CN105233012A - Pharmaceutical composition promoting wound healing and application thereof - Google Patents
Pharmaceutical composition promoting wound healing and application thereof Download PDFInfo
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- CN105233012A CN105233012A CN201510604884.6A CN201510604884A CN105233012A CN 105233012 A CN105233012 A CN 105233012A CN 201510604884 A CN201510604884 A CN 201510604884A CN 105233012 A CN105233012 A CN 105233012A
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Abstract
The invention relates to a pharmaceutical composition promoting wound healing and application thereof. The composition is prepared from, by weight, 28-36 parts of rhizome of Paris chinensis, 26-35 parts of corn stigma, 10-15 parts of oriental paperbush flower, 12-18 parts of Arnebia root, 26-35 parts of Chinese sage herb, and 26-35 parts of Chinese fan palm seed. The composition may promote local blood circulation of a wound through external treatment to reduce local swelling of the wound, thus being good for healing of a stasis zone, shedding of necrotic tissues and growth of epithelial tissues; the composition can heal the wound within a short time and enables pathological scars after healing to be substantially reduced.
Description
Technical field
The invention belongs to medical art, the pharmaceutical composition promoting wound and wound surface to heal in particular to a kind of and application thereof.
Background technology
Skin is the maximum organ of human body, is also one of most important organ of human body, mainly carries protection health, perspire, feels cold and hot and the function of pressure; Skin covers whole body, and it to make in body various tissue and organ from the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.Meanwhile, skin trauma is also a kind of common surgery frequently-occurring disease, and the factors such as the burn in daily life, scald, knife injury, infection, medicine and immunoreation all may make skin histology sustain damage.It is more of a specified duration that the healing of wound delays, and the cicatrix after healing is also more not easy disappearance, the chronic dermal chronic ulcer such as all kinds of skin surface ulcer of decubital ulcer and diabetics then more needed to the quick growth reparation of superficial epithelium.Therefore, to the ideal treatment index of all kinds of skin trauma be control secondary infection and promote wound healing.
Summary of the invention
In view of the inherent advantage that the traditional Chinese medical science exists in treatment wound, the object of the present invention is to provide a kind of pharmaceutical composition promoting wound and wound surface to heal.
In order to realize object of the present invention, inventor, by lot of experiments research also persistent exploration, finally obtains following technical scheme:
A kind of pharmaceutical composition promoting wound and wound surface to heal, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Rhizoma Paridis 28-36 part, Stigma Maydis 26-35 part, flowers of Edgeworthia chrysantha Lindl 10-15 part, Radix Arnebiae (Radix Lithospermi) 12-18 part, Herba Salviae Chinensis 26-35 part, Chinese fanpalm seed 26-35 part.
Further preferably, a kind of pharmaceutical composition promoting wound and wound surface to heal as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Rhizoma Paridis 31-34 part, Stigma Maydis 29-31 part, flowers of Edgeworthia chrysantha Lindl 11-13 part, Radix Arnebiae (Radix Lithospermi) 14-16 part, Herba Salviae Chinensis 29-31 part, Chinese fanpalm seed 29-31 part.
In the most preferred embodiment of the present invention, a kind of pharmaceutical composition promoting wound and wound surface to heal as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Rhizoma Paridis 33 parts, Stigma Maydis 30 parts, flowers of Edgeworthia chrysantha Lindl 12 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Salviae Chinensis 30 parts, Chinese fanpalm seed 30 parts.
Above-mentioned traditional Chinese medicinal material raw materials compositions promotes the application in the external used medicine of wound and wound surface healing in preparation.External used medicine preferably described further comprises gel, ointment and ointment.
The preparation method of the pharmaceutical composition of the promotion wound and wound surface healing that the present invention relates to comprises the steps: to take Rhizoma Paridis 28-36 part, Stigma Maydis 26-35 part, flowers of Edgeworthia chrysantha Lindl 10-15 part, Radix Arnebiae (Radix Lithospermi) 12-18 part, Herba Salviae Chinensis 26-35 part and Chinese fanpalm seed 26-35 part, mixing, be placed in extraction vessel, add purified water, soak, then intense fire boils rear slow fire boiling 0.5-2 hour, filter to get filtrate, filtering residue repeats to extract 1-3 time, merging filtrate, heating is concentrated into thick paste, dry, pulverize, obtain extract dry powder, then gel is mixed with into substrate, ointment or ointment.
