CN105233141A

CN105233141A - Pharmaceutical composition for treating tuberculous pleural effusion and preparation method of pharmaceutical composition

Info

Publication number: CN105233141A
Application number: CN201510795791.6A
Authority: CN
Inventors: 胡海波
Original assignee: Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
Current assignee: Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
Priority date: 2014-04-11
Filing date: 2014-04-11
Publication date: 2016-01-13
Also published as: CN103861017B; CN103861017A

Abstract

The invention discloses a pharmaceutical composition for treating tuberculous pleural effusion and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following raw medicinal materials: folium sennae, aloes, semen pruni, euphorbia kansui, lilac daphne flower buds, pokeberry roots, cypripedium franchetii roots, caulis sinomenii, radix stephaniae tetrandrae, sweetgum fruits, cortex acanthopanacis, rhizoma atractylodis, mangnolia officinalis, fructus amomi, fructus tsaoko, tuckahoe, semen coicis, Chinese wax gourd peel, corn stigma, calabash, semen hoveniae, citron, radix codonopsis, astragalus, white atractylodes rhizome, rhodiola rosea, radix rehmanniae preparata, fructus broussonetiae and rhizoma polygonati. The pharmaceutical composition has the main beneficial effects of reinforcing qi and nourishing blood, inducing diuresis to alleviate edema as well as promoting blood circulation to remove blood stasis according to the traditional Chinese medicine theory in China and has the advantages of quickness to take effect, exact curative effect, high safety, no toxic or side effect and no recurrence.

Description

Pharmaceutical composition being used for the treatment of tuberculous pleural effusion and preparation method thereof

This case is divisional application, and the denomination of invention of original application is: Chinese medicine composition being used for the treatment of tuberculous pleural effusion and preparation method thereof, and the applying date of original application is: 2014-04-11, and the application number of original application is: 201410145260.8.

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of pharmaceutical composition being used for the treatment of tuberculous pleural effusion and preparation method thereof.

Background technology

Have 3 ~ 15ml liquid in normal person's pleural space, the lubricate when respiratory movement, but the hydrops amount in pleural space not immobilizes.Even normal person, every also have the liquid of 500 ~ 1000ml to be formed for 24 hours and absorb.Pleura intracavity liquid absorbs from the vein end of blood capillary again, and remaining liquid is recycled to blood by lymphsystem, filters and is in dynamic equilibrium with absorption.If because whole body or local patholoic change destroy this kind of dynamic equilibrium, pleura intracavity liquid is caused to be formed too fast or absorbed slow, clinical generation hydrothorax (abbreviation chest fluid).Hydrothorax is a part for chest general disease, and etiological treatment is particularly important, and omission timber is everlasting and is corrected Absorbable rod after the cause of disease, and hydrothorax can be divided into by the difference according to the cause of disease: tuberculous pleural effusion, malignant pleural effusion and lung inflammatory hydrothorax.

Wherein, tuberculous pleural effusion is the body pleural space due to mycobacterium tuberculosis and metabolite entry altitude allergic state thereof, invasion and attack pleura and cause the inflammation of pleura, and pleura is congested, ooze out, edema, hypertrophy, fibrosis etc., and produces hydrothorax.Tuberculous pleural effusion is common clinical, frequently-occurring disease, is pleuritis the most common, is apt to occur in person between twenty and fifty.In recent years, China's pulmonary tuberculosis rate rises to some extent, tuberculous pleuritis is also in the trend risen year by year, the annual new trouble tuberculosis patient of report China is had to reach more than 1,130,000, wherein tuberculous pleuritis accounts in phthisical 4.7%-17.6, Tuberculous pleural effusion transudate because of containing a large amount of fibrin, hydrothorax forms 5 days and namely has adhesive band formation, and within 7 days, adhesive band can increase thick change greatly, within 10 days, can form encapsulated effusion.Therefore, often owing to treating not in time or treating lack of standardization, fibrin is caused to be deposited on pleura widely, machineization forms the complication such as pachynsis pleurae, adhesion, parcel, Thoracic sink distortion gradually, affect pulmonary function and quality of life, therefore want early diagnosis, active treatment.

Clinical symptoms is primarily of the following aspects: (1) can have the clinical symptoms such as heating, cough, uncomfortable in chest, chest pain; (2) hydrothorax sign is had; (3) chest x-ray, the impact of B ultrasonic fire spiral CT are learned and are checked display hydrothorax; (4) meet transudate, leukocyte count increases, based on lymphocyte and mononuclear cell, chest fluid ADA Adenosine deaminase (ADA) is greater than 45U/L, chest fluid ADA/ serum ADA > 1, tuberculin test is strong positive, and pleura has typical Tuberculous pathological change.

The method of current treatment tuberculous pleural effusion mostly is antituberculosis drugs treat and thoracic puncture drainage.Antituberculotics generally adopts streptomycin (SM), isoniazid (INH) and rifampicin (RFP) or streptomycin (SM) isoniazid (INH) ethambutol (EMB) therapeutic alliance, streptomycin (SM) intramuscular injection, isoniazid (INH), rifampicin, ethambutol decoction being taken at a draught, above-mentioned oral drugs take 1.0 ~ 1.5 years all continuously, treatment time is long, and therapeutic process must be noted that the side effect of antituberculotics, as the change of audition, the change of vision and liver function etc., during generation should according to circumstances decrement or stop using.Due to tuberculous pleuritis chest fluid protein content and fiber protein content high, easily cause pleural adhesion, therefore hydrops in most thoracic cavity should be taken out as early as possible in principle, 2 ~ 3 times weekly, drawing liquid does not exceed 700ml first, and about 1000ml is measured in each extraction later, does not exceed 1500ml at most.As there is re-expansion pulmonary edema, should rescue accordingly.Thoracic cavity drawing liquid has following effect: (1) alleviates poisoning symptom, accelerates to bring down a fever; (2) remove lungs and cardiovascular pressurized, improve respiratory and circulatory function; (3) prevent pleural adhesion caused by fibrin calmness plump.But western medical treatment tuberculous pleural effusion complication is more, untoward reaction is more, as too much in drawing liquid, too fast, can due to intrathoracic pressure power rapid drawdown generation reexpansion pulmonary edema and circulatory failure, can occur that dizziness, perspiration, pale complexion, pulse are thin and delicate, the untoward reaction such as cold extremities, blood pressure drops, and western medical treatment tuberculous pleural effusion, curative effect is not desirable especially, relapse rate is higher, and medical expense is relatively high, client need bears more medical care expenses, and extensive patients is not easy to accept Modern medical therapy scheme.

