mesh sieve, obtain mixed powder for subsequent use;

2, take Bulbus Allii Fistulosi, the Rhizoma Zingiberis Recens of corresponding weight portion by formula, after juice extractor squeezing, obtain mixed juice for subsequent use;

3, take the Oleum Caryophylli of corresponding weight portion by formula, mix with gained mixed powder and mixed juice, after stirring, at 50 ~ 60 DEG C, simmer down to relative density is the thick extractum of 1.25 ~ 1.32, finally makes plaster and uses;

The preparation of step 2, oral preparations: the crude drug taking corresponding weight by formula adds suitable quantity of water decoction 3 ~ 5 times, each 1 ~ 2h, after having decocted at every turn, elimination residue, merge fried liquid, obtain admixing medical solutions, gained admixing medical solutions is made tablets after concentrated, drying.

Embodiment three: a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis, Mirabilitum, Fructus Gleditsiae Abnormalis, Bulbus Allii Fistulosi, Rhizoma Zingiberis Recens, Semen Sojae Preparatum, Fructus Piperis, Oleum Caryophylli; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae, Ootheca Mantidis, Herba Cynomorii, Rhizoma Polygonati Odorati, Herba basellae rubrae, Caulis et Folium Ipomoeae aquaticae, Semen Torreyae, Fructus Fici, Fructus Cannabis, Semen Cassiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Ophiopogonis.

Further, a kind of Chinese medicine composition for the treatment of constipation of old people, comprises externally applied formulation and oral preparations, and described externally applied formulation comprises following raw material: Cipangopaludina chinensis 15g, Mirabilitum 8g, Fructus Gleditsiae Abnormalis 6g, Bulbus Allii Fistulosi 18g, Rhizoma Zingiberis Recens 16g, Semen Sojae Preparatum 14g, Fructus Piperis 5g, Oleum Caryophylli 7g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 6g, Ootheca Mantidis 10g, Herba Cynomorii 12g, Rhizoma Polygonati Odorati 14g, Herba basellae rubrae 16g, Caulis et Folium Ipomoeae aquaticae 15g, Semen Torreyae 9g, Fructus Fici 13g, Fructus Cannabis 9g, Semen Cassiae 17g, Semen Plantaginis 19g, Radix Angelicae Sinensis 17g, Radix Ophiopogonis 15g.

A preparation method for the Chinese medicine composition of above-mentioned treatment constipation of old people, comprises the following steps:

The preparation of step one, externally applied formulation:

1, take the Cipangopaludina chinensis of corresponding weight portion, Mirabilitum, Fructus Gleditsiae Abnormalis, Semen Sojae Preparatum and Fructus Piperis removing impurity post-drying by formula, pulverize, cross 60 mesh sieve, obtain mixed powder for subsequent use;

2, take Bulbus Allii Fistulosi, the Rhizoma Zingiberis Recens of corresponding weight portion by formula, after juice extractor squeezing, obtain mixed juice for subsequent use;

3, take the Oleum Caryophylli of corresponding weight portion by formula, mix with gained mixed powder and mixed juice, after stirring, at 50 ~ 60 DEG C, simmer down to relative density is the thick extractum of 1.25 ~ 1.32, finally makes plaster and uses;

The preparation of step 2, oral preparations: the crude drug taking corresponding weight by formula adds suitable quantity of water decoction 3 ~ 5 times, each 1 ~ 2h, after having decocted at every turn, elimination residue, merge fried liquid, obtain admixing medical solutions, gained admixing medical solutions is made tablets after concentrated, drying.

Clinical data:

1, physical data: from May, 2010 ~ in May, 2012, chooses the outpatient service constipation patient 120 of Duo Jia hospital, wherein man 68, female 52,55 ~ 75 years old age, 64 years old mean age; Be divided into test group and matched group at random, test group 60, man 40, female 20,55 ~ 65 years old age, 61 years old mean age, the course of disease 6 months to 15 months, matched group 60, man 28, female 32, at 66 ~ 75 years old age, 69 years old mean age, 18 15th day of a month of the course of disease were by 30 months; Matched group is divided into again simple externally applied formulation group, simple oral preparations group and external application and oral preparations in conjunction with group, often organizes each 20, and each group patient no significant difference (P>0.05) in sex, age, the course of disease, can compare.

