CN105233225A - Drug for treating chicken infectious bursal disease and preparation method thereof - Google Patents
Drug for treating chicken infectious bursal disease and preparation method thereof Download PDFInfo
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- CN105233225A CN105233225A CN201510764180.5A CN201510764180A CN105233225A CN 105233225 A CN105233225 A CN 105233225A CN 201510764180 A CN201510764180 A CN 201510764180A CN 105233225 A CN105233225 A CN 105233225A
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Abstract
Provided is a drug for treating a chicken infectious bursal disease and a preparation method thereof. The drug for treating the chicken infectious bursal disease is prepared from, by weight, 8-12 parts of agastache rugosa, 8-12 parts of orange peels, 8-12 parts of gypsum, 17-23 parts of honeysuckles, 17-23 parts of milkvetch roots, 17-23 parts of cortex phellodendri, 17-23 parts of licorice roots, 35-45 parts of dandelions, 35-45 parts of folium isatidis, 35-45 parts of radix isatidis and 8-12 parts of ginger. The drug has the better efficacy, the preparation method is simple, chitosan clarificant is used, loss of effective components can be effectively reduced, the drug purity is increased, and the production cost is reduced; the loss ratio of the effective components of the extraction method ranges from 14 percent to 21 percent, and the loss ratio of the effective components through a traditional water-extraction and alcohol-precipitation method ranges from 30 percent to 40 percent.
Description
The present invention relates to the field of Chinese medicines, particularly a kind of medicine being used for the treatment of infectious bursal disease and preparation method thereof.
Background technology
Infectious bursal disease is high degree in contact sexuality dye, and virus is by propagation such as contaminated environment, feedstuff, drinking-water, bedding and padding, feces, apparatus, medicated clothing, insecticides, and without thoroughly, effectively isolating, disinfectant measure is difficult to control.The general sickness rate of this disease is high, can reach 100%, suffer from chicken lethargy, inappetence, necking down, downrights holded up, dysentery, collapse and dead.The chicken house of this disease occurs, usually occurs the immuning failure of the vaccination such as newcastle, Marek, this immunosuppressant phenomenon often makes M & M sharply rise.In prior art, the existing herbal medicine that uses is used for the treatment of this disease, as Chinese patent 201210347968.2 disclosed " a kind of pharmaceutical composition being used for the treatment of infectious bursal disease and preparation method thereof ", its pharmaceutical composition is formed by Herba Pogostemonis, Gypsum Fibrosum, Flos Lonicerae, Radix Scutellariae, Cortex Phellodendri, Radix Glycyrrhizae, Herba Taraxaci, Folium Isatidis, Radix Isatidis, Rhizoma Zingiberis Recens compatibility, and therapeutic effect is better.
In Chinese medicine preparation is produced, often first will carry out the purifying of effective ingredient to Chinese crude drug, its main purpose removes and the incoherent material of effective ingredient, as impurity such as the protein in extracting solution, starch, oils and fats, natural gum, phlegmatic temperament, part saccharides.At present in the production of Chinese medicine preparation as dosage forms such as granule, oral liquid, injection, employing be widely used water extract-alcohol precipitation method for refining, namely first with water, Chinese crude drug is carried out to the extraction of effective ingredient, then carries out precipitate with ethanol removal impurity with ethanol.This kind of method comparatively maturation also generally uses, and ethanol used in precipitate with ethanol also can reclaim repetitive cycling and uses, but the amount of the ethanol often needed aborning is many, and reclaims also more complicated, and Effective Component of Chinese Medicine loss is larger.The method of purification of tcm is except conventional water extract-alcohol precipitation and ethanol extract from water precipitation, also has a kind of flocculation technique, namely in Chinese medicine leaching liquid, a certain amount of clarifier is added, them are utilized to have some macromolecule impurity of degradable, reducing the characteristics such as medicinal liquid viscosity maybe can adsorb, enclose solid particle to accelerate the sedimentation of suspended particles in medicinal liquid, obtaining a kind of method of clarification medicinal liquid through filtering disgorging; It can retain the medicinal ingredient in medicinal liquid preferably, and removing impurity, simple to operate, clarifier consumption is little, and energy consumption is low.
Summary of the invention
Object of the present invention is just to provide a kind of medicine being used for the treatment of infectious bursal disease and preparation method thereof, and simple to operate, cost is low, better can retain Effective Component of Chinese Medicine.