Tuberculous pleural effusion when belonging to the traditional Chinese medical science " hydrothorax " category, is cause the defeated cloth of water liquid, dysfunction of the spleen in transportation and transformation owing to infecting " consumptive disease worm ", and make pathogenic fluid-retention stop amassing in the breast side of body, " Medical Treasures of the Golden Chamber " is said: " under the current side of body, dragging pain due to cough and spitting, the hydrothorax of meaning ".Many because of patient's ferritic weakness, or other chronic diseases original, asthenia of pulmonosplenic qi, impairment of dispersing and descending function of the lung, spleen loses transporting, and Liver Channel catharsis is unfavorable, and network gas is got along well, and QI-blood circulation is smooth, water liquid Metabolic disorder, the drain breast side of body.It is full that clinical symptoms mostly is the breast side of body, dragging pain due to cough and spitting, and dyspnea with rapid and short breath can not be put down sleeping, or has pulmonary tuberculosis medical history, under belonging to the drain side of body.Chinese traditional treatment tuberculous pleural effusion, from entirety, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, carry out entirety conditioning whole body according to patient self different situations, toxic and side effects is low, and untoward reaction is few, and effective percentage is high, instant effect, and relapse rate is low, taking convenience, and patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, a kind of pharmaceutical composition for the treatment of tuberculous pleural effusion and preparation method thereof is provided, this pharmaceutical composition is based on benefiting QI and nourishing blood, inducing diuresis to remove edema, blood circulation promoting and blood stasis dispelling, and the pharmaceutical composition for the treatment of tuberculous pleural effusion has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition being used for the treatment of tuberculous pleural effusion, wherein, following raw medicinal material is comprised: Folium Sennae, Aloe, Semen Pruni, Radix Kansui, Flos Genkwa, Radix Phytolaccae, decorated archway seven, Caulis Sinomenii, Radix Stephaniae Tetrandrae, Fructus Liquidambaris, Cortex Acanthopancis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Fructus Amomi, Fructus Tsaoko, Poria, Semen Coicis, Exocarpium Benincasae, Stigma Maydis, calabash, Semen Hoveniae (Fructus Hoveniae), Fructus Citri, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, Radix Rehmanniae Preparata, Fructus Broussonetiae and Rhizoma Polygonati.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Folium Sennae 10-25 weight portion, Aloe 15-28 weight portion, Semen Pruni 10-20 weight portion, Radix Kansui 10-20 weight portion, Flos Genkwa 10-20 weight portion, Radix Phytolaccae 10-20 weight portion, decorated archway seven 15-25 weight portion, Caulis Sinomenii 10-20 weight portion, Radix Stephaniae Tetrandrae 10-25 weight portion, Fructus Liquidambaris 15-28 weight portion, Cortex Acanthopancis 10-25 weight portion, Rhizoma Atractylodis 15-28 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Fructus Amomi 10-15 weight portion, Fructus Tsaoko 10-20 weight portion, Poria 15-23 weight portion, Semen Coicis 15-28 weight portion, Exocarpium Benincasae 15-25 weight portion, Stigma Maydis 10-25 weight portion, calabash 10-25 weight portion, Semen Hoveniae (Fructus Hoveniae) 15-25 weight portion, Fructus Citri 10-15 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Fructus Broussonetiae 10-25 weight portion and Rhizoma Polygonati 10-20 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Folium Sennae 15-20 weight portion, Aloe 18-23 weight portion, Semen Pruni 13-18 weight portion, Radix Kansui 12-17 weight portion, Flos Genkwa 15-20 weight portion, Radix Phytolaccae 10-15 weight portion, decorated archway seven 18-20 weight portion, Caulis Sinomenii 10-20 weight portion, Radix Stephaniae Tetrandrae 15-20 weight portion, Fructus Liquidambaris 19-25 weight portion, Cortex Acanthopancis 15-20 weight portion, Rhizoma Atractylodis 18-25 weight portion, Cortex Magnoliae Officinalis 18-25 weight portion, Fructus Amomi 10-15 weight portion, Fructus Tsaoko 10-15 weight portion, Poria 18-23 weight portion, Semen Coicis 19-27 weight portion, Exocarpium Benincasae 18-20 weight portion, Stigma Maydis 16-25 weight portion, calabash 15-25 weight portion, Semen Hoveniae (Fructus Hoveniae) 18-20 weight portion, Fructus Citri 10-13 weight portion, Radix Codonopsis 15-20 weight portion, Radix Astragali 15-20 weight portion, Rhizoma Atractylodis Macrocephalae 15-20 weight portion, Radix Rhodiolae 15-20 weight portion, Radix Rehmanniae Preparata 10-15 weight portion, Fructus Broussonetiae 15-20 weight portion and Rhizoma Polygonati 13-17 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Folium Sennae 18 weight portion, Aloe 21 weight portion, Semen Pruni 15 weight portion, Radix Kansui 15 weight portion, Flos Genkwa 17 weight portion, Radix Phytolaccae 12 weight portion, decorated archway 7 19 weight portion, Caulis Sinomenii 15 weight portion, Radix Stephaniae Tetrandrae 17 weight portion, Fructus Liquidambaris 22 weight portion, Cortex Acanthopancis 18 weight portion, Rhizoma Atractylodis 21 weight portion, Cortex Magnoliae Officinalis 22 weight portion, Fructus Amomi 12 weight portion, Fructus Tsaoko 13 weight portion, Poria 20 weight portion, Semen Coicis 23 weight portion, Exocarpium Benincasae 19 weight portion, Stigma Maydis 19 weight portion, calabash 20 weight portion, Semen Hoveniae (Fructus Hoveniae) 19 weight portion, Fructus Citri 12 weight portion, Radix Codonopsis 18 weight portion, the Radix Astragali 17 weight portion, the Rhizoma Atractylodis Macrocephalae 18 weight portion, Radix Rhodiolae 17 weight portion, Radix Rehmanniae Preparata 13 weight portion, Fructus Broussonetiae 17 weight portion and Rhizoma Polygonati 15 weight portion.

Described pharmaceutical composition also comprises: grass, Pericarpium Lagenariae hispidae, box fruit rattan and Fructus Jujubae before semen juglandis, Radix caricis siderostictae, water.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Folium Sennae 10-25 weight portion, Aloe 15-28 weight portion, Semen Pruni 10-20 weight portion, Radix Kansui 10-20 weight portion, Flos Genkwa 10-20 weight portion, Radix Phytolaccae 10-20 weight portion, decorated archway seven 15-25 weight portion, Caulis Sinomenii 10-20 weight portion, Radix Stephaniae Tetrandrae 10-25 weight portion, Fructus Liquidambaris 15-28 weight portion, Cortex Acanthopancis 10-25 weight portion, Rhizoma Atractylodis 15-28 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Fructus Amomi 10-15 weight portion, Fructus Tsaoko 10-20 weight portion, Poria 15-23 weight portion, Semen Coicis 15-28 weight portion, Exocarpium Benincasae 15-25 weight portion, Stigma Maydis 10-25 weight portion, calabash 10-25 weight portion, Semen Hoveniae (Fructus Hoveniae) 15-25 weight portion, Fructus Citri 10-15 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Fructus Broussonetiae 10-25 weight portion, Rhizoma Polygonati 10-20 weight portion, semen juglandis 15-25 weight portion, Radix caricis siderostictae 10-20 weight portion, careless 15-20 weight portion before water, Pericarpium Lagenariae hispidae 10-25 weight portion, box fruit rattan 15-20 weight portion and Fructus Jujubae 10-20 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Folium Sennae 17 weight portion, Aloe 18 weight portion, Semen Pruni 15 weight portion, Radix Kansui 15 weight portion, Flos Genkwa 15 weight portion, Radix Phytolaccae 15 weight portion, decorated archway 7 20 weight portion, Caulis Sinomenii 15 weight portion, Radix Stephaniae Tetrandrae 17 weight portion, Fructus Liquidambaris 19 weight portion, Cortex Acanthopancis 17 weight portion, Rhizoma Atractylodis 19 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Fructus Amomi 12 weight portion, Fructus Tsaoko 15 weight portion, Poria 18 weight portion, Semen Coicis 18 weight portion, Exocarpium Benincasae 21 weight portion, Stigma Maydis 18 weight portion, calabash 17 weight portion, Semen Hoveniae (Fructus Hoveniae) 20 weight portion, Fructus Citri 12 weight portion, Radix Codonopsis 15 weight portion, the Radix Astragali 15 weight portion, the Rhizoma Atractylodis Macrocephalae 15 weight portion, Radix Rhodiolae 18 weight portion, Radix Rehmanniae Preparata 15 weight portion, Fructus Broussonetiae 17 weight portion, Rhizoma Polygonati 15 weight portion, semen juglandis 20 weight portion, Radix caricis siderostictae 15 weight portion, careless 18 weight portions before water, Pericarpium Lagenariae hispidae 18 weight portion, box fruit rattan 17 weight portion and Fructus Jujubae 15 weight portion.