2, diagnostic criteria: patient age 55 years old or more than, the defecation of 40% is had at least to be less than weekly 4 times in 6 months, and there is following symptom: even if having awareness of defecation but difficult defecation, constipation with dry stool and with anus distending pain, long-time without awareness of defecation and just go out just measure less, through medical inspection eliminating large intestine organic disease.

3, Therapeutic Method:

Simple externally applied formulation group only uses externally applied formulation (i.e. plaster), and each 1 ~ 2 pastes, and every day sooner or later respectively once;

Simple oral preparations group only takes oral preparations (i.e. tablet), each 2 ~ 4, every day three times, and point morning, noon and afternoon take with warm water after meal;

External application and oral preparations use externally applied formulation and oral preparations in conjunction with group simultaneously, and externally applied formulation each 1 ~ 2 pastes, and every day, sooner or later respectively once each 2 ~ 4 of oral preparations, every day three times, divided morning, noon and afternoon to take with warm water after meal;

Matched group is to taking Tongbianling Capsules, and each 1 ~ 2, every day three times, point morning, noon and afternoon take with warm water after meal.

4, criterion of therapeutical effect:

Cure: though have awareness of defecation but difficult defecation, constipation with dry stool and with anus distending pain, long-time just go out just to measure the symptom such as less disappear completely without awareness of defecation, defecation is normal, returns to every day 1 ~ 3 time, without recurring;

Effective: above-mentioned symptom makes moderate progress, but do not disappear completely;

Invalid: above-mentioned symptom is not improved.

5, therapeutic outcome: see the following form:

Group	Sum	Cure	Effectively	Invalid	Cure rate	Total effective rate
							Simple externally applied formulation group	20	10	4	6	50%	70%
Simple oral preparations group	20	12	5	3	60	85%
							External application and oral preparations are in conjunction with group	20	16	3	1	80%	95%
Matched group	60	24	12	24	40%	60%

6, interpretation of result: from data in table, when gained externally applied formulation of the present invention and oral preparations use simultaneously, cure rate (80%) and total effective rate (95%) the highest, therapeutic effect is best, and meanwhile, no matter gained preparation of the present invention is independent medication, or composite reagent, its cure rate and total effective rate are all higher than matched group, and compared to prior art, the present invention achieves comparatively significant therapeutic effect.

More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (6)

1. treat a Chinese medicine composition for constipation of old people, comprise externally applied formulation and oral preparations, it is characterized in that, described externally applied formulation comprises following raw material: Cipangopaludina chinensis, Mirabilitum, Fructus Gleditsiae Abnormalis, Bulbus Allii Fistulosi, Rhizoma Zingiberis Recens, Semen Sojae Preparatum, Fructus Piperis, Oleum Caryophylli; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae, Ootheca Mantidis, Herba Cynomorii, Rhizoma Polygonati Odorati, Herba basellae rubrae, Caulis et Folium Ipomoeae aquaticae, Semen Torreyae, Fructus Fici, Fructus Cannabis, Semen Cassiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Ophiopogonis.

2. a kind of Chinese medicine composition for the treatment of constipation of old people as claimed in claim 1, comprise externally applied formulation and oral preparations, it is characterized in that, described externally applied formulation comprises following raw material: Cipangopaludina chinensis 9 ~ 15g, Mirabilitum 6 ~ 8g, Fructus Gleditsiae Abnormalis 4 ~ 6g, Bulbus Allii Fistulosi 16 ~ 18g, Rhizoma Zingiberis Recens 12 ~ 16g, Semen Sojae Preparatum 10 ~ 14g, Fructus Piperis 3 ~ 5g, Oleum Caryophylli 5 ~ 7g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 2 ~ 6g, Ootheca Mantidis 4 ~ 10g, Herba Cynomorii 6 ~ 12g, Rhizoma Polygonati Odorati 8 ~ 14g, Herba basellae rubrae 10 ~ 16g, Caulis et Folium Ipomoeae aquaticae 7 ~ 15g, Semen Torreyae 5 ~ 9g, Fructus Fici 9 ~ 13g, Fructus Cannabis 1 ~ 9g, Semen Cassiae 11 ~ 17g, Semen Plantaginis 15 ~ 19g, Radix Angelicae Sinensis 11 ~ 17g, Radix Ophiopogonis 13 ~ 15g.

