CN105219636B - 一种药敏板条及其制备方法 - Google Patents
一种药敏板条及其制备方法 Download PDFInfo
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- CN105219636B CN105219636B CN201510675384.1A CN201510675384A CN105219636B CN 105219636 B CN105219636 B CN 105219636B CN 201510675384 A CN201510675384 A CN 201510675384A CN 105219636 B CN105219636 B CN 105219636B
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- 239000003814 drug Substances 0.000 title claims abstract description 254
- 229940079593 drug Drugs 0.000 title claims abstract description 198
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000003908 quality control method Methods 0.000 claims abstract description 36
- 238000010790 dilution Methods 0.000 claims abstract description 15
- 239000012895 dilution Substances 0.000 claims abstract description 15
- 230000003115 biocidal effect Effects 0.000 claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims description 20
- 229940088710 antibiotic agent Drugs 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 12
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 238000007605 air drying Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- SJHPCNCNNSSLPL-CSKARUKUSA-N (4e)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical compound O1C(=O)C(=C/OCC)\N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-CSKARUKUSA-N 0.000 claims 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims 1
- 229960003022 amoxicillin Drugs 0.000 claims 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims 1
- 229960000723 ampicillin Drugs 0.000 claims 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims 1
- VYVRIXWNTVOIRD-LRHBOZQDSA-N ciguatoxin CTX1B Chemical compound C([C@@]12[C@@H](C)[C@@H]([C@@H]3[C@H]([C@H]([C@H](C)[C@H]4O[C@H]5C[C@@H](C)C[C@H]6O[C@@]7(C)[C@H](O)C[C@H]8O[C@H]9C=C[C@H]%10O[C@H]%11C[C@@H]%12[C@H]([C@@H]([C@H]%13O[C@H](C=CC[C@@H]%13O%12)\C=C\[C@H](O)CO)O)O[C@@H]%11C=C[C@@H]%10O[C@@H]9C\C=C/C[C@@H]8O[C@@H]7C[C@@H]6O[C@@H]5C[C@@H]4O3)O)O2)C)[C@H](O)CO1 VYVRIXWNTVOIRD-LRHBOZQDSA-N 0.000 claims 1
- 229960002182 imipenem Drugs 0.000 claims 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims 1
- 229960002292 piperacillin Drugs 0.000 claims 1
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 claims 1
- ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 claims 1
- 229960004659 ticarcillin Drugs 0.000 claims 1
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 21
- 230000035945 sensitivity Effects 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 description 32
- 238000000034 method Methods 0.000 description 12
- 229920001817 Agar Polymers 0.000 description 7
- 239000008272 agar Substances 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 6
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 5
- 229930182566 Gentamicin Natural products 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 5
- 229960002518 gentamicin Drugs 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 description 4
- 229960002100 cefepime Drugs 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 238000003113 dilution method Methods 0.000 description 3
- 238000010894 electron beam technology Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 238000002814 agar dilution Methods 0.000 description 2
- 238000002815 broth microdilution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010042566 Superinfection Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001596 poly (chlorostyrenes) Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (20)
Priority Applications (1)
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CN201510675384.1A CN105219636B (zh) | 2015-10-19 | 2015-10-19 | 一种药敏板条及其制备方法 |
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CN201510675384.1A CN105219636B (zh) | 2015-10-19 | 2015-10-19 | 一种药敏板条及其制备方法 |
Publications (2)
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CN105219636A CN105219636A (zh) | 2016-01-06 |
CN105219636B true CN105219636B (zh) | 2018-03-20 |
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CN201510675384.1A Active CN105219636B (zh) | 2015-10-19 | 2015-10-19 | 一种药敏板条及其制备方法 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109330988A (zh) * | 2018-11-14 | 2019-02-15 | 广西达庆生物科技有限公司 | 一种含有抗菌药物的药敏胶囊及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN2544282Y (zh) * | 2002-04-26 | 2003-04-09 | 莱芜钢铁集团有限公司医院 | 可拆装组合的微量稀释药敏试剂盒 |
CN201107274Y (zh) * | 2007-11-20 | 2008-08-27 | 郑州安图绿科生物工程有限公司 | 一种支原体药敏检测板 |
CN202279818U (zh) * | 2011-11-09 | 2012-06-20 | 黑龙江八一农垦大学 | 液面可视及放置稳定的pcr管支撑托架 |
CN103088102B (zh) * | 2013-01-09 | 2015-05-20 | 苏州麦克威尔生物医药科技有限公司 | 一种无菌速溶型药膜及其肿瘤药敏测试用途 |
CN103233058A (zh) * | 2013-05-01 | 2013-08-07 | 苏州麦克威尔生物医药科技有限公司 | 一种测试抗菌药物对病原微生物敏感性的方法 |
CN103454414B (zh) * | 2013-09-25 | 2015-04-01 | 河南科技大学 | 一种96孔反应板 |
CN103820310B (zh) * | 2014-02-15 | 2017-11-07 | 江苏中新医药有限公司 | 一种药物敏感试验用浓度梯度检测试剂盒与测试方法 |
CN205115476U (zh) * | 2015-10-19 | 2016-03-30 | 山东鑫科生物科技股份有限公司 | 一种药敏板条 |
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2015
- 2015-10-19 CN CN201510675384.1A patent/CN105219636B/zh active Active
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
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GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210918 Address after: 100176 China Aviation Technology Plaza, Daxing District Economic and Technological Development Zone, Beijing a603 Patentee after: BEIJING XINJI JINNUO MEDICAL EQUIPMENT Co.,Ltd. Patentee after: PEKING UNION MEDICAL COLLEGE Hospital Address before: 252000 East head of Weier Road, Fenghuang Industrial Park, Liaocheng City, Shandong Province Patentee before: SHANDONG XINKE BIOLOGICAL TECHNOLOGY Co.,Ltd. Patentee before: PEKING UNION MEDICAL COLLEGE Hospital |
|
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Xu Yingchun Inventor after: Pang Chao Inventor after: Xiao Meng Inventor after: Zhang Huicui Inventor after: Zhao Ying Inventor after: Guo Lina Inventor after: Lu Ming Inventor after: Zhao Jiabin Inventor after: Cui Chenbo Inventor before: Xu Yingchun Inventor before: Pang Chao Inventor before: Xiao Meng Inventor before: Zhang Huicui Inventor before: Zhao Ying Inventor before: Guo Lina Inventor before: Lu Ming Inventor before: Zhao Jiabin Inventor before: Cui Chenbo |
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PP01 | Preservation of patent right | ||
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Effective date of registration: 20240205 Granted publication date: 20180320 |