In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the pharmaceutical composition of tuberculous pleural effusion, wherein, the dosage form of described pharmaceutical composition is tablet, and described preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

The dosage form of described pharmaceutical composition is oral liquid, and described preparation method comprises the following steps:

The first step, Radix Stephaniae Tetrandrae, Fructus Liquidambaris, Cortex Acanthopancis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis and the Radix Astragali are mixed, add relative to mixture 5 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 4 times, each 3 ~ 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.36 ~ 1.38, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 3 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.34;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 60 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: pharmaceutical composition of the present invention, utilize the theory of Chinese medical science that China is traditional, based on benefiting QI and nourishing blood, inducing diuresis to remove edema, blood circulation promoting and blood stasis dispelling, the pharmaceutical composition for the treatment of tuberculous pleural effusion has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Detailed description of the invention

The invention provides a kind of pharmaceutical composition being used for the treatment of tuberculous pleural effusion, wherein, Folium Sennae, Aloe, Semen Pruni, Radix Kansui, Flos Genkwa, Radix Phytolaccae, decorated archway seven, Caulis Sinomenii, Radix Stephaniae Tetrandrae, Fructus Liquidambaris, Cortex Acanthopancis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Fructus Amomi, Fructus Tsaoko, Poria, Semen Coicis, Exocarpium Benincasae, Stigma Maydis, calabash, Semen Hoveniae (Fructus Hoveniae), Fructus Citri, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, Radix Rehmanniae Preparata, Fructus Broussonetiae and Rhizoma Polygonati is comprised; Preferably, pharmaceutical composition also comprises: grass, Pericarpium Lagenariae hispidae, box fruit rattan and Fructus Jujubae before semen juglandis, Radix caricis siderostictae, water.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Folium Sennae: sweet, bitter, cold.Return large intestine channel.Cure mainly the row that purges heat stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.These product contain Sennoside A and Sennoside B, and containing Herba Alii fistulosi ketone derivatives: aloe-emodin, chrysophanol, chrysophanic acid etc.Have Folium Sennae and can make medicinal discharge function and antibacterial action, Folium Sennae also has curariform action mask.Under gastroscope, be sprayed on gastrorrhagia place with this product infusion, direct-view has anastalsis at once as seen.

Aloe: bitter in the mouth is cold in nature, removing heat from the liver, relieving constipation, parasite killing; In addition for headache, constipation, pediatric epilepsy scared, infantile malnutrition infections furuncle and phyma, burn and scald, tinea skin ulcer, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, exudative dermatitis etc.Containing more than 200 kinds of compounds in the blade of Aloe, in the middle of include 20 kinds of mineral, 18 seed amino acids, 12 kinds of vitamin and other various different nutrients, comprise multiple mucopolysaccharide, fatty acid, Anthraquinones and flavone compound, sugar, organized enzyme etc.Anthraquinones has another name called Anthraquinone Complex, has effect of disinfection, is mainly present in juice.

Semen Pruni: pungent, bitter, sweet, flat.Return spleen, large intestine, small intestine meridian.Function cures mainly: moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic.For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, dysuria.Contained by Semen Pruni, Semen Pruni glycoside has strong discharge function to laboratory animal.The protein component IR-A raised from Semen Pruni and IR-B intravenously administrable have antiinflammatory and analgesic activity.Semen Pruni has the significant effect promoting small intestinal peristalsis. and strongly fragrant Lee's glucoside has strong discharge function to laboratory animal, also has calmness and diuresis.

Radix Kansui: bitter in the mouth, cold in nature.Return spleen channel, lung meridian, kidney channel, urinary bladder channel, large intestine channel, small intestine meridian.Removing water retention by purgation by swollen, dispersing swelling and dissipating binds.Cure mainly edema, ascites, prolonged fluid-retention blocked-up chest, epilepsy, breath with cough, sphincter disturbance.Radix Kansui can stimulate intestinal tube, increases enterokinesia, produces discharge function.Carry out induced labor experiment with Radix Kansui ethanol soluble extraction to pregnant guinea pig, find no matter be abdominal cavity or intramuscular injection Radix Kansui extractum, all present certain antifertility action.And think that Radix Kansui induced laboring effect and dosage have substantial connection, can induced laboring effect be there is when dosage is 10mg/kg.Raw Radix Kansui can make isolated frog heart contractility strengthen in a small amount, but does not change its frequency, then suppresses in a large number.Radix Kansui is high to rush down, poisonous.Can cause vomiting, suffer from abdominal pain, the toxicity such as dyspnea, blood pressure drops.Give mouse mainline after one week continuously by 10mg/kg dosage, postmortem finds that the heart, liver, kidney have certain toxic Histological change.

Flos Genkwa: bitter, acrid, cold; Return lung, spleen, kidney channel." property of medicine opinion ": " control trusted subordinate's distension, anhydrate gas, and sharp the five internal organs cold-phlegm, tears saliva is as glue person.Main promoting blood circulation, control malignant boil migratory arthralgia and wet, all malicious wind, extremity contraction is anxious, can not go step, can removing water retention by purgation swelling expire." " herbal classic ": " main cough with dyspnea, laryngeal stridor is breathed heavily, and pharyngeal swelling is losed heart, terrible malaria, hernia abdominal mass, carbuncle." parasite killing detoxifies for removing fluid-retention by purgation, expelling phlegm for arresting cough.Cure mainly edema tympanites, the phlegm retention hypochondriac lump, hypochondriac pain of breathing with cough, carbuncle furuncle scabies.Have a delicate constitution, body fluid loses, deficiency of spleen-YANG and kidneyYANG, anemia of pregnant woman, and heart disease, Peptic Ulcers, digestive tract hemorrhage person prohibit clothes.Vinegar Flos Genkwa and the benzene genkwanol aqueous extract of in vitro tests 1:50 concentration all have inhibitory action to streptococcus pneumoniae, Streptococcus hemolyticus, hemophilus influenzae.Faint from fear in experiment at anti-strychnine or caffeine sodium benzoate, have obvious anticonvulsant action, the peaceful convulsion effect of anti-soil is stronger; In addition, Flos Genkwa obviously can also strengthen the anesthetic action of amobarbital sodium to dog.

Radix Phytolaccae: its bitter in the mouth, cold in nature, return lung, kidney, large intestine channel.To relieve oedema or abdominal distension through diuresis or purgation detumescence, smoothening secretion, the function of detoxicating and resolving stagnation of pathogens.Cure mainly edema distension, constipation and anuresis, scrofula, sore etc.This savors decoct, tincture, water logging agent have obvious phlegm-dispelling functions to mouse stomach.Mice ammonia spraying draws to be coughed laboratory method and proves: Radix Phytolaccae slightly carries that alkaloid is oral obvious antitussive effect.This product root extract perfusion Bufo siccus kidney or directly instillation frog kidney, can make urine volume increase, and its mechanism of action may be stimulate vasomotor center, telangiectasis, and blood flow increases, and makes the result that blood circulation of kidney accelerates.The triterpenic acid extracted from Radix Phytolaccae has antiinflammatory action, similar to hydrocortisone to the antiinflammation of rat swollen feet.Radix Phytolaccae infusion has the effect killing Ability of Culex Pipiens Larvae.