It should be noted that, the Chinese crude drug of pharmaceutical composition of the present invention selected by preparation process has following source: Rhizoma Paridis selects the dry rhizome of liliaceous plant China Rhizoma Paridis ParischinensisFranch..Stigma Maydis selects dry style and the fresh idea of grass family Zea plant Zea mays ZeamaysL..Flowers of Edgeworthia chrysantha Lindl selects the alabastrum of Isolated From Thymelaeaceae Species Edgeworthia chrysantha Lindl. EdgeworthiachrysanthaLindl..Radix Arnebiae (Radix Lithospermi) selects the dry root of comfrey Radix Arnebiae (Radix Lithospermi) LithospermumerythrorhizonSieb.etZucc..Herba Salviae Chinensis selects the dry herb of Lamiaceae Salvia platymiscium Herba Salviae Chinensis SalviachinensiaBenth..Chinese fanpalm seed selects the dry seed of babassu Semen livistonae chinensis Livistonachinensis (Jacq.) R.Br..
Found by animal experiment research, golden pharmaceutical composition of the present invention significantly can shorten wound healing time by external, and short time internal therapy can improve Wound healing rate.Based on above result of study, the present invention also provides a kind of pharmaceutical applications, that is: above-mentioned traditional Chinese medicinal material raw materials compositions promotes the purposes in the external used medicine of wound and wound surface healing in preparation.
Compared with prior art, pharmaceutical composition of the present invention can promote wound surface local blood circulation by external curing, alleviate wound surface local swelling, therefore be conducive to the growth of the recovery of wound surface blood stasis and stagnant zone, the coming off of slough, epithelial tissue, it can reach the object of healing within a short period of time, makes to greatly reduce pathologic scar more afterwards.Meanwhile, this medicine preparation technology is simple, with low cost, easy to use and safety, is convenient to town and country extensive use.
Detailed description of the invention
Following examples are only some embodiments of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from essentiality content of the present invention; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
The preparation of embodiment 1 extract A ointment
Take Rhizoma Paridis 3.3kg, Stigma Maydis 3.0kg, flowers of Edgeworthia chrysantha Lindl 1.2kg, Radix Arnebiae (Radix Lithospermi) 1.5kg, Herba Salviae Chinensis 3.0kg and Chinese fanpalm seed 3.0kg, mixing, be placed in extraction vessel, add 15 times of purified water, soak 30 minutes, then intense fire boils rear slow fire boiling 1 hour, and four layers of filtered through gauze obtain filtrate, and filtering residue repeats to extract once, merge twice filtrate, heating is concentrated into thick paste, dry, pulverize, obtain extract dry powder A.
Accurately take 5g extract dry powder A, in the vaseline joining 25g melting and 20mL soybean oil, stir, precision takes 0.5g ethyl hydroxybenzoate as antiseptic, adds, and mixing, obtains extract A ointment.
Embodiment 2: the preparation of extract B ointment
Take Rhizoma Paridis 3.3kg, Stigma Maydis 3.0kg and Radix Arnebiae (Radix Lithospermi) 1.5kg, mixing, be placed in extraction vessel, add 15 times of purified water, soak 30 minutes, then intense fire boils rear slow fire boiling 1 hour, four layers of filtered through gauze obtain filtrate, and filtering residue repeats to extract once, merges twice filtrate, heating is concentrated into thick paste, dry, pulverize, obtain extract dry powder B.
Accurately take 5g extract dry powder B, in the vaseline joining 25g melting and 20mL soybean oil, stir, precision takes 0.5g ethyl hydroxybenzoate as antiseptic, adds, and mixing, obtains extract B ointment.