The object of the invention is with following technical proposals realize:
A kind of medicine being used for the treatment of infectious bursal disease, be made up of the raw material of following weight portion: Herba Pogostemonis 8-12 part, Pericarpium Citri tangerinae 8-12 part, Gypsum Fibrosum 8-12 part, Flos Lonicerae 17-23 part, Radix Scutellariae 17-23 part, Cortex Phellodendri 17-23 part, Radix Glycyrrhizae 17-23 part, Herba Taraxaci 35-45 part, Folium Isatidis 35-45 part, Radix Isatidis 35-45 part, Rhizoma Zingiberis Recens 8-12 part; Be made up of the raw material of following weight portion further: Herba Pogostemonis 10 parts, Pericarpium Citri tangerinae 10 parts, 10 parts, Gypsum Fibrosum, Flos Lonicerae 20 parts, Radix Scutellariae 20 parts, Cortex Phellodendri 20 parts, 20 parts, Radix Glycyrrhizae, Herba Taraxaci 40 parts, Folium Isatidis 40 parts, Radix Isatidis 40 parts, 10 parts, Rhizoma Zingiberis Recens.
Be used for the treatment of the preparation method of the medicine of infectious bursal disease as above, comprise the following steps:
(1) mixed by each crude drug, add water reflux, extract, crosses leaching filtrate;
(2) filtrate is centrifugal, go precipitation, supernatant concentration is to extractum;
(3) in concentrated solution, add chitosan clarifier, leave standstill, filter, get filtrate recentrifuge, get supernatant concentration to extractum;
(4) in extractum, add adjuvant maltodextrin and sucrose, granulate, be drying to obtain final drug.
Step (1) is divided into extracted twice, and the multiple that adds water for the first time is 9-10 times of mixed material medicine, after soaking 20-30min, and heating and refluxing extraction 1.5-2h, crosses leaching filtrate; Second time adds 7-8 times of water of mixed material medicine in filtering residue, heating and refluxing extraction 1-1.5h, crosses leaching filtrate, merges twice filtrate.
Centrifugation rate is 8000-10000r/min.
Described extractum relative density is 1.28-1.30.
Step (3) the chitosan clarifier aqueous acetic acid of 1% mass fraction dissolves, and the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1-0.2%.
In step (4) extractum with the weight proportion of adjuvant be: extractum 1-2 part, maltodextrin 2-4 part, sucrose 1-2 part.
The drug particles for the treatment of infectious bursal disease provided by the invention, the formula basis of patent 201210347968.2 adds Pericarpium Citri tangerinae and Rhizoma Zingiberis Recens; Except the effect with heat-clearing and toxic substances removing, also can function of spleen and stomach regulating, nourishing the stomach protect stomach, therefore while good treatment infectious bursal disease, sick chicken spleen stomach, appetite, body weight also obtain good recovery, and therefore medicine of the present invention has better drug effect, and preparation method is simple, use chitosan clarifier, effectively can reduce the loss of effective ingredient, pharmaceutical purity increases, and reduces production cost; The loss rate using extracting method effective ingredient of the present invention is 14-21%, and adopts the loss rate of traditional decoction and alcohol sedimentation technique effective ingredient to be 30-40%.
Detailed description of the invention
embodiment 1
A kind of medicine being used for the treatment of infectious bursal disease, be made up of the raw material of following weight portion: Herba Pogostemonis 8-12 part, Pericarpium Citri tangerinae 8-12 part, Gypsum Fibrosum 8-12 part, Flos Lonicerae 17-23 part, Radix Scutellariae 17-23 part, Cortex Phellodendri 17-23 part, Radix Glycyrrhizae 17-23 part, Herba Taraxaci 35-45 part, Folium Isatidis 35-45 part, Radix Isatidis 35-45 part, Rhizoma Zingiberis Recens 8-12 part.
Be used for the treatment of the preparation method of the medicine of infectious bursal disease as above, comprise the following steps:
(1) mixed by each crude drug, add water reflux, extract, twice, and the multiple that adds water for the first time is 9-10 times of mixed material medicine, after soaking 20-30min, and heating and refluxing extraction 1.5-2h, crosses leaching filtrate; Second time adds 7-8 times of water of mixed material medicine in filtering residue, heating and refluxing extraction 1-1.5h, crosses leaching filtrate, merges twice filtrate, crosses leaching filtrate;
(2) filtrate is centrifugal, centrifugation rate is 8000-10000r/min, and go precipitation, supernatant concentration to relative density is 1.28-1.30;
(3) be down to temperature in the concentrated solution of room temperature and slowly add chitosan clarifier, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1-0.2%, the chitosan clarifier aqueous acetic acid of 1% dissolves, leave standstill, filter, get filtrate recentrifuge, centrifugation rate is 8000-10000r/min, get supernatant concentration to extractum, extractum relative density is 1.28-1.30;
(4) in extractum, add adjuvant maltodextrin and sucrose, extractum with the weight proportion of adjuvant be: extractum 1-2 part, maltodextrin 2-4 part, sucrose 1-2 part, granulate, be drying to obtain final drug.