Decorated archway seven: micro-hardship, cold.Function cures mainly: regulate the flow of vital energy, cough-relieving, pain relieving.For stagnation of QI cough, pain in chest and hypochondrium.

Caulis Sinomenii: bitter, pungent; Return liver, spleen channel.Compendium of Material Medica: " paralysis pruritus, damage skin ulcer swells, and enters in yeast for brewing rice wine and uses for dispelling the wind and dampness pathogens multiple abscess, severe and migratory arthralgia crane knee joint." " will planted by Tianmu Mountains of Zhejiang Province medicine ": " row water diuresis, it is damp and hot to rush down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system.Control edema caused by wind, beriberi, Fengshi Guanjie pain, facial hemiparalysis, carbuncle malignant boil." function wind-damp dispelling, the meridian dredging, diuresis.For rheumatic arthralgia, arthroncus, paralysis pruritus.Caulis Sinomenii dispersing wind and cold arthralgia chiefly caused by damp pathogen, energy relaxing muscles and tendons to promote blood circulation, boneset sharp marrow, therefore syndrome caused by wind pathogen weakness, and the card that strength is attached undue importance to one thing to the neglect of the other by force, take informal dress for a long time, make outstanding contributions greatly.Must be apt to also with Radix Angelicae Sinensis, the Fructus Lycii side of share.Sinomenine, in the test with mice electrostimulation, hot plate method and rabbit photo-thermal stimulus method, all proves the analgesic activity with affirmative.Sinomenium acutum total alkali is to anesthesia or not anaesthesia experiment animal (dog, cat, rabbit, rat), and intravenous injection or gavage all have the acute antihypertensive effect of affirmative.

Radix Stephaniae Tetrandrae: nature and flavor are bitter, cold." property of medicine opinion " is said: " Radix Stephaniae Tetrandrae: bitter in the mouth, slightly poisonous.Radix cocculi laurifolii: bitter in the mouth is pungent ".Enter bladder, spleen, kidney channel.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.Cure mainly: edema beriberi, dysuria, eczema sore, rheumatic arthralgia, vascular hypertension.It is generally acknowledged, the effect of Radix Stephaniae Tetrandrae inducing diuresis to remove edema is comparatively strong, and the effect of Radix cocculi laurifolii wind-expelling pain-stopping is better.Containing multiple alkaloid, be mainly sinomenine, demethyl sinomenine.Pharmacology: the effect having analgesia, antipyretic, antiinflammatory, of flaccid muscles, diuresis, antianaphylaxis shock and reduce blood pressure.

Fructus Liquidambaris: bitter is flat; Return liver, kidney channel." detailed outline is picked up any lost article from the road ": " maple fruit, tree like Cortex Populi dividianae, inner circle as honeycomb, i.e. Fructus Liquidambaris.The large acupoints of twelve meridians that can pass through of its property, therefore " the lifesaving sea of bitterness " harnesses the river, swelling is with it, can search by FUSHUI also with it." " modern Practical Chinese medicinal ": " ashing is outer for skin exudative dermatitis, anal fistula etc., has convergence, antiinflammatory, disinfective action." dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.The property of Fructus Liquidambaris tool tonneau, function promoting the circulation of QI to alleviate the stagnation in middle-JIAO and pain relieving, clinically for abdominal distention, the disease such as not well of defecating, can be equal to the Radix Aucklandiae, the Radix Linderae, Fructus Aurantii and use.This product has again effect of inducing diuresis to remove edema, for edema, can with the compatibilities such as Cortex Sclerotii Poriae, Cortex Mori, Exocarpium Benincasae.

Cortex Acanthopancis: be the root bark of Araliaceae machaka acanthopanax gracilistylus and Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem. drying.Have another name called Cortex Acanthopanacis Radicis, order bone, chase after that wind makes, CORTEX ACANTHOPANACIS etc.Main product in Hubei, Hunan, Henan, Anhui, the ground such as Sichuan.Chinese medicine Cortex Acanthopancis has wind-damp dispelling, invigorating the liver and kidney, the effects such as bone and muscle strengthening.Record in Compendium of Material Medica: " invigorating the spleen and replenishing QI, dispelling the wind and dampness pathogens flaccidity syndrome and arthralgia syndrome, strengthening bone and muscle." modern study, this product also has the effects such as antitumor, resisting fatigue, reduction whole blood viscosity, atherosclerosis formation.Cortex Acanthopancis is easy to use, decoct soup, enter ball, fall apart or leaching slender acanthopanax bark spirit, but hyperactivity of fire caused by deficiency of YIN person is cautious use of.

Rhizoma Atractylodis: nature and flavor are pungent, bitter, temperature.Return spleen, stomach, Liver Channel." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slides and rushes down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".Cure mainly: the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.For dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur.

Cortex Magnoliae Officinalis: bitter, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Function: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and have stomach invigorating digestion-aid effect.Experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis. and experiment shows, compare with other 61 kinds of Chinese medicines, the effect of Cortex Magnoliae Officinalis to Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi is the strongest.It act as bactericidal action to Staphylococcus albus and bacillus subtilis. and in vitro, to the inhibitory action of staphylococcus aureus, comparatively Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei are strong to Cortex Magnoliae Officinalis. and when decoct (1:1) is diluted to 1/640, its bacteriostasis is still better than chlortetracycline.The antibacterial action of decoct does not destroy because of heating.

Fructus Amomi: acrid in the mouth, warm in nature; Return spleen channel, stomach warp, kidney channel.Materia Medica of Decoction: " contracting sand, with Symplocoris Paniculatae, Fructus Amomi Rotundus for making, enters lung, with Radix Ginseng, Fructus Alpiniae Oxyphyllae for making, enters spleen, with Cortex Phellodendri, Poria for making, enters kidney, with red, Kaolin for making, enters large and small intestinal." " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.The pungent loose temperature of these product is led to, fragrant, and its removing dampness is amusing, and the effect of circulation of qi promoting warming middle-JIAO is all good, and ancients say it: " adjust stomach key medicine for being amusing." therefore all cards of incoordination between the spleen and stomach such as all dampness or the abdominal distention caused by the stagnation of QI are conventional, especially cold-damp stagnation of QI person is the most suitable.These product kind energy warming middle-JIAO warming the stomach is to reach the merit of preventing or arresting vomiting antidiarrheal, but it focuses on warming the spleen.Alonely can grind into powder and swallow, or with the medicine such as Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata with using

Fructus Tsaoko: acrid in the mouth, warm in nature, nontoxic; Enter spleen channel, stomach warp.Compendium of Material Medica: " Fructus Tsaoko, use same with the Rhizoma Anemarrhenae, controls subtertian malaria cold and heat, and get the evil of its monoyin and monoyang without inclined victory, it is cold that lid Fructus Tsaoko controls lunar only victory, and the fire that Rhizoma Anemarrhenae Zhi Yangming solely wins also." " herbal classic is met former ": " except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on sharp diaphragm, separates wheaten food, fish, all poison of meat." dampness is except cold, eliminate the phlegm preventing the attack (or recurrence) of malaria, and help digestion relieving dyspepsia.Cure mainly malaria, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.Concoct: be soaked in water, clean, slightly steam after profit, cut skin and block in time or cut sheet, drying.Medication is avoided: the deficiency of YIN and without damp and hot, deficiency and coldness spermatorrhea, the careful clothes of collapse of QI person.Collective Notes to the Canon of Materia medica: " Chinese small iris makes for it.Dislike and hold back in vain.Fear Rhizoma Paridis tetraphyllae, Radix Sanguisorbae, Realgar, Radix Gentianae Macrophyllae, Carapax Et Plastrum Testudinis." " must book on Chinese herbal medicine be joined ": " collapse of QI, water dry up xerostomia all forbid ".

Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, there is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea, Semen Coicis can be used as medicine, and is used for treating edema, beriberi, diarrhea due to hypofunction of the spleen etc.Make skin smooth, reduce wrinkle, eliminate effect of pigment spot.Have obvious curative effect to face acne and pachylosis, in addition, it also has absorbability to ultraviolet, and its extractive matter adds in cosmetics also can reach sun-proof and effect that is anti-ultraviolet.Be suitable for various cancer patient, arthritis, acute and chronic nephritis edema, cancer ascites, puffiness of the face and limbs, vitamin B1 deficiency edema person, warty vegetation, beauty treatment person, juvenile verruca plana, common wart, molluscum contagiosum, young acne pimple and the coarse person of other skin malnutrition, be suitable for consumptive lung disease, lung abscess person eats.

Exocarpium Benincasae: sweet in the mouth, cold nature; Return lung meridian, spleen channel, small intestine meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " quench the thirst, expectorant, diuresis.Control apoplexy." clearing away heat and promoting diuresis, detumescence.Cure mainly edema, dysuria, have loose bowels, skin ulcer swells.This product is cool in nature, has the effect of clearing away summer-heat, thirsty for controlling summer summer-heat, oliguria with reddish urine.Non renal edema reconvalescent takes Exocarpium Benincasae decoct 2 liang orally, and the 1000ml that drinks water, discharge in 2 hours after the tablet has been ingested urine volume comparatively matched group significantly increase, between 2-4 hour, then comparatively matched group reduces.Human trial, these product 62g decocts as 100ml oral, separately makes own control with water 100ml, proves diuresis.

Stigma Maydis: sweet in the mouth is put down, Compendium of Material Medica: " Limonitum, hands, the positive bright blood system heavy prescription of foot are also.Its property is puckery, therefore all diseases before and after the main part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.The first poem of Li Zhi is said, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels has the difficult meeting of patient, must use surplus grain Halloysitum Rubrum." " book on Chinese herbal medicine is looked for the truth ": " Limonitum merit is identical with Halloysitum Rubrum, and the matter of Limonitum, overweight Halloysitum Rubrum, the temperature of Halloysitum Rubrum, too surplus grain, must distinguish." there is the effect such as inducing diuresis to remove edema, blood pressure lowering, hemostasis, function of gallbladder promoting, can various diseases be treated.Stigma Maydis can accelerate Blood Coagulation Process, improves number of platelets, can anti-hemolysis, so can to hold concurrently diuretic as hemorrhage, is applied to bladder and lithangiuria, can also be used for acute hemolytic anemia.Because it has anti-allergic effects, so also may be used for treating urticaria and asthma etc.The function of detoxification of Stigma Maydis can be used for treating mastitis etc.In addition, Stigma Maydis also has appetizing effect.

Calabash: calabash sweet in the mouth, property is smoothly nontoxic, and it is climing, palpus, leaf, flower, son, shell all can be used as medicine, and cures various diseases.Record according to ancient medical book, flower of Herba Eichhorniae sweet in the mouth, property is put down, nontoxic, can do the medicine detoxified, particularly effective to various fistula skin ulcer.Climing, must the property of medicine with spend identical, numb skin ulcer can be controlled.Calabash flesh and son, bitter in the mouth, cold in nature, poisonous, can odontopathy be controlled, gingiva or swollen or dew, odontoseisis.Appearance, edema in the extremities can be controlled again, urinary obstruction, nasal obstruction, and all carbuncle malignant boil.Especially the highest with the medical value of calabash shell, its sweet in the mouth, property is put down, and nontoxic, for heat reliving and toxin-eliminating, lung moistening is convenient.

Semen Hoveniae (Fructus Hoveniae): property is put down, sweet in the mouth.Enter heart channel, spleen channel.Supplement to the Herbal: " sharp defecation, go heat on diaphragm, function is as honey for relieving restlessness of quenching the thirst, moistening five ZANG-organs." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control the right paralysis of all left paralysiss, rheumatic numbness, energy alcoholic intoxication; Or steep in wine and take it, also can relaxing muscles and tendons network.Children's takes it, changes worm, supports spleen." relieving restlessness of quenching the thirst, disappear damp and hot, alcoholic intoxication.For middle alcoholism, excessive thirst vomiting, difficulty in urination and defecation.Semen Hoveniae (Fructus Hoveniae) has significant diuresis, and Semen Hoveniae (Fructus Hoveniae) Saponin has hypotensive effect, and Semen Hoveniae (Fructus Hoveniae) homogenate has lipoid peroxidization resistant and strengthens cold-resistant and heat-resisting function.Containing a large amount of glucose, organic acid in Semen Hoveniae (Fructus Hoveniae), the blood volume of human body can be expanded, again can alcoholic intoxication, therefore the effect having relieving alcoholic intoxication to calm the nerves.Containing a large amount of calcium and Semen Hoveniae (Fructus Hoveniae) Saponin in Semen Hoveniae (Fructus Hoveniae), there is central inhibitory action, can convulsion, prevent tetany spasm, can be used to the disease for the treatment of rheumatic arthralgia numbness.

Fructus Citri: acrid in the mouth, sweet, nontoxic." explaining abstruseness of the canon of materia medica ": " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is inverse, feed, spleen invigorating." " book on Chinese herbal medicine is new again ": " suppressing the hyperactive liver Shu Yu, reason lung qi, stimulate the menstrual flow diuretic, controls waist beriberi." function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.Boil wine to drink, control mental disorder cough.Decoct water, control pain due to disorder of QI under the heart.Root leaf is skin-deep same.These product are pungent can manage it loose, and the catharsis of bitter energy, enters Liver Channel and can unclog and readjust irritability and pain relieving.The strongly fragrant distending pain in the chest and hypochondrium for the treatment of the liver, gas perfume (or spice) is amusing, and pungent row hardship is let out, and enters taste with promoting the circulation of QI to alleviate the stagnation in middle-JIAO.With the abdominal distention controlling stagnation of QI in spleen and stomach, bitter dry the falling of these product is let out with preventing phlegm from forming and stopping coughing, and pungent row enters lung and the chest stuffiness relieving of regulating the flow of vital energy.With controlling abundant expectoration, cough, uncomfortable in chest etc.Hesperidin contained by these product to Cavia porcellus for want of vitamin C and cause eyes bulbar conjunctiva intravascular cells cohesion and capillary resistance reduce be improved effect, the cohesion of horse blood cell can be reduced.Hesperidin has prevention cold injury and suppresses the aldehyde reductase effect of rat lens.Obacunone has the effect strengthening isolated rabbit intestinal tension force and amplitude.