Embodiment 3: Chinese medicine ointment is tested the impact of mice wound tissue healing effect
SPF level KM mice 36, female, weight 18 ~ 22g, is divided into model control group, test A group and test B group at random by weight after adaptability raises one week, often organizes 12 mices.Back depilation is carried out with 10% sodium sulfide, the next day with 5% chloral hydrate intraperitoneal injection of anesthesia, 3cm × 4cm iron staff is placed in boiling water 10min, take out iron staff and be affixed on depilation mouse back immediately without hair position also lasting 10s, copy deep II degree burn wound model, wound area is about 1cm × 2cm, drug treatment immediately after wound, 2 times/d.Test A group gives extract A ointment prepared by embodiment 1 and is coated with outward and treats, and test B group gives extract B ointment prepared by embodiment 2 and treats, and model control group all adopts the blank ointment base of not dosing to carry out exterior coating treatment.After treatment 10d, measure Wound healing rate, method is as follows: traced on onionskin by wound surface, then as template, homogeneous hard paper is cut into pattern size, indirectly represents wound surface size with hard paper weight.Not Wound healing rate (%)=(scalding area-do not heal wound surface area in beginning)/start scalding area.In addition, record and add up time of each group of wounds in mice healing.Can be found out by the test statistics result of table 1, compare with model control group, test A group significantly can shorten wound healing time (P < 0.01), improve Wound healing rate (P < 0.01), and test B group and in 10d Wound healing rate, compare model control group make moderate progress (P < 0.05), but in the effect accelerated in wound healing time and not obvious (P > 0.05), this imply that pharmaceutical composition of the present invention has and promote skin wound healing effect preferably.
Table 1 respectively group mice wound tissue healing situation compares
Compare with model control group,
★p < 0.05;
★ ★p < 0.01; Compare with test B group,
p < 0.05;
p < 0.01.
Claims (5)
1. the pharmaceutical composition promoting wound and wound surface to heal, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, it is characterized in that, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Rhizoma Paridis 28-36 part, Stigma Maydis 26-35 part, flowers of Edgeworthia chrysantha Lindl 10-15 part, Radix Arnebiae (Radix Lithospermi) 12-18 part, Herba Salviae Chinensis 26-35 part, Chinese fanpalm seed 26-35 part.
2. a kind of pharmaceutical composition promoting wound and wound surface to heal as claimed in claim 1, it is characterized in that: described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Rhizoma Paridis 31-34 part, Stigma Maydis 29-31 part, flowers of Edgeworthia chrysantha Lindl 11-13 part, Radix Arnebiae (Radix Lithospermi) 14-16 part, Herba Salviae Chinensis 29-31 part, Chinese fanpalm seed 29-31 part.
3. a kind of pharmaceutical composition promoting wound and wound surface to heal as claimed in claim 2, it is characterized in that, described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Rhizoma Paridis 33 parts, Stigma Maydis 30 parts, flowers of Edgeworthia chrysantha Lindl 12 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Herba Salviae Chinensis 30 parts, Chinese fanpalm seed 30 parts.
4. the traditional Chinese medicinal material raw materials compositions described in any one of claim 1-3 promotes the application in the external used medicine of wound and wound surface healing in preparation.
5. application according to claim 4, is characterized in that, described external used medicine comprises gel, ointment and ointment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510604884.6A CN105233012A (en) | 2015-09-22 | 2015-09-22 | Pharmaceutical composition promoting wound healing and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510604884.6A CN105233012A (en) | 2015-09-22 | 2015-09-22 | Pharmaceutical composition promoting wound healing and application thereof |
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| Publication Number | Publication Date |
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| CN105233012A true CN105233012A (en) | 2016-01-13 |
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| CN201510604884.6A Pending CN105233012A (en) | 2015-09-22 | 2015-09-22 | Pharmaceutical composition promoting wound healing and application thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003306446A (en) * | 2002-02-14 | 2003-10-28 | Fancl Corp | Skin ageing-preventing agent and/or pimple-improving agent kit |
| CN104523780A (en) * | 2014-12-25 | 2015-04-22 | 李健 | Pharmaceutical composition for promoting healing of skin wound and preparation method of pharmaceutical composition |
-
2015
- 2015-09-22 CN CN201510604884.6A patent/CN105233012A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003306446A (en) * | 2002-02-14 | 2003-10-28 | Fancl Corp | Skin ageing-preventing agent and/or pimple-improving agent kit |
| CN104523780A (en) * | 2014-12-25 | 2015-04-22 | 李健 | Pharmaceutical composition for promoting healing of skin wound and preparation method of pharmaceutical composition |
Non-Patent Citations (2)
| Title |
|---|
| 何一成: "《糖尿病就要这样吃》", 30 June 2014 * |
| 张俊庭: "《中华名医高新诊疗通鉴》", 31 May 2000 * |
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Application publication date: 20160113 |