embodiment 2
Get Herba Pogostemonis 50g, Pericarpium Citri tangerinae 50g, Gypsum Fibrosum 50g, Flos Lonicerae 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Radix Glycyrrhizae 100g, Herba Taraxaci 200g, Folium Isatidis 200g, Radix Isatidis 200g, Rhizoma Zingiberis Recens 50g, be placed in extraction pot, add purified water 12L wherein, soak after 20 minutes, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; In filtering residue, add the purified water of 8.4L, to mixture heating and refluxing extraction 1 hour, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 8000r/min, and removing impurity, is the extractum of 1.28 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 1 part of extractum, 2 portions of maltodextrins, granulate after 1 part of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 20%, conventional alcohol method loss 30%-40%.
embodiment 3
Get Herba Pogostemonis 50g, Pericarpium Citri tangerinae 50g, Gypsum Fibrosum 50g, Flos Lonicerae 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Radix Glycyrrhizae 100g, Herba Taraxaci 200g, Folium Isatidis 200g, Radix Isatidis 200g, Rhizoma Zingiberis Recens 50g, be placed in extraction pot, add purified water 12L wherein, soak after 30 minutes, to mixture heating and refluxing extraction 2 hours, cross leaching filtrate; In filtering residue, add the purified water of 8.4L, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 10000r/min, and removing impurity, is the extractum of 1.30 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 1 part of extractum, 3 portions of maltodextrins, granulate after 1 part of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 17%, conventional alcohol method loss 30%-40%.
embodiment 4
Get Herba Pogostemonis 50g, Pericarpium Citri tangerinae 50g, Gypsum Fibrosum 50g, Flos Lonicerae 100g, Radix Scutellariae 100g, Cortex Phellodendri 100g, Radix Glycyrrhizae 100g, Herba Taraxaci 200g, Folium Isatidis 200g, Radix Isatidis 200g, Rhizoma Zingiberis Recens 50g, be placed in extraction pot, add purified water 12L wherein, soak after 20 minutes, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; In filtering residue, add the purified water of 9.6L, to mixture heating and refluxing extraction 1 hour, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is, 9000r/min, and removing impurity, is the extractum of 1.29 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.2%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 2 parts of extractum, 3 portions of maltodextrins, granulate after 2 parts of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 18%, conventional alcohol method loss 30%-40%.
embodiment 5
Get Herba Pogostemonis 45g, Pericarpium Citri tangerinae 45g, Gypsum Fibrosum 40g, Flos Lonicerae 85g, Radix Scutellariae 90g, Cortex Phellodendri 105g, Radix Glycyrrhizae 85g, Herba Taraxaci 175g, Folium Isatidis 205g, Radix Isatidis 195, Rhizoma Zingiberis Recens 60g, is placed in extraction pot, add purified water 10.17L wherein, soak after 30 minutes, to mixture heating and refluxing extraction 2 hours, cross leaching filtrate; In filtering residue, add the purified water of 9.04L, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 10000r/min, and removing impurity, is the extractum of 1.30 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.15%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 2 parts of extractum, 4 portions of maltodextrins, granulate after 2 parts of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 15%, conventional alcohol method loss 30%-40%.
embodiment 6
Get Herba Pogostemonis 60g, Pericarpium Citri tangerinae 50g, Gypsum Fibrosum 40g, Flos Lonicerae 110g, Radix Scutellariae 110g, Cortex Phellodendri 90g, Radix Glycyrrhizae 95g, Herba Taraxaci 195g, Folium Isatidis 200g, Radix Isatidis 215g, Rhizoma Zingiberis Recens 40g, be placed in extraction pot, add purified water 12.05L wherein, soak after 20 minutes, to mixture heating and refluxing extraction 2 hours, cross leaching filtrate; In filtering residue, add the purified water of 8.44L, to mixture heating and refluxing extraction 1 hour, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 8000r/min, and removing impurity, is the extractum of 1.28 by gained supernatant concentration to relative density; After temperature lowers, in concentrated solution, slowly add chitosan clarifier, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 1 part of extractum, 4 portions of maltodextrins, granulate after 1 part of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 19%, conventional alcohol method loss 30%-40%.