Radix Codonopsis: property is put down, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, and effect person of modern times joins and is more weak, is applicable to various deficiency of vital energy deficiency person.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to human body multi viscera, can improve the adaptability of human body.Have antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.In addition, these product are the normal and eliminating evil medicine compatibility such as diaphoretic medicine, cathartic drug also, and the card that the dominations of pathogen such as deficiency of qi and blood are weakened body resistance for deficiency of vital energy diseases caused by exogenous pathogenic factor or interior-excess accumulation of heat, with strengthening vital QI to eliminate pathogenic factors, makes to attack heresy and healthy energy is not hindered.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis." Bencao Jingshu ": " the real table of function, person does not use pathogenic factor in the exterior; Can help gas, QI excess person does not use; Can interiorly fill in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use; Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it; Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it; The many anger of patient, disharmony in liver-QI person do not take; Variola blood system heat is notably forbidden.”

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, Canis familiaris L. have effect.To not anaesthetizing Canis familiaris L. intravenous injection decoct 0.05-0.25g/kg, urine volume increase can reach more than 9 times, and medication after 5 hours still higher than normally.The Rhizoma Atractylodis Macrocephalae has obvious inhibitory action to platelet aggregation, Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg gavage l-4 week, the time of energy significant prolongation rat prothrombing.The Rhizoma Atractylodis Macrocephalae has vasorelaxation action.Be inhibitory action to heart, can cause when dosage is excessive and stop winning, anesthetized dog intravenous injection decoct 0.1g/kg, blood pressure slightly decline 0.25g/kg time, blood pressure sharply declines, and has no recovery in 3-4 hour.

Radix Rhodiolae: sweet is bitter, flat; Return lung, heart channel.Radix Rhodiolae is the dry root welding technology of crassulaceae plants Radix Rhodiolae, and effect of Radix Rhodiolae and effect are can the kidney invigorating, regulate the flow of vital energy and nourish blood, and has promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, the side effect of Radix Rhodiolae does not temporarily find.Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation is in a lot of advancing of disease process, plays very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Regarding assay utilizes mouse to make object, and test Radix Rhodiolae is movable to controlling the glycemic index of type-II diabetes, ferment and some antioxidative.

Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, enters liver, kidney channel, Compendium of Material Medica: " fill out bone marrow, longue meat, promoting generation of vital essence and blood.Tonifying five ZANG-organs internal injury is not enough, and promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." there is YIN nourishing of enriching blood, beneficial essence fills out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, and seminal emission sexual impotence, infertility, menoxenia, metrostaxis, early whitening of beard and hair, quenches one's thirst, the cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.This product character is sticky, and comparatively Radix Rehmanniae more very, hinders digestion, and all stagnation of QI abundant expectoration, abdominal distention, anorexia and loose stool person avoid clothes.Reuse for a long time clothes should with Pericarpium Citri Reticulatae, fry core and be equal to use, prevent from stickyly hindering stomach.Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress.Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis stove and simple necrosis.Wine Radix Rehmanniae Preparata and cook Radix Rehmanniae and have significant hypotensive effect, systolic pressure and diastolic pressure all significantly decline.

Fructus Broussonetiae: sweet, cold.Enter liver, spleen, kidney channel." Japan hanako materia medica ": " tonify deficiency labor, helps waist knee joint, beneficial color for strengthening bone and muscle, aid yang qi." " your name book on Chinese herbal medicine ": " strengthening bone and muscle, aid yang qi, tonify deficiency labor, help waist knee joint, beneficial color." the kidney invigorating liver heat removing, improving eyesight, diuresis.To swoon blurred vision, the raw nebula film of order, edema distension for soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, sand.Fructus Broussonetiae, book speech sweet in the mouth gas is trembled with fear, though have benefit in all dirty cloudy blood.Obtain this color profit, muscles and bones is strengthened, and waist knee joint is good for, and muscle fills, and edema disappears, so that impotence rises, and yang-energy helps, and be that its positive prosperous the moon of bright finger is weak, obtaining this cloudy blood has benefit, therefore sun can be made to help very, and non-cloud sexual impotence declines due to sun, and obtaining this can be also supporing yang.If can YANG invigorating with the product of pure the moon, then very do not conform in reason.Join book cloud again, bone available Fructus Broussonetiae of choking decocts soup with clothes, and paper ashing sustainability is taken after mixing with liquid, and to control metrorrhagia bruise, the empty people's forbidding of taste, clothes of a specified duration make us the atrophic debility of bones, Isn't that property belongs to YIN-cold, and void then by its benefit, crosses the meaning then increasing its evil.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.In vitro tests shows, Rhizoma Polygonati water extraction fluid (1:320) has inhibitory action to Bacillus typhi, staphylococcus aureus, acid-fast bacilli, and 2% Rhizoma Polygonati has inhibitory action in various degree to common causative fungus in sabouraud culture medium.Rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.The blood glucose that Rhizoma Polygonati extractum causes epinephrine is too high in remarkable inhibitory action.Rhizoma Polygonati decoct, 20% concentration is soaked Folium Mori and is fed silkworm, has the effect extending the silkworm larva phase.

Semen juglandis: sweet; Puckery; Warm in nature.Return kidney; Liver; Lung meridian; Function cures mainly: tonifying the kidney to consolidate the essence; Warming the lung Dingchuan; Loosening bowel to relieve constipation.Main lumbago flaccidity of the lower limbs; Frequent micturition; The enuresis; Sexual impotence; Seminal emission; Chronic cough dyspnea with rapid and short breath; Dryness of the intestine constipation; Stranguria caused by urinary stone and skin infection scrofula.

Radix caricis siderostictae: sweet in the mouth is pungent, warm in nature, nontoxic.Function cures mainly: control married woman's vim and vigour, and five kinds of strain and seven kinds of impairment.

Grass before water: pungent; Bitter; Cool.Return liver; Urinary bladder channel.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main anemopyretic cold; Laryngopharynx swelling and pain; Jaundice; Gonorrhea; Edema; Arthritis; Carbuncle; Burn.

Pericarpium Lagenariae hispidae: bitter in the mouth; Light; Cold in nature.Function cures mainly: inducing diuresis to remove edema.Interarea order extremity edema; Expand; Urinary obstruction.

Box fruit rattan: sweet, micro-pungent, flat.Function cures mainly: inducing diuresis to remove edema, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly edema, constipation; The anaphase of bone fracture meridians contracture is controlled in external.

Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Function cures mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.

Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Folium Sennae 10-25 weight portion, Aloe 15-28 weight portion, Semen Pruni 10-20 weight portion, Radix Kansui 10-20 weight portion, Flos Genkwa 10-20 weight portion, Radix Phytolaccae 10-20 weight portion, decorated archway seven 15-25 weight portion, Caulis Sinomenii 10-20 weight portion, Radix Stephaniae Tetrandrae 10-25 weight portion, Fructus Liquidambaris 15-28 weight portion, Cortex Acanthopancis 10-25 weight portion, Rhizoma Atractylodis 15-28 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Fructus Amomi 10-15 weight portion, Fructus Tsaoko 10-20 weight portion, Poria 15-23 weight portion, Semen Coicis 15-28 weight portion, Exocarpium Benincasae 15-25 weight portion, Stigma Maydis 10-25 weight portion, calabash 10-25 weight portion, Semen Hoveniae (Fructus Hoveniae) 15-25 weight portion, Fructus Citri 10-15 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Fructus Broussonetiae 10-25 weight portion and Rhizoma Polygonati 10-20 weight portion.

