CN105232398A - Biologically-allergy-proof cosmetic composition and preparation method thereof - Google Patents
Biologically-allergy-proof cosmetic composition and preparation method thereof Download PDFInfo
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- CN105232398A CN105232398A CN201510731970.3A CN201510731970A CN105232398A CN 105232398 A CN105232398 A CN 105232398A CN 201510731970 A CN201510731970 A CN 201510731970A CN 105232398 A CN105232398 A CN 105232398A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention provides a biologically-allergy-proof cosmetic composition. The biologically-allergy-proof cosmetic composition is prepared from the following components in parts by weight: 70-85 parts of mycosporine-like amino acid, 1-10 parts of a water-soluble ultraviolet light absorber, 10-15 parts of a superfine powder pigment, and 0.20-0.45 part of bisabolol. The invention further provides a preparation method of the biologically-allergy-proof cosmetic composition. The biologically-allergy-proof cosmetic composition has the beneficial effect of resisting ultraviolet rays and allergy without chemical stimulation.
Description
Technical field
The present invention relates to hypo-allergenic cosmetic technical field.More particularly, the present invention relates to the hypo-allergenic cosmetic composition of biology of anti-ultraviolet and the hypo-allergenic excellent specific property had without chemical stimulation.
Background technology
When Ozone hole problem is day by day serious, the ultraviolet radiation (especially UVB) arriving ground and water body is more and more stronger.The effect of the ultraviolet radiation that all aquatiles all may be strengthened day by day, these effects comprise the change of the macromolecular substances such as protein and DNA structure, and the chronic suppression of reacting some key physiological and acute injury etc.
In addition, along with the obvious decline of air quality, skin contact allergy or damage also annoying people, moreover, the electronic product such as computer of our contact skin at ordinary times, and and experience less than computer, mobile phone, microwave oven, bat X-ray all can be subjected to electromagenetic wave radiation, cause the change of skin corium cell function, very large to skin lesion, and belong to the injury of accumulation property, can cause that skin is dark and gloomy, aging, even canceration, along with people are to the raising of the requirement of cosmetics quality, biological Pure natural cosmetic more and more obtains popular liking.
Bisabolol has good stability and good skin-friendliness, and long-term preservation can not variable color, also can not ooze out plastic containers, not only have antiinflammatory performance, be also proved to be bacteriostatic activity.
Summary of the invention
As the result of various extensive and careful research and experiment, the present inventor has been found that, when adding pure-natural biological composition containing specific anti-ultraviolet and hypo-allergenic natural plant extract in cosmetics, described biological components contributes to improving the anti-ultraviolet of cosmetics and hypo-allergenic performance.Based on this discovery, complete the present invention.
An object of the present invention is to solve at least the problems referred to above or defect, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide a kind of hypo-allergenic cosmetic composition of biology with anti-ultraviolet, it can by adding the composition of the anti-ultraviolet equivalent damage skin of biological pure natural, prevent the damage of outer bound pair skin, skin is had no stimulation, use natural gentleness.
A further object of the invention is the hypo-allergenic material bisabolol by adding in the hypo-allergenic cosmetic composition of biology by extracting from Chamomile; improve the utilization rate containing various effective ingredient plant, better pure natural plant ingredients that is moist and protective effect is played to skin to obtain.
In order to realize according to these objects of the present invention and other advantage, provide a kind of biological hypo-allergenic cosmetic composition, described compositions comprises following component by weight: 70 ~ 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 ~ 10 part, superfine powder pigment 10 ~ 15 parts, bisabolol 0.20 ~ 0.45 part.
Preferably, wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property.
Preferably, wherein, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization.
Preferably, wherein, described acrylamides is the one in acrylamide, N, N-dimethylaminopropylacryl amide and N, N-diethyl amino propyl acrylamide.
Preferably, wherein, the hypo-allergenic cosmetic composition of described biology comprises by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts, bisabolol 0.35 part.
