CN105213977A - A kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type - Google Patents
A kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type Download PDFInfo
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Abstract
The invention discloses a kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type, comprise cap, the two ends of cap are provided with medicine bag, medicine bag is built with ZHICHUANG GAO, wherein, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-40g of the Radix Aucklandiae, the each 10-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-15g; The middle part of cap is gradually thin, the outer wrap of the medicine bag of cap side has administration head in anus, anus external administration head is enclosed with in the medicine bag of the opposite side of cap, in anus administration head, anus external administration head wall on be integratedly provided with some dosing holes, be connected between dosing holes and corresponding medicine bag, in anus, the front end of administration head is integrated is provided with the expansion wing, launches to be provided with soft plastic layer between the wing and medicine bag outer wall.Proportioning of the present invention is simple, and easy to use, for damp heat downward flowing type hemorrhoid, the effective speed of external is fast.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type.
Background technology
Hemorrhoid (being commonly called as hemorrhoid) are a kind of common diseases being positioned at anus position, and any age all can fall ill, but with age, sickness rate increases gradually.Hemorrhoid are divided into internal hemorrhoid, external hemorrhoid, mixed hemorrhoid by the difference of happening part.A jagged visible line is had anal canal pectinate line in the junction of anal canal skin and rectal mucosa.Is internal hemorrhoid more than pectinate line, the supporting structure of anus pad, venous plexus and arteriovenous anastomosis Zhi Fasheng pathological change or displacement, coating rectal mucosa, because internal sphincter shrinks, anus pad is divided into left side, forward right side, right lateral side three pieces with Y type ditch, and therefore internal hemorrhoid is common in left side, forward right side and right lateral side; Be external hemorrhoid below pectinate line, coating anal canal mucosa, can be divided into connective tissue external hemorrhoid, varicose external hemorrhoid, thrombosed external hemorrhoid; What have internal hemorrhoid and external hemorrhoid concurrently is mixed hemorrhoid, is that internal hemorrhoid is merged by venous plexus and corresponding external hemorrhoid, and namely upper and lower venous plexus is identical, and mixed hemorrhoid is deviate from outside anus, during in plum blossom-shaped, is called annular hemorrhoid, if by sphincter incarceration, and formation strangulated hemorrhoid.Ancient times advocate " heat-clearing and toxic substances removing, cooling blood and dissolving stasis to Zhiduo County in hemorrhoid." Song dynasty Dou Han minister in ancient times says in " skin infection experience pandect ": " and with all hemorrhoid, all kinds of difference ... more than half based on removing heat from blood, slowly get effect." the Yuan Dynasty Zhu Zhenheng advocate " hemorrhoid are specially based on removing heat from blood " (" danxi's experiential therapy ").Liu Yuansu calls: " burnt when rushing down three, intimately move back, gold is brought about the desired sensation and breaks through wood, the restricted then five worm not lifes of wood, hemorrhoid have more " (" interchannel medical science. hemorrhoid opinion ").Dong Yuan, son and also think there is fire, has heat.Treatment is used acupuncture and moxibusion, ledebouriellae and Gentianae Macrophyllae Decoction, pain relieving as refreshing soup etc., main with heat clearing and blood cooling, dehumidifying blood stasis dispelling.These method for the treatment of in clinical, determined curative effect.But have because of wind, wet, dry, hot and patient clinically; There is deficiency of both QI and blood, spleen, lung, to suffer from a deficiency of the kidney and patient; There is simulataneous insufficiency and excessive person.So just should treat with card in treatment, should righting, eliminating evil again.Chinese traditional treatment hemorrhoid are emphasize the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, select suitable prescriptions of Chinese medicine exactly according to the body constitution of patient and symptom.The qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the traditional Chinese medical science improves the blood-activating and stasis-removing (as: Radix Angelicae Sinensis, Flos Carthami) of blood circulation effect by tool usually to the treatment of hemorrhoid, the heat clearing and damp drying of the clear scorching effect of tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.This omnipotent side's effect is not omnipotent, if not to type, then produces little effect.