When the dosage form of described pharmaceutical composition is tablet, described preparation method comprises the following steps:

When the dosage form of pharmaceutical composition is oral liquid, described preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

Embodiments provide a kind of pharmaceutical composition being used for the treatment of tuberculous pleural effusion, the parts by weight of its each raw medicinal material are: Folium Sennae 18 weight portion, Aloe 21 weight portion, Semen Pruni 15 weight portion, Radix Kansui 15 weight portion, Flos Genkwa 17 weight portion, Radix Phytolaccae 12 weight portion, decorated archway 7 19 weight portion, Caulis Sinomenii 15 weight portion, Radix Stephaniae Tetrandrae 17 weight portion, Fructus Liquidambaris 22 weight portion, Cortex Acanthopancis 18 weight portion, Rhizoma Atractylodis 21 weight portion, Cortex Magnoliae Officinalis 22 weight portion, Fructus Amomi 12 weight portion, Fructus Tsaoko 13 weight portion, Poria 20 weight portion, Semen Coicis 23 weight portion, Exocarpium Benincasae 19 weight portion, Stigma Maydis 19 weight portion, calabash 20 weight portion, Semen Hoveniae (Fructus Hoveniae) 19 weight portion, Fructus Citri 12 weight portion, Radix Codonopsis 18 weight portion, the Radix Astragali 17 weight portion, the Rhizoma Atractylodis Macrocephalae 18 weight portion, Radix Rhodiolae 17 weight portion, Radix Rehmanniae Preparata 13 weight portion, Fructus Broussonetiae 17 weight portion and Rhizoma Polygonati 15 weight portion.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 340 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.25 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 oral liquid

Embodiments provide a kind of pharmaceutical composition being used for the treatment of tuberculous pleural effusion, the parts by weight of its each raw medicinal material are: Folium Sennae 17 weight portion, Aloe 18 weight portion, Semen Pruni 15 weight portion, Radix Kansui 15 weight portion, Flos Genkwa 15 weight portion, Radix Phytolaccae 15 weight portion, decorated archway 7 20 weight portion, Caulis Sinomenii 15 weight portion, Radix Stephaniae Tetrandrae 17 weight portion, Fructus Liquidambaris 19 weight portion, Cortex Acanthopancis 17 weight portion, Rhizoma Atractylodis 19 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Fructus Amomi 12 weight portion, Fructus Tsaoko 15 weight portion, Poria 18 weight portion, Semen Coicis 18 weight portion, Exocarpium Benincasae 21 weight portion, Stigma Maydis 18 weight portion, calabash 17 weight portion, Semen Hoveniae (Fructus Hoveniae) 20 weight portion, Fructus Citri 12 weight portion, Radix Codonopsis 15 weight portion, the Radix Astragali 15 weight portion, the Rhizoma Atractylodis Macrocephalae 15 weight portion, Radix Rhodiolae 18 weight portion, Radix Rehmanniae Preparata 15 weight portion, Fructus Broussonetiae 17 weight portion, Rhizoma Polygonati 15 weight portion, semen juglandis 20 weight portion, Radix caricis siderostictae 15 weight portion, careless 18 weight portions before water, Pericarpium Lagenariae hispidae 18 weight portion, box fruit rattan 17 weight portion and Fructus Jujubae 15 weight portion.

Its preparation method comprises the following steps:

The first step, mixes Radix Stephaniae Tetrandrae, Fructus Liquidambaris, Cortex Acanthopancis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis and the Radix Astragali, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 3 times, each 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 3 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.33;

3rd step, the described mastic mixing that the first step, second step are obtained, 75 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 36 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.25; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 70 minutes, and temperature is 160 DEG C;

Toxicity test

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data

Case selection: fetch the 126 routine tuberculous pleural effusion patients coming from the court patient, man 67 example, female 59 example; Age 29-60 year.126 routine patients are divided into 3 groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, sex, age, hydrothorax degree before three groups of patient treatments, to fall ill to the situation such as consultation time, clinical symptoms through statistical procedures there are no significant difference, there is comparability.

Wherein, before all above-mentioned patients make a definite diagnosis rear any treatment and when checking after treatment, chest x-ray and CT examination must be done, hydrothorax amount is measured, and pleura thickness change before and after comparison therapy, adhesion and parcel situation.The hydrothorax amount criteria for classifying: a, a small amount of hydrops: the visible hydrothorax of x-ray rabat is the below horizontal or only rib diaphragm angle person of flattening at front four ribs, b, middle amount hydrops: the visible hydrothorax of x-ray the first two rib person below horizontal, c, a large amount of hydrops: the visible hydrothorax of x-ray is the above person of the first two rib level.

Diagnostic criteria: (1) can have the clinical symptoms such as heating, cough, uncomfortable in chest, chest pain; (2) hydrothorax sign is had; (3) chest x-ray, the impact of B ultrasonic fire spiral CT are learned and are checked display hydrothorax; (4) hydrothorax inspection: a, transudate is met, leukocyte count increases, based on lymphocyte and mononuclear cell, b, chest fluid ADA Adenosine deaminase (ADA) are greater than 45U/L, chest fluid ADA/ serum ADA > 1, c, tuberculin test are strong positive, d, biopsy of pleura: pleura has typical Tuberculous pathological change to make a definite diagnosis, e, except the hydrothorax that causes of other reasons, antituberculosis therapy effectively can be diagnosed.

Case inclusive criteria: (1) age 25-60 one full year of life, (2) meet inclusive criteria, diagnostic criteria, (3) course of disease≤6 week, (4) experimenter's voluntary participation clinical investigation, and sign Informed Consent Form.

Case discharges standard: (1) age is not within 25-60 one full year of life, (2) other inflammatory hydrothorax, Cancerous Pleural Effusion and mesothelioma of pleura etc., (3) course of disease was more than 6 weeks, (4) bronchopleural fistula patient, (5) severe cardiac, lung, liver, kidney and nerve, psychiatric patient, (6) gestation and women breast-feeding their children.

Therapeutic Method:

Embodiment group 1: take tablet prepared by the embodiment of the present invention 1, every day three times, each 4 15 days is a course for the treatment of, treats 2-12 the course for the treatment of continuously;

Embodiment group 2: take oral liquid prepared by the embodiment of the present invention 2, every day three times, each 30ml 15 days is a course for the treatment of, treats 2-12 the course for the treatment of continuously;

Matched group: usage chain mycin (SM), isoniazid (INH) and rifampicin (RFP) therapeutic alliance, streptomycin intramuscular injection, isoniazid and rifampicin decoction being taken at a draught, oral drugs take half a year all continuously to a year and a half;

Wherein, treatment time monthly to calculate for 30 days; In above-mentioned experimental group, the patient belonging to a large amount of hydrops not only needs to use said method to treat, and also needs regularly to carry out tapping, and tapping is until after hydrops amount is reduced to middle amount hydrops standard, only adopt above-mentioned Therapeutic Method to proceed treatment.