Object of the present invention still further provides the preparation method of biological hypo-allergenic cosmetic composition, and described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to acrylamide, N, N-dimethylaminopropylacryl amide or N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, acrylamide, N, N-dimethylaminopropylacryl amide or N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1 ~ 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The extraction of step 3, bisabolol: choose the extraction source of Chamomile as bisabolol, bisabolol is extracted, specifically comprise: adopt the bisabolol active component of subcritical alcohol extraction process to Chamomile to carry out extraction and obtain bisabolol extracting solution, adopted by described bisabolol extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain bisabolol viscous liquid, wherein, the alcohol that described subcritical alcohol extraction process adopts is ethanol, Extracting temperature is 135 ~ 145 DEG C, extraction time is 48 ~ 50min, and liquid ratio is (13 ~ 15): 1;
Step 4, the preparation of biological hypo-allergenic cosmetic composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, class mycetocyte element sample aminoacid 70 ~ 85 weight portion that described step one is obtained, dissolve after water-soluble copolymer product 1 ~ 10 weight portion of the powder solid that described step 2 obtains and bisabolol viscous liquid 0.20 ~ 0.45 weight portion obtained mixing of described step 3, add superfine powder pigment described in 10-15 weight portion wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological hypo-allergenic cosmetic composition.
Preferably, wherein, in described step 2 acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1.
Preferably, wherein, in described step 3, the Extracting temperature of described subcritical alcohol extraction process is 140 DEG C, and extraction time is 50min, and liquid ratio is 14: 1.
Preferably, wherein, what the ultramicronising in described step 4 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
The present invention at least comprises following beneficial effect:
The biological hypo-allergenic cosmetic composition of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in Traditional makeup, adopt Pure natural cosmetic composition, therefore, it is possible to effective protection skin is not by the damage of the foul such as extraneous various ray and grieshoch, adopt biological anti-ultraviolet composition and hypo-allergenic composition, total care is carried out to skin, the crowd of sensitive skin can be widely used in; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising has been carried out to the hypo-allergenic cosmetic composition of biology formed, skin can be absorbed better.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below in conjunction with the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
< example 1>
A kind of biological hypo-allergenic cosmetic composition, described compositions comprises following component by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts, bisabolol 0.35 part.
Wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization, acrylamides is N, N-diethyl amino propyl acrylamide.
The preparation method of the hypo-allergenic cosmetic composition of described biology, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The extraction of step 3, bisabolol: choose the extraction source of Chamomile as bisabolol, bisabolol is extracted, specifically comprise: adopt the bisabolol active component of subcritical alcohol extraction process to Chamomile to carry out extraction and obtain bisabolol extracting solution, adopted by described bisabolol extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain bisabolol viscous liquid, wherein, the alcohol that described subcritical alcohol extraction process adopts is ethanol, Extracting temperature is 140 DEG C, extraction time is 50min, and liquid ratio is 14: 1;
Step 4, the preparation of biological hypo-allergenic cosmetic composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, class mycetocyte element sample aminoacid 80 weight portion that described step one is obtained, dissolve after water-soluble copolymer product 8 weight portion of the powder solid that described step 2 obtains and bisabolol viscous liquid 0.35 weight portion obtained mixing of described step 3, add superfine powder pigment described in 12 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological hypo-allergenic cosmetic composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 160MPa, operating temperature is 25 DEG C.
The obtained hypo-allergenic cosmetic composition of biology is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 2>
A kind of biological hypo-allergenic cosmetic composition, described compositions comprises following component by weight: 70 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 part, superfine powder pigment 10 parts, bisabolol 0.20 part.
Wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization, acrylamides is N, N-dimethylaminopropylacryl amide.
The preparation method of the hypo-allergenic cosmetic composition of described biology, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to N, the acetonitrile solution of N-dimethylaminopropylacryl amide, wherein, N, N-dimethylaminopropylacryl amide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The extraction of step 3, bisabolol: choose the extraction source of Chamomile as bisabolol, bisabolol is extracted, specifically comprise: adopt the bisabolol active component of subcritical alcohol extraction process to Chamomile to carry out extraction and obtain bisabolol extracting solution, adopted by described bisabolol extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain bisabolol viscous liquid, wherein, the alcohol that described subcritical alcohol extraction process adopts is ethanol, Extracting temperature is 135 DEG C, extraction time is 50min, and liquid ratio is 13: 1;
Step 4, the preparation of biological hypo-allergenic cosmetic composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, class mycetocyte element sample aminoacid 70 weight portion that described step one is obtained, dissolve after water-soluble copolymer product 1 weight portion of the powder solid that described step 2 obtains and bisabolol viscous liquid 0.20 weight portion obtained mixing of described step 3, add superfine powder pigment described in 10 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological hypo-allergenic cosmetic composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 150MPa, operating temperature is 20 DEG C.
The obtained hypo-allergenic cosmetic composition of biology is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 3>
A kind of biological hypo-allergenic cosmetic composition, described compositions comprises following component by weight: 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 10 parts, superfine powder pigment 15 parts, bisabolol 0.45 part.
Wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization, acrylamides is acrylamide.
The preparation method of the hypo-allergenic cosmetic composition of described biology, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to the acetonitrile solution of acrylamide, wherein, acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The extraction of step 3, bisabolol: choose the extraction source of Chamomile as bisabolol, bisabolol is extracted, specifically comprise: adopt the bisabolol active component of subcritical alcohol extraction process to Chamomile to carry out extraction and obtain bisabolol extracting solution, adopted by described bisabolol extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain bisabolol viscous liquid, wherein, the alcohol that described subcritical alcohol extraction process adopts is ethanol, Extracting temperature is 145 DEG C, extraction time is 48min, and liquid ratio is 15: 1;
Step 4, the preparation of biological hypo-allergenic cosmetic composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, class mycetocyte element sample aminoacid 85 weight portion that described step one is obtained, dissolve after water-soluble copolymer product 10 weight portion of the powder solid that described step 2 obtains and bisabolol viscous liquid 0.45 weight portion obtained mixing of described step 3, add superfine powder pigment described in 15 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological hypo-allergenic cosmetic composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 180MPa, operating temperature is 25 DEG C.
The obtained hypo-allergenic cosmetic composition of biology is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
Visible, the biological hypo-allergenic cosmetic composition of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in Traditional makeup, adopt Pure natural cosmetic composition, therefore, it is possible to effective protection skin is not by the damage of the foul such as extraneous various ray and grieshoch, adopt biological anti-ultraviolet composition and hypo-allergenic composition, total care is carried out to skin, the crowd of sensitive skin can be widely used in; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising has been carried out to the hypo-allergenic cosmetic composition of biology formed, skin can be absorbed better.Through system destructive testing, to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (9)
1. the hypo-allergenic cosmetic composition of biology, described compositions comprises following component by weight: 70 ~ 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 ~ 10 part, superfine powder pigment 10 ~ 15 parts, bisabolol 0.20 ~ 0.45 part.
2. biological hypo-allergenic cosmetic composition as claimed in claim 1, wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property.
3. biological hypo-allergenic cosmetic composition as claimed in claim 2, wherein, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization.
4. biological hypo-allergenic cosmetic composition as claimed in claim 3, wherein, described acrylamides is the one in acrylamide, N, N-dimethylaminopropylacryl amide and N, N-diethyl amino propyl acrylamide.
5. biological hypo-allergenic cosmetic composition as claimed in claim 1, wherein, the hypo-allergenic cosmetic composition of described biology comprises by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts, bisabolol 0.35 part.
6. a preparation method for the hypo-allergenic cosmetic composition of biology, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to acrylamide, N, N-dimethylaminopropylacryl amide or N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, acrylamide, N, N-dimethylaminopropylacryl amide or N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1 ~ 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The extraction of step 3, bisabolol: choose the extraction source of Chamomile as bisabolol, bisabolol is extracted, specifically comprise: adopt the bisabolol active component of subcritical alcohol extraction process to Chamomile to carry out extraction and obtain bisabolol extracting solution, adopted by described bisabolol extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain bisabolol viscous liquid, wherein, the alcohol that described subcritical alcohol extraction process adopts is ethanol, Extracting temperature is 135 ~ 145 DEG C, extraction time is 48 ~ 50min, and liquid ratio is (13 ~ 15): 1;
Step 4, the preparation of biological hypo-allergenic cosmetic composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, class mycetocyte element sample aminoacid 70 ~ 85 weight portion that described step one is obtained, dissolve after water-soluble copolymer product 1 ~ 10 weight portion of the powder solid that described step 2 obtains and bisabolol viscous liquid 0.20 ~ 0.45 weight portion obtained mixing of described step 3, add superfine powder pigment described in 10-15 weight portion wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological hypo-allergenic cosmetic composition.
7. the preparation method of biological hypo-allergenic cosmetic composition as claimed in claim 6, wherein, in described step 2 acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1.
8. the preparation method of biological hypo-allergenic cosmetic composition as claimed in claim 6, wherein, in described step 3, the Extracting temperature of described subcritical alcohol extraction process is 140 DEG C, and extraction time is 50min, and liquid ratio is 14: 1.
9. the preparation method of biological hypo-allergenic cosmetic composition as claimed in claim 6, wherein, what the ultramicronising in described step 4 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
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