3. a kind of Chinese medicine composition for the treatment of constipation of old people as claimed in claim 1 or 2, comprise externally applied formulation and oral preparations, it is characterized in that, described externally applied formulation comprises following raw material: Cipangopaludina chinensis 12g, Mirabilitum 7g, Fructus Gleditsiae Abnormalis 5g, Bulbus Allii Fistulosi 17g, Rhizoma Zingiberis Recens 14g, Semen Sojae Preparatum 12g, Fructus Piperis 4g, Oleum Caryophylli 6g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 4g, Ootheca Mantidis 7g, Herba Cynomorii 9g, Rhizoma Polygonati Odorati 11g, Herba basellae rubrae 13g, Caulis et Folium Ipomoeae aquaticae 11g, Semen Torreyae 7g, Fructus Fici 11g, Fructus Cannabis 5g, Semen Cassiae 14g, Semen Plantaginis 17g, Radix Linderae 19g, Radix Betae 13g, Semen Sesami Nigrum 14g, Semen pini koraiensis 17g, Fructus Citri Sarcodactylis 9g, Rhopilema esculenta 14g, semen juglandis 6g, Radix Angelicae Sinensis 14g, Radix Ophiopogonis 14g.

4. a kind of Chinese medicine composition for the treatment of constipation of old people as claimed in claim 1 or 2, comprise externally applied formulation and oral preparations, it is characterized in that, described externally applied formulation comprises following raw material: Cipangopaludina chinensis 9g, Mirabilitum 6g, Fructus Gleditsiae Abnormalis 4g, Bulbus Allii Fistulosi 16g, Rhizoma Zingiberis Recens 12g, Semen Sojae Preparatum 10g, Fructus Piperis 3g, Oleum Caryophylli 5g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 2g, Ootheca Mantidis 4g, Herba Cynomorii 6g, Rhizoma Polygonati Odorati 8g, Herba basellae rubrae 10g, Caulis et Folium Ipomoeae aquaticae 7g, Semen Torreyae 5g, Fructus Fici 9g, Fructus Cannabis 1g, Semen Cassiae 11g, Semen Plantaginis 15g, Radix Angelicae Sinensis 11g, Radix Ophiopogonis 13g.

5. a kind of Chinese medicine composition for the treatment of constipation of old people as claimed in claim 1 or 2, comprise externally applied formulation and oral preparations, it is characterized in that, described externally applied formulation comprises following raw material: Cipangopaludina chinensis 15g, Mirabilitum 8g, Fructus Gleditsiae Abnormalis 6g, Bulbus Allii Fistulosi 18g, Rhizoma Zingiberis Recens 16g, Semen Sojae Preparatum 14g, Fructus Piperis 5g, Oleum Caryophylli 7g; Described oral preparations comprises following component: Rhizoma sagittariae sagittifoliae 6g, Ootheca Mantidis 10g, Herba Cynomorii 12g, Rhizoma Polygonati Odorati 14g, Herba basellae rubrae 16g, Caulis et Folium Ipomoeae aquaticae 15g, Semen Torreyae 9g, Fructus Fici 13g, Fructus Cannabis 9g, Semen Cassiae 17g, Semen Plantaginis 19g, Radix Angelicae Sinensis 17g, Radix Ophiopogonis 15g.

6. a kind of preparation method for the treatment of the Chinese medicine composition of constipation of old people as described in a claim any in claim 1 ~ 5, is characterized in that, comprise the following steps:

The preparation of step one, externally applied formulation:

1, take the Cipangopaludina chinensis of corresponding weight portion, Mirabilitum, Fructus Gleditsiae Abnormalis, Semen Sojae Preparatum and Fructus Piperis removing impurity post-drying by formula, pulverize, cross 60 mesh sieve, obtain mixed powder for subsequent use;

2, take Bulbus Allii Fistulosi, the Rhizoma Zingiberis Recens of corresponding weight portion by formula, after juice extractor squeezing, obtain mixed juice for subsequent use;

3, take the Oleum Caryophylli of corresponding weight portion by formula, mix with gained mixed powder and mixed juice, after stirring, at 50 ~ 60 DEG C, simmer down to relative density is the thick extractum of 1.25 ~ 1.32, finally makes plaster and uses;

The preparation of step 2, oral preparations: the crude drug taking corresponding weight by formula adds suitable quantity of water decoction 3 ~ 5 times, each 1 ~ 2h, after having decocted at every turn, elimination residue, merge fried liquid, obtain admixing medical solutions, gained admixing medical solutions is made tablets after concentrated, drying.