Hemorrhoid are caused a disease because being divided into several type by modern Chinese medicine: as, wind hinders intestinal network, damp invasion of lower energizer, qi depression to blood stasis, sinking of QI due to deficiency of the spleen, deficiency of YIN dryness of the intestine etc., and causing a disease because of difference, then method for making is different.For the type of damp invasion of lower energizer, patient's color of having blood in stool is scarlet, measures more, and in anus, swollen beyond the region of objective existence takes off, and can bounce back voluntarily, or emersion object transudate is more, mucosal erosion, or companion stool is viscid not well, burning sensation of the anus, moist uncomfortable, red tongue, yellow and greasy fur, soft and rapid pulse or sliding number.Method for the treatment of: heat clearing away eliminating dampness by diuresis is stopped blooding.The decoction of taking of prior art is, square medicine: Rhizoma Dioscoreae Septemlobae eliminating dampness by diuresis soup.Rhizoma Dioscoreae Septemlobae divides Qinghua turbid; Cortex Moutan clearing away liver-fire and the hemostasis of removing heat from blood repercussive, Cortex Phellodendri is wet with hardship victory, with cold heat clearing away; Poria, Semen Coicis, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis are with light eliminating dampness by diuresis.All medicines share, and play the merit of heat clearing away eliminating dampness by diuresis hemostasis altogether.But oral result is slow.In view of this technical problem, need to occur that a kind of proportioning is simple, easy to use, for damp heat downward flowing type hemorrhoid, the effective fireballing a kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type of external.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of proportioning simple, easy to use, for damp heat downward flowing type hemorrhoid, and the effective fireballing a kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type of external.
For solving this object, the invention discloses a kind of hemorrhoid external plaster for the treatment of damp heat downward flowing type, comprise cap, the two ends of cap are provided with medicine bag, medicine bag is built with ZHICHUANG GAO, wherein, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-40g of the Radix Aucklandiae, the each 10-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-15g;
The middle part of cap is gradually thin, the outer wrap of the medicine bag of cap side has administration head in anus, anus external administration head is enclosed with in the medicine bag of the opposite side of cap, administration head in anus, integratedly on the wall of anus external administration head be provided with some dosing holes, be connected between dosing holes and corresponding medicine bag, in anus, the front end of administration head is integrated is provided with the expansion wing, launch to be provided with soft plastic layer between the wing and medicine bag outer wall, the end of anus external administration head is integrated is provided with shrouding, shrouding is ellipticity, administration head in anus, anus external administration head is rubber, administration head in anus, be adhesively fixed between anus external administration head and cap.
Further, capsule built with 10-20g ointment.
The medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-50g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-30g of the Radix Aucklandiae, the each 10-15g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-12g.
The medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 50-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 30-40g of the Radix Aucklandiae, the each 15-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12-15g.
In order to better realize the object of the invention, the present invention has the preparation method of the hemorrhoid external plaster disclosing treatment damp heat downward flowing type, as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
Ointment of the present invention, clearing heat and expelling damp to medical gypsum, Rhizoma Atractylodis, warming middle-JIAO hemostasis be monarch drug to medicine Radix Aconiti Lateralis Preparata, humus flava usta, break full of the medicine Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae with spleen invigorating, warming middle-JIAO to promote flow of QI to medicine Cortex Cinnamomi, Pericarpium Citri Reticulatae, clearing gallbladder purge heat to medicine Radix Gentianae, Radix Bupleuri, benefiting qi and raising yang to the medicine Radix Astragali, Rhizoma Cimicifugae, warming middle-JIAO to relieve pain be ministerial drug to medicine Fructus Amomi, the Radix Aucklandiae, with the Semen Cassiae of intestine moistening, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, the Qin Jiu of damp eliminating removing toxic substances, Herba Siegesbeckiae, the Cornu Bubali of clearing away heat and cooling blood, Herba Artemisiae Annuae is adjuvant drug; With Flos Chrysanthemi for making medicine.