The standard of curative effect evaluation:

(1) fully recover: clinical symptom disappearance, breast CT or x-ray check that hydrothorax all absorbs, without pachynsis pleurae and adhesion, and nothing recurrence in two months;

(2) effective: clinical symptom disappearance, breast CT or x-ray check that hydrothorax all absorbs, slight pachynsis pleurae and adhesion, and nothing recurrence in two months;

(3) take a turn for the better: clinical symptoms takes a turn for the better, breast CT or x-ray check that hydrothorax major part absorbs, companion's pachynsis pleurae, adhesion and parcel;

(4) invalid: not reach above therapeutic effect, breast CT or x-ray inspection form encapsulated effusion with pachynsis and adherence of pleura;

Wherein, reach recovery from illness and be effectively effective, surface treatment is effective.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt the pharmaceutical composition of medicine composite for curing tuberculous pleural effusion of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt medicine composite for curing tuberculous pleural effusion of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

The each experimental group of table 1 is treated respectively and is terminated rear Clinical efficacy comparison example

Group	Number of cases	Recovery from illness	Effective	Take a turn for the better	Invalid	Effective percentage
							Embodiment group 1	42	21	12	7	2	78.57%
Embodiment group 2	42	23	11	8	0	80.95%
							Matched group	42	13	11	11	7	57.14%

The each experimental group of table 2 is treated respectively and is terminated rear healing and effective number and time comparative example (%)

Group	Number of cases	1-2 month	3-4 month	5-6 month	7-18 month
						Embodiment group 1	33	8（24.2%）	15（45.5%）	10（30.3%）	0（0%）
Embodiment group 2	34	9（26.5%）	16（47.1%）	9（26.5%）	0（0%）
						Matched group	24	5（20.8%）	4（16.7%）	7（29.2%）	8（33.3%）

According to the clinical statistics in above table, pharmaceutical composition provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Cure embodiment group 1-2 and matched group and effective follow-up of patients 1 year, result is added up simultaneously, and in the healing of embodiment group 1 and effective 33 routine patients, cure patient and all do not recur, have 1 example to recur in effective 12 routine patients, relapse rate is 3%; In the healing of embodiment group 2 and effective 34 routine patients, cure patient and effective patient is recurrence; In the healing of matched group and effective 24 routine patients, 13 examples are cured in patients 3 example recurrences, and have 5 routine Patients on Recurrences in 11 routine effective patients, relapse rate is 33.3%.

Model case: Lin, man, 46 years old, there is the symptom of heating, cough and chest pain, above-mentioned symptom continues to come to go to a doctor for one month, chest X-ray display hydrothorax, belong to middle amount hydrops, diagnostic puncture hydrothorax checks: transudate leukocyte count increases, and based on lymphocyte and mononuclear cell, chest fluid ADA Adenosine deaminase (ADA) is greater than 45U/L, chest fluid ADA/ serum ADA > 1, tuberculin test is strong positive, and pleura has typical Tuberculous pathological change to make a definite diagnosis, and is diagnosed as tuberculous pleural effusion.Use the oral liquid of the embodiment of the present invention 2 to treat, every day three times, each 30ml 15 days is a course for the treatment of, treats 4 courses for the treatment of continuously, is almost recovered, continues to take 2 courses for the treatment of, recovery from illness, follows up a case by regular visits to 1 year without recurrence.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. be used for the treatment of the pharmaceutical composition of tuberculous pleural effusion, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: grass, Pericarpium Lagenariae hispidae, box fruit rattan and Fructus Jujubae before Folium Sennae, Aloe, Semen Pruni, Radix Kansui, Flos Genkwa, Radix Phytolaccae, decorated archway seven, Caulis Sinomenii, Radix Stephaniae Tetrandrae, Fructus Liquidambaris, Cortex Acanthopancis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Fructus Amomi, Fructus Tsaoko, Poria, Semen Coicis, Exocarpium Benincasae, Stigma Maydis, calabash, Semen Hoveniae (Fructus Hoveniae), Fructus Citri, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Rhodiolae, Radix Rehmanniae Preparata, Fructus Broussonetiae, Rhizoma Polygonati, semen juglandis, Radix caricis siderostictae, water.

2. the pharmaceutical composition being used for the treatment of tuberculous pleural effusion according to claim 1, is characterized in that, described pharmaceutical composition is made up of the raw medicinal material of following parts by weight: Folium Sennae 10-25 weight portion, Aloe 15-28 weight portion, Semen Pruni 10-20 weight portion, Radix Kansui 10-20 weight portion, Flos Genkwa 10-20 weight portion, Radix Phytolaccae 10-20 weight portion, decorated archway seven 15-25 weight portion, Caulis Sinomenii 10-20 weight portion, Radix Stephaniae Tetrandrae 10-25 weight portion, Fructus Liquidambaris 15-28 weight portion, Cortex Acanthopancis 10-25 weight portion, Rhizoma Atractylodis 15-28 weight portion, Cortex Magnoliae Officinalis 15-28 weight portion, Fructus Amomi 10-15 weight portion, Fructus Tsaoko 10-20 weight portion, Poria 15-23 weight portion, Semen Coicis 15-28 weight portion, Exocarpium Benincasae 15-25 weight portion, Stigma Maydis 10-25 weight portion, calabash 10-25 weight portion, Semen Hoveniae (Fructus Hoveniae) 15-25 weight portion, Fructus Citri 10-15 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Radix Rhodiolae 15-20 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Fructus Broussonetiae 10-25 weight portion, Rhizoma Polygonati 10-20 weight portion, semen juglandis 15-25 weight portion, Radix caricis siderostictae 10-20 weight portion, careless 15-20 weight portion before water, Pericarpium Lagenariae hispidae 10-25 weight portion, box fruit rattan 15-20 weight portion and Fructus Jujubae 10-20 weight portion.

3. the pharmaceutical composition being used for the treatment of tuberculous pleural effusion according to claim 1 and 2, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Folium Sennae 17 weight portion, Aloe 18 weight portion, Semen Pruni 15 weight portion, Radix Kansui 15 weight portion, Flos Genkwa 15 weight portion, Radix Phytolaccae 15 weight portion, decorated archway 7 20 weight portion, Caulis Sinomenii 15 weight portion, Radix Stephaniae Tetrandrae 17 weight portion, Fructus Liquidambaris 19 weight portion, Cortex Acanthopancis 17 weight portion, Rhizoma Atractylodis 19 weight portion, Cortex Magnoliae Officinalis 23 weight portion, Fructus Amomi 12 weight portion, Fructus Tsaoko 15 weight portion, Poria 18 weight portion, Semen Coicis 18 weight portion, Exocarpium Benincasae 21 weight portion, Stigma Maydis 18 weight portion, calabash 17 weight portion, Semen Hoveniae (Fructus Hoveniae) 20 weight portion, Fructus Citri 12 weight portion, Radix Codonopsis 15 weight portion, the Radix Astragali 15 weight portion, the Rhizoma Atractylodis Macrocephalae 15 weight portion, Radix Rhodiolae 18 weight portion, Radix Rehmanniae Preparata 15 weight portion, Fructus Broussonetiae 17 weight portion, Rhizoma Polygonati 15 weight portion, semen juglandis 20 weight portion, Radix caricis siderostictae 15 weight portion, careless 18 weight portions before water, Pericarpium Lagenariae hispidae 18 weight portion, box fruit rattan 17 weight portion and Fructus Jujubae 15 weight portion.

4. the preparation method being used for the treatment of the pharmaceutical composition of tuberculous pleural effusion according to any one of claim 1-3, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and described preparation method comprises the following steps:

5. the preparation method being used for the treatment of the pharmaceutical composition of tuberculous pleural effusion according to any one of claim 1-4, is characterized in that, the dosage form of described pharmaceutical composition is oral liquid, and described preparation method comprises the following steps: