CN105342902A - Biological ultraviolet-proof and sunscreen composition and preparation method thereof - Google Patents
Biological ultraviolet-proof and sunscreen composition and preparation method thereof Download PDFInfo
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- CN105342902A CN105342902A CN201510728126.5A CN201510728126A CN105342902A CN 105342902 A CN105342902 A CN 105342902A CN 201510728126 A CN201510728126 A CN 201510728126A CN 105342902 A CN105342902 A CN 105342902A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The invention provides a biological ultraviolet-proof and sunscreen composition. The biological ultraviolet-proof and sunscreen composition is prepared from the following components in parts by weight: 70-85 parts of mycosporine-like amino acids, 1-10 parts of a water-soluble ultraviolet light absorber, and 10-15 parts of a superfine powder pigment. The invention further provides a preparation method of the biological ultraviolet-proof and sunscreen composition. The biological ultraviolet-proof and sunscreen composition has the beneficial effects of biological ultraviolet-proofing function without chemical stimulation and good water solubility.
Description
Technical field
The present invention relates to sunscreen composition technical field.More particularly, the present invention relates to the biological anti-ultraviolet sunscreen composition with biological anti-ultraviolet and good water solubility excellent specific property.
Background technology
When Ozone hole problem is day by day serious, the ultraviolet radiation (especially UVB) arriving ground and water body is more and more stronger.The effect of the ultraviolet radiation that all aquatiles all may be strengthened day by day, these effects comprise the change of the macromolecular substances such as protein and DNA structure, and the chronic suppression of reacting some key physiological and acute injury etc.
Class mycetocyte element aminoacid be a kind of have uv-protection, with the pure natural anti-ultraviolet biologic artifact of Cutaneous permeation compatibility effect, it exists in a large number in Thallus Porphyrae, and its non-stimulated anti-ultraviolet function be applied in cosmetics exists important value.
Summary of the invention
As the result of various extensive and careful research and experiment, the present inventor has been found that, when adding the natural plant extract of the UV absorbent of pure-natural biological composition containing specific anti-ultraviolet and good water solubility in biological sunscreen composition, described bio-extract component contributes to improving the anti-ultraviolet of sun care preparations and water miscible performance.Based on this discovery, complete the present invention.An object of the present invention is to solve at least the problems referred to above or defect, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide a kind of biological sunscreen composition with anti-ultraviolet, and it by adding the composition of the anti-ultraviolet of biological pure natural, can prevent the damage of outer bound pair skin, to skin without any stimulation, using natural gentleness.
A further object of the invention is by adding Water-soluble UV-absorbents in biological sunscreen composition, improves the water solublity of biological sunscreen composition, additionally by interpolation superfine powder pigment, improves sunscreen composition absorbance in skin.
In order to realize according to these objects of the present invention and other advantage, provide a kind of biological anti-ultraviolet sunscreen composition, described compositions comprises following component by weight: 70 ~ 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 ~ 10 part, superfine powder pigment 10-15 part.
Preferably, wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property.
Preferably, wherein, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization.
Preferably, wherein, described acrylamides is the one in acrylamide, N, N-dimethylaminopropylacryl amide and N, N-diethyl amino propyl acrylamide.
Preferably, wherein, the hypo-allergenic cosmetic composition of described biology comprises by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts.
Object of the present invention still further provides the preparation method of biological anti-ultraviolet sunscreen composition, and described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to acrylamide, N, N-dimethylaminopropylacryl amide or N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, acrylamide, N, N-dimethylaminopropylacryl amide or N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1 ~ 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The preparation of step 3, biological anti-ultraviolet sunscreen composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, water-soluble copolymer product 1 ~ 10 parts by weight of the powder solid that class mycetocyte element sample aminoacid 70 ~ 85 weight portion described step one obtained obtains with described step 2 mixes rear dissolving by a certain percentage, add superfine powder pigment described in 10-15 weight portion wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological anti-ultraviolet sunscreen composition.
Preferably, wherein, in described step 2 acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1.