Proportioning of the present invention is simple, and easy to use, for damp heat downward flowing type hemorrhoid, the effective speed of external is fast.When the present invention uses, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The mode of this inside and outside directly administration of the present invention, except being directly administered into focus, can also partly by intestinal absorption, therapeutic effect is good, and responding time is fast.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present invention.
Fig. 2 is Fig. 1 side-looking direction schematic diagram.
Detailed description of the invention
As Figure 1-Figure 2, Fig. 1 is structural representation of the present invention.Fig. 2 is Fig. 1 side-looking direction schematic diagram.
The present invention treats the hemorrhoid external plaster of damp heat downward flowing type, comprise cap 5, the two ends of cap 5 are provided with medicine bag 7, medicine bag 7 is built with ZHICHUANG GAO, wherein, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-40g of the Radix Aucklandiae, the each 10-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-15g;
The middle part of cap 5 is gradually thin, the outer wrap of the medicine bag 7 of cap 5 side to have in anus administration 3, anus external administration head 6 is enclosed with in the medicine bag 7 of the opposite side of cap 5, administration 3 in anus, integratedly on the wall of anus external administration head 6 be provided with some dosing holes 4, be connected between dosing holes 4 and corresponding medicine bag 7, in anus, integrated being provided with in the front end of administration 3 launches the wing 1, launch to be provided with soft plastic layer 2 between the wing 1 and medicine bag 7 outer wall, the end of anus external administration head 6 is integrated is provided with shrouding 8, shrouding 8 is ellipticity, administration 3 in anus, anus external administration head 6 is rubber, administration 3 in anus, be adhesively fixed between anus external administration head 6 and cap.
Further, capsule built with 10-20g ointment.
Or, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-50g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-30g of the Radix Aucklandiae, the each 10-15g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-12g.
Or, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 50-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 30-40g of the Radix Aucklandiae, the each 15-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12-15g.
The hemorrhoid external plaster for the treatment of damp heat downward flowing type, it is characterized in that, preparation method is as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
Comparative test:
Modling model, get 50 rats, male and female are random, and the end grass in rat nest drenches, and repeatedly feeding, after rat anesthesia, anal downward rectal mucosa seromuscular layer injects 1% carrageenin 0.1mL, respectively at 6,24,48,72,96h compasses measure the diameter of whole perianal tissue swelling, get the average of long and short two diameter, as the index of measured swelling degree, after 6 days, swelling anus place's swelling 1 is doubly had a surplus, and model is one-step forming just.After this stop injecting carrageenin, adhere to every day interval 2 hours in nest near water, and maintain temperature 25 degrees Celsius in nest, after 12d, get a rat and do rectum film-making.Histological indications shows: have a large amount of single-column columnar epithelium cell detachment, the visible pus stove of mucosa is formed, body of gland goblet cell reduces, a large amount of neutrophil infiltration and ulcer a large amount of or in blocks between body of gland, also significantly swelling around serous coat under mucosa, normal mucosa wrinkle wall disappears, and mucosal epithelial cells activity reduces, vasodilation under sticking to mould, and have leukocyte and fibrin to infiltrate.Observe rat, find rat have blood in stool, color is scarlet, measures more, anus swell beyond the region of objective existence take off, emersion object transudate is more, mucosal erosion, burning sensation of the anus.Namely after 12d, damp invasion of lower energizer Establishment of Rat Model.
Get 40 in 50 rat models, be divided into four groups at random, first group uses the present invention, make the cap of the present invention of ting model, smear ointment of the present invention inside and outside anus simultaneously, be preferably (each 50g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 30g of the Radix Aucklandiae, the each 15g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster; )
Second group uses the general prescription of background technology: the qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the heat clearing and damp drying of the clear scorching effect of (as: Radix Angelicae Sinensis, Flos Carthami), tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.Decoct as decoction, every day feeding three times, each 5ml.