embodiment 7
Get Herba Pogostemonis 50g, Pericarpium Citri tangerinae 45g, Gypsum Fibrosum 60g, Flos Lonicerae 105g, Radix Scutellariae 85g, Cortex Phellodendri 90g, Radix Glycyrrhizae 105g, Herba Taraxaci 215g, Folium Isatidis 175g, Radix Isatidis 205g, Rhizoma Zingiberis Recens 55g, be placed in extraction pot, add purified water 11.3L wherein, soak after 25 minutes, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; In filtering residue, add the purified water of 8.9L, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 10000r/min, and removing impurity, is the extractum of 1.28 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.2%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 2 parts of extractum, 2 portions of maltodextrins, granulate after 2 parts of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 17%, conventional alcohol method loss 30%-40%.
embodiment 8
Get Herba Pogostemonis 40g, Pericarpium Citri tangerinae 60g, Gypsum Fibrosum 50g, Flos Lonicerae 100g, Radix Scutellariae 110g, Cortex Phellodendri 110g, Radix Glycyrrhizae 100g, Herba Taraxaci 190g, Folium Isatidis 225g, Radix Isatidis 200g, Rhizoma Zingiberis Recens 60g, be placed in extraction pot, add purified water 12.45L wherein, soak after 30 minutes, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; In filtering residue, add the purified water of 9.34L, to mixture heating and refluxing extraction 1.5 hours, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 8000r/min, and removing impurity, is the extractum of 1.28 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 1 part of extractum, 2 portions of maltodextrins, granulate after 1 part of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 19%, conventional alcohol method loss 30%-40%.
embodiment 9
Get Herba Pogostemonis 60g, Pericarpium Citri tangerinae 50g, Gypsum Fibrosum 45g, Flos Lonicerae 105g, Radix Scutellariae 115g, Cortex Phellodendri 85g, Radix Glycyrrhizae 115g, Herba Taraxaci 225g, Folium Isatidis 215g, Radix Isatidis 200g, Rhizoma Zingiberis Recens 50g, be placed in extraction pot, add purified water 11.38L wherein, soak after 20 minutes, to mixture heating and refluxing extraction 2 hours, cross leaching filtrate; In filtering residue, add the purified water of 8.86L, to mixture heating and refluxing extraction 1 hour, cross leaching filtrate; Merge twice filtrate, by the filtrate centrifugal treating after merging, centrifugation rate is 10000r/min, and removing impurity, is the extractum of 1.30 by gained supernatant concentration to relative density; In concentrated solution, slowly chitosan clarifier is added after temperature lowers, the chitosan clarifier aqueous acetic acid of 1% dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.15%, leave standstill, filter and get filtrate supernatant, being concentrated into extractum by after filtrate recentrifuge; By 2 parts of extractum, 3 portions of maltodextrins, granulate after 1 part of sucrose mixing, are drying to obtain drug particles.As calculated, Effective Component of Chinese Medicine loss rate of the present invention is 17%, conventional alcohol method loss 30%-40%.
In embodiment 10-20, pharmaceutical formulation of the present invention is in table 1, and other are with embodiment 2.
table 1 embodiment of the present invention 10-20 pharmaceutical formulation table
test example
Only, unexpected large quantities of morbidity during 4 week age, can involve the chicken of about 60% to chicken farm, Luohe, Henan raising broiler more than 2000 in 2 ~ 3 days, and after morbidity, death in 3 ~ 4 days peaks, dead stopping after 7 ~ 8 days.Disease just spirit is depressed, and feed intake reduces, and drinking-water increases, and some is from anus pecking door, arranges white water sample loose stool, and severe one is dewatered, and does not rise sleepingly, extremely feeble, finally death.Resistance to Anemia in Chicken of crossing is become thin, poor growth.Dead chicken cuts open that the visible fabricius bursa of inspection be yellow glue peptone sample edema, matter firmly, mucosa is coated with cream-colored fibrinous exudate.Some fabricius bursa mucosa severe inflammation, hemorrhage, downright bad, atrophy.In addition, the chicken that dies of illness performance dehydration, lower limb and chest muscle often have hemorrhage, and color is dark red.Renal swelling is swollen, and renal tubules and ureter are full of white urate; Spleen and glandular stomach and muscular stomach intersection mucosal bleeding.
Complex clinical symptom and pathology cut open inspection and are diagnosed as chicken bursal disease.
The sick chicken 500 of random selecting, body weight 1-2Kg, is divided into five groups, gives medicine respectively; Measure index of correlation, the results are shown in Table 2.
1-3 group gives the embodiment of the present invention 2-4 medicine prepared respectively; 4 groups give control drug, 5 groups of diet but not administration.
Control drug: capsule must be controlled (Xin Ruitai bio tech ltd, Shanghai, lot number: 20150326).
Infected group diet but not administration.