Preferably, wherein, what the ultramicronising in described step 3 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
The present invention at least comprises following beneficial effect:
The biological sunscreen composition of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in traditional sunscreen composition, the present invention adopts Pure natural cosmetic composition, therefore, it is possible to effective protection skin is not by the damage of the foul such as extraneous various ray and grieshoch, adopt biological anti-ultraviolet composition and Water-soluble UV-absorbents composition, to skin without any stimulation, total care is carried out to skin, the crowd of sensitive skin can be widely used in; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising has been carried out to the biological sun care preparations formed, skin can be absorbed better.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below in conjunction with the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
< example 1>
A kind of biological anti-ultraviolet sunscreen composition, described compositions comprises following component by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts.
Wherein, described Water-soluble UV-absorbents be by 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound with uv absorption property that becomes with acrylamide of benzophenone,
The preparation method of described biological anti-ultraviolet sunscreen composition, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to the acetonitrile solution of acrylamide, wherein, acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
Step 3, the preparation of biological anti-ultraviolet sunscreen composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, water-soluble copolymer product 8 parts by weight of the powder solid that class mycetocyte element sample aminoacid 80 weight portion described step one obtained obtains with described step 2 mixes rear dissolving by a certain percentage, add superfine powder pigment described in 12 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological anti-ultraviolet sunscreen composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 160MPa, operating temperature is 25 DEG C.
Obtained water-soluble biological anti-ultraviolet sunscreen composition is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 2>
A kind of biological anti-ultraviolet sunscreen composition, described compositions comprises following component by weight: 70 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 part, superfine powder pigment 10 parts.
Wherein, described Water-soluble UV-absorbents be by 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound with uv absorption property of benzophenone and N, N-dimethylaminopropylacryl amide copolymerization.
The preparation method of described biological anti-ultraviolet sunscreen composition, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to N, the acetonitrile solution of N-dimethylaminopropylacryl amide, wherein, N, N-dimethylaminopropylacryl amide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
Step 3, the preparation of biological anti-ultraviolet sunscreen composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, water-soluble copolymer product 1 parts by weight of the powder solid that class mycetocyte element sample aminoacid 70 weight portion described step one obtained obtains with described step 2 mixes rear dissolving by a certain percentage, add superfine powder pigment described in 10 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological anti-ultraviolet sunscreen composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 150MPa, operating temperature is 20 DEG C.
Obtained water-soluble biological anti-ultraviolet sunscreen composition is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 3>
A kind of biological anti-ultraviolet sunscreen composition, described compositions comprises following component by weight: 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 10 parts, superfine powder pigment 15 parts.
Wherein, described Water-soluble UV-absorbents be by 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound with uv absorption property that becomes of benzophenone and N, N-diethyl amino propyl acrylamide.
The preparation method of described biological anti-ultraviolet sunscreen composition, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 14: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
Step 3, the preparation of biological anti-ultraviolet sunscreen composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, water-soluble copolymer product 10 parts by weight of the powder solid that class mycetocyte element sample aminoacid 85 weight portion described step one obtained obtains with described step 2 mixes rear dissolving by a certain percentage, add superfine powder pigment described in 15 weight portions wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological anti-ultraviolet sunscreen composition, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 180MPa, operating temperature is 25 DEG C.
Obtained water-soluble biological anti-ultraviolet sunscreen composition is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
Visible, the biological sunscreen composition of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in traditional sunscreen composition, the present invention adopts Pure natural cosmetic composition, therefore, it is possible to effective protection skin is not by the damage of the foul such as extraneous various ray and grieshoch, adopt biological anti-ultraviolet composition and Water-soluble UV-absorbents composition, to skin without any stimulation, total care is carried out to skin, the crowd of sensitive skin can be widely used in; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising has been carried out to the biological sun care preparations formed, skin can be absorbed better.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (8)
1. a biological anti-ultraviolet sunscreen composition, described compositions comprises following component by weight: 70 ~ 85 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 1 ~ 10 part, superfine powder pigment 10-15 part.
2. biological anti-ultraviolet sunscreen composition as claimed in claim 1, wherein, described Water-soluble UV-absorbents is the water-soluble high-molecular compound with uv absorption property.