3rd group uses the general prescription of background technology: the qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the heat clearing and damp drying of the clear scorching effect of (as: Radix Angelicae Sinensis, Flos Carthami), tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.According to preparation method preparation of the present invention in ointment, smear in anus, outside anus simultaneously.
4th group uses the decoction oral in background technology, as: acupuncture and moxibusion.Fang Xie: with Radix Rehmanniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra removing heat from blood and blood in side; Radix Scutellariae, Rhizoma Coptidis, Radix Trichosanthis clearing away heat-fire; Radix Sanguisorbae, the Fructus Sophorae can the fire of clear large intestine and cooling blood for hemostasis, are equipped with Rhizoma Cimicifugae, Radix Glycyrrhizae etc. with heat-clearing and toxic substances removing; Herba Schizonepetae expelling pathogenic wind from the body surface, cooling blood for hemostasis.Decoct as decoction, every day feeding three times, each 5ml.
Above-mentioned four groups of administrations are after 8 days
| group | symptom | rectum is cut into slices |
| first group | only, swelling disappears anus blood, and mucosa wrinkle wall recovers normal, and mucosal epithelial cells activation recovering, rectal temperature is as usual. | epithelial cell, the numerical value of body of gland goblet cell is within normal range, and neutrophil is even infiltration. |
| second group | anus swelling is progressively disappeared, vasodilation under sticking to mould, and intumescence has outer de-, and with transudate, blood does not stop.Rectal temperature is high. | mucosa is rotten to the corn as seen, and goblet cell reduces, and a large amount of neutrophil infiltration, intercellular substance comes off. |
| 3rd group | only, slightly with swelling, mucosal epithelium still has ulcer to hepatic portal blood, and rectal temperature is micro-high. | accidental neutrophil infiltration between body of gland, Interstitial edema, goblet cell reduces, and ulcer is few. |
| 4th group | anus swelling is disappeared substantially, vasodilation under sticking to mould, and with mucosal erosion, intumescence has outer de-, and with transudate.Rectal temperature is high. | mucosa is rotten to the corn as seen, and goblet cell reduces, and a large amount of neutrophil infiltration, intercellular substance comes off. |
By upper table comparison, can find, just use direct administration for first group, the 3rd group, effective directly to medicinal medicine for focus, but the 3rd group of therapeutic effect is not enough.To first group, second group, the 3rd group these three groups are carried out blood examination discovery upon administration half an hour:
The blood of first group, second group all detects, alkaloids active component, glycoside active component, terpenoid active component, lactone active component, alcohol, aldehyde and ketone active component, organic acid active component, phenolic active components.But the numerical value of first group is between the 1/2-3/4 of second group of numerical value, that is, blood drug level is not as second group.And the blood examination of the 3rd group, only detected alkaloids active component, glycoside active component, terpenoid active component, lactone active component, alcohol, organic acid active component, and blood drug level is the 1/8-1/5 of second group of numerical value.Can infer, launch the wing and scraped by the fold of one section of rectal wall, be blocked in by feces and launch outside the wing, what improve injury and intestinal absorbs situation, and ointment of the present invention is more direct for such hemorrhoid effect.
Object lesson 1
Feng, clerk, long-term sitting, humid day internal hemorrhoid with prolapse of rectum skin ulcer recurs, and patient's color of having blood in stool is scarlet, measure more, in anus, swollen beyond the region of objective existence takes off, and emersion object transudate is more, mucosal erosion, and companion stool is viscid not well, burning sensation of the anus, moist uncomfortable, red tongue, yellow and greasy fur, soft and rapid pulse or sliding number.