Criterion of cure: prothymia, diet is for normally, and feather is glossy, and cut open inspection internal organs without urate deposition, color and luster is ruddy.
the grouping of table 2 test chicken and curative effect
Result of the test shows, medicine of the present invention and use commercially available capsule must treatment infectious bursal disease, all has good effect; Medicine of the present invention is compared commercially available capsule and must be controlled, and mortality rate obviously reduces, better effects if.
Claims (8)
1. one kind is used for the treatment of the medicine of infectious bursal disease, it is characterized in that being made up of the raw material of following weight portion: Herba Pogostemonis 8-12 part, Pericarpium Citri tangerinae 8-12 part, Gypsum Fibrosum 8-12 part, Flos Lonicerae 17-23 part, Radix Scutellariae 17-23 part, Cortex Phellodendri 17-23 part, Radix Glycyrrhizae 17-23 part, Herba Taraxaci 35-45 part, Folium Isatidis 35-45 part, Radix Isatidis 35-45 part, Rhizoma Zingiberis Recens 8-12 part.
2. be used for the treatment of the medicine of infectious bursal disease as claimed in claim 1, it is characterized in that being made up of the raw material of following weight portion: Herba Pogostemonis 10 parts, Pericarpium Citri tangerinae 10 parts, 10 parts, Gypsum Fibrosum, Flos Lonicerae 20 parts, Radix Scutellariae 20 parts, Cortex Phellodendri 20 parts, 20 parts, Radix Glycyrrhizae, Herba Taraxaci 40 parts, Folium Isatidis 40 parts, Radix Isatidis 40 parts, 10 parts, Rhizoma Zingiberis Recens.
3. the preparation method being used for the treatment of the medicine of infectious bursal disease as described in claim 1-2, is characterized in that comprising the following steps:
(1) mixed by each crude drug, add water reflux, extract, crosses leaching filtrate;
(2) filtrate is centrifugal, go precipitation, supernatant concentration is to extractum;
(3) in concentrated solution, add chitosan clarifier, leave standstill, filter, get filtrate recentrifuge, get supernatant concentration to extractum;
(4) in extractum, add adjuvant maltodextrin and sucrose, granulate, be drying to obtain final drug.
4. be used for the treatment of the preparation method of the medicine of infectious bursal disease as claimed in claim 3, it is characterized in that step (1) is divided into extracted twice, the multiple that adds water for the first time is 9-10 times of mixed material medicine, after soaking 20-30min, heating and refluxing extraction 1.5-2h, crosses leaching filtrate; Second time adds 7-8 times of water of mixed material medicine in filtering residue, heating and refluxing extraction 1-1.5h, crosses leaching filtrate, merges twice filtrate.
5. be used for the treatment of the preparation method of the medicine of infectious bursal disease as claimed in claim 3, it is characterized in that centrifugation rate is 8000-10000r/min.
6. be used for the treatment of the preparation method of the medicine of infectious bursal disease as claimed in claim 3, it is characterized in that described extractum relative density is 1.28-1.30.
7. be used for the treatment of the preparation method of the medicine of infectious bursal disease as claimed in claim 3, it is characterized in that step (3) the chitosan clarifier aqueous acetic acid of 1% mass fraction dissolves, the mass body volume concentrations of chitosan clarifier finally in concentrated solution is 0.1-0.2%.
8. be used for the treatment of the preparation method of the medicine of infectious bursal disease as claimed in claim 3, it is characterized in that the middle extractum of step (4) and with the weight proportion of adjuvant be: extractum 1-2 part, maltodextrin 2-4 part, sucrose 1-2 part.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106236946A (en) * | 2016-08-29 | 2016-12-21 | 旌德县德源农业开发有限公司 | A kind of Chinese medicine composition treating a bursa of Fabricius in poultry |
| CN108272914A (en) * | 2018-03-15 | 2018-07-13 | 亳州市乾元动物药业有限责任公司 | A kind of production method of public affairs English ultramarine particle |
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2015
- 2015-11-11 CN CN201510764180.5A patent/CN105233225A/en active Pending
Non-Patent Citations (2)
| Title |
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| 李敬云: "中兽医从肺论治鸡呼吸道病八法", 《中兽医医药杂志》 * |
| 胡元亮: "《兽医处方手册》", 30 June 2005, 中国农业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236946A (en) * | 2016-08-29 | 2016-12-21 | 旌德县德源农业开发有限公司 | A kind of Chinese medicine composition treating a bursa of Fabricius in poultry |
| CN108272914A (en) * | 2018-03-15 | 2018-07-13 | 亳州市乾元动物药业有限责任公司 | A kind of production method of public affairs English ultramarine particle |
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Application publication date: 20160113 |