3. biological anti-ultraviolet sunscreen composition as claimed in claim 2, wherein, described water-soluble high-molecular compound be 2-hydroxyl-4-acrylate-based-water-soluble high-molecular compound of benzophenone and acrylamides copolymerization.
4. biological anti-ultraviolet sunscreen composition as claimed in claim 3, wherein, described acrylamides is the one in acrylamide, N, N-dimethylaminopropylacryl amide and N, N-diethyl amino propyl acrylamide.
5. biological anti-ultraviolet sunscreen composition as claimed in claim 1, wherein, the hypo-allergenic cosmetic composition of described biology comprises by weight: 80 parts, class mycetocyte element sample aminoacid, Water-soluble UV-absorbents 8 parts, superfine powder pigment 12 parts.
6. a preparation method for biological anti-ultraviolet sunscreen composition, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
Step 2, the synthesis of Water-soluble UV-absorbents: by acrylate-based for a certain amount of 2-hydroxyl-4--benzophenone is dissolved in anhydrous acetonitrile, under the protection of nitrogen, be warming up to 75 ~ 80 DEG C, add the acetonitrile solution of the azodiisobutyronitrile of catalytic amount, be added dropwise to acrylamide, N, N-dimethylaminopropylacryl amide or N, the acetonitrile solution of N-diethyl amino propyl acrylamide, wherein, acrylamide, N, N-dimethylaminopropylacryl amide or N, N-diethyl amino propyl acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 12: 1 ~ 16: 1, reaction proceeds to not till generation precipitation, filter, use 100mL ethanol and 150mL washing with acetone filter cake successively, it is dry that filter cake after washing is placed in vacuum drying oven, obtain the water-soluble copolymer product of powder solid,
The preparation of step 3, biological anti-ultraviolet sunscreen composition: select surface to be coated with the superfine powder titanium dioxide of ferrum oxide as superfine powder pigment, water-soluble copolymer product 1 ~ 10 parts by weight of the powder solid that class mycetocyte element sample aminoacid 70 ~ 85 weight portion described step one obtained obtains with described step 2 mixes rear dissolving by a certain percentage, add superfine powder pigment described in 10-15 weight portion wherein, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological anti-ultraviolet sunscreen composition.
7. the preparation method of biological anti-ultraviolet sunscreen composition as claimed in claim 6, wherein, in described step 2 acrylamide and 2-hydroxyl-4-acrylate-based-mol ratio of benzophenone is 16: 1.
8. the preparation method of biological anti-ultraviolet sunscreen composition as claimed in claim 6, wherein, what the ultramicronising in described step 3 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101061995A (en) * | 2007-05-22 | 2007-10-31 | 汕头大学 | Cosmetic including natural substance having sun-screening function |
| GB2472021A (en) * | 2009-07-21 | 2011-01-26 | Jurlique R & D Pty Ltd | Cosmetic sunscreen composition |
| CN102727411A (en) * | 2012-07-11 | 2012-10-17 | 福建春伦茶业集团有限公司 | Sun cream formula based on natural plant components and preparation method of sun cream formula |
| CN103340798A (en) * | 2013-07-15 | 2013-10-09 | 福州萍晴日用化妆品有限公司 | Natural plant sun cream and preparation process thereof |
-
2015
- 2015-10-31 CN CN201510728126.5A patent/CN105342902A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101061995A (en) * | 2007-05-22 | 2007-10-31 | 汕头大学 | Cosmetic including natural substance having sun-screening function |
| GB2472021A (en) * | 2009-07-21 | 2011-01-26 | Jurlique R & D Pty Ltd | Cosmetic sunscreen composition |
| CN102727411A (en) * | 2012-07-11 | 2012-10-17 | 福建春伦茶业集团有限公司 | Sun cream formula based on natural plant components and preparation method of sun cream formula |
| CN103340798A (en) * | 2013-07-15 | 2013-10-09 | 福州萍晴日用化妆品有限公司 | Natural plant sun cream and preparation process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 秦吉喜: "水溶性高分子紫外线吸收剂的合成与性能", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
| 陶岑: "类菌胞素氨基酸（MAAs）Porphyra-334的提取及其新功能研究", 《中国学位论文全文数据库》 * |
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