Use the present invention: each 50g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 30g of the Radix Aucklandiae, the each 15g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 10 days, replys as usual.Visit after half a year, period recurrence once, uses the present invention to reply again after 6 days as usual during recurrence.
Example 2
Week certain, slaughter hall workman, is in hygrothermal environment throughout the year, and patient's color of having blood in stool is scarlet, measures more, and in anus, swollen beyond the region of objective existence takes off, and emersion object transudate is more, mucosal erosion, and companion stool is viscid not well, burning sensation of the anus, moist uncomfortable, red tongue, yellow and greasy fur, soft and rapid pulse or sliding number.
Use the present invention: each 45g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 35g of the Radix Aucklandiae, the each 16g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 9 days, replying as usual, visits after half a year, without recurrence.
Example 3
Lee, publilc baths workman, is in hygrothermal environment throughout the year, and patient's color of having blood in stool is scarlet, measures more, and in anus, swollen beyond the region of objective existence takes off, and can bounce back voluntarily, mucosal erosion, defecates viscid not well, burning sensation of the anus, moist uncomfortable, red tongue, yellow and greasy fur, soft and rapid pulse or sliding number.
Use the present invention: each 40g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25g of the Radix Aucklandiae, the each 10g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 12 days, replys as usual, visits after three months, without recurrence.
The plaster of object lesson 1: screen 160 routine patients in 4 hospitals, before test 1 week, carries out Continuous Observation to this crowd, record symptom and change, be divided into two groups, experimental group and matched group at random, experimental group uses embodiment 1 products obtained therefrom, and matched group takes the general prescription in background technology
Curative effect situation criterion: cure: after using this product, swelling disappears, and only, ulcer surface disappears blood, and defecation is normal; Effective: after taking and using this product, malaise symptoms makes moderate progress, blood only; Invalid: after using this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1:
| Group | Drug categories | Case load | Efficiently individual quantity | Healing number | Invalid number | Recurrence number | Cure rate | Total effective rate |
| Matched group | General prescription in background technology | 80 | 60 | 28 | 20 | 22 | 35% | 80% |
| Experimental group | The present invention | 80 | 77 | 71 | 3 | 6 | 88.7% | 96.2% |
Ointment of the present invention, clearing heat and expelling damp to medical gypsum, Rhizoma Atractylodis, warming middle-JIAO hemostasis be monarch drug to medicine Radix Aconiti Lateralis Preparata, humus flava usta, break full of the medicine Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae with spleen invigorating, warming middle-JIAO to promote flow of QI to medicine Cortex Cinnamomi, Pericarpium Citri Reticulatae, clearing gallbladder purge heat to medicine Radix Gentianae, Radix Bupleuri, benefiting qi and raising yang to the medicine Radix Astragali, Rhizoma Cimicifugae, warming middle-JIAO to relieve pain be ministerial drug to medicine Fructus Amomi, the Radix Aucklandiae, with the Semen Cassiae of intestine moistening, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, the Qin Jiu of damp eliminating removing toxic substances, Herba Siegesbeckiae, the Cornu Bubali of clearing away heat and cooling blood, Herba Artemisiae Annuae is adjuvant drug; With Flos Chrysanthemi for making medicine.
Proportioning of the present invention is simple, and easy to use, for damp heat downward flowing type hemorrhoid, the effective speed of external is fast.When the present invention uses, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The mode of this inside and outside directly administration of the present invention, except being directly administered into focus, can also partly by intestinal absorption, therapeutic effect is good, and responding time is fast.
Claims (4)
1. treat the hemorrhoid external plaster of damp heat downward flowing type for one kind, comprise cap (5), the two ends of cap (5) are provided with medicine bag (7), medicine bag (7) is built with ZHICHUANG GAO, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-40g of the Radix Aucklandiae, the each 10-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-15g;
The middle part of cap (5) is gradually thin, the outer wrap of the medicine bag (7) of cap (5) side has administration head (3) in anus, anus external administration head (6) is enclosed with in the medicine bag (7) of the opposite side of cap (5), administration head (3) in anus, integratedly on the wall of anus external administration head (6) be provided with some dosing holes (4), be connected between dosing holes (4) with corresponding medicine bag (7), in anus, integrated being provided with in the front end of administration head (3) launches the wing (1), launch to be provided with soft plastic layer (2) between the wing (1) and medicine bag (7) outer wall, the end of anus external administration head (6) is integrated is provided with shrouding (8), shrouding (8) is ellipticity, administration head (3) in anus, anus external administration head (6) is rubber, administration head (3) in anus, be adhesively fixed between anus external administration head (6) and cap.
2. treat the hemorrhoid external plaster of damp heat downward flowing type according to claim 1, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 40-50g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 25-30g of the Radix Aucklandiae, the each 10-15g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 10-12g.
3. treat the hemorrhoid external plaster of damp heat downward flowing type according to claim 1, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: each 50-60g of Gypsum Fibrosum, Rhizoma Atractylodis, Radix Aconiti Lateralis Preparata, humus flava usta, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Radix Gentianae, Radix Bupleuri, the Radix Astragali, Rhizoma Cimicifugae, Fructus Amomi, each 30-40g of the Radix Aucklandiae, the each 15-20g of Semen Cassiae, Semen Pruni, Radix Polygoni Multiflori, Herba Cistanches, Qin Jiu, Herba Siegesbeckiae, Cornu Bubali, Herba Artemisiae Annuae, Flos Chrysanthemi 12-15g.
4., according to the hemorrhoid external plaster of the arbitrary described treatment damp heat downward flowing type of claim 1-3, it is characterized in that, preparation method is as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152331A (en) * | 2007-09-18 | 2008-04-02 | 尹克山 | Traditional Chinese medicine for treating Qi asthenia type hemorrhoid hemorrhage |
| CN201414996Y (en) * | 2009-03-13 | 2010-03-03 | 赵学 | Procto disease treatment and procto health care device |
| CN103070954A (en) * | 2013-01-12 | 2013-05-01 | 张石柱 | Traditional Chinese medicine powder for treating haemorrhoids and preparation method of same |
| CN104027576A (en) * | 2014-06-19 | 2014-09-10 | 杨邱月 | Preparation for treating third-stage internal hemorrhoid and capable of promoting blood circulation and eliminating dampness and production method of preparation |
| CN204619147U (en) * | 2015-03-11 | 2015-09-09 | 石福英 | A kind of gynaecology medicine-applying device |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152331A (en) * | 2007-09-18 | 2008-04-02 | 尹克山 | Traditional Chinese medicine for treating Qi asthenia type hemorrhoid hemorrhage |
| CN201414996Y (en) * | 2009-03-13 | 2010-03-03 | 赵学 | Procto disease treatment and procto health care device |
| CN103070954A (en) * | 2013-01-12 | 2013-05-01 | 张石柱 | Traditional Chinese medicine powder for treating haemorrhoids and preparation method of same |
| CN104027576A (en) * | 2014-06-19 | 2014-09-10 | 杨邱月 | Preparation for treating third-stage internal hemorrhoid and capable of promoting blood circulation and eliminating dampness and production method of preparation |
| CN204619147U (en) * | 2015-03-11 | 2015-09-09 | 石福英 | A kind of gynaecology medicine-applying device |
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| 屠佑堂: "《中医使用诊疗大全》", 31 March 2013, 湖北科学技术出版社 * |
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Effective date of registration: 20190115 Address after: 510470 Third Industrial Zone of Renzhen Aigang Village, Baiyun District, Guangzhou City, Guangdong Province Applicant after: Baicaotang pharmaceutical Limited by Share Ltd Address before: 266000 Zhenye Building, Market Second Road, North District, Qingdao City, Shandong Province 1044 Applicant before: Sun Guizhi |
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